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| 1 | High-performance silicon−graphene hybrid plasmonic waveguide photodetectors beyond 1.55μm显示文摘Graphene has attracted much attention for the realization of high-speed photodetection for silicon photonics over a wide wavelength range.However,the reported fast graphene photodetectors mainly operate in the 1.55μm wavelength band.In this work,we propose and realize high-performance waveguide photodetectors based on bolometric/photoconductive effects by introducing an ultrathin wide silicon−graphene hybrid plasmonic waveguide,which enables efficient light absorption in graphene at 1.55μm and beyond.When operating at 2μm,the present photodetector has a responsivity of ~70 mA/W and a setup-limited 3 dB bandwidth of >20 GHz.When operating at 1.55μm,the present photodetector also works very well with a broad 3 dB bandwidth of >40 GHz(setup-limited)and a high responsivity of ~0.4 A/W even with a low bias voltage of−0.3 V.This work paves the way for achieving highresponsivity and high-speed silicon-graphene waveguide photodetection in the near/mid-infrared ranges,which has applications in optical communications,nonlinear photonics,and on-chip sensing. | Jingshu Guo Jiang Li Chaoyue Liu Yanlong Yin Wenhui Wang Zhenhua Ni Zhilei Fu Hui Yu Yang Xu Yaocheng Shi Yungui Ma Shiming Gao Limin Tong Daoxin Dai | 2020 | Light(Science & Applications)2020，9，1： | 10 |
| 2 | IUKF neural network modeling for FOG temperature drift显示文摘A novel neural network based on iterated unscented Kalman filter(IUKF) algorithm is established to model and compensate for the fiber optic gyro(FOG) bias drift caused by temperature. In the network, FOG temperature and its gradient are set as input and the FOG bias drift is set as the expected output. A2-5-1 network trained with IUKF algorithm is established. The IUKF algorithm is developed on the basis of the unscented Kalman filter(UKF). The weight and bias vectors of the hidden layer are set as the state of the UKF and its process and measurement equations are deduced according to the network architecture. To solve the unavoidable estimation deviation of the mean and covariance of the states in the UKF algorithm, iterative computation is introduced into the UKF after the measurement update. While the measurement noise R is extended into the state vectors before iteration in order to meet the statistic orthogonality of estimate and measurement noise. The IUKF algorithm can provide the optimized estimation for the neural network because of its state expansion and iteration. Temperature rise(-20-20 C) and drop(70-20 C)tests for FOG are carried out in an attemperator. The temperature drift model is built with neural network, and it is trained respectively with BP, UKF and IUKF algorithms. The results prove that the proposed model has higher precision compared with the backpropagation(BP) and UKF network models. | Feng Zha Jiangning Xu Jingshu Li Hongyang He | 2013 | Journal of Systems Engineering and Electronics2013，24，5： | 4 |
| 3 | Silicon/2D-material photodetectors: from nearinfrared to mid-infrared显示文摘Two-dimensional materials(2DMs)have been used widely in constructing photodetectors(PDs)because of their advantages in flexible integration and ultrabroad operation wavelength range.Specifically,2DM PDs on silicon have attracted much attention because silicon microelectronics and silicon photonics have been developed successfully for many applications.2DM PDs meet the imperious demand of silicon photonics on low-cost,high-performance,and broadband photodetection.In this work,a review is given for the recent progresses of Si/2DM PDs working in the wavelength band from near-infrared to mid-infrared,which are attractive for many applications.The operation mechanisms and the device configurations are summarized in the first part.The waveguide-integrated PDs and the surface-illuminated PDs are then reviewed in details,respectively.The discussion and outlook for 2DM PDs on silicon are finally given. | Chaoyue Liu Jingshu Guo Laiwen Yu Jiang Li Ming Zhang Huan Li Yaocheng Shi Daoxin Dai | 2021 | Light(Science & Applications)2021，10，7： | 3 |
| 4 | Purification, characterization and anticancer activity of a polysaccharide from Panax ginseng显示文摘 | Cong Li Jianping Cai Jingshu Geng Yinghong Li Zhenyu Wang Rui Li | 2012 | International Journal of Biological Macromolecules2012，，5： | 2 |
