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| 1 | Importance of adequate immunosuppressive therapy for the recovery of patients with 'life-threatening' severe exacerbation of chronic hepatitis B显示文摘AIM: Hepatitis B virus (HBV) re-activation often occurs spontaneously or after withdrawal of immunosuppressive therapy in patients with chronic hepatitis B. Severe exacerbation, sometimes developing into fulminant hepatic failure, is at high risk of mortality. The efficacy of corticosteroid therapy in 'clinically severe' exacerbation of chronic hepatitis B has not been well demonstrated. In this study we evaluated the efficacy of early introduction of high-dose corticosteroid therapy in patients with lifethreatening severe exacerbation of chronic hepatitis B.METHODS: Twenty-two patients, 14 men and 8 women,were defined as 'severe' exacerbation of chronic hepatitis B using uniform criteria and enrolled in this study. Eleven patients were treated with corticosteroids at 60 mg or more daily with or without anti-viral drugs within 10 d after the diagnosis of severe disease ('early high-dose'group) and 11 patients were either treated more than 10 d or untreated with corticosteroids ('non-early high-dose'group).RESULTS: Mean age, male-to-female ratio, mean prothrombin time (PT) activity, alanine transaminase (ALT)level, total bilirubin level, positivity of HBeAg, mean IgMHBc titer, and mean HBV DNA polymerase activity did not differ between the two groups. Ten of 11 patients of the 'early high-dose' group survived, while only 2 of 11 patients of the 'non-early high-dose' group survived (P<0.001). During the first 2 wk after the introduction of corticosteroids, improvements in PT activities and total bilirubin levels were observed in the 'early high-dose'group. Both ALT levels and HBV DNA polymerase levels fell in both groups.CONCLUSION: The introduction of high-dose corticosteroid can reverse deterioration in patients with 'clinically lifethreatening' severe exacerbation of chronic hepatitis B,when used in the early stage of illness. | Keiichi Fujiwara Osamu Yokosuka Hiroshige Kojima Tatsuo Kanda Hiromitsu Saisho Hiroyuki Hirasawa Hiroshi Suzuki | 2005 | World Journal of Gastroenterology2005，11，8： | 20 |
| 2 | Corticosteroid and nucleoside analogue for hepatitis B virus-related acute liver failure显示文摘The early introduction of combination therapy of high-dose corticosteroid and nucleoside analogue is beneficial for the rescue of severe acute exacerbation of chronic hepatitis B. | Keiichi Fujiwara Shin Yasui Osamu Yokosuka | 2015 | World Journal of Gastroenterology2015，21，36： | 6 |
| 3 | Outcomes of gastrointestinal defect closure with an overthe-scope clip system in a multicenter experience: An analysis of a successful suction method显示文摘AIM To demonstrate the clinical outcomes of a multicenter experience and to suggest guidelines for choosing a suction method. METHODS This retrospective study at 5 medical centers involved 58 consecutive patients undergoing over-the-scope clips(OTSCs) placement. The overall rates of technical success (TSR), clinical success (CSR), complications, and procedure time were analyzed as major outcomes. Subsequently, 56 patients, excluding two cases that used the Anchor device, were divided into two groups: 14 cases of simple suction (SS-group) and 42 cases using the Twin Grasper (TG-group). Secondary evaluation was performed to clarify the predictors of OTSC success.RESULTS The TSR, CSR, complication rate, and median procedure time were 89.7%, 84.5%, 1.8%, and 8 (range 1-36) min, respectively, demonstrating good outcomes. However, significant differences were observed between the two groups in terms of the mean procedure time (5.9 min vs 14.1 min). The CSR of the SS- and TG-groups among cases with a maximum defect size ≤ 10 mm and immediate or acute refractory bleeding was 100%, which suggests that SS is a better method than TG in terms of time efficacy. The CSR in the SS-group (78.6%), despite the technical success of the SS method (TSR, 100%), tended to decrease due to delayed leakage compared