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| 1 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 2 | Impact of urbanization on changes in temperature extremes in Beijing during 1978–2008显示文摘To quantify the impact of urbanization on changes in observed surface air temperature and extremes,a homogenized dataset of daily mean,maximum and minimum temperature(Tm,Tmax and Tmin)observations at 20 stations in Greater Beijing(GBJ)from1978 to 2008 is analyzed.In contrast with previous studies,a cluster analysis is done to objectively classify observing stations into four categories(urbanized,suburban,rural and mountain),which is checked with remote-sensing night-light images since the1990s.At urbanized sites,there is an added warming trend in annual mean Tm representing an average of 10.9%(up to 18.4%or0.12°C/decade at the most strongly influenced site)of overall warming.Corresponding contributions for Tmin are 12.7%(up to20.8%or 0.19°C/decade)and 24%for diurnal temperature range DTR(up to 37.4%or 0.149°C/decade)over the last three decades.Although it has not had a significant impact on daytime records(Tmax),urbanization has enhanced the increasing(decreasing)trend of extremely warm(cold)nights by an average of 12.7%or 2.07 d/decade(29.0%or 5.06 d/decade)at the urbanized sites since the 1970s. | WANG Jun YAN ZhongWei LI Zhen LIU WeiDong WANG YingChun | 2013 | Chinese Science Bulletin2013，58，36： | 18 |
| 3 | Constrained large-eddy simulation and detached eddy simulation of flow past a commercial aircraft at 14 degrees angle of attack显示文摘With the development of computational power and numerical algorithms,computational fluid dynamics(CFD) has become an important strategy for the design of aircraft,which significantly reduces the reliance on wind-tunnel and flight tests.In this paper,we conducted a numerical investigation on the flow past a full commercial aircraft at Mach number 0.2 and 14 degrees angle of attack by means of Reynolds-averaged Navier-Stokes(RANS),detached-eddy simulation(DES) and our newly developed constrained large-eddy simulation(CLES).The objective of this paper is to study the capability of these models in simulating turbulent flows.To our knowledge,this is the first large-eddy simulation method for full commercial aircraft simulation.The results show that the CLES can predict the mean statistical quantities well,qualitatively consistent with traditional methods,and can capture more small-scale structures near the surface of the aircraft with massive separations.Our study demonstrates that CLES is a promising alternative for simulating real engineering turbulent flows. | CHEN ShiYi CHEN YingChun XIA ZhenHua QU Kun SHI YiPeng XIAO ZuoLi LIU QiuHong CAI QingDong LIU Feng LEE Cunbiao ZHANG RiKui CAI JinSheng | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，2： | 14 |
| 4 | Existence of Qiongnan suture zone on the north margin of South China Sea显示文摘This paper aims to explore whether paleo-suture zone exists in the pre-Cenozoic basement of South China Sea (SCS). By taking advantage of integrated geophysical surveying data, including multi-channel reflection seismicity, oceanic bottom seismicity, gravity and magnetic data as well as paleomagnetism and drilling information, a comprehensive analysis on sedimentary stratigraphy, seismic stratigraphy, magmatic and metamorphic petrology, geochemistry, gravity study, magnetics, paleogeomagnetics as well as geotectonics was carried out, and the results clearly indicate that a pre-Cenozoic suture zone, i.e. “Qiongnan (south Hainan Island) suture zone”, does exist on the north margin of SCS. This suture zone starts in the west from the Jiusuo-Lingshui fault zone in the south of Hainan Island, extends eastward across the continental slope to the north of SCS, and links with Shoufeng fault in Taiwan. It is inferred that the Qiongnan suture zone was sutured approximately in Indosinian (Triassic) Epoch and is actually the vestige of “Qiongnan ocean basin”, the extension of the main paleo-Tethys ocean basin in SCS. The formation of Qiongnan suture zone marked the collision-accretion of the Qiongnan Block toward the Qiongzhong Block. The Qiongnan suture zone is linked to the west with the southward extension of the principal suture zone of the Paleo-Tethys at Bitu-Changning-Menglian-Bentong-Raub, across the southern segment of the Red River-East Vietnam-Wanna strike-slip fault zone, and connected to the east with the suture zone emplaced into the south margin of the Oki-Hida Pre-Jurassic