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| 1 | Effect of cadmium on photosynthetic pigments,lipid peroxidation,antioxidants,and artemisinin in hydroponically grown Artemisia annua显示文摘The effects of different cadmium(Cd) concentrations(0,20,60,and 100 μmol/L) on hydroponically grown Artemisia annua L.were investigated.Cd treatments applied for 0,4,12,24,72,144,216,and 336 hr were assessed by measuring the changes in photosynthetic pigments,electrolyte leakage,malondialdehyde(MDA) and antioxidants(ascorbic acid and glutathione),while the artemisinin content was tested after 0,12,144,216,and 336 hr.A significant decrease was observed in photosynthetic pigment levels over time with increasing Cd concentration.Chlorophyll b levels were more affected by Cd than were chlorophyll a or carotenoid levels.The cell membrane was sensitive to Cd stress,as MDA content in all treatment groups showed insignificant differences from the control group,except at 12 hr treatment time.Ascorbic acid(AsA) content changed slightly over time,while glutathione(GSH) content took less time to reach a maximum as Cd concentration increased.Cd was found to promote synthesis and accumulation of artemisinin,especially at concentrations of 20 and 100 μmol/L.In conclusion,Cd stress can damage to photosynthetic pigments,and vigorously growing A.annua showed a strong tolerance for Cd stress.Appropriate amounts of added Cd aided synthesis and accumulation of artemisinin. | Xuan Li Manxi Zhao Lanping Guo Luqi Huang | 2012 | Journal of Environmental Sciences2012，24，8： | 9 |
| 2 | Effects of ecological factors on secondary metabolites and inorganic elements of Scutellaria baicalensis and analysis of geoherblism显示文摘This study analyzed the effects of ecological factors on secondary metabolites of Scutellaria baicalensis using two sources:92individual roots of S.baicalensis from all over China,and secondary metabolites,medicinal materials and inorganic element contents obtained from the testing of 92 S.baicalensis rhizosphere soil samples.The study used environmental data from the Genuine Medicinal Material Spatial Analysis Database.Most of the chemical constituents of S.baicalensis were negatively correlated to latitude and positively correlated to temperature;generally,the contents of 21 chemical constituents were higher at low latitudes than that at high latitudes.By gradual regression analysis,it was found that the content of baicalin in S.baicalensis was negatively correlated to latitude and generally the content of inorganic elements in soil was excessively high(excluding Mg and Ca),which has a negative effect on the accumulation of chemical constituents in S.baicalensis.Based on the cluster analysis of 21 constituents,S.baicalensis from different places of origin was divided into two groups,and S.baicalensis was not genuine only in a specific small region.Within the zone from Chifeng,Inner Mongolia to Taibai,Shaanxi is suitable for accumulation of secondary metabolites of S.baicalensis and such a zone represents a suitable distribution and potential genuine producing area. | GUO LanPing WANG Sheng ZHANG Ji YANG Guang ZHAO ManXi MA WeiFeng ZHANG XiaoBo LI Xuan HAN BangXing CHEN NaiFu HUANG LuQi | 2013 | Science China(Life Sciences)2013，56，11： | 7 |
| 3 | Biodegradation of n-hexadecane by bacterial strains B1 and B2 isolated from petroleum-contaminated soil显示文摘Two hydrocarbon-biodegrading bacterial strains,B1 and B2,were isolated from petroleum-contaminated soil collected from Tianjin,China.The strains were identified as Pseudomonas aeruginosa(B1) and Acinetobacter junii(B2).The degradation rate of n-hexadecane by B1 and B2 reached 96% and 78% respectively after 7 days,though the strains employed different mechanisms of degradation.The results showed that B2 was not able to use glucose as carbon source.B1 could produce glycolipid surfactants using glucose as the carbon source,according to the results of blue agar plate analysis and thin layer chromatography(TLC),and the bacterial culture of B1 had a high oil discharge and emulsification activity.Both B1 and B2 could produce biosurfactants with hexadecane as the sole carbon source,but their modes of action were different.The carbon source was found to affect the cell surface hydrophobicity.Cell surface hydrophobicity was poor with glucose as the carbon source,but enhanced when hexadecane was used as the carbon source. | LIU Tao WANG FengHua GUO LanPing LI XiaoLiang YANG XiaoJin LIN Ai Jun | 2012 | Science China Chemistry2012，55，9： | 4 |
