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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 3 | Trust as a social reality显示文摘 | Lewis J D Weigert A | 1985 | Social Forces1985，63，4： | 1 |
| 4 | Trust as a Social Reality 显示文摘 | Lewis J D Weigert A | 1985 | Social Force1985，63，4： | 1 |
| 5 | Knee joint motion and ligament forces before and after ACL reconstruction 显示文摘 | Lewis J L Lew W D Hill J A | 1989 | Journal of Biomechanical Engineering1989，111，： | 1 |
| 6 | The Effect of Ceramic Fiber Coatings on the Room-Temperature Mechanical Behavior of Ceramic?Fiber Composites显示文摘 | R W Rice J R Spann D Lewis | 1984 | Ceramic Engineering and Science Proceedings1984，5，78： | 1 |
| 7 | Predictors of persistent pain after total knee arthroplasty: a systematic review and meta-analysis 显示文摘 | Lewis G N Rice D A McNair P J | 2015 | Br J Anaesth2015，114，4： | 1 |
| 8 | Ablation of solids under femtosecond laser pulses显示文摘 | Perez D Lewis L J | 2002 | Phys Rev Lett2002，89，25： | 1 |
| 9 | Structure-function relations of heparin-mimetic sulphated xylan-oligosaccharides inhibition of Human Immunodeficiency Virus-1 infectivity in vitro显示文摘 | Stone A L Melton D J Lewis M S | 1998 | GlycoconjugateJournal1998，15，： | 1 |
| 10 | A universal dye for all fibers are disperse dyes capable of fulfilling this vision? 显示文摘 | Broadbent P J | 1997 | JSDC1997，113，： | 1 |
| 11 | Phase-field models for eutectic solidification显示文摘 | Lewis D J Pusztai T Granasy L | 2004 | JOM2004，，4： | 1 |
| 12 | Organizing cell renewal in the intestine:stem cells,signals and combinatorial control显示文摘 | CROSNIER C STAMATAKI D LEWIS J | 2006 | Nat Rev Genet2006，7，5： | 1 |
| 13 | Storage of sediment-associated nutrients and contaminants in river channel and floodplain systems显示文摘 | Walling D E Owens P N Carter J Leeks G J L Lewis S Meharg A A and Wright J | 2003 | Applied Geochemistry2003，18，： | 1 |
| 14 | Thalassiosira species (Bacillariophyceae) from a Scottish sea-loch 显示文摘 | Harris A S D Medlim L K Lewis J | 1995 | European Journal ofPhycology1995，30，2： | 1 |
| 15 | Complement activationcontributes to both glomerular and tubulointerstitial damagein adriamycin nephropathy in mice显示文摘 | Tumberg D Lewis M Moss J | 2006 | J Immunol2006，177，6： | 1 |
| 16 | Multi temporal MODIS Landsat Data Fusion for Relative Radiometric Normalization,Gap Filling,and Prediction of Landsat Data显示文摘 | Roy D P Ju J Lewis P | 2008 | Remote Sensing of Environment2008，112，： | 1 |
| 17 | An intercomparison of sampling techniques for nicotine in indoor environments显示文摘 | Caka F M Eatough D J Lewis E A | 1994 | Environmental Science and Technology1994，24，8： | 1 |
| 18 | Recurrent epidemic cycles in an infectious disease model with a time delay in loss of vaccine immunity 显示文摘 | Greenhalgh D Khan Q J A Lewis F I | 2005 | Nonl Anal TMA2005，63，6： | 1 |
| 19 | Induction of tumorigen-esis and metastasis by the murine orthologue of tumor protein D52 显示文摘 | Lewis J D Payton L A Whitford J G | 2007 | Mol Cancer Res2007，5，2： | 1 |
| 20 | Conventional hemangiopericytoma: Modem analysis of outcome 显示文摘 | Espat NJ Lewis J J Leung D | 2002 | Cancer2002，95，8： | 1 |
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