terranes in southwest Japan, across the northerni2 e segment of the Manila trench fault zone in the northeast side of Taiwan Island. The discovery of this suture zone is believed to be potentially significant toward study of the pre-Cenozoic geotectonic pattern of SCS, the temporal and spatial distribution of the east paleo-Tethys structural domain in SCS and the relationship of recombination and superimposition between the east paleo-Tethys structural domain and the west Pacific structural domain, in addition to the oil/gas geological potentials in the pre-Cenozoic marine vestige-superimposed basin in the study area. | LIU Hailing YAN Pin LIU Yingchun DENG Hui | 2006 | Chinese Science Bulletin2006，51，B12： | 12 |
| 5 | Hypoxia-induced factor-1 alpha upregulates vascular endothelial growth factor C to promote lymphangiogenesis and angiogenesis in breast cancer patients显示文摘Hypoxia-induced factor-1 alpha(HIF-1α)affects many effector molecules and regulates tumor lymphangiogenesis and angiogenesis during hypoxia.The aim of this study was to investigate the role of HIF-1αin the regulation of vascular endothelial growth factor C(VEGF-C)expression and its effect on lymphangiogenesis and angiogenesis in breast cancer.Lymphatic vessel density(LVD),microvessel density(MVD)and the expressions of HIF-1αand VEGF-C proteins were evaluated by immunohistochemistry in 75 breast cancer samples.There was a significant correlation between HIF-1αand VEGF-C(P=0.014,r=0.273,Spearman's coefficient of correlation).HIF-1αand VEGF-C overexpression was significantly correlated with higher LVD(P=0.003 and P=0.017,respectively),regional lymph nodal involvement(P=0.002 and P=0.004,respectively)and advanced tumor,node,metastasis(TNM)classification(P=0.001 and P=0.01,respectively).Higher MVD was observed in the group expressing higher levels of HIF-1αand VEGF-C(P=0.033 and P=0.037,respectively).Univariate analysis showed shorter survival time in patients expressing higher levels of HIF-1αand VEGF-C.HIF-1αwas also found to be an independent prognostic factor of overall survival in multivariate analysis.The results suggest that HIF-1αmay affect VEGF-C expression,thus acting as a crucial regulator of lymphangiogenesis and angiogenesis in breast cancer.This study highlights promising potential of HIF-1αas a therapeutic target against tumor lymph node metastasis. | Xiaojian Ni Yingchun Zhao Jingjing Ma Tiansong Xia Xiaoan Liu Qiang Ding Xiaoming Zha Shui Wang | 2013 | The Journal of Biomedical Research2013，27，6： | 10 |
| 6 | Downward continuation of airborne geomagnetic data based on two iterative regularization methods in the frequency domain显示文摘Downward continuation is a key step in processing airborne geomagnetic data. However,downward continuation is a typically ill-posed problem because its computation is unstable; thus, regularization methods are needed to realize effective continuation. According to the Poisson integral plane approximate relationship between observation and continuation data, the computation formulae combined with the fast Fourier transform(FFT)algorithm are transformed to a frequency domain for accelerating the computational speed. The iterative Tikhonov regularization method and the iterative Landweber regularization method are used in this paper to overcome instability and improve the precision of the results. The availability of these two iterative regularization methods in the frequency domain is validated by simulated geomagnetic data, and the continuation results show good precision. | Liu Xiaogang Li Yingchun Xiao Yun Guan Bin | 2015 | Geodesy and Geodynamics2015，6，1： | 8 |
| 7 | A unified model for the formation and distribution of both conventional and unconventional hydrocarbon reservoirs显示文摘The discovery and large-scale exploration of unconventional oil/gas resources since 1980s have been considered as the most important advancement in the history of petroleum geology;that has not only changed the balance of supply and demand in the global energy market,but also improved our understanding of the formation mechanisms and distribution characteristics of oil/gas reservoirs.However,what is the difference of conventional and unconventional resources and why they always related to each other in petroliferous basins is not clear.As the differences and correlations between unconventional and conventional resources are complex challenging issues and very critical for resources assessment and hydrocarbon exploration,this paper focused on studying the relationship