| 5 | Crystallization Behavior of Polypropylene/Polyamide 1010 Blends Using Polypropylene-graft-glycidyl Methacrylate as Compatihilizer显示文摘 | Zhang Xiaomin Li Gang Li Jingshu | 1997 | Die Angewandte Makeromolekulare Chemie1997，248，： | 1 |
| 6 | Expression of Astrocyte Elevated Gene-1: A Novel Marker of the Pathogenesis, Progression, and Poor Prognosis for Endometrial Cancer显示文摘 | Hongtao Song Cong Li Renbo Lu Yuan Zhang Jingshu Geng | 2010 | International Journal of Gynecological Cancer2010，，7： | 1 |
| 7 | Semen Analysis and Fecundity Association Among Women with Polycystic Ovary Syndrome Experiencing Ovulatory Dysfunction Treated by Ovulation Induction显示文摘In this study,normal values of semen analysis were set for a general infertile population of couples among which most women had normal ovulation.The predictive capacity values of sperm quality,including concentration,motile count,progressive motile count,and morphology,are unclear for women with polycystic ovary syndrome(PCOS).A secondary analysis was conducted based on a randomized controlled trial investigating infertility among women with PCOS experiencing ovulatory disorder between 2011 and 2016 in China.A total of 1000 women received ovulation induction(acupuncture and clomiphene).We randomized the women with PCOS in 27 hospitals in China who received one of four interventions(acupuncture plus clomiphene,sham acupuncture plus clomiphene,acupuncture plus placebo,or sham acupuncture plus placebo).Semen analysis was performed for every male partner according to the World Health Organization(WHO)criteria.The outcomes included conception,clinical pregnancy,and live birth.Logistic regression was used to evaluate the predictive value of semen analysis among ovulatory women for conception,clinical pregnancy,and live birth.Among the 1000 couples,the number of couples who attained ovulation,conception,clinical pregnancy,and live birth were 780,320,235,and 205,respectively.Semen volume and motility were applied and used as prediction parameters for conception(area under the curve(AUC)of 0.62(95%confidence interval(CI),0.55–0.69)),clinical pregnancy(AUC of 0.67(95%CI:0.61–0.73)),and live birth(AUC of 0.57(95%CI:0.50–0.64)).No poor calibration was shown for these models in Hosmer–Lemeshow tests.The predictive capacity of semen analysis for treatment outcome in PCOS women with PCOS experiencing with ovulatory dysfunction is limited. | Jingshu Gao Yu Wang Mubai Li Mengyi Zhu Xuekui Liu Hongli Ma Yijuan Cao Lu Li Xinming Yang Xiaoke Wu | 2021 | Engineering2021，7，11： | 1 |
| 8 | AEG -1 Overexpression: A Novel Indicator for Peritoneal Dissemination and Lymph Node Metastasis in Epithelial Ovarian Cancers显示文摘 | Cong Li Junjun Liu Renbo Lu Ge Yu Xiaochuan Wang Yulan Zhao Hongtao Song Ping Lin Xicai Sun Xiaoguang Yu Yuan Zhang Xiaoming Ning Jingshu Geng | 2011 | International Journal of Gynecological Cancer2011，，4： | 1 |
| 9 | Global trends and regional differences in non-transport unintentional injuries mortality among children and adolescents, 1990 to 2019: results from the Global Burden of Disease 2019 study显示文摘Background::Non-transport unintentional injuries(NTUIs)are major public concerns,especially among children and adolescents in low-and middle-income countries.With environmental and cognitive changes,a recent systematic description of global trends and regional differences concerning NTUIs is urgently needed for the global agenda of relevant policy-making and intervention target findings.Methods::We used mortality,population,and socio-demographic-index(SDI)data from Global Burden of Disease 2019 to analyze the trends of NTUIs mortality.We applied the slope index of inequality(SII)and relative index of inequality(RII)to measure the absolute and relative inequality between countries and territories.The concentration curve and concentration index(CI)were also used to measure the inequality.We conducted a sensitivity analysis to make our findings credible.Results::In 2019,there were 205,000 deaths due to NTUIs among children and adolescents aged 5 to 24 years,which decreased from 375,000 in 1990.In 2019,the age-standardized mortality rate(ASMR)was 8.13 per 100,000,ranging from the lowest in the Netherlands(0.90 per 100,000)to the highest in the Solomon Islands(29.34 per 100,000).The low-middle SDI group had the highest ASMR of NTUIs,while the low SDI