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| 1 | Inactivation of the positive LuxR-type oligomycin biosynthesis regulators OlmRI and OlmRII increases avermectin production in Streptomyces avermitilis显示文摘Oligomycins are a group of 26 macrocyclic lactones that exhibit broad biological activities,including antifungal,anticancer and nematocidal activities.Analysis of the oligomycin biosynthetic gene cluster (olm) in S.avermitilis revealed 2 tandem LuxR-type regulators,OlmRI (931 aa) and OlmRII (941 aa),with shared identity of 38%.Gene replacement of olmRI or olmRII abolished oligomycin production,and this production could be partially restored in the disruptants by introducing cloned olmRI and olmRII with their native promoters,demonstrating the essential role of OlmRI and OlmRII for oligomycin biosynthesis.Quantitative real-time RT-PCR analysis revealed that transcription of 14 olm genes was differentially affected by the deletion of olmRI and olmRII.Unexpectedly,avermectin production in both mutants was enhanced at least 4-fold.The identification of the positive cluster-situated regulators,OlmRI and OlmRII,paves the way for the transcriptional analysis of oligomycin biosynthesis and for the enhancement of oligomycin and avermectin production through regulator engineering. | YU Qing BAI LinQuan ZHOU XiuFen DENG ZiXin | 2012 | Chinese Science Bulletin2012，57，8： | 4 |
| 2 | Soft switching PWM three level coverters显示文摘 | Ruan Xinbo Zhou Linquan | 2001 | IEEE Transactions on Power Electronics2001，，5： | 1 |
| 3 | Abnormal thermal shock behavior in electrical conductivity of Ti2SnC显示文摘Some ternary carbide and nitride ceramics have been demonstrated to exhibit abnormal thermal shock behavior in mechanical properties. However, the influence of thermal shock on other properties is not clear. This work reports on the influence of thermal shock on electrical conductivity of Ti_2SnC as a representative member of ternary carbides. Abnormal change in electrical conductivity was first demonstrated during quenching Ti_2 SnC in water at 500-800 ℃. The residual electrical conductivity of the quenched Ti_2SnC gradually decreased with increasing temperature, but abnormally increased after quenching at 600 ℃. The microstructure of surface cracks was characterized. The main mechanism for the abnormal electrical conductivity recovery is that some narrow branching cracks are filled by metallic Sn precipitating from Ti_2SnC. | Linquan Zhang Shibo Li Xiaodong Chen Yang Zhou | 2017 | Progress in Natural Science:Materials International2017，27，4： | 1 |
| 4 | Soft-switching PWM threelevel converters 显示文摘 | Xinbo Ruan Linquan Zhou Yangguang Yah | 2001 | IEEE Transactions on Power Electronics2001，16，5： | 1 |
| 5 | Soft-switching PWM three-level converters显示文摘 | Ruan Xinbo Zhou Linquan Yan Yangguang | 2001 | IEEE Transactions on Power Electronics2001，16，5： | 1 |
| 6 | Soft-switching pwm three-level converters显示文摘 | Ruan Xinbo Zhou Linquan Yan Yangguang | 2001 | IEEE Transactions on Power Electronics2001，16，5： | 1 |
| 7 | Zero-voltage-switching pwm three-level converter with two clamping diodes显示文摘 | Ruan Xinbo Xu Dayu Zhou Linquan | 2002 | IEEE Transactions on Industrial Electronics2002，49，4： | 1 |
| 8 | Soft-switching PWM three-level converters显示文摘 | Ruan Xinbo Zhou Linquan Yan Yangguang | 2001 | IEEE Trans on Power Electronics2001，16，5： | 1 |
| 9 | Soft-switching PWM three-level converters显示文摘 | Xinbo Ruan Linquan Zhou Yangguang Yan | | 0，，05： | 1 |
| 10 | Incomplete β-Ketone Processing as a Mechanism for Polyene Structural Variation in the FR-008/Candicidin Complex显示文摘 | Yongjun Zhou Jialiang Li Jing Zhu Shi Chen Linquan Bai Xiufen Zhou Houming Wu Zixin Deng | 2008 | Chemistry & Biology2008，，： | 1 |