of formations and distributions among different oil/gas reservoirs.Drilling results of 12,237 exploratory wells in 6 representative petroliferous basins of China and distribution characteristics for 52,926 oil/gas accumulations over the world were applied to clarify the formation conditions and genetic relations of different oil/gas reservoirs in a petroliferous basin,and then to establish a unified model to address the differences and correlations of conventional and unconventional reservoirs.In this model,conventional reservoirs formed in free hydrocarbon dynamic field with high porosity and permeability located above the boundary of hydrocarbon buoyancy-driven accumulation depth limit.Unconventional tight reservoirs formed in confined hydrocarbon dynamic field with low porosity and permeability located between hydrocarbon buoyancy-driven accumulation depth limit and hydrocarbon accumulation depth limit.Shale oil/gas reservoirs formed in the bound hydrocarbon dynamic field with low porosity and ultra-low permeability within the source rock layers.More than 75%of proved reserves around the world are discovered in the free hydrocarbon dynamic field,which is estimated to contain only 10%of originally generated hydrocarbons.Most of undiscovered resources distributed in the confined hydrocarbon dynamic field and the bound hydrocarbon dynamic field,which contains 90%of original generated hydrocarbons,implying a reasonable and promising area for future hydrocarbon explorations.The buried depths of hydrocarbon dynamic fields become shallow with the increase of heat flow,and the remaining oil/gas resources mainly exist in the deep area of“cold basin”with low geothermal gradient.Lithology changing in the hydrocarbon dynamic field causes local anomalies in the oil/gas dynamic mechanism,leading to the local formation of unconventional hydrocarbon reservoirs in the free hydrocarbon dynamic field or the occurrence of oil/gas enrichment sweet points with high porosity and permeability in the confined hydrocarbon dynamic field.The tectonic movements destroy the medium conditions and oil/gas components,which leads to the transformation of conventional oil/gas reservoirs formed in free hydrocarbon dynamic field to unconventional ones or unconventional ones formed in confined and bound hydrocarbon dynamic fields to conventional ones. | Xiongqi Pang Chengzao Jia Junqing Chen Maowen Li Wenyang Wang Qinhong Hu Yingchun Guo Zhangxin Chen Junwen Peng Keyu Liu Keliu Wu | 2021 | Geoscience Frontiers2021，12，2： | 8 |
| 8 | Dislocations-induced precipitates and their effect on mechanical properties of Mg-Gd-Y-Zr alloy显示文摘Optical microscope(OM),scanning electron microscope(SEM),transmission electron microscope(TEM)and tensile machine were used to characterize the microstructures and mechanical properties of as-forged and aged Mg-9.5Gd-3.8Y-0.6Zr alloys.The results show that a novel kind of dislocation arrays,comprising parallel arranged dislocations,were obtained in the forged alloy.The arrays tend to extend parallel and are heterogeneously distributed with adjacent distances varying from 0.3μm to 1.4μm.After aging the alloy at 265°C,a large number of preferential-oriented phases were precipitated on the dislocation arrays,forming a structure of'precipitation chains'(PCs),which results in simultaneous increments of strength and ductility. | Chao You Churning Liu Yingchun Wan Bei Tang Bizheng Wang Yonghao Gao Xiuzhu Han | 2019 | Journal of Magnesium and Alloys2019，7，3： | 8 |
| 9 | Visible light photodegradation of methylene blue by AgBr-TiO_2/SiO_2@Fe_3O_4 magnetic photocatalysts显示文摘Visible photoactive AgBr/TiO_2 was immobilized on a SiO_2@Fe_3O_4 magnetic support by solvothermal and sol-gel methods to form a AgBr-TiO_2/SiO_2@Fe_3O_4 magnetic photocatalyst.Samples were characterized by X-ray diffraction,high-resolution transmission electron microscopy and magnetometry.Hetero-structured AgBr/TiO_2 was well seeded on the shell-core SiO_2@Fe_3O_4 structure.The AgBr-TiO_2/SiO_2@Fe_3O_4 magnetic photocatalyst exhibited high photocatalytic activity in the degradation of methylene blue under visible light.The photocatalyst was superparamagnetic,which is beneficial for facile magnetic separation. | Jianjun Liu Shengli Zuo Liming Yu Yingchun Yu Baoshan Li Pengwan Chen | 2013 | Particuology2013，11，6： | 7 |