to that in the TG-group (TSR, CSR; 88.1%), indicating that TG may be desirable for leaks and fistulae with defects of the entire layer. CONCLUSION OTSC system is a safe and effective therapeutic option for gastrointestinal defects. Individualized selection of the suction method based on particular clinical conditions may contribute to the improvement of OTSC success. | Hideki Kobara Hirohito Mori Shintaro Fujihara Noriko Nishiyama Taiga Chiyo Takayoshi Yamada Masao Fujiwara Keiichi Okano Yasuyuki Suzuki Masayuki Murota Yoshitaka Ikeda Makoto Oryu Mohamed Abo Ellail Tsutomu Masaki | 2017 | World Journal of Gastroenterology2017，23，9： | 3 |
| 4 | Emergence of entecavir-resistant mutations in nucleos(t)ide-naive Japanese patients infected with hepatitis B virus: Virological breakthrough is also dependent on adherence to medication显示文摘 | Hidehiro Kamezaki Tatsuo Kanda Shuang Wu Shingo Nakamoto Makoto Arai Hitoshi Maruyama Keiichi Fujiwara Fumio Imazeki Osamu Yokosuka | 2011 | Scandinavian Journal of Gastroenterology2011，，9： | 1 |
| 5 | Complexity in the treatment of pulmonary large cell neuroendocrine carcinoma显示文摘 | Toshiyuki Kozuki Nobukazu Fujimoto Hiroshi Ueoka Katsuyuki Kiura Keiichi Fujiwara Katsuhiko Shiomi Koichi Mizobuchi Masahiro Tabata Shuji Hamazaki Mitsune Tanimoto | 2005 | Journal of Cancer Research and Clinical Oncology2005，，3： | 1 |
| 6 | Efficacy of combination therapy of antiviral and immunosuppressive drugs for the treatment of severe acute exacerbation of chronic hepatitis B显示文摘 | Keiichi Fujiwara Shin Yasui Yutaka Yonemitsu Kenichi Fukai Makoto Arai Fumio Imazeki Akihiro Suzuki Hiroshi Suzuki Tomohito Sadahiro Shigeto Oda Osamu Yokosuka | 2008 | Journal of Gastroenterology2008，，9： | 1 |
| 7 | Simple assay based on restriction fragment length polymorphism associated with IL28B in chronic hepatitis C patients显示文摘 | Shingo Nakamoto Tatsuo Kanda Fumio Imazeki Shuang Wu Makoto Arai Keiichi Fujiwara Osamu Yokosuka | 2011 | Scandinavian Journal of Gastroenterology (-)2011，，7： | 1 |
| 8 | Water‐soluble argatroban for antithrombogenic surface coating of tissue‐engineered cardiovascular tissues显示文摘 | Yasuhide Nakayama Saori Yamaoka Masashi Yamanami Megumi Fujiwara Masami Uechi Keiichi Takamizawa Hatsue Ishibashi‐Ueda Marie Nakamichi Kingo Uchida Taiji Watanabe Keiichi Kanda Hitoshi Yaku | 2011 | J Biomed Mater Res2011，，2： | 1 |
| 9 | Opportunistic infection in patients with acute liver failure显示文摘 | Makoto Arai Tatsuo Kanda Shin Yasui Keiichi Fujiwara Fumio Imazeki Akira Watanabe Takeyuki Sato Shigeto Oda Osamu Yokosuka | 2014 | Hepatology International2014，，2： | 1 |
| 10 | Simple assay based on restriction fragment length polymorphism associated with IL28B in chronic hepatitis C patients显示文摘 | Shingo Nakamoto Tatsuo Kanda Fumio Imazeki Shuang Wu Makoto Arai Keiichi Fujiwara Osamu Yokosuka | 2011 | Scandinavian Journal of Gastroenterology (-)2011，，7： | 1 |
| 11 | Laparoscopic splenectomy for patients with liver cirrhosis: Improvement of liver function in patients with Child-Pugh class B显示文摘 | Naoki Yamamoto Keiichi Okano Minoru Oshima Shitaro Akamoto Masao Fujiwara Joji Tani Hisaaki Miyoshi Hirohito Yoneyama Tsutomu Masaki Yasuyuki Suzuki | 2015 | Surgery2015，，6： | 1 |
| 12 | Opportunistic infection in the patients with acute liver failure: a report of three cases with one fatality显示文摘 | Makoto Arai Fumio Imazeki Yutaka Yonemitsu Tatsuo Kanda Keiichi Fujiwara Kenichi Fukai Akira Watanabe Takeyuki Sato Shigeto Oda Osamu Yokosuka | 2009 | Clinical Journal of Gastroenterology2009，，6： | 1 |
| 13 | Quantification of hepatitis B surface antigen can help predict spontaneous hepatitis B surface antigen seroclearance显示文摘 | Makoto Arai Seiko Togo Tatsuo Kanda Keiichi Fujiwara Fumio Imazeki Osamu Yokosuka | 2012 | European Journal of Gastroenterology & Hepatology2012，，4： | 1 |
| 14 | Phase H study of combination chemotherapy with docetaxel and carbo platin for locally advanced or recurrent cervical cancer显示文摘 | Shigeki Takekida Keiichi Fujiwara Shoji Nagao | 2010 | International Journal of Gynecological Cancer2010，，9： | 1 |