| 11 | Soft-swithing PWM threelevel converters显示文摘 | Xinbo Ruan Linquan Zhou Yangguang Yah | 2001 | IEEE Transactions on Power Electronics2001，16，5： | 1 |
| 12 | Soft- switching PWM three-level converters显示文摘 | Ruan Xinbo Zhou Linquan Yan Yangguang | 2001 | IEEE Transactions on Power Electronics2001，16，5： | 1 |
| 13 | Zero-voltage-switching pwm three- level converter with two clamping diodes显示文摘 | Xinbo Ruan Dayu Xu Linquan Zhou | 2002 | IEEE Transactions on Industrial Electronics2002，49，4： | 1 |
| 14 | Soft switching PWM three-level converters显示文摘 | Ruan Xinbo Zhou Linquan Yan Yangguang | 2001 | IEEE Transac- tions on Power Electronics2001，16，5： | 1 |
| 15 | Soft-switching PWM three-level converters显示文摘 | Xinbo Ruan Linquan Zhou Yangguang Yan | 2001 | IEEE Transaction on Power Electronics2001，16，5： | 1 |
| 16 | Zero- voltage-switching PWM three-level converter with two clamping diodes显示文摘 | Ruan Xinbo Xu Dayu Zhou Linquan | 2002 | IEEE Transactions on Industrial Electronics2002，49，4： | 1 |
| 17 | Zaro-voltage-switching pwm three-level converter with two clarnping diodes显示文摘 | Xinbo Ruan Dayu Xu Linquan Zhou | 2002 | IEEE Transactions on Industrial Elecuonics2002，4，94： | 1 |
| 18 | Enhanced validamycin production and gene expression at elevated temperature in Streptomyces hygroscopicus subsp. jingangensis 5008显示文摘Cultivation shift from 30℃ to 37℃ significantly enhanced validamycin (VAL) production. Analyzed by reverse-transcription PCR, the transcription of three val genes, valA, valK and valG, representing the three operons of the cluster was simultaneously increased at elevated temperature. Furthermore, the transcription of valP and valQ, a pair of two-component regulators in validamycin biosynthetic gene cluster, was also increased at 37℃. Inactivation of valP and valQ reduced validamycin production at 37℃ to the yield level of wild type strain at 30℃, and the val genes showed reduced expression in the mutant LL-8 at 37℃. These results revealed that the two-component regulator valP and valQ contribute to the elevated validamycin production. | LI Lei BAI LinQuan ZHOU XiuFen DENG ZiXin | 2009 | Chinese Science Bulletin2009，54，7： | 0 |
| 19 | Very Short-Term Probabilistic Prediction Method for Wind Speed Based on ALASSO-Nonlinear Quantile Regression and Integrated Criterion显示文摘To enhance the performance of the prediction intervals (PIs), a novel very short-term probabilistic prediction method for wind speed via nonlinear quantile regression (NQR) based on adaptive least absolute shrinkage and selection operator (ALASSO) and integrated criterion (IC) is proposed. The ALASSO method is studied for shrinkage of output weights and selection of variables. Furthermore, for the better performance of PIs, composite weighted linear programming (CWLP) is proposed to modify the conventional linear programming cost function of quantile regression (QR), by combining it with Bayesian information criterion (BIC) as an IC to optimize the coefficients of PIs. Then, the multiple fold cross model (MFCM) is utilized to improve the PIs performance. Multistep probabilistic prediction of 15-minute wind speed is performed based on the real wind farm data from the northeast of China. The effectiveness of the proposed approach is validated through the performances' comparisons with conventional methods. | Yan Zhou Yonghui Sun Sen Wang Linquan Bai Dongchen Hou Rabea Jamil Mahfoud Peng Wang | 2023 | CSEE Journal of Power and Energy Systems2023，9，6： | 0 |
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