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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Recanalization of extracranial internal carotid artery occlusion A 12-year retrospective study显示文摘This study aimed to summarize therapy experience of carotid endarterectomy, carotid endarterec-tomy combined with Fogarty catheter embolectomy, and hybrid surgery for the treatment of extrac-ranial internal carotid artery occlusion. The study included 65 patients with extracranial internal ca-rotid artery occlusion who underwent carotid endarterectomy, carotid endarterectomy combined with Fogarty catheter embolectomy, or hybrid surgery in the Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, China between January 2006 and December 2012. Prior to surgery, all patients underwent perfusion CT or xenon CT to evaluate the occlusion. The procedure for each patient was chosen according to digital subtraction angiography data. The carotid artery was successfully recanalized in 46 of 51 patients who underwent carotid endarterectomy, 9 of 10 patients who underwent carotid endarterectomy combined with Fogarty catheter embolectomy, and 3 of 4 patients who underwent hybrid surgery. In patients with symptomatic carotid artery occlusion, the carotid artery can be recanalized by choosing a treatment procedure based on imaging ex-amination findings. | Liqun Jiao Gang Song Yang Hua Yan Ma Yanfei Chen Yabing Wang Feng Ling | 2013 | Neural Regeneration Research2013，8，23： | 19 |
| 3 | TRPV1 activation improves exercise endurance and energy metabolism through PGC-1α upregulation in mice显示文摘 | Zhidan Luo Liqun Ma Zhigang Zhao Hongbo He Dachun Yang Xiaoli Feng Shuangtao Ma Xiaoping Chen Tianqi Zhu Tingbing Cao Daoyan Liu Bernd Nilius Yu Huang Zhencheng Yan Zhiming Zhu | 2012 | Cell Research2012，22，3： | 18 |
| 4 | Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis显示文摘 | Yongting Luo Hongxia Duan Yining Qian Liqun Feng Zhenzhen Wu Fei Wang Jing Feng Dongling Yang Zhihai Qin Xiyun Yan | 2017 | Cell Research2017，27，3： | 18 |
| 5 | Genotypic variations in the accumulation of Cd exhibited by different vegetables显示文摘It is an important approach to use the Cd-contaminated soils properly by growing low accumulator or excluder plants for Cd to produce safe foods. To find the suitable vegetable species for growing in Cd-contaminated soils, in the present study the variations in the Cd accumulation for twenty eight vegetable species and several cultivars of five common vegetables (cowpea, kidney pea, bitter gourd, cucumber and squash) were investigated in two soil Cd levels (1 and 2 mg/kg Cd). Experimental results showed that highly significant differences in Cd concentration were evident among 28 vegetables. For example, spinach Cd concentrations were 110-fold and 175-fold higher than that of sweet pea under the 1 and 2 mg/kg Cd exposures, respectively. For Cd accumulation, the order of vegetable species was: leafy vegetables > solanaceous vegetables > kale vegetables > root vegetables > allimus > melon vegetables > legumes. Distinctive differences were also identified when comparing different cultivars of the five common vegetables with an average range of 0.003–0.094 mg/kg Cd. Our results indicated that a large genotypic variation existed among vegetable species or cultivars when subjected to Cd exposure. Therefore, it is important and feasible to elect/breed vegetable species/cultivars with low accumulation of Cd, especially in mildly Cd-contaminated soils. | Junxing Yang Haitao Guo Yibing Ma Liqun Wang Dongpu Wei Luo Hua | 2010 | Journal of Environmental Sciences2010，22，8： | 16 |