| 10 | High-throughput characterization methods for lithium batteries显示文摘The development of high-performance lithium ion batteries requires the discovery of new materials and the optimization of key components.By contrast with traditional one-by-one method,high-throughput method can synthesize and characterize a large number of compositionally varying samples,which is able to accelerate the pace of discovery,development and optimization process of materials.Because of rapid progress in thin film and automatic control technologies,thousands of compounds with different compositions could be synthesized rapidly right now,even in a single experiment.However,the lack of rapid or combinatorial characterization technologies to match with high-throughput synthesis methods,limit the application of high-throughput technology.Here,we review a series of representative highthroughput characterization methods used in lithium batteries,including high-throughput structural and electrochemical characterization methods and rapid measuring technologies based on synchrotron light sources. | Yingchun Lyu Yali Liu Tao Cheng Bingkun Guo | 2017 | Journal of Materiomics2017，3，3： | 6 |
| 11 | Structure,rheology and electrospinning of zein and poly(ethylene oxide) in aqueous ethanol solutions显示文摘Electrospun fiber mats (EFM) integrated proteins and biocompatible polymers have been widely used as tissue scaffold, wound dressing and food packaging. The morphology of EFM has strong correlation with the structure and rheology of the solutions. We studied the structure and rheology of polyethylene oxide (PEO) and zein in 80% ethanol aqueous solutions and the resulted EFM. In solutions, zein with rod-like conformation tends to aggregate and form oligomer, the number of proteins in the oligomer spans from 2.5 to 55.2, while PEO always behaves like Gaussian chain in good solvent. Zein preferred to distribute along PEO chains in their mixed solutions, and the structures decomposed from small angle X-ray scattering have consistent relaxation spatial-temporal characteristics with rheological behaviors.Further, the aging of zein solutions enhanced shear thinning and resulted thicker fibers in EFM, which are attributed to the rod-like growth of zein aggregates. Aggregates in viscous media with long enough relaxation time are probably crucial for the formation of continuous electrospun fibers or ribbons. This study provides a clear correlation of the structure, rheology of solutions with the morphologies of EFM made up of proteins and polymers. | Ce Shi Shixia Xi Yingchun Han Hao Zhang Jingsheng Liu Yunqi Li | 2019 | Chinese Chemical Letters2019，30，2： | 5 |
| 12 | Multiple Dolomitization and Fluid Flow Events in the Precambrian Dengying Formation of Sichuan Basin, Southwestern China显示文摘The Precambrian Dengying Formation is a set of large-scale, extensively dolomitized, carbonate reservoirs occurring within the Sichuan Basin. Petrographic and geochemical studies reveal dolomitization was a direct result of precipitation by chemically distinct fluids occurring at different times and at different intensities. Based on this evidence, dolomitization and multiple fluid flow events are analyzed, and three types of fluid evolution models are proposed. Results of analysis show that Precambrian Dengying Formation carbonates were deposited in a restricted peritidal environment(630–542 Ma). A high temperature and high Mg^(2+) concentration seawater was a direct result of dolomitization for the micrite matrix, and for fibrous aragonite in primary pores. Geochemical evidence shows low δ^(18)O values of micritic dolomite varying from-1.29‰ to-4.52‰ PDB, abundant light rare earth elements(REEs), and low dolomite order degrees. Microbes and meteoric water significantly altered dolomite original chemical signatures, resulting in algal micritic dolomite and the fine-grained, granular, dolosparite dolomite having very negative δ^(18)O values. Finely crystalline cement dolomite(536.3–280 Ma) and coarsely crystalline cement dolomite have a higher crystallization degree and higher order degree. The diagenetic sequence and fluid inclusion evidence imply a linear correlation between their burial depth and homogenization temperatures, which closely resemble the temperature of generated hydrocarbon. Compared with finely crystalline dolomite, precipitation of coarsely crystalline dolomite was more affected by restricted basinal fluids. In addition, there is a trend toward a more negative δ^(18)O value, higher salinity, higher Fe and Mn concentrations, REE-rich. Two periods of hydrothermal fluids are identified, as the exceptionally high temperatures as opposed to the temperatures of