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| 1 | Prostate cancer in Asia:A collaborative report显示文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers. | Rui Chen Shancheng Ren 无 Ming Kwong Yiu Ng Chi Fai Wai Sam Cheng Lap Hong Ian Seiji Naito Tadashi Matsuda Elijah Kehinde Ali Kural Jason Yichun Chiu Rainy Umbas Qiang Wei Xiaolei Shi Liqun Zhou Jian Huang Yiran Huang Liping Xie Lulin Ma Changjun Yin Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Xin Gao Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tiejun Pan Qiang Ding Fengshuo Jin Benkang Shi Gongxian Wang Xiuheng Liu Dongwen Wang Zhoujun Shen Xiangbo Kong Wanhai Xu Yaoliang Deng Haibo Xia Alexa NCohen Xu Gao Chuanliang Xu Yinghao Sun | 2014 | Asian Journal of Urology2014，1，1： | 13 |
| 2 | Percent free prostate-specific antigen for prostate cancer diagnosis in Chinese men with a PSA of 4.0-10.0 ng/mL:Results from the Chinese Prostate Cancer Consortium显示文摘Objective:To test the diagnostic performance of percent free prostate-specific antigen(%fPSA)in predicting any prostate cancer(PCa)and high-grade prostate cancer(HGPCa)in a retrospective multi-center biopsy cohort with a PSA level of 4.0e10.0 ng/mL in China.Methods:Consecutive patients with a PSA of 4.0-10.0 ng/mL who underwent transrectal ultrasound-guided biopsy were enrolled at 16 Chinese medical centers from January 1st,2010 to December 31st,2013.Total and free serum PSA determinations were performed using three types of electro-chemiluminescence immunoassays recalibrated to the World Health Organization(WHO)standard.The diagnostic accuracy of PSA,%fPSA,and %fPSA in combination with PSA(%fPSA t PSA)was determined using the area under the receiver operating characteristic(ROC)curve(AUC).Results:A total of 2310 consecutive men with PSA levels between 4.0 and 10.0 ng/mL were included,and the detection rate of PCa was 25.1%.The AUC of%fPSA and %fPSA t PSA in predicting any PCa was superior to PSA alone in men aged≥60 years(0.623 vs.0.534,p<0.0001)but not in men aged 40e59 years(0.517 vs.0.518,p=0.939).Similar result was yield in predicting HGPCa.Conclusion:In a clinical setting of Chinese men with 4.0e10.0 ng/mL PSA undergoing initial prostate biopsy,adding %fPSA to PSA can moderately improve the diagnostic accuracy for any PCa and HGPCa compared with PSA alone in patients≥60 but not in patients aged 40-59 years. | Rui Chen Liping Xie Xiaobing Cai Yiran Huang Liqun Zhou Lulin Ma Xu Gao Chuanliang Xu Shancheng Ren Pengfei Shao Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Li Lu Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tie Zhou Fubo Wang Biming He Yinghao Sun | 2015 | Asian Journal of Urology2015，2，2： | 8 |
| 3 | Spatial and temporal variation in magnetic properties of street dust in Lanzhou City,China显示文摘Urban environmental problems are of increasing concern. Lanzhou is a large industrial city in North-west China. Street dust samples representing different temporal and spatial scales were collected for magnetic properties study. Magnetic measurements indicate a high concentration of magnetic minerals in Lanzhou street dust, dominated by pseudo-single domain (PSD) magnetite. The concentration of magnetic materials is distinctly high in winter and spring, low in autumn. Similarly, higher concentra-tions associated with heavy industry, concentrated residential development, and vehicular traffic sug-gest mixed contributions of magnetic material from both anthropogenic and natural sources. χ_lf and SOFT% are effective magnetic parameters that denote seasonal differences among magnetic proper-ties in street dust, convenient and economical methods for monitoring street dust pollution. | WANG Guan XIA DunSheng LIU XiuMing CHEN FaHu YU Ye YANG LiPing CHEN JianHui ZHOU AiFeng | 2008 | Chinese Science Bulletin2008，53，12： | 7 |
