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| 1 | Extract of buckwheat sprouts scavenges oxidation and inhibits pro-inflammatory mediators in lipopolysaccharide-stimulated macrophages (RAW264.7)显示文摘OBJECTIVE: Buckwheat has been considered as a potential source of nutraceutical components on the world market of probiotic foodstuffs. The purpose of this study was to evaluate the effects of tartary buckwheat (Fagopyrum tataricum) sprouts on oxidation and pro-inflammatory mediators. METHODS: The anti-oxidant effects of buckwheat extract (BWE) and rutin were evaluated by using 1,1-diphenyl-2-picrylhydrazyl (DPPH)-and nitric oxide (NO)-scavenging activities, serum peroxidation and chelating assays. Lipopolysaccharide (LPS)-stimulated RAW264.7 cells were used to evaluate anti-inflammatory activities of buckwheat and rutin. NO production in LPS-stimulated RAW264.7 cells was determined by using Griess reagent. The expressions of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), nuclear factor-kappa B (NF-κB) p65 subunit in cytosolic and nuclear portions were determined by Western blot analysis. Also, the production of inflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) was determined by enzyme-linked immunosorbent assay. RESULTS: Inhibitory concentration 50 values for DPPHand NO-scavenging activities of BWE were 24.97 and 72.54 μg/mL respectively. BWE inhibited serum oxidation and possessed chelating activity. Furthermore, BWE inhibited IL-6 and TNF-α production in LPS-stimulated RAW264.7 cells. Also, BWE inhibited iNOS and COX-2 expression and NF-κB p65 translocation. CONCLUSION: Buckwheat sprouts possessed strong antioxidant activity and inhibited production of pro-inflammatory mediators in the applied model systems. Thus, buckwheat can be suggested to be beneficial in inflammatory diseases by inhibiting the free radicals and inflammatory mediators. | Rajendra Karki Cheol-Ho Park Dong-Wook Kim | 2013 | Journal of Integrative Medicine2013，11，4： | 17 |
| 2 | 腹的洞的主要恶意的含纤维的 histiocytoma : CT 调查结果和病理学的关联显示文摘 AIM:To study computed tomography(CT)features of abdominal malignant fibrous histiocytoma(MFH)in various rare locations.METHODS:We retroprospectively identified cases of MFH involving the abdominal cavity.Particular attention was paid to details regarding imaging features and histological types.RESULTS:The study population consisted of seven men and one woman,with a mean age of 52.5 years.Seven patients had some physical symptoms,while one was incidentally detected.The sites of origin were liver(n=3),greater omentum(n=1),superior mesentery(n=1),ileum(n=1),right psoas muscle(n=1)and right kidney(n=1).With the exception of the ileum lesion,all were of huge size.The contour of the lesions was more or less clear.Foci of necrosis were present in six lesions(n=6).On plain CT scan,all lesions were hypo to iso dense.The lesion in the greater omentum was cystic.One lesion(n=1)showed significant enhancement and the cystic lesion showed mild peripheral enhancement.An abundance of blood vessels surrounding the mass was seen in two lesions(n=2)and both were of the inflammatory variety.Pathological examination revealed storiform-pleomorphic variety(n=4),inflammatory variety(n=3)and myxoid variety(n=1).Two of the patients with inflammatory MFH had a clinical presentation of fever and one was afebrile,however,blood investigations in all three showed leukocytosis.CONCLUSION:Primary MFHs of the abdominal viscera and gastrointestinal tract are generally huge soft tissue masses containing areas of low attenuation and mild to moderate contrast enhancement. | Bivek Karki | 2012 | World Journal of Radiology2012，4，4： | 15 |