burial history, in addition to the presence of high salinity fluid inclusions. The early hydrothermal fluid flow event was characterized by hot magnesium-and silicon-rich fluids, as demonstrated by the recrystallized matrix dolomite that is intimately associated with flint, opal, and microcrystalline quartz in intergranular or intercrystalline pores. This event was likely the result of a seafloor hydrothermal chimney eruption during Episode I of the Tongwan Movement(536.3±5.5 Ma). In contrast, later hydrothermal fluids, which caused precipitation of saddle dolomite, were characterized by high salinity(15–16.05 wt% NaCl equivalent) and homogenization temperatures(250 to 265°C), δ^(18)O values that were more enriched, and REE signatures. Geochemical data and the paragenetic sequence indicate that this hydrothermal fluid was related to extensive Permian large igneous province activity(360–280 Ma). This study demonstrates the presence of complicated dolomitization processes occurring during various paleoclimates, tectonic cycles, and basinal fluids flow; results are a useful reference for these dolomitized Precambrian carbonates reservoirs. | PENG Bo LI Zongxing LI Guorong LIU Chenglin ZHU Shifa ZHANG Wang ZUO Yinhui GUO Yingchun WEI Xiaojie | 2018 | Acta Geologica Sinica(English Edition)2018，92，1： | 5 |
| 13 | Impact of Urbanization on Low-Temperature Precipitation in Beijing during 1960–2008显示文摘Daily precipitation and temperature records at 13 stations for the period 1960–2008 were analyzed to identify climatic change and possible effects of urbanization on low-temperature precipitation [LTP, precipitation of 0.1 mm d 1occurring under a daily minimum temperature(Tmin) of 0 C] in the greater Beijing region(BJR), where a rapid process of urbanization has taken place over the last few decades. The paper provides a climatological overview of LTP in BJR. LTP contributes 61.7% to the total amount of precipitation in BJR in the cold season(November–March). There is a slight increasing trend [1.22 mm(10 yr) 1] in the amount of total precipitation for the cold season during 1960–2008. In contrast, the amount of LTP decreases by 0.6 mm(10 yr) 1. The warming rate of Tmin in BJR is 0.66 C(10 yr) 1. Correspondingly, the frequency of LTP decreases with increasing Tmin by 0.67 times per C. The seasonal frequency and amount of LTP in southeast BJR(mostly urban sites) are 17%–20% less than those in the northwestern(rural and montane sites). The intensity of LTP for the urban sites and northeastern BJR exhibited significant enhancing trends [0.18 and 0.15 mm d 1(10 yr) 1, respectively]. The frequency of slight LTP(<0.2 mm d 1) significantly decreased throughout BJR [by about 15.74%(10 yr) 1in the urban area and northeast BJR], while the contribution of the two heaviest LTP events to total LTP amount significantly increased by 3.2%(10 yr) 1. | HAN Zuoqiang YAN Zhongwei LI Zhen LIU Weidong WANG Yingchun | 2014 | Advances in Atmospheric Sciences2014，31，1： | 5 |
| 14 | Modulation of nitrate-induced phosphate response by the MYB transcription factor RLI1/HINGE1 in the nucleus显示文摘The coordinated utilization of nitrogen(N)and phosphorus(P)is vital for plants to maintain nutrient balance and achieve optimal growth.Previously,we revealed a mechanism by which nitrate induces genes for phosphate utilization;this mechanism depends on NRT1.1B-facilitated degradation of cytoplasmic SPX4,which in turn promotes cytoplasmic-nuclear shuttling of PHR2,the central transcription factor of phosphate signaling,and triggers the nitrate-induced phosphate response(NIPR)and N-P coordinated utilization in rice.In this study,we unveiled a fine-tuning mechanism of NIPR in the nucleus regulated by Highly Induced by Nitrate Gene 1(HINGE1,also known as RLI1),a MYB-transcription factor closely related to PHR2.RLI1/HINGE1,which is transcriptionally activated by PHR2 under nitrate induction,can directly activate the expression of phosphate starvation-induced genes.More importantly,RLI1/HINGE1 competes with PHR2 for binding to its repressor proteins in the nucleus(SPX proteins),and consequently releases PHR2 to further enhance phosphate response.Therefore,RLI1/HINGE1 amplifies the phosphate response in the nucleus downstream of the cytoplasmic SPX4-PHR2 cascade,thereby enabling fine-tuning of N-P balance when nitrate supply is sufficient. | Zhihua Zhang Zhao Li Wei Wang Zhimin Jiang Liping Guo Xiaohan Wang Yangwen Qian Xiahe Huang Yongqiang Liu Xiujie Liu Yahong Liu Aifu Li Yu Yan Junpeng Xie Shouyun Cao Stanislav Kopriva Legong Li Fanjiang Kong Baohui Liu Yingchun Wang Bin Hu Chengcai Chu | 2021 | Molecular Plant2021，14，3： | 4 |