| 4 | Variation of soil enzyme activity and microbial biomass in poplar plantations of different genotypes and stem spacings显示文摘To improve the productivity of poplar plantations, a field experiment of split-plot design with four tree spacings and three poplar clones was established, and four soil enzyme activities and microbial biomass were monitored in the trial.Soil enzyme activities, in most cases,were significantly higher in topsoil(0–10 cm) than in lower horizons(10–20 cm).Soil cellulase, catalase and protease activities during the growing season were higher than during the non-growing season, while invertase activity followed the opposite trend.Soil invertase, cellulase and catalase activities varied by poplar clone but soil protease activity did not.Cellulase and protease activities in the plantation at 5×5 m spacing were significantly higher than in the other spacings.The highest catalase activity was recorded at 6×6 m spacing.At the same planting density, invertase activity was greater in square spacings than in rectangular spacings.Soil microbial biomass was also significantly affected by seedling spacing and poplar clone.The mean soil MBC was significantly lower in topsoil than in the lower horizon, while MBN showed the opposite pattern.Significantly positive correlations were observed among soil cellulase, protease and catalase activities(p<0.01), whereas soil invertase activity was negatively and significantly correlated with cellulase, protease and catalase activities(p<0.01).Soil microbial biomass and enzyme activities were not correlated except for a significantly negative correlation between soil MBC and catalase activities.Variations in soil enzyme activity and microbial biomass in different poplar plantations suggest that genotype and planting spacing should be considered when modeling soil nutrient dynamics and managing for long-term site productivity. | Ye Li Liping Zhang Shengzuo Fang Ye Tian Jiao Guo | 2018 | Journal of Forestry Research2018，29，4： | 5 |
| 5 | A nonsynonymous SNP in human cytosolic sialidase in a small Asian population results in reduced enzyme activity: potential link with severe adverse reactions to oseltamivir显示文摘oseltamivir 的使用,广泛地是的 stockpiled 为在可能的鸟的流行性感冒的使用的药之一流行,被报导了与 neuropsychiatricdisorders 和严重皮肤反应被联系,首先在日本。这里,我们在 dbSNP 数据库识别了非同义的 SNP (单个核苷酸多型性) , R41Q 在 humancytosolic sialidase 的酶的活跃地点附近,是 oseltamivir 的目标的病毒 neuraminidase 的一个相当或相同事物。在欧洲、非洲的美国人口的 9.29% 亚洲人口和没有的这 SNPoccurred。Ourstructural 分析和 Ki 大小使用试管内 sialidase 试金显示这 SNPcould 增加人的 sialidase 的非计划中的有约束力的亲密关系到 oseltamivir 羧化物, oseltamivir 的活跃形式,因此减少 sialidase 活动。另外,这 SNP 自己与一项内在地更低的 sialidase 活动导致酶,由它的增加的 Km 证明 Vmax 珍视并且减少。理论上,到有这 SNP 的人的 oseltamivir 的管理可能进一步减少他们的 sialidase 活动。我们注意 oseltamivir 的 reportedneuropsychiatric 副酌和人的 sialidase-relateddisorders 的已知的症状的类似。我们建议这个充实亚洲人的 sialidase 变化由 SNP 引起了,在同型结合的形式可能,可以与对 oseltamivir 的某些严重不利反应被联系。 | Chuan-Yun Li Quan Yu Zhi-Qiang Ye Ying Sun Quanyuan He Xiao-Mo Li Wuxue Zhang Jingchu Luo Xiaocheng Gu Xiaofeng Zheng Liping Wei | 2007 | Cell Research2007，17，4： | 5 |
| 6 | Construction,Characterization,and Chromosomal Mapping of a Fosmid Library of the White-Cheeked Gibbon (Nomascus leucogenys)显示文摘Gibbons have experienced extensive karyotype rearrangements during evolution and represent an ideal model for studying the underlying molecular mechanism of evolutionary chromosomal rearrangements. It is anticipated that the cloning and sequence characterization of evolutionary chromosomal breakpoints will provide vital insights into the molecular force that has driven such a radical karyotype reshuffle in gibbons. We constructed and characterized a high-quality fosmid li-brary of the white-cheeked gibbon (Nomascus leucogenys) containing 192,000 non-redundant clones with an average insert size of 38 kb and 2.5-fold genome coverage. By end sequencing of 100 randomly selected fosmid clones,we generated 196 se-quence tags for the library. These end-sequenced fosmid clones were then mapped onto the chromosomes of the white-cheeked gibbon by fluorescence in situ hy-bridization,and no spurious chimeric clone was detected. BLAST search against the human genome showed a good correlation between the number of hit clones and the number of chromosomes,an indication of unbiased chromosomal distribu-tion of the fosmid library. The chromosomal distribution of the mapped clones is also consistent with the BLAST search result against human and white-cheeked gibbon genomes. The fosmid library and the mapped clones will serve as a valu-able resource for further studying gibbons' chromosomal rearrangements and the underlying molecular mechanism as well as for comparative genomic study in the lesser apes. | Liping Chen Jianping Ye Yan Liu Jinghuan Wang Weiting Su Fengtang Yang Wenhui Nie | 2007 | Genomics, Proteomics & Bioinformatics2007，5，3： | 5 |
