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| 1 | Phase II clinical trial using camrelizumab combined with apatinib and chemotherapy as the first-line treatment of advanced esophageal squamous cell carcinoma显示文摘Background:Effective therapeutic options are limited for patients with advanced esophageal squamous cell carcinoma(ESCC).The incorporation of an immune checkpoint inhibitor and a molecular anti-angiogenic agent into the commonly adopted chemotherapy may produce synergistic effects.Therefore,we aimed to investigate the efficacy and safety of camrelizumab plus apatinib combined with chemotherapy as the first-line treatment of advanced ESCC.Methods:In this single-arm prospective phase II trial,patients with unresectable locally advanced or recurrent/metastatic ESCC received camrelizumab 200 mg,liposomal paclitaxel 150 mg/m2,and nedaplatin 50 mg/m2 on day 1,and apatinib 250 mg on days 1-14.The treatments were repeated every 14 days for up to 9 cycles,followed by maintenance therapy with camrelizumab and apatinib.The primary endpoint was objective response rate(ORR)according to the Response Evaluation Criteria in Solid Tumors(version 1.1).Secondary endpoints included disease control rate(DCR),progression-free survival(PFS),overall survival(OS),and safety.Results:We enrolled 30 patients between August 7,2018 and February 23,2019.The median follow-up was 24.98 months(95%confidence interval[CI]:23.05-26.16 months).The centrally assessed ORR was 80.0%(95%CI:61.4%-92.3%),with a median duration of response of 9.77 months(range:1.54 to 24.82+months).The DCR reached 96.7%(95%CI:82.8%-99.9%).The median PFS was 6.85 months(95%CI:4.46-14.20 months),and the median OS was 19.43 months(95%CI:9.93 months–not reached).The most common grade 3-4 treatmentrelated adverse events(AEs)were leukopenia(83.3%),neutropenia(60.0%),and increased aspartate aminotransferase level(26.7%).Treatment-related serious AEs included febrile neutropenia,leukopenia,and anorexia in one patient(3.3%),and single cases of increased blood bilirubin level(3.3%)and toxic epidermal necrolysis(3.3%).No treatment-related deaths occurred.Conclusions:Camrelizumab plus apatinib combined with liposomal paclitaxel and nedaplatin as first-line treatment demonstrated feasible anti-tumor activity and manageable safety in patients with advanced ESCC.Randomized trials to evaluate this new combination strategy are warranted.Trial registration:This trial was registered on July 27,2018,at ClinicalTrials.gov(identifier:NCT03603756). | Bo Zhang Ling Qi Xi Wang Jianping Xu Yun Liu Lan Mu Xingyuan Wang Lidan Bai Jing Huang | 2020 | Cancer Communications2020，40，12： | 38 |
| 2 | Study on the Effects of Probiotics on the Growth of Cyprinus carpiod and Water Quality显示文摘[Objective] The aim was to discuss the effects of probiotics on the growth of Cyprinus carpiod and water quality. [Method] Taking C. carpiod as the research object, probiotics were supplemented in the fodder and water to study their effects on the growth of C. carpiod and water quality. [Result] Probiotics had promoting effects on the growth of C. carpiod and its optimum dosage was 6%. pH, ammonia nitrogen content and nitrite content in water body in experimental groups were all lower than those in control group. [Conclusion] Compound probiotics had a broad application foreground in the aquatic breeding industry. | Wanqing GUO Lidan BAI Hai WANG Xiaowei LI Wei SHI Shuo SUN | 2015 | Agricultural Science & Technology2015，16，6： | 1 |
| 3 | The -22018A allele matches the lactase persistence phenotype in northern Chinese populations显示文摘 | Lidan Xu Haiming Sun Xuelong Zhang Jingwei Wang Donglin Sun Feng Chen Jing Bai Songbin Fu | 2010 | Scandinavian Journal of Gastroenterology2010，，2： | 1 |
| 4 | Advances and applications of machine learning and intelligent optimization algorithms in genome‑scale metabolic network models显示文摘Due to the increasing demand for microbially manufactured products in various industries,it has become important to find optimal designs for microbial cell factories by changing the direction of metabolic flow and its flux size by means of metabolic engineering such as knocking out competing pathways and introducing exogenous pathways to increase the yield of desired products.Recently,with the gradual cross-fertilization between computer science and bioinformatics fields,machine learning and intelligent optimization-based approaches have received much attention in Genome-scale metabolic network models(GSMMs)based on constrained optimization methods,and many high-quality related works have been published.Therefore,this paper focuses on the advances and applications of machine learning and intelligent optimization algorithms in metabolic engineering,with special emphasis on GSMMs.Specifically,the development history of GSMMs is first reviewed.Then,the analysis methods of GSMMs based on constraint optimization are presented.Next,this paper mainly reviews the development and application of machine learning and intelligent optimization algorithms in genome-scale metabolic models.In addition,the research gaps and future research potential in machine learning and intelligent optimization methods applied in GSMMs are discussed. | Lidan Bai Qi You Chenyang Zhang Jun Sun Long Liu Hengyang Lu Qidong Chen | 2023 | Systems Microbiology and Biomanufacturing2023，3，2： | 0 |