| 6 | Targeting cancer stem cell pathways for cancer therapy显示文摘Since cancer stem cells(CSCs)were first identified in leukemia in 1994,they have been considered promising therapeutic targets for cancer therapy.These cells have self-renewal capacity and differentiation potential and contribute to multiple tumor malignancies,such as recurrence,metastasis,heterogeneity,multidrug resistance,and radiation resistance.The biological activities of CSCs are regulated by several pluripotent transcription factors,such as OCT4,Sox2,Nanog,KLF4,and MYC.In addition,many intracellular signaling pathways,such as Wnt,NF-κB(nuclear factor-κB),Notch,Hedgehog,JAK-STAT(Janus kinase/signal transducers and activators of transcription),PI3K/AKT/mTOR(phosphoinositide 3-kinase/AKT/mammalian target of rapamycin),TGF(transforming growth factor)/SMAD,and PPAR(peroxisome proliferator-activated receptor),as well as extracellular factors,such as vascular niches,hypoxia,tumor-associated macrophages,cancer-associated fibroblasts,cancer-associated mesenchymal stem cells,extracellular matrix,and exosomes,have been shown to be very important regulators of CSCs.Molecules,vaccines,antibodies,and CAR-T(chimeric antigen receptor T cell)cells have been developed to specifically target CSCs,and some of these factors are already undergoing clinical trials.This review summarizes the characterization and identification of CSCs,depicts major factors and pathways that regulate CSC development,and discusses potential targeted therapy for CSCs. | Liqun Yang Pengfei Shi Gaichao Zhao Jie Xu Wen Peng Jiayi Zhang Guanghui Zhang Xiaowen Wang Zhen Dong Fei Chen Hongjuan Cui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 12 |
| 7 | NLRP3-dependent pyroptosis is required for HIV-1 gp120- induced neuropathology显示文摘The human immunodeficiency virus-1(HIV-1)envelope protein gp120 is the major contributor to the pathogenesis of HIVassociated neurocognitive disorder(HAND).Neuroinflammation plays a pivotal role in gp120-induced neuropathology,but how gp120 triggers neuroinflammatory processes and subsequent neuronal death remains unknown.Here,we provide evidence that NLRP3 is required for gp120-induced neuroinflammation and neuropathy.Our results showed that gp120-induced NLRP3-dependent pyroptosis and IL-1βproduction in microglia.Inhibition of microglial NLRP3 inflammasome activation alleviated gp120-mediated neuroinflammatory factor release and neuronal injury.Importantly,we showed that chronic administration of MCC950,a novel selective NLRP3 inhibitor,to gp120 transgenic mice not only attenuated neuroinflammation and neuronal death but also promoted neuronal regeneration and restored the impaired neurocognitive function.In conclusion,our data revealed that the NLRP3 inflammasome is important for gp120-induced neuroinflammation and neuropathology and suggest that NLRP3 is a potential novel target for the treatment of HAND. | Xiaolong He Weijun Yang Zhijie Zeng Yi Wei Jie Gao Bao Zhang Li Li Liqun Liu Yu Wan Qing Zeng Zelong Gong Liting Liu Hanyun Zhang Yubin Li Shaojie Yang Tongtong Hu Lixian Wu Eliezer Masliah Shenghe Huang Hong Cao | 2020 | Cellular & Molecular Immunology2020，17，3： | 11 |
| 8 | APOBEC:From mutator to editor显示文摘APOBECs(apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) are a family of cytidine deaminases that prefer single-stranded nucleic acids as substrates. Besides their physiological functions,APOBEC family members have been found to cause hypermutations of cancer genomes, which could be correlated with cancer development and poor prognosis. Recently, APOBEC family members have been combined with the versatile CRISPR/Cas9 system to perform targeted base editing or induce hypermutagenesis. This combination improved the CRISPR/Cas9-mediated gene editing at single-base precision, greatly enhancing its usefulness. Here, we review the physiological functions and structural characteristics of APOBEC family members and their roles as endogenous mutators that contribute to hypermutations during carcinogenesis. We also review the various iterations of the APOBEC-CRISPR/Cas9 gene-editing tools, pointing out their features and limitations as well as the possibilities for future developments. | Bei Yang Xiaosa Li Liqun Lei Jia Chen | 2017 | Journal of Genetics and Genomics2017，44，9： | 8 |
