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| 1 | 血液透析患者血压水平的地域和季节性差异显示文摘季节和气候对一般人群以及血液透析患者的血压调节有影响。目前这个现象在世界各地是否有所不同尚不清楚。研究者对来自7个欧洲国家(西班牙、意大利、法国、比利时、德国、英国和瑞典)2005-2011年间参加国际透析预后与实践模式研究(dialysis outcomes and practice patterns study,DOPPS)的患者进行了研究,目的是探究来自不同地理位置的血液透析患者的血压季节差异。 | 刘青 叶鹏 Duranton F Kramer A Szwarc I Bieber B Gayrard N Jover B Vetromile F Massy ZA Combe C Tentori F Jager KJ Servel MF Argilés | 2018 | 中华高血压杂志2018，26，1： | 5 |
| 2 | Diffuse cortical necrosis in a neonate with incontinentia piginenti and an encephalitis - like presentation 显示文摘 | Wolf NI Kramer N Harting I | 2005 | AJNR2005，26，： | 1 |
| 3 | Transition metal transport 显示文摘 | KRAMER U TALKE I N HANIKENNE M | 2007 | FEBS Lett2007，581，12： | 1 |
| 4 | Develop- ment of a partition-controlled dosing system for cell assays 显示文摘 | Kramer N I Busser F J Oosterwijk M T | 2010 | Chemical Research in Toxicology2010，23，11： | 1 |
| 5 | 早期将抗生素由静脉转为口服治疗严重社区获得性肺炎:多中心随机试验显示文摘目的比较早期由静脉转换成口服抗生素与常规静脉使用7天抗生素治疗严重社区获得性肺炎(CAP)的疗效。设计多中心随机对照试验。地点荷兰5家教学医院和2所大学的医学中心。参加者非 ICU 住院的严重 CAP 患者302例,其中265例满足研究要求。干预静脉抗生素治疗3天,病情稳定后换成口服抗生素,或静脉使用抗生素治疗7天。主要评价结果临床治愈和住院天数。结果 302例患者被随机分组(平均年龄69.5岁,标准差14.0),肺炎严重度评分平均112.7(26.0)。37例患者因为提前3天退出而未纳入分析,对其余265例患者进行分析研究。第28天的死亡率在干预组是4%,对照组是6%(平均差2%,95%可信区间-3%~8%)。临床治愈率在干预组是83%,对照组是85%(2%;-7%~10%)。与对照组相比,干预组患者静脉治疗时间为3.4天[3.6(1.5)比7.0(2.0)天;2.8~3.9],患者住院天数减少1.9天[9.6(5.0)比11.5(4.9)天;0.6~3.2]。结论早期将抗生素由静脉应用转换成口服治疗严重 CAP 是安全的,并且可以减少住院时间2天。试验注册号临床试验 NCT00273676。 | Jan Jelrik Oosterheert Marc J M Bonten Margriet M E Schneider Erik Buskens Jan-Willem J Lammers Willem M N Hustinx Mark H H Kramer Jan M Prins Peter H Th J Slee Karin Kaasjager Andy I M Hoepelman 王伟巍(译) 童朝辉(校) | 2007 | 英国医学杂志中文版2007，10，2： | 1 |
| 6 | Zinc-dependent global transcriptional control, transcriptional deregulation, and higher gene copy number for genes in metal homeostasis of the hyperaccumulator Arabidopsis halleri 显示文摘 | TALKE I N HANIKENNE M KRAMER U | 2006 | Plant Physiology2006，142，1： | 1 |
| 7 | 查看详情显示文摘 | Dils B De Maziere M Muller J F Blumenstock T Buchwitz M de Beek R Demoulin P Duchatelet P Fast H Frankenberg C Gloude- mans A Griffith D Jones N Kerzenmacher T Kramer I Mahieu E Mellqvist J Mittermeier R L Notholt J Rinsland C P Schrijver | | 0，，： | 1 |
| 8 | Intraventricular hemorrhage volume predicts poor outcomes but not delayed ischemic neurological deficits among patients with ruptured cerebral aneurysms 显示文摘 | Kramer AH Mikolaenko I Deis N | 2010 | Neurosurgery2010，67，： | 1 |
| 9 | Zinc-dependent global transcriptional control, transcriptional deregulation, and higher gene copy number for genes in metal homeostasis of the hyperaccumulator Arabidopsis halleri显示文摘 | TALKE I N HANIKENNE M KRAMER U | 2006 | Plant Physiology2006，142，： | 1 |
| 10 | Nanoindentation-induced defect-interface interactions: Phenomena, methods and limitations 显示文摘 | GERBERICH W W KRAMER D E TYMIAK N I | 1999 | Acta Materialia1999，47，15： | 1 |
| 11 | Deflection and stress analysis of hlgh-speed mechanisms with elastic links 显示文摘 | Imam I Sandor G N Kramer S N | 1973 | ASME Journal of Engineering for Industry1973，95，： | 1 |
| 12 | Marginal quality and wearof extended posterior resin composite restorations: Eiit-year resultsin vivo显示文摘 | Kramer N Klissner P Molmaen I | 2015 | J Mech Behav Biomed Mater2015，50，18： | 1 |