| 7 | Epstein-Barr virus-encoded RNAs as a survival predictor in nasopharyngeal carcinoma显示文摘 | Ke Kengjian Wang Haiyun Fu Sha Zhang Zichen Duan Liping Liu Dabo Ye Jin | 2014 | Chinese Medical Journal2014，，2： | 5 |
| 8 | Self-crosslinkable chitosan-hyaluronic acid dialdehyde nanoparticles for CD44-targeted siRNA delivery to treat bladder cancer显示文摘Bladder cancer is one of the concerning malignancies worldwide,which is lacking effective targeted therapy.Gene therapy is a potential approach for bladder cancer treatment.While,a safe and effective targeted gene delivery system is urgently needed for prompting the bladder cancer treatment in vivo.In this study,we confirmed that the bladder cancer had CD44 overexpression and small interfering RNAs(siRNA)with high interfere to Bcl2 oncogene were designed and screened.Then hyaluronic acid dialdehyde(HAD)was prepared in an ethanol-water mixture and covalently conjugated to the chitosan nanoparticles(CS-HAD NPs)to achieve CD44 targeted siRNA delivery.The in vitro and in vivo evaluations indicated that the siRNA-loaded CS-HAD NPs(siRNA@CS-HAD NPs)were approximately 100 nm in size,with improved stability,high siRNA encapsulation efficiency and low cytotoxicity.CS-HAD NPs could target to CD44 receptor and deliver the therapeutic siRNA into T24 bladder cancer cells through a ligand-receptor-mediated targeting mechanism and had a specific accumulation capacity in vivo to interfere the targeted oncogene Bcl2 in bladder cancer.Overall,a CD44 targeted gene delivery system based on natural macromolecules was developed for effective bladder cancer treatment,which could be more conducive to clinical application due to its simple preparation and high biological safety. | Ye Liang Yonghua Wang Liping Wang Zhijuan Liang Dan Li Xiaoyu Xu Yuanbin Chen Xuecheng Yang Hongbo Zhang Haitao Niu | 2021 | Bioactive Materials2021，6，2： | 5 |
| 9 | An Outbreak of Multidrug-Resistant Tuberculosis in a Secondary School --Hubei Province, 2019显示文摘What is already known about this topic?Multidrug-resistant tuberculosis(MDR-TB)is a type of tuberculosis with resistance to common treatments such as isoniazid and rifampicin.MDR-TB is a major global health challenge and needs to be controlled tightly through prevention measures,early diagnosis,and full treatment and management.What is added by this report?This outbreak was the first MDR-TB related public health emergency in Hubei Province.In total,five MDR-TB cases and nine clinically diagnosed cases were identified within one class in a secondary school.Students and teachers from other classes were monitored,but no other cases were found.What are the implications for public health practice?The implementation of TB prevention and control measures in schools is important to increase knowledge on TB and to raise awareness on protecting personal wellbeing.The Automatic Early Warning Information System alerted the local health department and allowed for a timely response to prevent further disease spread. | Mengxian Zhang Tang Wang Shuangyi Hou Jianjun Ye Liping Zhou Zhong Zhang Zhiqiang Deng Qin Da Guoming Li Shiyue Li | 2019 | China CDC weekly2019，1，5： | 5 |
| 10 | Adjuvant hormone therapy after radical prostatectomy in highrisk localized and locally advanced prostate cancer: First multicenter, observational study in China显示文摘Objective: Potential of combined androgen blockade(CAB) has not been explored extensively in Chinese males with prostate cancer(PCa). Therefore, this study evaluated the 2-year prostate-specific antigen(PSA) recurrence rate and quality of life(Qo L) in patients with high-risk localized and locally advanced PCa receiving adjuvant hormone therapy(HT) after radical prostatectomy(RP).Methods: This prospective, multicenter, observational study conducted in 18 centers across China enrolled patients with high-risk factor(preoperative PSA>20 ng/m L or Gleason score >7) or locally advanced PCa. Different adjuvant HT were administered after RP according to investigator’s decision in routine clinical practice.Relationship of baseline and postoperative characteristics was assessed with recurrence rate. PSA recurrence rate and Functional Assessment of Cancer Therapy-Prostate(FACT-P) Qo L scores were recorded at 12 months and 24 months. Kaplan-Meier analysis was used to construct the PSA recurrence rate during follow-up.Results: A total of 189 patients(mean age: 