| 9 | Distribution and risk factors of hand, foot, and mouth disease in Changchun, northeastern China显示文摘Hand,foot,and mouth disease(HFMD)is a public health problem,and there have been increasing numbers of outbreaks in China's Mainland since 2008.Over17,000 HFMD cases have been reported in Changchun between 2008 and 2011.This study characterized the temporal and spatial distribution of the disease and identified the risk factors for HFMD.The main findings were as follows:(i)there were significant differences in HFMD incidence among age groups,with 86.8%of reported cases in children younger than 5 years old,and boys showed a higher incidence than girls(\6 years);(ii)The disease affected the whole region and spanned a large geographic area,but there was a higher incidence in urban areas(median=242 per 10,000 persons)and urban–rural border areas(median=135 per 10,000 persons),compared with rural areas(median=75 per 10,000 persons);and(iii)the incidence of HFMD in Changchun was significantly associated with the distance to the nearest freeway,GDP per capita,and the type of township. | Li Yan Xinlou Li Yaqin Yu Sake J.de Vlas Yapin Li Dandan Wang Yanli Li Yuan Yin Jing Wu Hong Liu Hong Yang Bo Li Liqun Fang Wuchun Cao | 2014 | Chinese Science Bulletin2014，59，5： | 7 |
| 10 | Effect of Astragali and Angelica particle on proteinuria in Chinese patients with primary glomerulonephritis显示文摘OBJECTIVE: To investigate the effect of the traditional Chinese herbs Astragali and Angelicae Sinensis(A & As) particle [contains Huangqi(Radix Astragali Mongolica), Danggui(Radix Angelicae Sinensis),Huzhanggeng(Rhizoma Polygoni Cuspidati) and Danshen(Radix Salviae Miltiorrhizae)] on proteinuria in glomerulonephritis patients with stage 2 chronic kidney disease.METHODS: A prospective, multi-center, and randomized controlled clinical trial was performed for 24 weeks. From March 2011 to April 2012, 158 patients from nine hospitals in China participated.They were randomized into the A&As group(79 cases, A&As particle 15.2 g/day) and losartan group(79 cases, losartan 50 mg/day). At each follow-up visit, clinical data including blood pressure, urinalysis, 24-h-urinary protein excretion, serum albumin and serum creatinine were collected.RESULTS: All 158 patients completed the follow-up. Proteinuria in the losartan group exhibited a biphasic time-dependent decline with a significant steady reduction from baseline to week 12(P = 0.0014), and a platform level during the remaining 12-week follow-up(P > 0.05). In contrast, there was a continual significant decrease of proteinuria in the A & As group(P < 0.001). When compared with the losartan results, proteinuria in the A & As group from week 16 to week 24 was significantly reduced(P < 0.001). Stable e GFRs and blood pressure were also observed in both groups. Medication side effects were minimal and non-fatal.CONCLUSION: For Chinese glomerulonephritis patients with stage 2 chronic kidney disease, therapy with A & As particles may provide effective anti-proteinuria treatment. | Shen Peicheng Yang Xuejun He Liqun | 2016 | Journal of Traditional Chinese Medicine2016，36，3： | 6 |