group had the slowest decrease.After excluding the death caused by'exposure to forces of nature'and'other unintentional injuries',drowning accounted for the most deaths in almost every SDI group,gender,and age group,but the major causes of death varied in different subgroups.For example,animal contact was a major cause in low and low-middle SDI groups but less in high SDI groups,while high and high-middle SDI groups had a higher proportion of deaths for foreign body and poisonings.The SII showed a declining trend,but the RII and CI did not,which might indicate that inequality was persistent.Similar results were found in the sensitivity analysis.Conclusions::Despite the declining trend of the mortality rate and the narrowing gap between countries,there were still a large number of children and adolescents dying from NTUIs,and those experiencing social-economic disadvantages remained at high mortality.Embedding the prevention of NTUIs into sustainable development goals might contribute to the progress of reducing death and inequalities,which ensures that no one is left behind. | Yunfei Liu Yanhui Dong Xiaojin Yan Ning Ma Jiajia Dang Jingshu Zhang Panliang Zhong Luo Li Zhiyong Zou Yi Song Jun Ma | 2022 | Chinese Medical Journal2022，135，17： | 1 |
| 10 | Modulating the tumor microenvironment via oncolytic virus and PI3K inhibition synergistically restores immune checkpoint therapy response in PTEN-deficient glioblastoma显示文摘Dear Editor,Glioblastoma(GBM)is a lethal primary brain cancer,with a median survival of less than 2 years.1 Immune checkpoint blockades(ICBs)have revolutionized cancer therapy in the last decade,but they have little clinical benefit in GBM.1 Genomic and transcriptomic analysis revealed a significant enrichment of PTEN mutations in GBM patients resistant to ICBs.2 PTEN deficiency activates the phosphatidylinositol 3-kinase(PI3K)-AKT pathway to shape an immunosuppressive microenvironment. | Fan Xing Jingshu Xiao Junyu Wu Jiaming Liang Xiaoyu Lu Liping Guo Ping Li Panpan Hou Chunmei Li Deyin Guo | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 0 |
| 11 | Establishment of an indicator framework for global One Health Intrinsic Drivers index based on the grounded theory and fuzzy analytical hierarchy-entropy weight method显示文摘Background:One Health has become a global consensus to deal with complex health problems.However,the pro‑gress of One Health implementation in many countries is still relatively slow,and there is a lack of systematic evalua‑tion index.The purpose of this study was to establish an indicator framework for global One Health Intrinsic Drivers index(GOH-IDI)to evaluate human,animal and environmental health development process globally.Method:First,82 studies were deeply analyzed by a grounded theory(GT)method,including open coding,axial coding,and selective coding,to establish a three-level indicator framework,which was composed of three selective codes,19 axial codes,and 79 open codes.Then,through semi-structured interviews with 28 health-related experts,the indicators were further integrated and simplifed according to the inclusion criteria of the indicators.Finally,the fuzzy analytical hierarchy process combined with the entropy weight method was used to assign weights to the indi‑cators,thus,forming the evaluation indicator framework of human,animal and environmental health development process.Results:An indicator framework for GOH-IDI was formed consisting of three selective codes,15 axial codes and 61 open codes.There were six axial codes for“Human Health”,of which“Infectious Diseases”had the highest weight(19.76%)and“Injuries and Violence”had the lowest weight(11.72%).There were four axial codes for“Animal Health”,of which“Animal Epidemic Disease”had the highest weight(39.28%)and“Animal Nutritional Status”had the low‑est weight(11.59%).Five axial codes were set under“Environmental Health”,among which,“Air Quality and Climate Change”had the highest weight(22.63%)and“Hazardous Chemicals”had the lowest weight(17.82%).Conclusions:An indicator framework for GOH-IDI was established in this study.The framework were universal,balanced,and scientifc,which hopefully to be a tool for evaluation of the joint development of human,animal and environmental health in diferent regions globally. | Jiaxin Feng Zhaoyu Guo Lin Ai Jingshu Liu Xiaoxi Zhang Chunli Cao Jing Xu Shang Xia Xiao‑Nong Zhou Jin Chen Shizhu Li | 2022 | Infectious Diseases of Poverty2022，11，6： | 0 |