66.9±6.5 years) were recruited, among which 112(59.3%) patients showed serum PSA>20 ng/m L preoperatively. The highest postoperative pathological advancement noticed was from clinical T2(c T2) to pathological T3(p T3)(43.9%) stage. The majority of the patients(66.1%) received CAB as adjuvant HT, for a median duration of 20.0 months. The least recurrence(15.2%) was noticed in patients treated with CAB, followed by those treated with luteinizing hormone-releasing hormone agonist(LHRHa)(16.1%), and antiandrogen(19.0%), with non-significant difference noted among the groups. None of the baseline or postoperative characteristics was related with PSA recurrence in our study. The 24-month FACT-P Qo L score of119 patients treated for >12 months showed significant improvement above baseline compared with those treated for ≤12 months.Conclusions: Adjuvant CAB therapy after RP showed reduction trend in 2-year PSA recurrence rate in highrisk Chinese patients with localized and locally advanced PCa, compared with adjuvant anti-androgens(AA) or LHRHa therapy. Further long-term therapy(>12 months) significantly improved Qo L compared to short-term HT therapy, suggesting the beneficial effect of long-term CAB therapy in improving Qo L. | Dingwei Ye Wei Zhang Lulin Ma Chuanjun Du Liping Xie Yiran Huang Qiang Wei Zhangqun Ye Yanqun Na | 2019 | Chinese Journal of Cancer Research2019，31，3： | 4 |
| 11 | Balancing method without trial weights for rotor systems based on similitude scale model显示文摘 | Ruiduo YE Liping WANG Xiaojie HOU Zhong LUO Qingkai HAN | 2018 | Frontiers of Mechanical Engineering2018，13，4： | 3 |
| 12 | Effect of UV-C treatments on phenolic compounds and antioxidant capacity of minimally processed Satsuma mandarin during refrigerated storage显示文摘 | Yan Shen Yujing Sun Liping Qiao Jianchu Chen Donghong Liu Xingqian Ye | 2013 | Postharvest Biology and Technology2013，，： | 2 |
| 13 | Symmetry-enforced three-dimensional Dirac phononic crystals显示文摘Dirac semimetals,the materials featuring fourfold degenerate Dirac points,are critical states of topologically distinct phases.Such gapless topological states have been accomplished by a band-inversion mechanism,in which the Dirac points can be annihilated pairwise by perturbations without changing the symmetry of the system.Here,we report an experimental observation of Dirac points that are enforced completely by the crystal symmetry using a nonsymmorphic three-dimensional phononic crystal.Intriguingly,our Dirac phononic crystal hosts four spiral topological surface states,in which the surface states of opposite helicities intersect gaplessly along certain momentum lines,as confirmed by additional surface measurements.The novel Dirac system may release new opportunities for studying elusive(pseudo)and offer a unique prototype platform for acoustic applications. | Xiangxi Cai Liping Ye Chunyin Qiu Meng Xiao Rui Yu Manzhu Ke Zhengyou Liu | 2020 | Light(Science & Applications)2020，9，1： | 2 |
| 14 | Establishing Gene Delivery Systems Based on Small-Sized Chitosan Nanoparticles显示文摘Chitosan is a natural cationic polysaccharide,which is often used for preparing biomedical materials because of its high biocompatibility.In this study,chitosan with a molecular weight of 160 k Da was chosen to prepare chitosan nanoparticles(CSNPs) as gene vectors by ionic cross-linking with tripolyphosphate(TPP).CSNPs were characterized in terms of particle size,zeta potential,and polydispersity index(PDI) using a Zetasizer,and morphology was evaluated by transmission electron microscopy(TEM).Furthermore,the cytotoxicity and biocompatibility of CSNPs were correspondingly examined by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay and histological examination.Agarose gel electrophoresis and UV spectrophotometric methods were performed to measure the loading capacity.The cell transfection efficiency of CSNPs loaded with plasmids or si RNA was analyzed by fluorescence microscopy or laser scanning confocal microscopy.The results showed that CSNPs were prepared successfully by the ionic gelation method,which had a smaller particle size(100 nm-200 nm),stable dispersibility,low cytotoxicity,good tissue-biocompatibility,and high gene-loading efficiency.These CSNPs could transfer the plasmids or si RNA to cells.However,CSNPs might have a much higher transfection efficiency for si RNAs than for plasmids,which implies that CSNPs might be a safer and more efficient vector for delivering si RNAs rather than plasmids. | WANG Liping ZHANG Wenhua ZHOU Quan LIU Shihai XU Wenhua SUN Teng LIANG Ye | 2018 | Journal of Ocean University of China2018，17，5： | 2 |
