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| 1 | Association of high expression in rat gastric mucosal heat shock protein 70 induced by moxibustion pretreatment with protection against stress injury显示文摘AIM:To study the effect of moxibustion on Zusanli or Liangmeng point on gastric mucosa injury in stress-induced ulcer rats and its correlation with the expression of heat shock protein 70 (HSP70). METHODS:Sixty healthy SD rats (30 males,30 females) were divided into control group,injury model group,Zushanli point group,Liangmeng point group. Stress gastric ulcer model was induced by binding cold stress method. Gastric mucosa ulcer injury (UI) index was calculated by Guth method. Gastric mucosa blood flow (GMBF) was recorded with a biological signal analyzer. Protein content and gene expression in gastric mucosal HSP70 were detected by immunohistochemistry (IHC) and reverse transcription polymerase chain reaction (RT-PCR). Thiobarbital method was used to determine malondialdehyde (MDA) content. Gastric mucosal endothelin (ET) and prostaglandin E2 (PGE2) were analyzed by radioimmunoassay. RESULTS:High gastric mucosal UI index,high HSP70 expression,low GMBF and PGF2,elevated MDA and ET were observed in gastric mucosa of rats subjected to cold stress. Moxibustion on Zusanli or Liangmeng point decreased rat gastric mucosal UI index,MDA and ET. Conversely,the expression of HSP70,GMBF,and PGE2 was elevated in gastric mucosa after pretreatment with moxibustion on Zusanli or Liangmeng point. The observed parameters were significantly different between Zusanli and Liangmeng points. CONCLUSION:Pretreatment with moxibustion on Zusanli or Liangmeng point protects gastric mucosa against stress injury. This protection is associated with the higher expression of HSP70 mRNA and protein,leading to release of PGE2 and inhibition of MDA and ET,impairment of gastric mucosal index. | Xiao-Rong Chang La Peng Shou-Xiang Yi Yan Peng Jie Yan | 2007 | World Journal of Gastroenterology2007，13，32： | 22 |
| 2 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 3 | Modified Glasgow Prognostic Score, and Neutrophil/lymphocyte and Platelet/lymphocyte Ratios in Different Stages of Silicosis显示文摘Until now, although comprehensive management strategies have improved treatment, there are no treatments to alleviate symptoms and slow disease progression[1]. In the past few decades, there has been increasing evidence that inflammation plays a very important role in silicosis. Injury-induced inflammation is an effective strategy to remove harmful stimuli and initiate a healing process. However, it might be harmful to the organism and result in a permanent disease state if the inflammation is prolonged[2]. | HE La Gu WU Peng Fei PENG Yan Hua FENG Juan ZHONG Dai Ming ZHANG Gui Hua ZENG Lei ZHONG Yu Min WANG Xiao Ye YUAN Hua Min | 2019 | Biomedical and Environmental Sciences2019，32，5： | 3 |
| 4 | Testing the reliability of a new ultrasonic cardiac output monitor,the USCOM,by using aortic flowprobes in anesthetized dogs 显示文摘 | Critchlev LA Peng ZY Fok BS | 2005 | Anestb Analg2005，100，3： | 1 |
| 5 | Separation of lipid transport functions by mutations in the extracellular domainof TSE-1 显示文摘 | Connelly M A De la Llera-Moya M Peng Y | 2003 | J Biol Chem2003，278，25： | 1 |
| 6 | Testing the reliability of a new ultrasonic cardiac output monitor,the USCOM,by using aortic flowprobes in anesthetized dogs显示文摘 | Critchley LA Peng ZY Fok BS | 2005 | Anesth Analg2005，100，3： | 1 |
| 7 | Effects of norepinephrine during intra- abdominal hypertension on renal blood flow in bactere?mic dogs显示文摘 | Peng ZY Critchley LA Joynt GM | 2008 | Crit Care Med2008，36，3： | 1 |
| 8 | C3a and C5a pro- mote renal ischemia-reperfusion injury 显示文摘 | Peng Q Li K Smyth LA | 2012 | Journal of the American Society of Nephrology2012，23，9： | 1 |
| 9 | Despite differences between dendritic cells and Langerhans cells in the mechanism of papillomavirus-like particle antigen uptake, both cells cross-prime T cells 显示文摘 | Yan M Peng J Jabbar LA | 2004 | Virology2004，324，2： | 1 |
| 10 | Effects of norepinephrine during intra-abdominal hypertension on renal blood flow in bacteremic dogs显示文摘 | Peng ZY Critchley LA Joynt GM | 2007 | Crit Care Med2007，35，1： | 1 |
| 11 | The miR-200 family and the miR-183-96-182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers显示文摘 | Kundu ST Byers LA Peng DH | 2016 | Oncogene2016，35，2： | 1 |
| 12 | C3a and C5a promote renal ischemia-reperfusion injury显示文摘 | Peng Q Li K Smyth LA | 2012 | J Am Soc Nephrol2012，23，9： | 1 |
| 13 | Semaphorin 7a(+) regulatory T cells are associated with progressive idiopathic pulmonary fibrosis and are implicated in transforming growth factor-betal-induced pulmonary fibrosis显示文摘 | Reilkoff RA Peng H Murray LA | | 0，，02： | 1 |
| 14 | Multilevel converter-a new breed of power converters显示文摘 | La Jisheng Peng Angzheng | 1996 | IEEE Trans on Ind Appli1996，32，3： | 1 |
| 15 | Hydrogen peroxide -mediated transcriptional induction of macrophage colony -stimulation factor显示文摘 | Hong YH Peng HB La Fata V | 1997 | J Immunol1997，159，5： | 1 |
| 16 | Despite differences between dendritic cells and Langerhans cells in the mechanism of papillomavirus-like particle antigen uptake,both cells cross-prime T cells显示文摘 | Peng J Jabbar LA | 2004 | Virology2004，324，2： | 1 |
| 17 | Testing the reliability ofa new ultrasonic cardiac output monitor,the USCOM,by usingaortic flowprobes in anesthetized dogs显示文摘 | Critchley LA Peng ZY Fok BS | 2005 | Anesth Analg2005，100，3： | 1 |
| 18 | Effects of norepinephrine during intra-abdominal hypertension on renal blood flow in bacteremic dogs显示文摘 | Peng ZY Critchley LA Joynt GM | | 0，，： | 1 |
| 19 | Local apoptosis promotes collagen production by monocyte-derived cells in transforming growth factorβ1-induced lung fibrosis显示文摘 | Peng X Mathai SK Murray LA Russell T Reilkoff R Chen Q | 2011 | Fibrogenesis Tissue Repair2011，4，1： | 1 |
| 20 | Cytotoxic and vasogenie cerebral oedema in traumatic brain injury: Assessment with FLAIR and DWI imaging显示文摘 | Hudak AM Peng L Marquez de la Plata C | 2014 | Brain Inj2014，28，12： | 1 |
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