| 11 | Fabrication of room temperature continuous-wave operation GaN-based ultraviolet laser diodes显示文摘Two kinds of continuous-wave GaN-based ultraviolet laser diodes(LDs) operated at room temperature and with different emission wavelengths are demonstrated.The LDs epitaxial layers are grown on GaN substrate by metalorganic chemical vapor deposition,with a 10 × 600 μm^2 ridge waveguide structure.The electrical and optical characteristics of the ultraviolet LDs are investigated under direct-current injection at room temperature.The stimulated emission peak wavelength of first LD is 392.9 nm,the threshold current density and voltage is 1.5kA/cm^2 and 5.0 V,respectively.The output light power is 80 mW under the 4.0 kA/cm^2 injection current density.The stimulated emission peak wavelength of second LD is 381.9 nm,the threshold current density the voltage is2.8 kA/cm^2 and 5.5 V,respectively.The output light power is 14 mW under a 4.0 kA/cm^2 injection current density. | Degang Zhao Jing Yang Zongshun Liu Ping Chen Jianjun Zhu Desheng Jiang Yongsheng Shi Hai Wang Lihong Duan Liqun Zhang Hui Yang | 2017 | Journal of Semiconductors2017，38，5： | 6 |
| 12 | Benthic macro red alga:A new possible bio-precursor of Jurassic mudstone source rocks in the northern Qaidam Basin,northwestern China显示文摘Whether benthic macroalga can be an important type of bio-precursor of source rocks is a contentious issue in source-rock studies,and has not been well understood.This paper represents a case study of Jurassic mudstone source rocks from the northern Qaidam Basin,northwestern China,in which the benthic macro red algae were recognized for the first time based on combined organic petrological and biomarker works.We found not only cystocarps in the algae,representative of rhodophyta,but also diahopanes,which are diagnostic biomarkers of such algae.Thus,as many reservoired oils in the northern Qaidam Basin contain abundant diahopanes,it may indicate that the red algae have contributed to hydrocarbon accumulation.This was confirmed by integrated geological and geochemical analyses.Hence,this study provides new evidence for macroalga-generated hydrocarbons. | CAO Jian BIAN LiZeng HU Kai LIU YunTian WANG LiQun YANG ShaoYong CHEN Yan PENG XiaoQun | 2009 | Science China Earth Sciences2009，52，5： | 5 |
| 13 | Room-temperature continuous-wave electrically pumped InGaN/GaN quantum well blue laser diode directly grown on Si显示文摘Current laser-based display and lighting applications are invariably using blue laser diodes(LDs)grown on freestanding GaN substrates,which are costly and smaller in size compared with other substrate materials.1–3 Utilizing less expensive and large-diameter Si substrates for hetero-epitaxial growth of indium gallium nitride/gallium nitride(InGaN/GaN)multiple quantum well(MQW)structure can substantially reduce the cost of blue LDs and boost their applications.To obtain a high crystalline quality crack-free GaN thin film on Si for the subsequent growth of a blue laser structure,a hand-shaking structure was formed by inserting Al-composition step down-graded AlN/AlxGa1−xN buffer layers between GaN and Si substrate.Thermal degradation in InGaN/GaN blue MQWs was successfully suppressed with indium-rich clusters eliminated by introducing hydrogen during the growth of GaN quantum barriers(QBs)and lowering the growth temperature for the p-type AlGaN/GaN superlattice optical cladding layer.A continuous-wave(CW)electrically pumped InGaN/GaN quantum well(QW)blue(450 nm)LD grown on Si was successfully demonstrated at room temperature(RT)with a threshold current density of 7.8 kA/cm^(2). | Yi Sun Kun Zhou Meixin Feng Zengcheng Li Yu Zhou Qian Sun Jianping Liu Liqun Zhang Deyao Li Xiaojuan Sun Dabing Li Shuming Zhang Masao Ikeda Hui Yang | 2018 | Light(Science & Applications)2018，7，1： | 5 |