| 15 | Platelet count and sustained virological response in hepatitis C treatment显示文摘AIM:To examine the epidemiological data,hematological safety and treatment responses of peginterferonalpha 2a plus ribavirin therapy for hepatitis C.METHODS:Between March 2008 and February 2011,196 hepatitis C virus(HCV)genotype 1 infected Japanese(127 treatment-naive and 69 treatment-experienced patients)patients treated with peginterferonalpha 2a plus ribavirin were enrolled.We examined the epidemiological data and treatment responses were retrospectively analyzed in terms of hematological safety.HCV RNA was measured by the COBAS TaqMan HCV test.RESULTS:Overall sustained virological response(SVR)rates of treatment-naive and treatment-experienced patients were 56% and 39%,respectively.Multivariate logistic regression analysis showed that SVR was attained independently of early virological response in both treatment-naive and treatment-experienced patients.SVR rates did not differ between the pretreatment hemoglobin < 13 g/dL and ≥ 13 g/dL groups.However,in treatment-naive patients,the SVR rate of the pretreatment platelet count < 130000/μL group was significantly lower than that of the pretreatment platelet count ≥ 130000/μL group.CONCLUSION:Attention should be paid to potential thrombocytopenia in the treatment of chronic hepatitis C patients. | Tatsuo Kanda Keizo Kato Akihito Tsubota Nobuo Takada Takayoshi Nishino Shigeru Mikami Tatsuo Miyamura Daisuke Maruoka Shuang Wu Shingo Nakamoto Makoto Arai Keiichi Fujiwara Fumio Imazeki Osamu Yokosuka | 2013 | World Journal of Hepatology2013，5，4： | 0 |
| 16 | Histological study of the structural layers around the esophagus in the lower mediastinum显示文摘BACKGROUND In Japan,the transhiatal approach,including lower mediastinal lymph node dissection,is widely performed for Siewert type II esophagogastric junction adenocarcinoma.This procedure is generally performed in a magnified view using laparoscopy or a robotic system,therefore,the microanatomy of the lower mediastinum is important.However,mediastinal microanatomy is still unclear and classification of lower mediastinal lymph nodes is not currently based on fascia or other microanatomical structures.AIM To clarify the fascia and layer structures of the lower mediastinum and classify the lower mediastinal tissue.METHODS We dissected the esophagus and surrounding organs en-bloc from seven cadavers fixed in 10%formalin.Organs and tissues were then cut at the level of the lower thoracic esophagus,embedded in paraffin,and serially sectioned.Tissue sections were stained with Hematoxylin-Eosin(all cadavers)and immunostained for the lymphatic endothelial marker D2-40(three cadavers).We observed the periesophageal fasciae and layers,and defined lymph node boundaries based on the fasciae.Lymphatic vessels around the esophagus were observed on immunostained tissue sections.RESULTS We identified two fasciae,A and B.We then classified lower mediastinal tissue into three areas,paraesophageal,paraaortic,and intermediate,using these fasciae as boundaries.Lymph nodes were found to be present and were counted in each area.The dorsal part of the intermediate area was thicker on the caudal side than on the cranial side in all cadavers.On the dorsal side,no blood vessels penetrated the fasciae in six of the seven cadavers,whereas the proper esophageal artery penetrated fascia B in one cadaver.D2-40 immunostaining showed lymphatic vessel connections between the paraesophageal and intermediate areas on the lateral and ventral sides of the esophagus,but no lymphatic connection between areas on the dorsal side of the esophagus.CONCLUSION Histological studies identified two fasciae surrounding the esophagus in the lower mediastinum and the layers separated by these fasciae were used to classify the lower mediastinal tissues. | Toshifumi Saito Satoru Muro Hisashi Fujiwara Yuya Umebayashi Yuya Sato Masanori Tokunaga Keiichi Akita Yusuke Kinugasa | 2023 | World Journal of Gastrointestinal Surgery2023，15，7： | 0 |
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