| 15 | Mea6 controls VLDL transport through the coordinated regulation of COPil assembly显示文摘 | Yaqing Wang Liang Liu Hongsheng Zhang Junwan Fan FengZhang Mei Yu Lei Shi Lin Yang Sin Man Lam Huimin Wang Xiaowei Chen Yingchun Wang Fei Gao Guanghou Shui Zhiheng Xu | 2016 | Cell Research2016，26，7： | 4 |
| 16 | Cold spray additive manufacturing of Invar 36 alloy:microstructure,thermal expansion and mechanical properties显示文摘In this work,the Invar 36 alloys were manufactured using cold spray(CS)additive manufacturing technique.The systematic investigations were made on the microstructural evolution,thermal expansion and mechanical properties under as-sprayed(AS)and heat-treated(HT)conditions.XRD(X-ray diffraction)and ICP-AES(inductively coupled plasma atomic emission spectroscopy)analyses show that no phase transformation,oxidation,nor element content change have occurred.The X-ray computed tomography(XCT)exhibited a near fully dense structure with a porosity of 0.025%in the helium-produced sample under as-sprayed condition,whereas the nitrogen-produced samples produced at 5 MPa and 800℃show more irregular pore defects.He-AS sample shows a more prominent grain refinement than that of nitrogen samples due to the more extensive plastic deformation.The post heat-treatment exhibited a promoted grain growth,inter-particle diffusion,as well as the formation of annealing twins.Between25℃and 200℃,the nitrogen samples possessed lower CTE(coefficient of thermal expansion)values(1.53×10^(-6)/℃)compared with those produced by casting and laser additive manufacturing.The He-AS samples exhibited a noticeable negative CTE value between 25℃and 200℃,which may due to the significant compressive residual stress(-272 MPa)compensating its displacement with temperature increase during CTE test.The N2-HT and He-HT Invar 36 samples present a notable balance between strength and ductility.In conclusion,the CS technique can be considered as a potential method to produce the Invar36 component with high thermal and mechanical performance. | Chaoyue Chen Yingchun Xie Longtao Liu Ruixin Zhao Xiaoli Jin Shanqing Li Renzhong Huang Jiang Wang Hanlin Liao Zhongming Ren | 2021 | Journal of Materials Science & Technology2021，，13： | 4 |
| 17 | Chokeberry(Aronia melanocarpa)as a new functional food relationship with health:an overview显示文摘As a consumer product,black chokeberry(Aronia melanocarpa)is diffi cult to consume due to its pungent taste.It is mainly used in various food industries to produce a variety of juices,preserves,extracts,fruit teas and nutritional supplements.Traditionally,Potawatomi Native Americans used black chokeberry to treat colds,coughs and fever.It has been found to contain numerous active ingredients.Currently,there are many health and medical products that contain black chokeberry.The purpose of this review is to understand the nutritional benefi ts of black chokeberry and to explore its benefi cial effects on biological systems in vitro,thereby emphasizing its therapeutic prospects. | Yiwen Zhang Yingchun Zhao Xinglong Liu Xueyan Chen Chuanbo Ding Ling Dong Jinping Zhang Shuwen Sun Qiteng Ding Sadia Khatoom Zhiqiang Cheng Wencong Liu Liqian Shen Fengyan Xiao | 2021 | Journal of Future Foods2021，1，2： | 3 |
| 18 | Layer-block tectonics of Cenozoic basements and formation of intra-plate basins in Nansha micro-plate, southern South China Sea显示文摘Layer-block tectonics (LBT) concept, with the core of pluralistic geodynamic outlook and multi- layer-sliding tectonic outlook, is one of new keys to study 3-dimensional solid and its 4-dimensional evolution history of global tectonic system controlled by global geodynamics system. The LBT concept is applied to study the lithospheric tectonics of the southern South China Sea (SCS). Based on the analysis of about 30 000 km of geophysical and geological data, some layer-blocks in the Nansha micro-plate can be divided as Nansha ultra-crustal layer-block, Zengmu crustal layer-block, Nanwei (Rifleman bank)-Andu (Ardasier bank) and Liyue (Reed bank)-North Palawan crustal layer-blocks, Andu-Bisheng and Liyue-Banyue basemental layer-blocks. The basic characteristics of the basemental layer-blocks have been dicussed, and three intra-plate basin groups are identified. The intra-plate basins within Nansha micro-plate can be divided into three basin groups of NanweiAndu, Feixin-Nanhua, and Liyue-North Palawan based on the different geodynamics. In the light of pluralistic geodynamic concept, the upheaving force induced by the mid-crust plastic layer is proposed as the main dynamical force which causes the formation of the intra-plate basins within the Nansha micro-plate. Finally, models of a face-to-face dip-slip-detachment of basemental layer- block and a unilateral dip-slip-detachment of basemental layer-block are put forward for the forming mechanisms of the Nanwei-Andu and Liyue-North Palawan intra-plate basin groups, respectively. | LIU Hailing XIE Guofa LIN Qiujin ZHENG Hongbo LIU Yingchun | 2009 | Acta Oceanologica Sinica2009，28，3： | 3 |