| 3 | Thin films as an emerging platform for drug delivery显示文摘Pharmaceutical scientists throughout the world are trying to explore thin films as a novel drug delivery tool. Thin films have been identified as an alternative approach to conventional dosage forms. The thin films are considered to be convenient to swallow, selfadministrable, and fast dissolving dosage form, all of which make it as a versatile platform for drug delivery. This delivery system has been used for both systemic and local action via several routes such as oral, buccal, sublingual, ocular, and transdermal routes. The design of efficient thin films requires a comprehensive knowledge of the pharmacological and pharmaceutical properties of drugs and polymers along with an appropriate selection of manufacturing processes. Therefore, the aim of this review is to provide an overview of the critical factors affecting the formulation of thin films, including the physico-chemical properties of polymers and drugs, anatomical and physiological constraints, as well as the characterization methods and quality specifications to circumvent the difficulties associated with formulation design. It also highlights the recent trends and perspectives to develop thin film products by various companies. | Sandeep Karki Hyeongmin Kim Seon-Jeong Na Dohyun Shin Kanghee Joa Jaehwi Lee | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，5： | 6 |
| 4 | 激光治疗甲真菌病的作用机制研究进展显示文摘甲真菌病是皮肤科常见的甲病变,指真菌引起的甲板和(或)甲下组织的感染。由于抗真菌药种类较少及其毒副作用,肝肾功能受损的甲真菌病患者,缺乏安全、有效的药物。近年来,以激光作为主要或辅助手段治疗甲真菌病备受国内外学者的关注,现就激光治疗甲真菌病作用机制的研究进展进行综述。 | 卢祥婷 Arun Karki 黄欣 赵敬军 | 2017 | 中国真菌学杂志2017，12，3： | 5 |
| 5 | 胸导管的磁共振水成像研究显示文摘胸导管是体内最粗大的淋巴管,形态和位置常有变异,可分为多种类型。胸导管结构细长、位置隐蔽,对其成像存在困难。随着磁共振水成像的广泛应用,其在无创性检测胸导管方面显示出良好的前景,现就国内外有关胸导管磁共振水成像的临床应用及其研究进展予以综述。 | 陈朔 许乙凯 Bivek karki 陈杰 | 2012 | 国际医学放射学杂志2012，35，6： | 5 |
| 6 | 桥本甲状腺炎合并甲状腺癌38例临床分析显示文摘目的:探讨桥本甲状腺炎(Hashimoto thyroiditis,HT)合并甲状腺癌患者的临床特征。方法:分析38例HT合并甲状腺癌患者的临床资料,重点分析实验室及辅助检查结果、治疗情况、近期疗效等。结果:38例中男5例,女33例,男:女为1:6.6,颈部有肿块32例,声嘶4例,颈部压痛1例,无症状1例。22例行甲状腺功能和相关抗体检查,血总T3升高1例,降低1例;T4升高1例,降低3例;TSH升高10例,降低3例;甲状腺球蛋白抗体升高9例,甲状腺过氧化物酶抗体升高18例(其他患者未见异常)。影像学检查均未提示HT。15例行甲状腺和淋巴结的细针穿刺检查,提示为甲状腺癌7例,提示为HT合并甲状腺癌3例,提示颈部淋巴结见甲状腺癌转移2例,其余未能作出诊断。38例患者均行手术治疗,所有患者术后服用左甲状腺素,100μg/d。随访时间9~65个月,3例肿瘤复发,2例失访,其余患者情况稳定。结论:女性HT较男性更容易合并甲状腺癌,其临床表现缺乏特异性,甲状腺相关抗体检查、影像学检查结合细针穿刺是诊断HT合并甲状腺癌的有效手段,手术治疗疗效较好。 | KARKI ANIL B 欧阳电 李秋梨 刘天润 陈福进 陈艳峰 | 2007 | 新医学2007，38，11： | 3 |
| 7 | Phytochemical profile and biological activity of Juglans regia显示文摘Juglans regia Linn.(Juglandaceae), popularly known as English or Persian walnut, is a valuable medicinal plant with a potency to cure various diseases in traditional medicine. Since ancient time, different local ethnic groups have used various part of J.regia for a wide array of ailments including helminthiasis, diarrhea, sinusitis, stomach ache, arthritis, asthma, eczema, scrofula, skin disorders, diabetes mellitus, anorexia, thyroid dysfunction, cancer and infectious diseases. Biological activities of J.regia have been reported in several peer review journals and scientific attention is increasing. The present review attempts to provide comprehensive information on plant description, ethnobotanical use, toxicity, phytochemical profile, pharmacology, clinical studies and current research prospective of the J.regia. Currently, there is an immense interest on isolation/identification of active constituents from walnut and screening those active compounds for pharmacological activities. In addition, researchers are performing clinical trials as well as screening various solvent extracts or fractions of J.regia in several animal diseases models to identify promising therapeutic benefits. In the present work, we review the latest information based on published scientific investigations of J.regia. | Nisha Panth Keshav Raj Paudel Rajendra Karki | 2016 | Journal of Integrative Medicine2016，14，5： | 2 |
