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| 1 | Highly sensitive and miniature microfiber-based ultrasound sensor for photoacoustic tomography显示文摘A microfiber with large evanescent field encapsulated in PDMS is proposed and demonstrated for ultrasound sensing.The compact size and large evanescent field of microfiber provide an excellent platform for the interaction between optical signal and ultrasound wave,exhibiting a high sensitivity of 3.5 mV/kPa,which is approximately 10 times higher than the single-mode fiber sensor.Meanwhile,a phase feedback stabilization module is introduced into the coherent demodulation system for long-term stable measurement.In addition,a photoacoustic tomography experiment with the microfiber ultrasound sensor is implemented to verify the excellent performance on imaging,with the depth of 12 mm,the highest lateral resolution of 65μm and axial resolution of 250μm,respectively.The highly sensitive microfiber ultrasound sensor provides a competitive alternative for various applications,such as industrial non-destructive testing,biomedical ultrasound and photoacoustic imaging. | Liuyang Yang Yanpeng Li Fang Fang Liangye Li Zhijun Yan Lin Zhang Qizhen Sun | 2022 | Opto-Electronic Advances2022，5，6： | 5 |
| 2 | Wearable Alignment‑Free Microfber‑Based Sensor Chip for Precise Vital Signs Monitoring and Cardiovascular Assessment显示文摘Continuous pulse wave signals monitoring is the essential basis for clinical cardiovascular diagnosis and treatment.Recent researches show the majority of current electronic pulse sensors usually face challenges in electrical safety concern,poor durability and demanding precision in position alignment.Thus,a highly sensitive,inherently electrical safe,robust and alignment-free device is highly desired.Here,we present a wearable alignment-free microfber-based sensor chip(AFMSC)for precise vital signs monitoring and cardiovascular health assessment.The AFMSC comprises an optical micro/nano fber sensor(MNF)and a fexible soft liquid sac while the MNF sensor is used to perceive the physiological signals and the liquid sac is used to eliminate the misalignment.The real-time and accurate monitoring of the pulse signals was realized by tracking the optical power variation of transmitted light from MNF.Then,the cardiovascular vital signs extracted from radial artery pulse signals were used to evaluate cardiovascular health condition and the results were in accordance with human physiological characteristics.Moreover,the pulse signals from diferent arterial area,the respiration signals from chest and the radial pulse signals before and after exercise were detected and analyzed.The non-invasive,continuous and accurate monitoring of cardiovascular health based on the reported wearable and alignment-free device is promising in both ftness monitoring and medical diagnostics for cardiovascular disease prevention and diagnosis. | Liangye Li Yunfei Liu Changying Song Shunfeng Sheng Liuyang Yang Zhijun Yan Dora Juan Juan Hu Qizhen Sun | 2022 | Advanced Fiber Materials2022，4，3： | 5 |
| 3 | Optical Microfber Neuron for Finger Motion Perception显示文摘To achieve dexterous motion controlling of robot,the sensors that function like human neurons for motion perception are essential.In this work,a silica microfber probe-based optical neuron(MPON)for robot fnger motion detection is proposed.The silica microfber probe was fabricated by snapping a biconical silica optical microfber that drawn from the standard optical fbre.Then it was embedded into thin polydimethylsiloxane(PDMS)to detect and recognize motions of robotic fnger.Specifcally,a PDMS-Tefon-Microfber-Tefon-PDMS composite structure was prepared to protect the waveguide structure of silica microfber probe and avoid the environmental pollution.With the help of this composite structure,the proposed MPON achieved the accurate measurement of bending angle with large range and fast response.The repeatability and stability of MPON were also investigated.Additionally,diferent fnger motions were successfully distinguished through observing the output power variation of MPON.The proposed MPON could serve as the perceptron of robot hand,which could be applied in dexterous gesture control even human machine interaction. | Yanpeng Li Shijie Tan Liuyang Yang Liangye Li Fang Fang Qizhen Sun | 2022 | Advanced Fiber Materials2022，4，2： | 3 |
