|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Antioxidative and anti-endotoxin effects of propofol on endothelial cells显示文摘Objective To investigate the antioxidant and anti-endotoxin effects of propofol on endothelial cells and the possible mechanisms.Methods Cultured endothelial cells were treated with hydrogen peroxide (H 2O 2), propofol + H 2O 2, lipopolysaccharide (LPS) and propofol + LPS, respectively. Endothelial cell damage was monitored for possible lactic dehydrogenase (LDH) release. The transcription and the protein expression levels of endothelial nitric oxide synthase (eNOS) were measured.Results LDH release was higher in groups treated with H 2O 2 or LPS than in the control group. After pretreatment with propofol, the effects induced by H 2O 2 were attenuated, but propofol did not decrease the LDH release induced by LPS. Both H 2O 2 and LPS significantly increased the eNOS transcript levels and the increases were significantly attenuated after pretreatment with propofol. Both H 2O 2 and LPS significantly increased the eNOS protein expression and the increase was attenuated after pretreatment with propofol. Conclusion Propofol could protect endothelial cells against oxidative stress by inhibiting eNOS transcription and protein expression, but could not antagonise endotoxin induced cell injuries. | 彭志勇 罗敏 叶仕桥 Critchley Lester AH Joynt Gavin M Ho Anthony MH 姚尚龙 | 2003 | Chinese Medical Journal2003，，5： | 7 |
| 2 | Oxygen therapy for hypercapnic patients with chronic obstructive pulmonary disease and acute respiratory failure:a randomized,controlled pilot study显示文摘 | Gomersall C D Joynt G M Freebairn R C | 2002 | Crit Care Med2002，30，1： | 1 |
| 3 | Depression and cardiovascular disease : mechanisms of interac-tion 显示文摘 | Joynt KE Whellan DJ O'Connor CM | 2003 | Biol Psychiatry2003，54，： | 1 |
| 4 | The source of shoulder pain in hemiplegia显示文摘 | Joynt RI | 1992 | Arch Phys Med Rehabil1992，73，5： | 1 |
| 5 | Effect of angiotensin-coverting enzyme inbibitors, beta blockers, statins and aspirin on C-reactive protein levels in outpatients with heart failure显示文摘 | Joynt KE Gattis WA Hasselblad V | 2004 | Am J Cardiol2004，93，6： | 1 |
| 6 | Late-stage adult respiratory distress syndrome caused by severe acute respiratory syndrome: abnormal findings at thin-section CT显示文摘 | Joynt GM Antonio GE Lam P | 2004 | Radiology2004，230，2： | 1 |
| 7 | Microbial community analysis of soils contaminated with lead, chromium and petroleum hydrocarbons显示文摘 | JOYNT J BISCHOFF M TURCO R | 2006 | Microbial Ecology2006，51，： | 1 |
| 8 | Avian influenza(H5N1):implications for intensive care显示文摘 | Gruber P C Gomersall C D Joynt G M | 2006 | Intensive Care Medicine2006，32，6： | 1 |
| 9 | Intra abdominal hypertension impli-cations for the intensive care physician 显示文摘 | Joynt GM Ramsay SJ Buckley TA | 2001 | Ann Acad Med Singao-pore2001，30，3： | 1 |
| 10 | Depression and cardiovascular disease:mechanisms of interaction显示文摘 | Whellan DJ Connor CM | 2003 | Biological Psychiatry2003，54，： | 1 |
| 11 | Neuraxial blockade and hematoma in Cardiac surgery, estimating the risk of a rare adverse event that has not (yet) occurred 显示文摘 | Ho AM Chung DC Joynt GM | 2000 | Chest2000，117，2： | 1 |
| 12 | Resuscitation of critically ill patients based on the results of gastric tonometry: a prospective, randomized, controlled trial显示文摘 | Gomersall C D Joynt G M Freebairn R C | 2000 | Crit Care Med2000，28，3： | 1 |
| 13 | Short-term outcome of critically ill patients with severe acute respiratory syndrome显示文摘 | Charles D. Gomersall Gavin M. Joynt Philip Lam Thomas Li Florence Yap Doris Lam Thomas A. Buckley Joseph J. Y. Sung David S. Hui Gregory E. Antonio Anil T. Ahuja Patricia Leung | 2004 | Intensive Care Medicine2004，，3： | 1 |
| 14 | Variation in surgical-readmis- sion rates and quality of hospital care显示文摘 | Tsai T C Joynt K E Orav E J | 2013 | The New England journal of medicine2013，369，12： | 1 |
| 15 | Intra-ahdominal hypertension-implications for the intensive care physician显示文摘 | Joynt GM Ramsay SJ Buckley TA | 2001 | Ann Acad Med Singapore2001，30，3： | 1 |
| 16 | Intra-abdominal hypertension-implication for the intensive care physician显示文摘 | Joynt GM Ramsay SJ Buckley TA | 2001 | Ann Acad Med Singapore2001，30，3： | 1 |
| 17 | Hepatic artery resistance before and after standard meal in subjects with diseased and healthy livers显示文摘 | Joynt LK Platt JF Rubin JM | 1995 | Radiology1995，196，： | 1 |
| 18 | Effects of norepinephrine during intra- abdominal hypertension on renal blood flow in bactere?mic dogs显示文摘 | Peng ZY Critchley LA Joynt GM | 2008 | Crit Care Med2008，36，3： | 1 |
| 19 | Effect of angiotensin-converting enzyme inhibitors, beta blockers, statins, and aspirin on C-reactive protein levels in outpatients with heart failure 显示文摘 | Joynt K E Gattis W A Hasselblad V | 2004 | Am J Cardiol2004，93，6： | 1 |
| 20 | Effects of norepinephrine during intra-abdominal hypertension on renal blood flow in bacteremic dogs显示文摘 | Peng ZY Critchley LA Joynt GM | 2007 | Crit Care Med2007，35，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员