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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Three-dimensional knotting of W_(17)O_(47)@PEDOT:PSS nanowires enables high-performance flexible cathode for dual-functional electrochromic and electrochemical device显示文摘An efficient integration of electrochromic and electrochemical devices into one flexible entity enables both energy storage and energy-saving dual-functionalities.For this purpose,achieving both high electrochromic and electrochemical performance is the key aspect.Herein,a new 3D architecture is successfully made by knotting W_(17)O_(47)@PEDOT(poly(3,4-ethylenedioxythiophene)):PSS(poly(styrenesulfonate))nanowires with NaWO_(3)nanoknots,and interestingly,the 3D W_(17)O_(47)/(NaWO_(3)-knots)@PEDOT:PSS cathode thus-made simultaneously exhibits a large optical modulation(79.7%at 633 nm),an ultra-long cycling life(76%of original optical modulation retained after 12400 cycles),and a high areal capacitance(55.1 mF cm^(-2)at 0.1 mA cm^(-2)).Our density functional theory(DFT)calculations demonstrate that the much improved dual-functional performance is correlated to the raised electronic conductivity and ion adsorption at the W_(17)O_(47)/(NaWO_(3)nanoknots)interface,together with the ion adsorption of PEDOT:PSS in the 3D-knotted architecture.As a proof-of-concept application,different-sized flexible dual-functional electrochromic/electrochemical devices(FDEDs)were assembled and investigated for various application scenarios,including a smart window(15 cm×10 cm),a wearable wristband(20 cm×2.5 cm),and a smart eyeglass.The smart window made of the FDED enables a large temperature difference of 27.6℃ confirm-tested in model houses,where the energy source also powers three light-emitting diodes(LEDs).The understandings of the key governing principles in the electrodes and dual-functionalities provide a timely foundation for the new generation flexible multifunctional devices. | Qi Zhao Jinkai Wang Xinghui Ai Yujuan Duan Zhenghui Pan Shaorong Xie John Wang Yanfeng Gao | 2022 | InfoMat2022，4，4： | 2 |
| 3 | Interleukin‐17 enhances the production of interferon‐γ and tumour necrosis factor‐α by bone marrow T lymphocytes from patients with lower risk myelodysplastic syndromes显示文摘 | Zheng Zhang Xiao Li Juan Guo Feng Xu Qi He Youshan Zhao Yujuan Yang Shucheng Gu Yan Zhang Lingyun Wu Chunkang Chang | 2013 | Eur J Haematol2013，，5： | 2 |
| 4 | Nonlinear Time Series Forecasting of RBF Neural Network Based on Genetic Algorithm显示文摘 | GUO Lanping YU Jianning ZHANG Jiangang QI Yujuan ZHANG Xudong | 2011 | Journal of Hebei Normal University2011，35，3： | 1 |
| 5 | TdIF1:a putative oncogene in NSCLC tumor progression显示文摘TdT-interacting factor 1(TdIF1)is a ubiquitously expressed DNA-and protein-binding protein that directly binds to terminal deoxynucleotidyl transferase(TdT)polymerase.Little is known about the functional role of TdIF1 in cancer cellular signaling,nor has it previously been identified as aberrant in any type of cancer.We report here for the first time that TdIF1 is abundantly expressed in clinical lung cancer patients and that high expression of TdIF1 is associated with poor patient prognosis.We further established that TdIF1 is highly expressed in human non-small cell lung cancer(NSCLC)cell lines compared to a normal lung cell line.shRNA-mediated gene silencing of TdIF1 resulted in the suppression of proliferation and anchorage-independent colony formation of the A549 adenocarcinoma cell line.Moreover,when these TdIF1-silenced cells were used to establish a mouse xenograft model of human NSCLC,tumor size was greatly reduced.These data suggest that TdIF1 is a potent regulator of lung tumor development.Several cell cycle-related and tumor growth signaling pathways,including the p53 and HDAC1/2 pathways,were identified as participating in the TdIF1 signaling network by in silico analysis.Microarray,transcriptome and protein-level analyses validated p53 and HDAC1/2 modulation upon TdIF1 downregulation in an NSCLC cellular model.Moreover,several other cell cycle regulators were affected at the transcript level by TdIF1 silencing,including an increase in CDKN1A/p21 transcripts.Taken together,these results indicate that TdIF1 is a bona fide tumor-promoting factor in NSCLC and a potential target for therapy. | Yujuan Zhang Zhigang Wang Yanqing Huang Muying Ying Yifan Wang Juan Xiong Qi Liu Fan Cao Rakesh Joshi Yanling Liu Derong Xu Meng Zhang Keng Yuan Nanjin Zhou James Koropatnick Weiping Min | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 0 |