| 4 | A silk-based self-adaptive flexible opto-electro neural probe显示文摘The combination of optogenetics and electrophysiological recording enables high-precision bidirectional interactions between neural interfaces and neural circuits,which provides a promising approach for the study of progressive neurophysiological phenomena.Opto-electrophysiological neural probes with sufficient flexibility and biocompatibility are desirable to match the low mechanical stiffness of brain tissue for chronic reliable performance.However,lack of rigidity poses challenges for the accurate implantation of flexible neural probes with less invasiveness.Herein,we report a hybrid probe(Silk-Optrode)consisting of a silk protein optical fiber and multiple flexible microelectrode arrays.The Silk-Optrode can be accurately inserted into the brain and perform synchronized optogenetic stimulation and multichannel recording in freely behaving animals.Silk plays an important role due to its high transparency,excellent biocompatibility,and mechanical controllability.Through the hydration of the silk optical fiber,the Silk-Optrode probe enables itself to actively adapt to the environment after implantation and reduce its own mechanical stiffness to implant into the brain with high fidelity while maintaining mechanical compliance with the surrounding tissue.The probes with 128 recording channels can detect high-yield well-isolated single units while performing intracranial light stimulation with low optical losses,surpassing previous work of a similar type.Two months of post-surgery results suggested that as-reported Silk-Optrode probes exhibit better implant-neural interfaces with less immunoreactive glial responses and tissue lesions. | Yu Zhou Chi Gu Jizhi Liang Bohan Zhang Huiran Yang Zhitao Zhou Meng Li Liuyang Sun Tiger H.Tao Xiaoling Wei | 2022 | Microsystems & Nanoengineering2022，8，6： | 1 |
| 5 | Infinite horizon linear quadratic differential games for discrete-time stochastic systems显示文摘这份报纸处理无限的地平线线性二次(LQ ) 为有状态和控制依赖者噪音的分离时间的随机的系统的微分游戏。为准确 observability 和分离时间的随机的系统的准确 detectability 的 Popov-Belevitch-Hautus (PBH ) 标准被介绍。借助于他们,我们为无限的地平线给最佳的策略(纳什平衡策略) 和最佳的费用价值随机的微分比赛。它显示无限的地平线 LQ 随机的微分比赛与四个联合珍视矩阵的方程被联系。而且,一个反复的算法被建议解决四个联合方程。最后,一个例子被给表明我们的结果。 | Huiying SUN Liuyang JIANG Weihai ZHANG | 2012 | 控制理论与应用(英文版)2012，10，3： | 1 |
| 6 | Enriched gestation activates the IGF pathway to evoke embryo-adult benefits to prevent Alzheimer’s disease显示文摘Background:Building brain reserves before dementia onset could represent a promising strategy to prevent Alzheimer’s disease(AD),while how to initiate early cognitive stimulation is unclear.Given that the immature brain is more sensitive to environmental stimuli and that brain dynamics decrease with ageing,we reasoned that it would be effective to initiate cognitive stimulation against AD as early as the fetal period.Methods:After conception,maternal AD transgenic mice(3×Tg AD)were exposed to gestational environment enrichment(GEE)until the day of delivery.The cognitive capacity of the offspring was assessed by the Morris water maze and contextual fear-conditioning tests when the offspring were raised in a standard environment to 7 months of age.Western blotting,immunohistochemistry,real-time PCR,immunoprecipitation,chromatin immunoprecipitation(ChIP)assay,electrophysiology,Golgi staining,activity assays and sandwich ELISA were employed to gain insight into the mechanisms underlying the beneficial effects of GEE on embryos and 7–10-month-old adult offspring.Results:We found that GEE markedly preserved synaptic plasticity and memory capacity with amelioration of hallmark pathologies in 7–10-m-old AD offspring.The beneficial effects of GEE were accompanied by global histone hyperacetylation,including those at bdnf promoter-binding regions,with robust BDNF mRNA and protein expression in both embryo and progeny hippocampus.GEE increased insulin-like growth factor 1(IGF1)and activated its receptor(IGF1R),which phosphorylates Ca^(2+)/calmodulin-dependent kinase IV(CaMKIV)at tyrosine sites and triggers its nuclear translocation,subsequently upregulating histone acetyltransferase(HAT)and BDNF transcription.The upregulation of IGF1 mimicked the effects of GEE,while IGF1R or HAT inhibition during pregnancy abolished the GEE-induced CaMKIV-dependent histone hyperacetylation and BDNF upregulation.Conclusions:These findings suggest that activation of IGF1R/CaMKIV/HAT/BDNF signaling by gestational environment enrichment may serve as a promising strategy to delay AD progression. | Enjie Liu Qiuzhi Zhou Ao-Ji Xie Mengzhu Li Shujuan Zhang Hezhou Huang Zhenyu Liuyang Yali Wang Bingjin Liu Xiaoguang Li Dongsheng Sun Yuping Wei Xiaochuan Wang Qun Wang Dan Ke Xifei Yang Ying Yang Jian-Zhi Wang | 2019 | Translational Neurodegeneration2019，8，1： | 1 |