| 13 | Transition metal transport 显示文摘 | Kramer U Talke I N Hanikenne M | 2007 | FEBS Letters2007，581，12： | 1 |
| 14 | Control of the SOST bone enhancer by PTH using MEF2 transcription factors显示文摘 | Leupin O Kramer I Collette N M | 2007 | J Bone Miner Res2007，22，12： | 1 |
| 15 | Observations and modeling of relativistic spin precession in PSR Jl141-6545显示文摘 | MANCHESTER R N KRAMER M STAIRS I H | 2010 | Astrophys J2010，710，2： | 1 |
| 16 | Elavated plasma levels of interleu- kin 8 in patients with acute anterior ischemic optic neuropa- thy显示文摘 | GOLDENBERG-COHEN N KRAMER M BAHAR I MONSEL- ISE Y WEINBERGER D | 2004 | Br J Ophthalmol2004，88，12： | 1 |
| 17 | Long-acting risperi- done and oral antipsychotics in schizophrenia显示文摘 | Kwatra S G Batson N E Kramer S I | 2011 | N Engl J Med2011，364，23： | 1 |
| 18 | The tomato genome sequence provides insights into fleshy fruit evolution 显示文摘 | Sato S Tabata S Hirakawa H Asamizu E Shlrasawa K Isobe S Kaneko T Nakamura Y Shibata D Aoki K Egholm M Knight J Bogden R Li C Shuang Y Xu X Pan S Cheng S Liu X Ren Y Wang J Albiero A Dal Pero F Todesco S Van Eck J Buels R M Bombarely A Gosselin J R Huang M Leto J A Menda N Strickler S Mao L Gao S Tecle I Y York T Zheng Y Vrebalov JT Lee J Zhong S Mueller L A Stiekema W J Ribeca P Alioto T Yang W Huang S Du Y Zhang Z Gao J Guo Y Wang X Li Y He J Li C Cheng Z Zuo J Ren J Zhao J Yan L Jiang H Wang B Li H Li Z Fu F Chen B Feng Q Fan D Wang Y Ling H Xue Y Ware D McCombie W R Lippman Z B Chia J M Jiang K Pasternak S Gelley L Kramer M Anderson L K Chang S B Royer S M Shearer L A Stack S M Rose J K Xu Y Eannetta N Matas A J McQuinn R Tanksley S D Camara F Guiga R Rombauts S Fawcett J Van de Peer Y Zamir D Liang C Spannagl M Gundlach H Bruggmann R Mayer K Jia Z Zhang J Ye Z Bishop G J Butcher S Lopez-Cobollo R Buchan D Filippis I Abbott J Dixit R Singh M Singh A Pal J K Pandit A Singh P K Mahato A K Gaikwad V D Sharma R R Mohapatra T Singh N K Causse M Rothan C Schiex T Noirot C Bellec A Klopp C Delalande C Berges H Mariette J Frasse P Vautrin S Zouine M Latch6 A Rousseau C Regad F Pech J C Philippot M Bouzayen M Pericard P Osorio S Fernandez del Carmen A Monforte A Granell A Fernandez-Mufioz R Conte M Lichtenstein G Carrari F De Bellis G Fuligni F Peano C Grandillo S Termolino P Pietrella M Fantini E Falcone G Fiore A Giuliano G Lopez L Facella P Perotta G Daddiego L Bryan G Orozco M Pastor X Torrents D van Schriek M G Feron R M van Oeveren J de Heer P daPonte L Jacobs-Oomen S Cariaso M Prins M van Eijk M J Janssen A van Haaren M J Jungeun Kim S H Kwon S Y Kim S Koo D H Lee S Hur C G Clouser C Rico A Hallab A Gebhardt C Klee K Jocker A Warfsmann J Gobel U Kawamura S Yano K Sherman J D Fukuoka H Negoro S Bhutty S Chowdhury P Chattopadhyay D Datema E Smit S Schijlen E G van de Belt J van Haarst J C Peters S A van Staveren M A Henkens M H Mooyman P J Hesselink T van Ham R C Jiang G Droege M Choi D Kang B C Kim B D Park M Kim S Yeom SI Lee YH Choi Y D Li G Gao J Liu Y Huang S Fernandez-Pedrosa V Collado C Zufiiga S Wang G Cade R Dietrich R A Rogers J Knapp S Fei Z White R A Thannhauser T W Giovannoni J J Botella M A Gilbert L Gonzalez R Goieoechea J L Yu Y Kudrna D Collura K Wissotski M Wing R Meyers BC Gurazada AB Green P J Vyas S M Solanke A U Kumar R Gupta V Sharma A K Khurana P Khurana J P Tyagi A K Dalmay T Mohorianu 1 Waits B Chamala S Barbazuk W B Li J Guo H Lee T H Wang Y Zhang