| 6 | Immunity-and-matrix-regulatory cells enhance cartilage regeneration for meniscus injuries: a phase I dose-escalation trial显示文摘Immunity-and-matrix-regulatory cells(IMRCs)derived from human embryonic stem cells have unique abilities in modulating immunity and regulating the extracellular matrix,which could be mass-produced with stable biological properties.Despite resemblance to mesenchymal stem cells(MSCs)in terms of self-renew and tri-lineage differentiation,the ability of IMRCs to repair the meniscus and the underlying mechanism remains undetermined.Here,we showed that IMRCs demonstrated stronger immunomodulatory and pro-regenerative potential than umbilical cord MSCs when stimulated by synovial fluid from patients with meniscus injury.Following injection into the knees of rabbits with meniscal injury,IMRCs enhanced endogenous fibrocartilage regeneration.In the dose-escalating phase I clinical trial(NCT03839238)with eighteen patients recruited,we found that intra-articular IMRCs injection in patients was safe over 12 months post-grafting.Furthermore,the effective results of magnetic resonance imaging(MRI)of meniscus repair and knee functional scores suggested that 5×107 cells are optimal for meniscus injury treatment.In summary,we present the first report of a phase I clinical trial using IMRCs to treat meniscus injury.Our results demonstrated that intra-articular injection of IMRCs is a safe and effective therapy by providing a permissive niche for cartilage regeneration. | Liangjiang Huang Song Zhang Jun Wu Baojie Guo Tingting Gao Sayed Zulfiqar Ali Shah Bo Huang Yajie Li Bo Zhu Jiaqi Fan Liu Wang Yani Xiao Wenjing Liu Yao Tian Zhengyu Fang Yingying Lv Lingfeng Xie Sheng Yao Gaotan Ke Xiaolin Huang Ying Huang Yujuan Li Yi Jia Zhongwen Li Guihai Feng Yan Huo Wei Li Qi Zhou Jie Hao Baoyang Hu Hong Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，12： | 0 |
| 7 | Association of SOST gene polymorphisms with peak bone mineral density in Chinese nuclear families with male-offspring显示文摘Peak bone mineral density(BMD)achieved during early adulthood is a highly heritable trait and a strong determinant of subsequent osteoporotic fracture risk.Evidence has already suggested that 50–80% of the variance in peak BMD is genetically determined [1].Human SOST gene comprises three exons and two introns,mapping to chromosomal region 17q12–q21.It inhibits osteoblastic bone formation by inhibiting the Wnt signaling pathway,which is critically important for the development and function of osteoblasts [2].Our previous study in large samples of postmenopausal Chinese women showed that the polymorphisms in the SOST gene are associated with BMD of the lumbar spine [3],but little is known in men.Thus,the objective of this study was to investigate whether polymorphisms in the SOST gene are associated with variations of peak BMD in Chinese nuclear families with male-offspring. | Luyue Qi Shoukui Xiang Li Li Jinwei He Wenzhen Fu Yujuan Liu Yunqiu Hu Zhenlin Zhang | 2019 | Acta Biochimica et Biophysica Sinica2019，51，3： | 0 |
| 8 | Effects of Huangzhou Radish Powder on the Quality of Silver Carp Surimi Products显示文摘[Objectives]This study was conducted to improve the quality of frozen silver carp surimi products.[Methods]Huangzhou radish powder and silver carp surimi were used as raw materials to analyze the effects of different amounts(1%,2%,3%,4%,5%)of Huangzhou radish powder on the water-holding capacity,cooking loss rate,whiteness value,TPA,gel strength and sensory quality of surimi products.[Results]When the addition amount of Huangzhou radish powder was 1%,water-holding capacity,hardness,chewiness and the gel strength of the surimi product reached their maximum values,which were 86.86%,3470.36 g,2628.50 g and 707.48 g·mm,respectively.Meanwhile,the cooking loss rate was reduced to a minimum value(13.66%),and the sensory quality reached the best.The whiteness of surimi products showed a decreasing trend with the increase of the addition amount of Huangzhou radish powder.However,the whiteness of the surimi product was not significantly affected when the addition amount of Huangzhou radish powder was 1%.Therefore,when the addition amount of Huangzhou radish powder was 1%,the quality of surimi products could be improved.[Conclusions]This study provides a new idea for the development and utilization of Huangzhou radish. | Qi YANG Xiaohong LIU Xinghui TIAN Yujuan JIN Yanyu YANG Fa QIU Siyao MA Peng WU Ting HU | 2023 | Agricultural Biotechnology2023，12，2： | 0 |
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