| 7 | Progress on Heat Transfer in Fractures of Hot Dry Rock Enhanced Geothermal System显示文摘Hot Dry Rock(HDR)is the most potential renewable geothermal energy in the future.Enhanced Geothermal System(EGS)is the most effective method for the development and utilization of HDR resources,and fractures are the main flow channels and one of the most important conditions for studying heat transfer process of EGS.Therefore,the heat transfer process and the heat transfer mechanism in fractures of EGS have been the hot spots of research.Due to the particularity of the mathematical models of heat transfer,research in this field has been at an exploratory stage,and its methods are mainly experimental tests and numerical simulations.This paper introduces the progress on heat transfer in fractures of Hot Dry Rock EGS in detail,provides a comparative analysis of the research results and prospects for future research directions:It is suggested that relevant scholars should further study the mathematical equations which are applicable to engineering construction of seepage heat transfer in irregular fractures of the rock mass,the unsteady heat transfer process between multiple fractures of the rock mass and the heat transfer mechanism of the complex three-dimensional models of EGS. | Yiya Wang Hailong Yu Shucheng Wu Li Liu Liuyang Huang Baozhong Zhu Yunlan Sun Enhai Liu | 2021 | Energy Engineering2021，118，4： | 0 |
| 8 | Non-equivalent D-A copolymerization strategy towards highly efficient polymer donor for polymer solar cells显示文摘D-A copolymerization is a broadly utilized molecular design strategy to construct high efficiency photovoltaic materials for polymer solar cells(PSCs),and all the D-A copolymer donors reported till now are the alternate D-A copolymers with equal D-and A-units.Here,we first propose a non-equivalent D-A copolymerization strategy with unequal D-and A-units,and develop three novel non-equivalent D-A copolymer donors(PM6-D1,PM6-D2 and PM6-D3 with D/A unit ratio of 1.1:0.9,1.2:0.8 and1.3:0.7,respectively)by inserting more D units into the alternate D-A copolymer PM6 backbone to finely tune the physicochemical and photovoltaic properties of the polymers.The three non-equivalent D-A copolymers show the down-shifted highest occupied molecular orbital(HOMO)energy levels,higher hole mobility,higher degree of molecular self-assembly and higher molecular crystallinity with the increase of D-unit ratio in comparison with the alternate D-A copolymer PM6.As a result,all the three non-equivalent D-A copolymer-based PSCs with Y6 as acceptor achieve improved power conversion efficiency(PCE)with higher V_(oc),larger J_(sc)and higher FF simultaneously.Particularly,the PM6-D1:Y6 based PSC achieved a high PCE of17.71%,which is significantly higher than that(15.82%)of the PM6:Y6 based PSC and is one of the highest performances in the binary PSCs. | Ziya Shang Liuyang Zhou Chenkai Sun Lei Meng Wenbin Lai Jinyuan Zhang Wenchao Huang Yongfang Li | 2021 | Science China Chemistry2021，64，6： | 0 |
| 9 | Simulation Research on Coal-Water Slurry Gasification of Oil-Based Drill Cuttings Based on Fluent显示文摘In this paper,based on Fluent software,a five-nozzle gasifier reactor was established to simulate the gasification process of oil-based drill cuttings coal-water slurry.The influence of concentration and oxygen/carbon atomic ratio on the gasification process of oil-based drill cuttings coal-water slurry was investigated.The results show that when the oxygen flow is constant,the outlet temperature of gasifier decreases,the content of effective gas increases,and the carbon conversion rate decreases with the increase of concentration;When the ratio of oxygen to carbon atoms is constant,the effective gas content rises and the temperature rises