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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study显示文摘 | Shamir R Mehta Salim Yusuf Ron JG Peters Michel E Bertrand Basil S Lewis Madhu K Natarajan Klas Malmberg Hans-Jürgen Rupprecht Feng Zhao Susan Chrolavicius Ingrid Copland Keith AA Fox | 2001 | The Lancet . 2001 (9281)2001，，9281： | 4 |
| 3 | Gain saturation in silica-fibre Raman amplifier 显示文摘 | LEWIS S A E CHERNIKOV S V TAYLOR J R | 1999 | Electron Lett1999，35，11： | 2 |
| 4 | Prevalence of anxiety and depression in patients with severe COPD: similar high levels with and without LTOT 显示文摘 | LEWIS K E ANNANDALE J A SYKES R N | 2007 | COPD2007，4，4： | 1 |
| 5 | A role for the AKT1 potassium channel in plant nutrition显示文摘 | Hirsch R E Lewis B D Spalding E P | 1998 | Science1998，280，： | 1 |
| 6 | Toxicity comparison of biosurfactants and synthetic surfactants used in oil spill remediation to two estuarine species显示文摘 | Edwards K R Lepo J E Lewis M A | 2003 | Marine Pollution Bulletin2003，46，10： | 1 |
| 7 | Triple wavelength pumped silica-fiber Raman amplifiers with 114 nm bandwith显示文摘 | LEWIS S A E CHERNIKOV S V TAYLOR J R | 1999 | Electronics Letters1999，35，20： | 1 |
| 8 | A New Method for the Measurement of the Optical Volume Scattering Function in the Upper Ocean显示文摘 | LEE Michael E MARLON R Lewis | 2003 | Journal of Atmospheric and Oceanic Technology2003，20，4： | 1 |
| 9 | Irrigation timing by the stress day index method 显示文摘 | Hiler E A Howell T A Lewis R B | 1974 | Transaction of ASAE1974，，17： | 1 |
| 10 | The effect of microbial phytase in a pearl millet-soybean meal diet on apparent digestibility and retention of nutrients,serum mineral concentration,and bone mineral density of nurscry pigs显示文摘 | MURRY A C LEWIS R D AMOS H E | 1997 | J Anim Sci1997，75，： | 1 |
| 11 | Tackling antibiotic resistance显示文摘 | Bush K Courvalin P Dantas G Davies J Eisenstein B Huovinen P Jacoby GA Kishony R Kreiswirth BN Kutter E Lerner SA Levy S Lewis K Lomovskaya O Miller JH Mobashery S Piddock LJ Projan S Thomas CM Tomasz A Tulkens PM Walsh TR Watson JD Witkowski J Witte W Wr | | 0，，： | 1 |
| 12 | Dredging impact on an urbanized Florida bayou, effects on benthos and algal-periphyton显示文摘 | LEWIS M A WEBER D E STANLEY R S | 2001 | Environmental Pollution2001，115，2： | 1 |
| 13 | Gain saturation in silica-fibre Raman amplifier 显示文摘 | Lewis S A E Chernikov S V Taylor J R | 1999 | Electron Letters1999，35，11： | 1 |
| 14 | Risk of early death and recurrent stroke and effect of heparin in 3169 patients with acute ischaemic stroke and atrial fibrillation in the International Stroke Trial显示文摘 | Saxena R Lewis S Berge E | 2001 | Stroke2001，32，： | 1 |
| 15 | Planar cell polarity acts through septins to control collective cell movement and ciliogenesis显示文摘 | Kim S K Shindo A Park T J Oh E C Ghosh S Gray R S Lewis R A Johnson C A | | 0，，5997： | 1 |
| 16 | A role for the AKT1 potassium channel in plant nutrition 显示文摘 | HIRSCII R E LEWIS B D SPALDING E P el al | 1998 | Science1998，280，5365： | 1 |
| 17 | Linear measures for polyhedral networks显示文摘 | Glieksman M E Rios P R Lewis D J | 2009 | International Journal of Materials Research2009，100，4： | 1 |
| 18 | Another look at the efficiency of zorporate travel management departments 显示文摘 | Anderson R I Lewis D Parker M E | 1999 | Journal of Travel Re- search1999，37，3： | 1 |
| 19 | Towards drug discovery for brain tumours:interaction of kinins and tumours at the blood brain barrier interface显示文摘 | Harford-Wright E Lewis KM Vink R | 2011 | Recent Pat CNS Drug Discov2011，6，1： | 1 |
| 20 | Differential activation of transcription factors induced by Ca^2+ response am-plitude anddurati显示文摘 | Dolmetsch R E Lewis R S Goodnow C C | | 0，，： | 1 |
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