| 19 | Rapid, automated, and reliable antimicrobial susceptibility test from positive blood culture by CAST‐R显示文摘Antimicrobial susceptibility tests(ASTs)are pivotal in combating multidrug resistant pathogens,yet they can be time‐consuming,labor‐intensive,and unstable.Using the AST of tigecycline for sepsis as the main model,here we establish an automated system of Clinical Antimicrobials Susceptibility Test Ramanometry(CAST‐R),based on D2O‐probed Raman microspectroscopy.Featuring a liquid robot for sample pretreatment and a machine learning‐based control scheme for data acquisition and quality control,the 3‐h,automated CAST‐R process accelerates AST by>10‐fold,processes 96 paralleled antibiotic‐exposure reactions,and produces high‐quality Raman spectra.The Expedited Minimal Inhibitory Concentration via Metabolic Activity is proposed as a quantitative and broadly applicable parameter for metabolism‐based AST,which shows 99%essential agreement and 93%categorical agreement with the broth microdilution method(BMD)when tested on 100 Acinetobacter baumannii isolates.Further tests on 26 clinically positive blood samples for eight antimicrobials,including tigecycline,meropenem,ceftazidime,ampicillin/sulbactam,oxacillin,clindamycin,vancomycin,and levofloxacin reveal 93%categorical agreement with BMD‐based results.The automation,speed,reliability,and general applicability of CAST‐R suggest its potential utility for guiding the clinical administration of antimicrobials. | Pengfei Zhu Lihui Ren Ying Zhu Jing Dai Huijie Liu Yuli Mao Yuandong Li Yuehui He Xiaoshan Zheng Rongze Chen Xiaoting Fu Lili Zhang Lijun Sun Yuanqi Zhu Yuetong Ji Bo Ma Yingchun Xu Jian Xu Qiwen Yang | 2022 | mLife2022，1，3： | 3 |
| 20 | A thermoresponsive composite separator loaded with paraffin@SiO_(2) microparticles for safe and stable lithium batteries显示文摘Lithium-ion batteries (LIBs)-related accidents have been reported for years and safety issues are stumbling blocks for the practical applications of lithium metal batteries (LMBs) with higher energy density. More effective strategies to shut down the battery at the early stage of thermal runaway with less side effects on the electrochemical performance are greatly desired. In this work, the core–shell structural paraffin@SiO_(2) microparticles were synthesized by in situ emulsion interfacial hydrolysis and polycondensation and the paraffin@SiO_(2)-loaded separator (PSS) was prepared by a facile filtration method. The introduction of hydrophilic silica shells in paraffin@SiO_(2) enhanced the wettability of carbonate electrolyte with the composite separator and improved the processability of soft paraffin. As a result, when used in LMBs at room temperature, the cell with PSS inside had a more uniform deposition of lithium, a much lower overpotential and a more stable electrochemical performance than the cell with the blank separator or the conventional pure paraffin-loaded separator inside. More significantly, when a heating stimulation (i.e. 115 ℃) was subjected to the cell with PSS inside, the paraffin in the core of paraffin@SiO_(2) could be released, blocking the gaps between particles and the pores in the separator and efficiently stopping the transportation of Li+ between two electrodes, resulting in the thermally-induced shutdown of the cell below the melting temperature of PE (~135 ℃) in the Celgard2325 separator. The core–shell structure of paraffin@SiO_(2) enables the maintaining of each component’s benefits while avoiding each one’s drawbacks by elaborating microstructural design. Therefore, the conventional dilemma between the electrochemcial performance and safety of LMBs could be solved in the future. | Hao Dong Peican Wang Shuaishuai Yan Yingchun Xia Baoguo Wang Xiaolin Wang Kai Liu | 2021 | Journal of Energy Chemistry2021，30，11： | 3 |
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