with the increase of the concentration,and the carbon conversion rate reaches the maximum value when the concentration of oil-based drill cuttings coal-water slurry is 65%;When the concentration is constant,the effective gas content decreases and the outlet temperature rises with the increase of the oxygen/carbon atom ratio,and the carbon conversion rate reaches 99.80%when the oxygen/carbon atom ratio is 1.03.It shows that this method can effectively decompose the organic matter in oilbased drill cuttings and realize the efficient and cooperative treatment of oil-based drill cuttings. | Liang Hu Hailong Yu Liuyang Huang Yayun Xu XuleiWu Yunlan Sun Baozhong Zhu | 2023 | Energy Engineering2023，120，9： | 0 |
| 10 | Long-term flexible penetrating neural interfaces:materials, structures, and implantation显示文摘Penetrating neural interface, which collects the neural electrophysiological signal and serves as a key component in brain-computer interface, has drawn great attention recently. The instability of chronic recording is the main challenge for the conventional neural interface. Novel neural probes with improved long-term performance have been developed based on advanced materials and engineered structures. Here, we review these emergent innovations contributing to chronic stable recording from the perspectives of materials,structures, and implantation methods. These advances make possible further developments in neuroscience research related to neural decoding, neural circuit mechanism analysis, and neurological disease treatment. | Chi GU Jianjuan JIANG Tiger H.TAO Xiaoling WEI Liuyang SUN | 2021 | Science China(Information Sciences)2021，64，12： | 0 |
| 11 | 2D-to-3D buckling transformability enabled reconfigurable metamaterials for tunable chirality and focusing effect显示文摘Recently,multifarious deformation approaches in nature have promoted dynamic manipulation for electromagnetic(EM)waves in metamaterials,and those representative strategies are mainly focused on the modulation of spectral parameters.Several works have also achieved tunable phase-gradient meta-devices.Here,to broaden the modulation freedom of mechanical deformation,we initially propose two reconfigurable metamaterials consisting of mirrored S-shaped meta-atoms selectively bonded on biaxially pre-stretched substrates.Planar meta-atoms with spin-insensitive transmittance are buckled into 3D morphologies to break residual symmetries by releasing the stress and to facilitate spin-dependent transmittance under circularly polarized incidence.Owing to the geometric anisotropy of S-shaped meta-atoms along the x and y axes,3D chiral meta-atoms exhibit discriminate circularly cross-polarized transmittance under opposite spins.The underlying physical mechanism reveals that EM resonance originates from the excitation of electric dipoles and magnetic dipoles,and their cross coupling finally triggers the chiral effects of 3D meta-atoms.By introducing the gradient-phase design that keeps unchanged under various strains,two types of meta-atoms with specified orientations are interleaved to design a double-foci metalens,and its 2D-to-3D morphology transformation shortens the focusing length and facilitates the intensity change of two foci.Our approach in designing reconfigurable EM metamaterials with 2D-to-3D buckling transformability can be further extended toward terahertz even optical wavebands,and it may assist with deriving more applicable multi-functionalities in the aspects of imaging,sensing,and holograms. | DONGHAI HAN WENKANG LI TAO SUN MIN LIU XIAOMING CHEN HONGYU SHI ZHENGJIE FAN FANQI MENG LIUYANG ZHANG XUEFENG CHEN | 2023 | Photonics Research2023，11，10： | 0 |