| 4 | Top-geoherbs of traditional Chinese medicine:common traits,quality characteristics and formation显示文摘Top-geoherbs used in China are always featured with high qualities,and they grow in specified areas with specific environment.Recently,researches on top-geoherbs have attracted increasing attention in China and other countries.In order to have a thorough knowledge of top-geoherbs,this article reviews the concept,historical evolution,common trait and quality characteristics of top-geoherbs,and explains the forming mechanism including genetic mechanism and environmental mechanism.In addition,it introduces the influence of human factors on the quality of top-geoherbs.Finally,it proposes some problems that should be paid attention to in the researches on top-geoherbs. | Luqi Huang Lanping Guo Chaoyi Ma Wei Gao Qingjun Yuan | 2011 | Frontiers of Medicine2011，5，2： | 2 |
| 5 | Study on the habitat characteristics of the geoherbs of Atractylodes lancea based on geograrhic information systems (GIS) 显示文摘 | Lanping Guo Luqi Huang Hong Yan | 2005 | Journal of US-China Medical Science2005，2，1： | 1 |
| 6 | Nonlinear Time Series Forecasting of RBF Neural Network Based on Genetic Algorithm显示文摘 | GUO Lanping YU Jianning ZHANG Jiangang QI Yujuan ZHANG Xudong | 2011 | Journal of Hebei Normal University2011，35，3： | 1 |
| 7 | Arbuscularmycorrhizal symbiosis and active ingredients of medicinalplants:current research status and prospectives显示文摘 | Zeng Yan Guo Lanping Chen Baodong | 2013 | Mycor-rhiza2013，23，4： | 1 |
| 8 | Visualizing the spatial distribution and alteration of metabolites in continuously cropped Salvia miltiorrhiza Bge using MALDI-MSI显示文摘Salvia miltiorrhiza Bge(SMB)has long been used in traditional Chinese medicine to treat cardiovascular and cerebrovascular diseases.Growing clinical usage has led to a huge demand for artificial planting of SMB.Thus,continuous cropping of SMB is an important challenge that needs to be addressed.Continuous cropping can alter the metabolic profile of plants,resulting in poor growth and low yield.In this study,we tried to image the spatial location and variation of endogenous metabolites in continuously cropped SMB using matrix-assisted laser desorption/ionization mass spectrometry imaging(MALDIMSI).Spatially resolved expressions of tanshinones,salvianolic acids,polyamines,phenolic acids,amino acids,and oligosaccharides in normal and continuously cropped SMB roots were compared.The expressions of dihydrotanshinone Ⅰ,tanshinone Ⅱ A,dehydromiltirone,miltirone,dehydrotanshinone ⅡA,spermine,salvianolic acid B/E,tetrasaccharide,and pentasaccharide in continuously cropped SMB roots were much lower than those in normal roots.There was little difference in the expressions of caffeic acid and salvianolic acid A in normal and continuously cropped SMB roots.Ferulic acid was more widely distributed in xylem of normal SMB but strongly expressed in xylem,phloem,and cambium of continuously cropped SMB.The spatially resolved metabolite information enhances our understanding of the metabolic signature of continuously cropped SMB and also provides insights into the metabolic effects of continuous cropping in other plants. | Chenglong Sun Li Cui Bingqian Zhou Xiao Wang Lanping Guo Wei Liu | 2022 | Journal of Pharmaceutical Analysis2022，12，5： | 1 |
| 9 | Association of C-reactive protein and metabolic syndrome in a rural Chinese population显示文摘 | Jiangping Wen Yuanbo Liang Fenghua Wang Lanping Sun Yongjun Guo Xinrong Duan Xiangyi Liu Qiushan Tao Tien Yin Wong Xinxin Lu Ningli Wang | 2009 | Clinical Biochemistry2009，，10： | 1 |
| 10 | Two-stage reproduction derived from cells of thallus could directly contribute to seeds for green tidal algal Enteromorpha(Ulva) prolifera/clathrata bloom,with disclosure of their ephemeral trait显示文摘Green tidal algal Enteromorpha species complete their life cycles by the isomorphic alternation of generations.The provenance of green tide caused by them in the western Yellow Sea has been disputed. The cell reproduction derived from adult thallus was observed on E. clathrata collected from Shantou City, Guangdong Province in this study. Subsequently, it further found that E. proliferia collected from Qingdao City, Shandong Province and Qinhuangdao City, Hebei Province, produced reproductive cells by somatic cells of its early infantile thallus or branch. The latter is functionally similar to that the seedlings of red alga Porphyra yezoensis produce the monospores, and could exquisitely explain the ephemeral or opportunistic trait and environmental adaptation ability of Enteromorpha species. Changes in growth conditions may induce the two types of cell reproduction.They contribute to the bloom, and can effectively reveal the seasonally occurring large-scale and on-year and offyear phenomenon. The latter may have played a decisive role in its formation. This paper analyses the legal status of the species name, the type of generation during bloom, ephemeral traits, the role of microscopic propagule, the area of origin, on-year and off-year phenomenon, early warning and prevention and control of the species, and so on. On this basis, further study on the influence of environmental factors on cell reproduction of early infantile thalli or branches will achieve a positive effect for early warning and prevention and control of the green tidal algal bloom. | Bingxin Huang Lanping Ding Yao Zhang Youxuan Guo Junxia Liang Yanqi Xie Yue Chu | 2023 | Acta Oceanologica Sinica2023，42，9： | 0 |