| 5 | Controllable shaping of high-index dielectric nanoparticles by exploiting the giant optical force of femtosecond laser pulses显示文摘Nanoparticles made of different materials usually support optical resonances in the visible to near infrared spectral range,such as the localized surface plasmons observed in metallic nanoparticles and the Mie resonances observed in dielectric ones.Such optical resonances,which are important for practical applications,depend strongly on the morphologies of nanoparticles.Laser irradiation is a simple but effective way to modify such optical resonances through the change in the morphology of a nanoparticle.Although laser-induced shaping of metallic nanoparticles has been successfully demonstrated,it remains a big challenge for dielectric nanoparticles due to their larger Young’s modulus and smaller thermal conductivities.Here,we proposed and demonstrated a strategy for realizing controllable shaping of high-index dielectric nanoparticles by exploiting the giant optical force induced by femtosecond laser pulses.It was found that both Si and Ge nanoparticles can be lit up by resonantly exciting the optical resonances with femtosecond laser pulses,leading to the luminescence burst when the laser power exceeds a threshold.In addition,the morphologies of Si and Ge nanoparticles can be modified by utilizing the giant absorption force exerted on them and the reduced Young’s modulus at high temperatures.The shape transformation from sphere to ellipsoid can be realized by laser irradiation,leading to the blueshifts of the optical resonances.It was found that Si and Ge nanoparticles were generally elongated along the direction parallel to the polarization of the laser light.Controllable shaping of Si and Ge can be achieved by deliberately adjusting the excitation wavelength and the laser power.Our findings are helpful for understanding the giant absorption force of femtosecond laser light and are useful for designing nanoscale photonic devices based on shaped highindex nanoparticles. | YUHENG MAO SHUWEN BAI MINGCHENG PANMAI LIDAN ZHOU SHIMEI LIU SHULEI LI HAIYING LIU HAIHUA FAN JUN DAI SHENG LAN | 2024 | Photonics Research2024，12，2： | 0 |
| 6 | Cysteine mutations impair the structural stability of phosphomannomutase 2(PMM2)in glycosylation-associated metabolic disorders显示文摘Glycosylation is a ubiquitous molecular modification in the process of cellular metabolism regulation,which plays a vital role in maintaining and regulating cellular functions.Deficiency in glycosylation enzymes may jeopardize the glycosylation process and eventually lead to the metabolic disease,manifesting with either a neurologic or multisystem phenotype,which is also known as congenital disorder of glycosylation(CDG).1 It could be classified into type I CDG and type II CDG,and the latter was referred to as the abnormal formation of nascent glycoprotein.Phosphomannomutase 2 CDG(PMM2-CDG),the most prevalent CDG with an incidence rate of 1 in 20,000 individuals,is mainly due to the metabolic disorder of phosphomannomutase 2(PMM2).2 PMM2 participates in the conversion of mannose-6-phosphate to mannose-1-phosphate.The cysteine residues,as one of the least abundant amino acids,have unique attributes to maintain the stability of protein structure,especially for catalytic activity and protein folding.3 Therefore,cysteine mutations have been identified in various diseases including PMM2-CDG.Suggested by the crystal structure of PMM2(PDB ID:7O5Z),4 four cysteine mutations in the hPMM2,C9Y,C103F,C192G,and C241S,have been found in PMM2-CDG.After bioinformatic analysis by PROVEAN,the four cysteine mutations were predicted with“Deleterious”,ranking with the best two were C103F and C192G(C9Y:−5.493,C103F:−6.339,C192G:−11.176,C241S:−2.986).However,the underlying pathological mechanism is still unclear.Among them,C103F and C192G have only been reported in clinical study without a detailed explanation,so they were selected for our research.Two mutants were located near the linker region 1 and 2;C103F was located on the No.4αhelix and C192G was located on the No.7αhelix(Fig.S1A).The purpose of this study was to explore the structure and function roles of PMM2 clinical mutation and investigate the role of cysteine in PMM2 which might provide new insights into preventive and therapeutic strategies for PMM2-CDG. | Yunfan Pan Li Lin Fan Yu Jingmiao Sun Guannan Bai Xinyu He Jianhua Mao Lidan Hu | 2023 | Genes & Diseases2023，10，5： | 0 |
| 7 | Recrystallization Behavior of the New Ni-Co-Based Superalloy with Fusion Structure Produced by Electron Beam Smelting Layered Solidification Technology显示文摘The new Ni-Co-based superalloy featuring a'fusion structure'was produced utilizing electron beam smelting layered solidification technology(EBSL).Experimental examination of hot compression deformation with varied settings for EBSL and conventional duplex process melting Ni-Co superalloys was performed.As per the study,EBSL-Ni-Co superalloys exhibited enhanced recrystallization susceptibility during hot deformation.Furthermore,elevating deformation temperature,lowering strain rate,and augmenting strain collectively contribute to enlarging the volume fraction of dynamically recrystallized grains.Aberrant growth of grains occurred when the deformation temperature equaledγ′sub-solvus temperature and the strain rate was slower.Moreover,exceeding theγ′solvus temperature during deformation significantly increases the particle size of dynamic recrystallization(DRX)grains.Theγ′phase can effectively modulate the DRX grain size through the pegging effect.Additionally,it was revealed that the presence of the fusion structure aids in the generation of continuous dynamic recrystallization,discontinuous dynamic recrystallization,and twinning-induced dynamic recrystallization while the alloy undergoes hot deformation.This mechanism promotes DRX granule formation and permits complete recrystallization.Ultimately,the fusion structure was identified as playing a catalytic role in the dynamic recrystallization process of the new Ni-Co superalloy. | Hongyang Cui Yi Tan Rusheng Bai Lidan Ning Chuanyong Cui Xiaogang You Pengting Li | 2023 | Acta Metallurgica Sinica(English Letters)2023，36，12： | 0 |
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