| 12 | A mosquito mouthpart-like bionic neural probe显示文摘Advancements in microscale electrode technology have revolutionized the field of neuroscience and clinicalapplications by offering high temporal and spatial resolution of recording and stimulation. Flexible neural probes, withtheir mechanical compliance to brain tissue, have been shown to be superior to rigid devices in terms of stability andlongevity in chronic recordings. Shuttle devices are commonly used to assist flexible probe implantation;however, theprotective membrane of the brain still makes penetration difficult. Hidden damage to brain vessels duringimplantation is a significant risk. Inspired by the anatomy of the mosquito mouthparts, we present a biomimeticneuroprobe system that integrates high-sensitivity sensors with a high-fidelity multichannel flexible electrode array.This customizable system achieves distributed and minimally invasive implantation across brain regions. Mostimportantly, the system’s nonvisual monitoring capability provides an early warning detection for intracranial softtissues, such as vessels, reducing the potential for injury during implantation. The neural probe system demonstratesexceptional sensitivity and adaptability to environmental stimuli, as well as outstanding performance in postoperativeand chronic recordings. These findings suggest that our biomimetic neural-probe device offers promising potential forfuture applications in neuroscience and brain-machine interfaces. | Yu Zhou Huiran Yang Xueying Wang Heng Yang Ke Sun Zhitao Zhou Liuyang Sun Jianlong Zhao Tiger H.Tao Xiaoling Wei | 2023 | Microsystems & Nanoengineering2023，9，4： | 0 |
| 13 | Living coccolithophores in the western Pacific Ocean with mesoscale eddies显示文摘Living coccolithophores(LCs)are regarded as a group of calcifiers and play important roles in global carbon cycle.This study used microscopic observations of LCs in the western Pacific Ocean to investigate their community structure and biodiversity,especially to test whether local physical traits(mesoscale eddies)could explain their biogeographic distributions during autumn of 2017.The coccolithophore calcite inventory based on carbon-volume transformation was estimated in this study.A total of 28 taxa of coccospheres and 19 types of coccoliths were identified from 161 samples.Gephyrocapsa oceanica was the most predominant species in all the coccolithophore community,followed by Florisphaera profunda,Emiliania huxleyi,Umbilicosphaera sibogae,Gladiolithusflabellatus and Umbellosphaera tenuis.The abundance of coccospheres and coccoliths ranged from 0 to 26.8×10^(3)cells/L and from 0 to 138.5×10^(3)coccoliths/L,averaged at 4.2×10^(3)cells/L and 10.9×10^(3)coccoliths/L,respectively.This study indicated that coccolithophore community in the survey area can be clustered into four groups.Three ecological niches of coccolithophores were characterized by their vertical profiles and multivariate statistical analysis.Coccolithophore abundance and species composition were remarkably different among warm-eddy region,G.oceanica dominated warm-eddy region,while F.profunda dominated warm-eddy and none-eddy region.The average values of estimated particulate inorganic carbon,particulate organic carbon were0.197μg/L and 0.140μg/L,respectively.The current field study widened the dataset of coccolithophores in western Pacific Ocean. | Danyue Huang Haijiao Liu Jun Sun Yuqiu Wei Liuyang Li Guicheng Zhang Laxman Pujari | 2021 | Acta Oceanologica Sinica2021，40，6： | 0 |
| 14 | Host Genetic Background Impacts Microbiome Composition in Newborn Alligator显示文摘Genetic factors play a key role in determination of the structure of the cloacal flora for newborn Chinese Alligators.We collected the cloacal microbiomes for 24 newborn Chinese Alligators from three different genetic backgrounds for 16S gene amplicon sequencing.The number of cloacal flora for the Chinese Alligators from different groups was comparable but differed structurally.There were variations in proportions of floral compositions at the phylum and family levels;however,the main difference was at the genus level.There were two significant differences in richness and evenness among the three groups.Non-metric multidimensional scaling NMDS analysis revealed that the 24 samples could be clearly divided into three categories based on their genetic backgrounds(stress=0.0244).Thus,we postulated that newborn Chinese Alligators with different genetic backgrounds have different immune strengths,which affects individual responses to environmental microorganisms.In summary,newborn Chinese Alligators from different genetic backgrounds exhibit variations in cloacal microbiome. | Huabin ZHANG Wengang LI Genjun TU Ke SUN Liuyang YANG Ziyi WANG Zirui WU Yongkang ZHOU Song ZHANG Hao SUN Changshun SHENG Xiaoping WANG Rongjun ZHANG Xiaobing WU Tao PAN | 2023 | Asian Herpetological Research2023，14，3： | 0 |
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