| 11 | Patterning of large area nanoscale domains in as-grown epitaxial ferroelectric PbTiO_(3)films显示文摘Effective tuning of nanoscale domain structures provides fundamental basis for controlling and engineering of various functionalities in ferroelectric materials.In this work,we demonstrate the precise patterning of nanoscopic domain structures in as-grown epitaxial PbTiO_(3)(PTO)films by merely introducing an ultrathin pre-patterned doping layer(e.g.,Fe-doped PTO).The doping layer can effectively reverse the interfacial built-in bias,consequent to a reversed initial polarization reorientation in the as-grown film,which makes it possible to transfer the nano-patterns in the doping layer into the domain structure of ferroelectric films.For instance,we have successfully fabricated large area ordered array of nanoscale cylindrical domains(downward polarization)embedded in the matrix domain with opposite polarization(upward polarization)in PTO film.These nanoscale cylinder domains also allow deterministic and reversible erasure and creation induced by biased tip scanning.The results provide an effective pathway for on-demand patterning of large area nanoscale domains in the as-grown films,which may find applications in a wide range of nanoelectronic devices. | Luyong Zhang Guo Tian Wenda Yang Dongfeng Zheng Chuanjie Lin Jianbiao Xian Yihang Guo Xingchen Zhang Xiuqin Qiu Lanping Zhang Zhen Fan Deyang Chen Zhipeng Hou Minghui Qin Jun-Ming Liu Xingsen Gao | 2023 | Journal of Materiomics2023，9，1： | 0 |
| 12 | Gut liver brain axis in diseases:the implications for therapeutic interventions显示文摘Gut-liver-brain axis is a three-way highway of information interaction system among the gastrointestinal tract,liver,and nervous systems.In the past few decades,breakthrough progress has been made in the gut liver brain axis,mainly through understanding its formation mechanism and increasing treatment strategies.In this review,we discuss various complex networks including barrier permeability,gut hormones,gut microbial metabolites,vagus nerve,neurotransmitters,immunity,brain toxic metabolites,β-amyloid(Aβ)metabolism,and epigenetic regulation in the gut-liver-brain axis.Some therapies containing antibiotics,probiotics,prebiotics,synbiotics,fecal microbiota transplantation(FMT),polyphenols,low FODMAP diet and nanotechnology application regulate the gut liver brain axis.Besides,some special treatments targeting gut-liver axis include farnesoid X receptor(FXR)agonists,takeda G protein-coupled receptor 5(TGR5)agonists,glucagon-like peptide-1(GLP-1)receptor antagonists and fibroblast growth factor 19(FGF19)analogs.Targeting gut-brain axis embraces cognitive behavioral therapy(CBT),antidepressants and tryptophan metabolism-related therapies.Targeting liver-brain axis contains epigenetic regulation and Aβmetabolism-related therapies.In the future,a better understanding of gut-liver-brain axis interactions will promote the development of novel preventative strategies and the discovery of precise therapeutic targets in multiple diseases. | Mengyao Yan Shuli Man Benyue Sun Long Ma Lanping Guo Luqi Huang Wenyuan Gao | 2024 | Signal Transduction and Targeted Therapy2024，9，1： | 0 |
| 13 | Effects of different doses of cadmium on secondary metabolites and gene expression in Artemisia annua L.显示文摘这研究瞄准位于 artemisinin 累积下面阐明的分子的机制由镉(Cd ) 导致了。Artemisia annua L 的生合成上的不同 Cd 集中(0, 20, 60,和 120 mol/L ) 的效果。被检验。中介和结束产品被 HPLC-ESI-MS/MS 分析确定。关键生合成酶的表示被 qRT-PCR 也决定。结果证明有为 3 天的 60 和 120 mol/L Cd 的处理的申请显著地改进了 artemisinic 酸, arteannuin B,和 artemisinin 的生合成。在 120 mol/L 的 artemisinic 酸, arteannuin B,和 artemisinin 的集中对待 Cd 的组分别地是比在控制组的那些高级 2.26, 102.08,和 33.63 倍的。在 60 mol/L 的 arteannuin B 和 artemisinin 的集中对待 Cd 的叶子分别地比在控制组的那些高 61.10 和 26.40 倍。HMGR, FPS,广告, CYP71AV1, DBR2, ALDH1,和 DXR 的相对表示层次在 120 mol/L 是起来调整的对待 Cd 的组因为在 3 天处理以后的 artemisinic 代谢物的增加的内容。因此, Cd 的适当剂量能增加在某个时间的代谢物指由的 artemisinic 的集中起来调整关键酶基因的相对表示层次在 artemisinin 包含了生合成。 | Liangyun Zhou Guang Yang Haifeng Sun Jinfu Tang Jian Yang Yizhan Wang Thomas Avery Garran Lanping Guo | 2017 | Frontiers of Medicine2017，11，1： | 0 |
| 14 | A Study on the Chemical Compositions of the Jasminum Sambac (L. ) Aiton in Various Farming Seasons During the Blossom Period in Fuzhou Region显示文摘The chemical compositions of the head space,essential oil and absolute of jasmin flowers in different farming seasons during the blossom period in Fuzhou were reported in this paper. | Guo Youjia, Dai Liang, Yang Lanping and Ren Qing (Fujian Institute of Reserch on the Structure of Matter, Academia sinica, Fuzhou, 350002) | 1998 | 福建分析测试1998，7，1： | 0 |
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