| 15 | Well-defined coordination environment breaks the bottleneck of organic synthesis:Single-atom palladium catalyzed hydrosilylation of internal alkynes显示文摘Single-atom site(SAS)catalysts have attracted considerable attention due to their excellent performance.However,most of the current research models of SAS catalysts are based on inorganic catalysts,where“metal and coordination atom interaction”cannot simulate the fine-tuning effect of organic ligands on metal catalytic centers in homogeneous catalysts.Therefore,certain chemical transformations in homogeneous catalysis cannot be perfectly replicated.Here,we used porous organic ligand polymers as the carrier,which effectively changes the charge regulation of nanoparticles and monoatomic metal catalysts.Drawing lessons from traditional homogeneous metal/ligand catalysis,we introduced various functional groups into the ligand polymers to adjust the electronic properties,and successfully realized the hydrosilylation of internal alkynes with high catalytic performance.The selectivity and catalytic efficiency under the Pd@POL-1 catalyst system were improved compared with previous studies.The internal alkynes with various structures can complete this reaction,and the ratio of E/Zcan reach up to 100:1. | Shicheng Ren Bochao Ye Siying Li Liping Pang Yingming Pan Haitao Tang | 2022 | Nano Research2022，15，2： | 2 |
| 16 | Twist1-induced miR-199a-3p promotes liver fibrosis by suppressing caveolin-2 and activating TGF-βpathway显示文摘The activation of hepatic stellate cells(HSCs)participates in liver fibrosis,and emerging evidences indicate that microRNAs(miRNAs)are abnormally expressed during HSC activation.However,the potential roles of miRNAs in liver fibrosis still remain elusive.Therefore,this study aimed to investigate the role of miR-199a-3p in liver fibrosis and its underlying mechanism.We found that miR-199a-3p expression was dramatically upregulated during HSC activation in vitro,and during liver fibrogenesis in CCl4-treated rats,and its liver expression was increased in the patients with cirrhosis.By the luciferase assay and RT-qPCR,we revealed that the expression of miR-199a-3p in HSCs was driven by the transcription factor Twist1 which could be further induced by TGF-βtreatment.Functional studies showed that inhibition of miR-199a-3p in both human LX2 cells and rat HSCs significantly decreased the expression of fibrotic markers,such as fibronectin and connective tissue growth factor(CTGF),whereas the forced expression of miR-199a-3p exhibited opposite effects,demonstrating the role of miR-199a-3p in promoting HSC activation.Mechanistically,miR-199a-3p plays an important role in TGF-βsignalling pathway activation through targeting CAV2 that negatively regulates the expression of transforming growth factor-beta receptor type I(TGFβRI).Importantly,administration of antagomiR-199a-3p in the CCl4-treated mice significantly ameliorated hepatic fibrosis.In conclusion,Twist1-induced miR-199a-3p mediates the activation of HSCs by suppressing CAV2 expression and subsequently increasing TGFβRI expression to promote TGF-βpathway.Our findings highlight the therapeutic potential of miR-199a-3p for hepatic fibrosis. | Xiaoxue Yang Liping Ma Rong Wei Tinghong Ye JianKang Zhou Maoyao Wen Ruoting Men Rami I.Aqeilan Yong Peng Li Yang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 17 | A novel CD4+CTL subtype characterized by chemotaxis and inflammation is involved in the pathogenesis of Graves’orbitopathy显示文摘Graves*orbitopathy(GO),the most severe manifestation of Graves'hyperthyroidism(GH),is an autoimmune-mediated inflammatory disorder,and treatments often exhibit a low efficacy.CD4+T cells have been reported to play vital roles in GO progression.To explore the pathogenic CD4-f T cell types that drive GO progression,we applied single-cell RNA sequencing(scRNA-Seq),T cell receptor sequencing(TCR-Seq),flow cytometry,immunofluorescence and mixed lymphocyte reaction(MLR)assays to evaluate CD4+T cells from GO and GH patients.scRNA-Seq revealed the novel GO-spedfic cell