| 14 | Characterization of bbtTICAM from amphioxus suggests the emergence of a MyD88-independent pathway in basal chordates显示文摘MyD88 独立的小径,发信号的二关键 TLR 之一发送,被认为是脊椎动物革新。然而,一个新奇 Toll/interleukin-1 受体(TIR ) 适配器,指明的 bbtTICAM,在基础脊索动物文昌鱼被识别,连接这条小径到无脊椎动物。bbtTICAM 的蛋白质建筑学类似于脊椎动物 TICAM1 的(包含 TIR 适配器 molecule-1,也作为 TRIF 知道) 当种系发生的分析基于 TIR 领域显示了那时, bbtTICAM 是脊椎动物 TICAM1 和 TICAM2 的最旧的 ortholog (包含 TIR 适配器 molecule-2,是也知道电车) 。类似于人的 TICAM1, bbtTICAM 激活 NF-κ以由与受体交往蛋白质交往的一种 MyD88 独立的方式的 B (裂开) 经由它的 RHIM 主题。如此的激活要求 bbtTICAM 形成 homodimers 在里面内涵体,和它可以被文昌鱼 SARM 否定地调整(无菌的 α并且犰狳包含主题的蛋白质) 并且 TRAF2。然而, bbtTICAM 没导致类型的生产我干扰素。因此,我们的学习不仅介绍脊椎动物 TICAM1 和 TICAM2 的祖先的特征,而且从基础脊索动物揭示 MyD88 独立的小径的进化起源,它将帮助理解脊椎动物 TLR 网络的开发。 | Manyi Yang Shaochun Yuan Shengfeng Huang Jun Li Liqun Xu Huiqing Huang Xin Tao Jian Peng Anlong Xu | 2011 | Cell Research2011，21，10： | 5 |
| 15 | Effect of microstructure of Au80Sn20 solder on the thermal resistance TO56 packaged GaN-based laser diodes显示文摘Au80Sn20 alloy is a widely used solder for laser diode packaging.In this paper,the thermal resistance of Ga N-based blue laser diodes packaged in TO56 cans were measured by the forward voltage method.The microstructures of Au80Sn20 solder were then investigated to understand the reason for the difference in thermal resistance.It was found that the microstructure with a higher content of Au-rich phase in the center of the solder and a lower content of(Au,Ni)Sn phase at the interface of the solder/heat sink resulted in lower thermal resistance.This is attributed to the lower thermal resistance of Au-rich phase and higher thermal resistance of(Au,Ni)Sn phase. | Hao Lin Deyao Li Liqun Zhang Pengyan Wen Shuming Zhang Jianping Liu Hui Yang | 2020 | Journal of Semiconductors2020，41，10： | 4 |
| 16 | Room-temperature continuous-wave operation of GaN-based blue-violet laser diodes with a lifetime longer than 1000h显示文摘GaN-based continuous-wave operated blue-violet laser diodes(LDs) with long lifetime are demonstrated, which are grown on a c-plane GaN substrate by metal organic chemical vapor deposition with a 10 × 600 μm^2 ridge waveguide structure.The electrical and optical characteristics of a blue-violet LD are investigated under direct-current injection at room temperature(25 °C). The stimulated emission wavelength and peak optical power of the LD are around 413 nm and over 600 mW, respectively.In addition, the threshold current density and voltage are as small as 1.46 kA/cm^2 and 4.1 V, respectively. Moreover, the lifetime is longer than 1000 hours under room-temperature continuous-wave operation. | Feng Liang Jing Yang Degang Zhao Zongshun Liu Jianjun Zhu Ping Chen Desheng Jiang Yongsheng Shi Hai Wang Lihong Duan Liqun Zhang Hui Yang | 2019 | Journal of Semiconductors2019，40，2： | 4 |
| 17 | High-power hybrid GaN-based green laser diodes with ITO cladding layer显示文摘Green laser diodes(LDs)still perform worst among the visible and near-infrared spectrum range,which is called the'green gap.'Poor performance of green LDs is mainly related to the p-type Al Ga N cladding layer,which on one hand imposes large thermal budget on In Ga N quantum wells(QWs)during epitaxial growth,and on the other hand has poor electrical property especially when low growth temperature has to be used.We demonstrate in this work that a hybrid LD structure with an indium tin oxide(ITO)p-cladding layer can achieve threshold current density as low as 1.6 k A∕cm^2,which is only one third of that of the conventional LD structure.The improvement is attributed to two benefits that are enabled by the ITO cladding layer.One is the reduced thermal budget imposed on QWs by reducing p-Al Ga N layer thickness,and the other is the increasing hole concentration since a low Al content p-Al Ga N cladding layer can be used in hybrid LD structures.Moreover,the slope efficiency is increased by 25%and the operation voltage is reduced by 0.6 V for hybrid green LDs.As a result,a 400 m W high-power green LD has been obtained.These results indicate that a hybrid LD structure can pave the way toward high-performance green LDs. | LEI HU XIAOYU REN JIANPING LIU AIQIN TIAN LINGRONG JIANG SIYI HUANG WEI ZHOU LIQUN ZHANG HUI YANG | 2020 | Photonics Research2020，8，3： | 4 |