D Paterson A H Wang X Tang H Barone A Chiusano M L Ereolano M R D' Agostino N Di Filippo M Traini A Sanseverino W Frusciante L Seymour G B Elharam M Fu Y Hua A Kenton S Lewis J Lin S Najar F Lai H Qin B Qu C Shi R White D White J Xing Y Yang K Yi J Yao Z Zhou L Roe B A Vezzi A D' Angelo M Zimbello R Sehiavon R Caniato E Rigobello C Campagna D Vitulo N Valle G Nelson D R De Paoli E Szinay D de Jong H H Bai Y Visser R G Klein R Beasley H McLaren K Nicholson C Riddle C Gianese G | 2012 | Nature2012，485，7400： | 1 |
| 19 | Influence of albu- min on sorption kinetics in solid-phase microextraction: Consequences for chemical analyses and absorption process- es 显示文摘 | Kramer N I Eijkeren V Hermens J L M | 2007 | Analytical Chemistry2007，79，18： | 1 |
| 20 | Impact of preoperative antibiotics and other variables on integrated microbiome-host transcriptomic data generated from colorectal cancer resections显示文摘BACKGROUND Integrative multi-omic approaches have been increasingly applied to discovery and functional studies of complex human diseases.Short-term preoperative antibiotics have been adopted to reduce site infections in colorectal cancer(CRC)resections.We hypothesize that the antibiotics will impact analysis of multi-omic datasets generated from resection samples to investigate biological CRC risk factors.AIM To assess the impact of preoperative antibiotics and other variables on integrated microbiome and human transcriptomic data generated from archived CRC resection samples.METHODS Genomic DNA(gDNA)and RNA were extracted from prospectively collected 51 pairs of frozen sporadic CRC tumor and adjacent non-tumor mucosal samples from 50 CRC patients archived at a single medical center from 2010-2020.The 16S rRNA gene sequencing(V3V4 region,paired end,300 bp)and confirmatory quantitative polymerase chain reaction(qPCR)assays were conducted on gDNA.RNA sequencing(IPE,125 bp)was performed on parallel tumor and non-tumor RNA samples with RNA Integrity Numbers scores≥6.RESULTS PERMANOVA detected significant effects of tumor vs nontumor histology(P=0.002)and antibiotics(P=0.001)on microbialβ-diversity,but CRC tumor location(left vs right),diabetes mellitus vs not diabetic and Black/African Ancestry(AA)vs not Black/AA,did not reach significance.Linear mixed models detected significant tumor vs nontumor histology*antibiotics interaction terms for 14 genus level taxa.QPCR confirmed increased Fusobacterium abundance in tumor vs nontumor groups,and detected significantly reduced bacterial load in the(+)antibiotics group.Principal coordinate analysis of the transcriptomic data showed a clear separation between tumor and nontumor samples.Differentially expressed genes obtained from separate analyses of tumor and nontumor samples,are presented for the antibiotics,CRC location,diabetes and Black/AA race groups.CONCLUSION Recent adoption of additional preoperative antibiotics as standard of care,has a measurable impact on-omics analysis of resected specimens.This study still confirmed increased Fusobacterium nucleatum in tumor. | Sarah A Malik Chencan Zhu Jinyu Li Joseph F LaComb Paula I Denoya Igor Kravets Joshua D Miller Jie Yang Melissa Kramer W Richard McCombie Charles E Robertson Daniel N Frank Ellen Li | 2021 | World Journal of Gastroenterology2021，27，14： | 0 |
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