type CD4+cytotoxic T lymphocytes(CTLs),which are characterized by chemotactic and inflammatory features.The clonal expansion of this CD4+CTL population,as demonstrated by TCR-Seq,along with their strong cytotoxic response to autoantigens,localization in orbital sites,and potential relationship with disease relapse provide strong evidence for the pathogenic roles of GZMB and IFN-y-secreting CD4+CTLs in GO.Therefore,cytotoxic pathways may become potential therapeutic targets for GO. | Yue Wang Ziyi Chen Tingjie Wang Hui Guo Yufeng Liu Ningxin Dang Shiqian Hu Liping Wu Chengsheng Zhang Kai Ye Bingyin Shi | 2021 | Cellular & Molecular Immunology2021，18，3： | 2 |
| 18 | Postzygotic single-nucleotide mosaicisms in whole-genome sequences of clinically unremarkable individuals显示文摘 | August Y Huang Xiaojing Xu Adam Y Ye Qixi Wu Linlin Yan Boxun Zhao Xiaoxu Yang Yao He Sheng Wang Zheng Zhang Bowen Gu Han-Qing Zhao Meng Wang Hua Gao Ge Gao Zhichao Zhang Xiaoling Yang Xiru Wu Yuehua Zhang Liping Wei | 2014 | Cell Research2014，24，11： | 2 |
| 19 | Impaired Parahippocampal Gyrus-Orbitofrontal Cortex Circuit Associated with Visuospatial Memory Deficit as a Potential Biomarker and Interventional Approach for Alzheimer Disease显示文摘The parahippocampal gyrus-orbitofrontal cortex(PHG-OFC)circuit in humans is homologous to the postrhinal cortex(POR)-ventral lateral orbitofrontal cortex(vlOFC)circuit in rodents.Both are associated with visuospatial malfunctions in Alzheimer’s disease(AD).However,the underlying mechanisms remain to be elucidated.In this study,we explored the relationship between an impaired POR-vlOFC circuit and visuospatial memory deficits through retrograde tracing and in vivo local field potential recordings in 5XFAD mice,and investigated alterations of the PHG-OFC circuit by multi-domain magnetic resonance imaging(MRI)in patients on the AD spectrum.We demonstrated that an impaired glutamatergic POR-vlOFC circuit resulted in deficient visuospatial memory in 5XFAD mice.Moreover,MRI measurements of the PHG-OFC circuit had an accuracy of 77.33%for the classification of amnestic mild cognitive impairment converters versus non-converters.Thus,the PHG-OFC circuit explains the neuroanatomical basis of visuospatial memory deficits in AD,thereby providing a potential predictor for AD progression and a promising interventional approach for AD. | Lin Zhu Zan Wang Zhanhong Du Xinyang Qi Hao Shu Duan Liu Fan Su Qing Ye Xuemei Liu Zheng Zhou Yongqiang Tang Ru Song Xiaobin Wang Li Lin Shijiang Li Ying Han Liping Wang Zhijun Zhang | 2020 | Neuroscience Bulletin2020，36，8： | 2 |
| 20 | Shear-Flow Induced Secondary Circulation in Parallel Underwater Topographic Corrugation and Its Application to Satellite Image Interpretation显示文摘This study aims to figure out satellite imaging mechanisms for submerged sand ridges in the shallow water region in the case of the flow parallel to the topography corrugation.Solving the disturbance governing equations of the shear-flow yields the analytical solutions of the secondary circulation.The solutions indicate that a flow with a parabolic horizontal velocity shear and a sinusoidal vertical velocity shear will induce a pair of vortexes with opposite signs distributed symmetrically on the two sides of central line of a rectangular canal.In the case of the presence of surface Ekman layer with the direction of Ekman current opposite to(coincident with) the mean flow,the two vortexes converge(diverge) at the central line of canal in the upper layer and form a surface current convergent(divergent) zone along the central line of the canal.In the case of the absence of surface Ekman layer,there is no convergent(divergent) zone formed over the sea surface.The theoretical results are applied to interpretations of three convergent cases,one divergent case and statistics of 27 cases of satellite observations in the submerged sand ridge region of the Liaodong Shoal in the Bohai Sea.We found that the long,finger-like,bright patterns on SAR images are corresponding to the locations of the canals(or tidal channels) formed by two adjacent sand ridges rather than the sand ridges themselves. | ZHENG Quanan ZHAO Qing YUAN Yeli LIU Xian HU Jianyu LIU Xuehai YIN Liping YE Xiaomin | 2012 | Journal of Ocean University of China2012，11，4： | 2 |
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