| 18 | EXAFS and SR-XRD study on Cu occupation sites in Zn_(1-x)Cu_xO diluted magnetic semiconductors显示文摘ZnO films, doped with 2.9 atom% Cu, were prepared by radio frequency magnetron sputtering on sapphire substrate at different substrate temperatures. No magnetic impurities such as Fe, Co and Ni were found in the PIXE spectra. The ZnO:Cu films possessed the wurtzite ZnO structure. No precipitates such as CuO and Cu2O or Cu cluster, were observed by synchrotron radiation X-ray diffraction in the ZnO:Cu films. Extended X-ray absorption fine structure (EXAFS) analysis showed that Cu atoms were incorporated into ZnO crystal lattice by occupying the sites of Zn atoms. | YANG Chen ZHANG Bin WANG Jianzhong SHI Liqun CHENG Huansheng YANG Tieying WEN Wen HU Fengchun | 2012 | Nuclear Science and Techniques2012，23，2： | 4 |
| 19 | Engineering self-healing adhesive hydrogels with antioxidant properties for intrauterine adhesion prevention显示文摘Intrauterine adhesion (IUA) is the fibrosis within the uterine cavity. It is the second most common cause of female infertility, significantly affecting women’s physical and mental health. Current treatment strategies fail to provide a satisfactory therapeutic outcome for IUA patients, leaving an enormous challenge for reproductive science. A self-healing adhesive hydrogel with antioxidant properties will be highly helpful in IUA prevention. In this work, we prepare a series of self-healing hydrogels (P10G15, P10G20, and P10G25) with antioxidant and adhesive properties. Those hydrogels exhibit good self-healing properties and can adapt themselves to different structures. They possess good injectability and fit the shape of the human uterus. Moreover, the hydrogels exhibit good tissue adhesiveness, which is desirable for stable retention and therapeutic efficacy. The in vitro experiments using P10G20 show that the adhesive effectively scavenges ABTS+, DPPH, and hydroxyl radicals, rescuing cells from oxidative stress. In addition, P10G20 offers good hemocompatibility and in vitro and in vivo biocompatibility. Furthermore, P10G20 lowers down the in vivo oxidative stress and prevents IUA with less fibrotic tissue and better endometrial regeneration in the animal model. It can effectively downregulate fibrosis-related transforming growth factor beta 1 (TGF-β1) and vascular endothelial growth factor (VEGF). Altogether, these adhesives may be a good alternative for the clinical treatment of intrauterine adhesion. | Luyao Feng Liqun Wang Yao Ma Wanglin Duan Sergio Martin-Saldana Ye Zhu Xianpeng Zhang Bin Zhu Chaowei Li Shibo Hu Mingjie Bao Ting Wang Yuan Zhu Fei Yang Yazhong Bu | 2023 | Bioactive Materials2023，，9： | 3 |
| 20 | A Co-N/C hollow-sphere electrocatalyst derived from a metanilic CoAl layered double hydroxide for the oxygen reduction reaction, and its active sites in various pH media显示文摘Transition-metal-coordinating 做氮的碳催化剂(M-N/C, M = 公司, Fe, Mn, Ni,等等) 为氧减小反应(ORR ) 被认为最有希望的 nonprecious 金属 electrocatalysts 之一。然而,他们受不了低 ORR 催化活动,和他们的活跃地点充分没被识别。此处,我们由在煤分层的双氢氧化物的层之间的 metanilic 阴离子的碳化报导多孔的 Co-N/C 空范围的 electrocatalyst 的合成。同样准备的 Co-N/C 催化剂展出了优秀 ORR 有在碱、中立的溶液的一个高一半波浪潜力和大散开有限水流的催化活动。催化剂的表演比得上商业 Pt/C electrocatalysts 的那些。通过调查面具离子的效果(在 Co-N/C 催化剂的 ORR 活动的 SCN 和 F ),并且在不同 pH 媒介在反对 x 地点的破坏前后比较 ORR 活动,我们断定反对 x 地点在酸、中立的答案直接充当 ORR 活跃地点,但是处于碱的条件在 ORR 活动有可以忽略的效果。 | Jun Wang Liqun Li Xu Chen Yanluo Lu Wensheng Yang Xue Duan | 2017 | Nano Research2017，10，7： | 3 |
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