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| 1 | Quantitative analysis of ruminal methanogenic microbial populations in beef cattle divergent in phenotypic residual feed intake(RFI)offered contrasting diets显示文摘Background:Methane(CH_4) emissions in cattle are an undesirable end product of rumen methanogenic fermentative activity as they are associated not only with negative environmental impacts but also with reduced host feed efficiency.The aim of this study was to quantify total and specific rumen microbial methanogenic populations in beef cattle divergently selected for residual feed intake(RFI) while offered(i) a low energy high forage(HF) diet followed by(ii) a high energy low forage(LF) diet.Ruminal fluid was collected from 14 high(H)and 14 low(L) RFI animals across both dietary periods.Quantitative real time PCR(qRT-PCR) analysis was conducted to quantify the abundance of total and specific rumen methanogenic microbes.Spearman correlation analysis was used to investigate the association between the relative abundance of methanogens and animal performance,rumen fermentation variables and diet digestibility.Results:Abundance of methanogens,did not differ between RFI phenotypes.However,relative abundance of total and specific methanogen species was affected(P< 0.05) by diet type,with greater abundance observed while animals were offered the LF compared to the HF diet.Conclusions:These findings suggest that differences in abundance of specific rumen methanogen species may not contribute to variation in CH_4 emissions between efficient and inefficient animals,however dietary manipulation can influence the abundance of total and specific methanogen species. | Ciara A Carberry David A Kenny Alan K Kelly Sinead M Waters | 2014 | Journal of Animal Science and Biotechnology2014，5，4： | 6 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 4 | SLC26A4 mutation testing for hearing loss associated with enlargement of the vestibular aqueduct显示文摘Pendred syndrome(PS) is characterized by autosomal recessive inheritance of goiter associated with a defect of iodide organification, hearing loss, enlargement of the vestibular aqueduct(EVA), and mutations of the SLC26A4 gene. However, not all EVA patients have PSor SLC26A4 mutations. Two mutant alleles of SLC26A4 are detected in 1/4 of North American or European EVA populations, one mutant allele is detected in another 1/4 of patient populations, and no mutations are detected in the other 1/2. The presence of two mutant alleles of SLC26A4 is associated with abnormal iodide organification, increased thyroid gland volume, increased severity of hearing loss, and bilateral EVA. The presence of a single mutant allele of SLC26A4 is associated with normal iodide organification, normal thyroid gland volume, less severe hearing loss and either bilateral or unilateral EVA. When other underlying correlations are accounted for, the presence of a cochlear malformation or the size of EVA does not have an effect on hearing thresholds. This is consistent with observations of an Slc26a4 mutant mouse model of EVA in which hearing loss is independent of endolymphatic hydrops or inner ear malformations. Segregation analyses of EVA in families suggest that the patients carrying one mutant allele of SLC26A4 have a second, undetected mutant allele of SLC26A4, and the probability of a sibling having EVA is consistent with its segregation as an autosomal recessive trait. Patients without any mutations are an etiologically heterogeneous group in which siblings have a lower probability of having EVA. SLC26A4 mutation testing can provide prognostic information to guide clinical surveillance and management, as well as the probability of EVA affecting a sibling. | Taku Ito Julie Muskett Parna Chattaraj Byung Yoon Choi Kyu Yup Lee Christopher K Zalewski Kelly A King Xiangming Li Philine Wangemann Thomas Shawker Carmen C Brewer Seth L Alper Andrew J Griffith | 2013 | World Journal of Otorhinolaryngology2013，3，2： | 2 |
| 5 | Robust analysis of the yeast proteome under 50 kDa by molecular-massbased fractionation and top-down mass spectrometry显示文摘 | Kellie J F Catherman A D Durbin K R Tran J C Tipton J D Norris J L Witkowski C E 2nd Thomas P M Kelleher N L | | 0，，01： | 1 |
| 6 | New in- sights into porcine-human synteny conservation 显示文摘 | Larsen N J Marklund S Kelly K A | 1999 | Mannalian Genome1999，10，5： | 1 |
| 7 | Digestive development of the early-weaned pig显示文摘 | KELLY D SMYTH J A McCRACKEN K J | 1991 | Br J Nutr1991，65，2： | 1 |
| 8 | Nonlinear model for lead-rubber bearings including axial-load effects 显示文摘 | Ryan K L Kelly J M Chopra A K | 2005 | Journal of Engineering Mechanics2005，131，12： | 1 |
| 9 | Nutrition intakes in long-stay mentally handicapped persons显示文摘 | Cunningham K Gibney M J Kelly A | 1990 | British Journal of Nutrition1990，64，1： | 1 |
| 10 | Lead tetrakis(imidazotyt)borate solids: anion exchange, sol- vent intercalation, and self assembly of an organic anion 显示文摘 | HAMILTON B H KELLY K A WAGLER T A | 2004 | Inorg Chem2004，43，1： | 1 |
| 11 | The contributions of wind forcing waves and surface heating to sea surface height observations in the Pacific Ocean 显示文摘 | Vivier F Kelly K A Thompson L | 1999 | J Geophys Res1999，104，20： | 1 |
| 12 | Marker assisted selection to improve drought resistance in common bean显示文摘 | SCHNEIDER K A BROTHERS M E KELLY J D | 1997 | Crop Sci1997，37，： | 1 |
| 13 | Red Blood Cell Transfusion and Ventilator-associated Pneumonia: A Po- tential Link?显示文摘 | Shorr A F Duh M S Kelly K M | 2004 | Crit Care Med2004，32，3： | 1 |
| 14 | Rate control for communication networks: shadow price, proportional fairness and stability显示文摘 | KELLY F P MAULLOO K A TAN H D K | 1998 | Journal of the Operational Re- search Society1998，49，3： | 1 |
| 15 | Development of nurse competencies to improve dementia care显示文摘 | Williams CL Hyer K Kelly A | 2005 | Geriatric Nurs2005，26，2： | 1 |
| 16 | Harnessing the response to tissue hypoxia:HIF-1 alpha and therapeutic angiogenesis显示文摘 | VINCENT K A FERON O KELLY R A | 2002 | Trends Cardiovasc Med2002，12，： | 1 |
| 17 | Randomized phase l]I trial of paelitaxel plus carboplatin versus vinorelbine plus cisplatin in the treatment of patients with advanced non-small -cell lung cancer: a Southwest Oncology Group trial 显示文摘 | Kelly K Crowley J Burro P A Jr | 2001 | J Clin Oncol2001，19，13： | 1 |
| 18 | CCR5 inhibition prevents cardiac dysfunction in the SIV/Macaque model of HIV显示文摘 | Kelly K M Tocchetti C G Lyashkov A | 2014 | JAm Heart Assoc2014，3，00： | 1 |
| 19 | Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors 显示文摘 | Benson A K Kelly S A Legge R | 2010 | Proceed Nat Acad Sci USA2010，107，18： | 1 |
| 20 | Digestive development of the early-weaned pig显示文摘 | Kelly D Smyth J A McCtacken K J | 1991 | Brit J Nutr1991，65，： | 1 |
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