| 12 | 3D limit analysis of rock slopes based on equivalent linear failure criterion with tension cut-off显示文摘Hoek-Brown (HB) failure criterion is widely used to predict the strength of intact or heavily jointed rock mass. For stability analysis of rock slopes governed by the HB failure criterion, the equivalent linearity to Mohr-Coulomb (MC) criterion is often adopted, leading to the well-known equivalent Mohr-Coulomb method (EMCM). Existing studies on EMCM analysis mainly consider the shear strength of rock material, while consideration of the tensile strength is rare. This contradicts the fact that the underlying tensile strength of rock mass has considerable impact on the rock slope stability in real world. In this regard, this paper proposes a limit analysis-based approach that can account for tension in the three-dimensional (3D) stability analysis of HB rock slope. This approach is established on the equivalent linearity of the HB criterion with consideration of tensile strength, known as the equivalent tension cut-off MC method (ETMCM), and using a horn-like 3D mechanism of limit analysis. The safety factor solutions given by the proposed approach are validated by previous studies and numerical results. Parametric studies are conducted to investigate the effect of rock tensile strength on slope stability. Results show that the consideration of tension leads to a more conservative safety factor and a sharper curvature of the failure surface, and these impacts tend to be more obvious with the increases in slope inclination and slope width. Finally, the stability of the HB rock slope under seepage conditions is studied using the proposed approach. The results indicate that the effect of tensile strength is highly remarkable in seepage circumstances. | Zhibin Sun Bowen Wang Yongxin Li Jingshu Xu Jian Ji | 2023 | Journal of Rock Mechanics and Geotechnical Engineering2023，15，12： | 0 |
| 13 | Development of a molecular feature-based survival prediction model of ovarian cancer using the deep neural network显示文摘Ovarian cancer(OC)is one of the most lethal gynecologic cancer worldwide,and survival prediction is meaningful for personalized treatment.^(1)The survival outcome of cancer patients mainly depended on the malignancy of the primary tumor which is tightly linked with the expression profile of the molecular features.^(2)Therefore,in this study,we developed a molecular feature-based survival prediction model of OC using a deep neural network(DNN). | Tingyuan Lang Muyao Yang Yunqiu Xia Jingshu Liu Yunzhe Li Lingling Yang Chenxi Cui Yunran Hu Yang Luo Dongling Zou Lei Zhou Zhou Fu Qi Zhou | 2023 | Genes & Diseases2023，10，4： | 0 |
| 14 | Disruption of KDM4C-ALDH1 A3 feed-forward loop inhibits sternness,tumorigenesis and chemoresistance of gastric cancer stem cells显示文摘Dear Editor,Gastric cancer(GC)is a considerable global health burden;the median survival of advaneed GC is less than 1 year.^(1)Cancer stem cells(CSCs),a small population of cancer cells with stem cell-like properties,are the major cause of treatme nt failure,in eluding GC,2 however,the mechanisms underlying stemness maintenanee of GC stem cells(GCSCs)are still poorly understood. | Tingyuan Lang Jia Xu Lei Zhou Zhiqi Zhang Xinli Ma Jiayi Gu Jingshu Liu Yunzhe Li Dongyan Ding Jiangfeng Qiu | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 0 |
| 15 | simple and effective aerosol pathogen disinfection test for a flowing air disinfector显示文摘Aerosol transmission is an important disease transmission route and has been especially pertinent to hospital and biosafety laboratories during the SARS-CoV-2 pandemic.The thermal resistance of airborne SARS-CoV-2 is lower than that of Bacillus subtilis spores,which are often used to test the effectiveness of SARS-CoV-2 and other pathogen disinfection methods.Herein,we propose a new method to test the disinfection ability of a flowing air disinfector(a digital electromagnetic induction air heater)using B.subtilis spores.The study provides an alternative air disinfection test method.The new test system combined an aerosol generator and a respiratory filter designed in-house and could effectively recover spores on the filter membrane at the air outlet after passing through the flowing air disinfector.The total number of bacterial spores used