| 8 | 全差分放大器(一)显示文摘差分信号固有的外部噪声抑制特性使其多年来普遍应用于音频、数据传输和电话系统。如今,差分信号技术正在高速数据采集领域日益普及,这种应用场合中ADC带有差分输入,需要差分放大器来驱动。差分信号还可减少偶次谐波和增加动态范围。重点讨论集成全差分放大器的结构、电压定义及应用(包括与差分ADC输入的接口电路,抗混叠滤波器以及驱动传输线)。 | James Karki AAP Precision Analog | 2007 | 国外电子元器件2007，，12： | 2 |
| 9 | 一种掺再生剂和RAP的沥青混合料配合比设计新方法显示文摘由于回收沥青路面材料(RAP)和回收沥青油毡瓦(RAS)等具有环保、节能、省税等优点,现已广泛应用于沥青路面工程中,并且发展规模日益壮大。然而这些回收材料已经高度老化,应用在实际工程中将会对沥青混合料的耐久性带来潜在的危害。再生剂能改善高含量RAP混合料的工程性质,因此受到道路界的广泛关注。该文提出了一种掺再生剂和RAP的沥青混合料配合比设计新方法,并且已经铺筑了试验路段。研究人员首先通过一系列的室内试验逐步选定沥青用量和再生剂掺量范围,然后采用沥青混合料配合比平衡设计法确定最佳沥青用量和最佳再生剂用量。试验结果表明:再生剂的掺量是平衡再生沥青混合料抗车辙性能和抗开裂性能的关键因素。 | 冯新军 张喆 赵梦龙 Soohyok Im Pravat Karki Fujie Zhou | 2018 | 中外公路2018，38，2： | 2 |
| 10 | 颅内动脉瘤的血管内栓塞治疗:历史回顾显示文摘1.Introduction Remarkable evolution of endovascular neurosurgery over the past few decades has brought an excellent transformation in the treatment of cerebrovascular diseases.Though aneurysm treatment was begun from the 19th century by means of Hunterian ligation,the concept of endovascular occlusion was first initiated by Luessenhop and Velasquez in 1964 using balloon catheter[1].Endovascular approach has turned out to be a miracle when Guido Guglielmi pioneered in detachable coils in 1990. | Tamrakar Karuna 段传志 Bivek Karki 龙霄翱 张炘 罗斌 李西锋 何旭英 权涛 | 2012 | 中华神经医学杂志2012，11，6： | 2 |
| 11 | Optimization of antibody binding to FcγRIIa enhances macrophage phagocytosis of tumor cells显示文摘 | RICHARDS JO KARKI S LAZAR GA | 2008 | Mol Cancer Ther2008，7，8： | 1 |
| 12 | Elastic Properties of Orthorhombic MgSiO3 Perovskite at Lower Mantle Pressures 显示文摘 | Karki B B Stixrude L Clark S J | 1997 | Am Mineral1997，82，： | 1 |
| 13 | Cost-effective wind energyutilization for reliable power supply显示文摘 | Karki R Billinton R | 2004 | IEEE Trans onEnergy Convers2004，19，2： | 1 |
| 14 | Reliability evaluation of generating systems containing wind power and energy storage显示文摘 | Hu P Karki R Billinton R | 2009 | IET Generation Transmission & Distribu- tion2009，3，8： | 1 |
| 15 | Structure and Elasticity of MgO at High Pressure 显示文摘 | Karki B B Stixrude L Clark S J | 1997 | Am Mineral1997，82，： | 1 |
| 16 | Study of accuracy of commonly used fetal parameters for estimation of gestational age显示文摘 | Karki D B Sharmqa U K Rauniyar R K | 2006 | JNMA J Nepal Med Assoc2006，45，162： | 1 |
| 17 | Association between pregnancy-in- duced hypertensive fundus changes and fetal outcomes显示文摘 | Karki P Malla P Das H | 2010 | Nepal J Ophthalmol2010，2，1： | 1 |
| 18 | Reliability/cost implication of PV and wind energy utilization in small isolated power systems 显示文摘 | KARKI R BILLINTON R | 2001 | IEEE Transactions on Energy Conversion2001，16，4： | 1 |
| 19 | Postulation of resistance genes to yellow rust in wild emmer wheat derivatives and advanced wheat lines from Nepal显示文摘 | S. Sharma J. M. Louwers C. B. Karki C. H. A. Snijders | 1995 | Euphytica1995，，3： | 1 |
| 20 | Cardiac and elec- trocardiographical manifestations of acute organo- phosphate poisoning显示文摘 | Karki P Ansari JA Bhandary S | 2004 | Singapore Med J2004，45，8： | 1 |
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