in the test was within the range of 5×10^(5)–5×10^(6)colony-forming units(CFUs)specified in the technical standard for disinfection.The calculation was based on the calculation method in Air Disinfection Effect Appraisal Test in Technical Standard for Disinfection(2002 Edition).At an air speed of 3.5 m/s,we used a digital electromagnetic induction air heater to disinfect flowing air containing 4.100×10^(6)CFUs of B.subtilis spores and determined that the minimum disinfection temperature was 350℃for a killing rate of 99.99%.At 400℃,additional experiments using higher spore concentrations(4.700×10^(6)±1.871×10^(5)CFU)and a higher airspeed(4 m/s)showed that the killing rate remained>99.99%.B.subtilis spores,as a biological indicator for testing the efficiency of dry-heat sterilization,were killed by the high temperatures used in this system.The proposed method used to test the flowing air disinfector is simple,stable,and effective.This study provides a reference for the development of test systems that can assess the disinfection ability of flowing air disinfectors. | Xuling Liu Zhiran Qin Linqing Wang Xiaoting Xie Yifang Fu Jianhai Yu Zuxin Liang Xiaoen He Jingshu Li Hong Dai Jinxiu Yao Qinghua Wu Weiwei Xiao Li Zhu Chengsong Wan Bao Zhang Wei Zhao | 2023 | Journal of Biosafety and Biosecurity2023，5，1： | 0 |
| 16 | A preliminary application of dental cementum incremental analysis to determine the season-of-death of equids from the Xujiayao site,China显示文摘Seasonality study of Paleolithic archaeological faunal assemblages is important for reconstructing modes of animal death and ancient hominin strategies for prey acquisition. The dental cementum of animal teeth records the season of an individual animal in which it died, providing the necessary evidence for determining any patterns in season of death. This article presents the procedure and preliminary results of the application of cementum incremental analysis to equid teeth, which comprise the dominant component of the fauna from the Xujiayao Site—an early Late Pleistocene archaeological site in China. Results show multi-seasonal use in both the upper and lower layers of this site. Furthermore, attention is given to the method's future application in seasonality studies at Paleolithic archaeological sites in China. | LI JingShu ZHANG ShuangQuan Henry T. BUNN Akshay SARATHI GAO Xing | 2017 | Science China Earth Sciences2017，60，6： | 0 |
| 17 | Structural diversification of bioactive bibenzyls through modular co-culture leading to the discovery of a novel neuroprotective agent显示文摘Bibenzyls,a kind of important plant polyphenols,have attracted growing attention for their broad and remarkable pharmacological activities.However,due to the low abundance in nature,uncontrollable and environmentally unfriendly chemical synthesis processes,these compounds are not readily accessible.Herein,one high-yield bibenzyl backbone-producing Escherichia coli strain was constructed by using a highly active and substrate-promiscuous bibenzyl synthase identified from Dendrobium officinale in combination with starter and extender biosynthetic enzymes.Three types of efficiently postmodifying modular strains were engineered by employing methyltransferases,prenyltransferase,and glycosyltransferase with high activity and substrate tolerance together with their corresponding donor biosynthetic modules.Structurally different bibenzyl derivatives were tandemly and/or divergently synthesized by co-culture engineering in various combination modes.Especially,a prenylated bibenzyl derivative(12)was found to be an antioxidant that exhibited potent neuroprotective activity in the cellular and rat models of ischemia stroke.RNA-seq,quantitative RT-PCR,and Western-blot analysis demonstrated that 12 could up-regulate the expression level of an apoptosis-inducing factor,mitochondria associated 3(Aifm3),suggesting that Aifm3 might be a new target in ischemic stroke therapy.This study provides a flexible plug-and-play strategy for the easy-to-implement synthesis of structurally diverse bibenzyls through a modular co-culture engineering pipeline for drug discovery. | Yuyu Liu Xinnan Li Songyang Sui Jingshu Tang Dawei Chen Yuying Kang Kebo Xie Jimei Liu Jiaqi Lan Lei Wu Ridao Chen Ying Peng Jungui Dai | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 0 |
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