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| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | Factors that impact health-related quality of life in adults with celiac disease:A multicenter study显示文摘AIM: To evaluate the factors involved in the impairment of health-related quality of life (HRQOL) in patients with celiac disease.METHODS: A multicenter, cross-sectional prospective study was performed in patients with celiac disease who completed two HRQOL questionnaires: the gastrointestinal quality of life index (GIQLI) and the EuroQol-5D (EQ).RESULTS: Three hundred and forty patients (163 controlled with a gluten-free diet, and 177 newly diagnosed with a normal diet) were included. The GIQLI score was significantly better in patients on a gluten-free diet (GFD) than in non-treated patients on their usual diet, both in terms of the overall score (3.3 vs 2.7, respectively; P < 0.001), as well as on the individual questionnaire dimensions. Both the preference value of the EQ as the visual analogue scale were significantly better in treated than in non-treated patients (0.93 vs 0.72 P < 0.001 and 80 vs 70 P < 0.001, respectively). Variables significantly associated with a worse HRQOL score were female gender, failure to adhere to a GFD, and symptomatic status.CONCLUSION: In untreated celiac disease, the most important factors that influence patient perception of health are the presence of symptoms and a normal diet. HRQOL improves to levels similar to those described in the general population in celiac disease patients well controlled with a GFD. | F Casellas L Rodrigo J López Vivancos S Riestra C Pantiga JS Baudet F Junquera V Puig Diví C Abadia M Papo J Gelabert JR Malagelada | 2008 | World Journal of Gastroenterology2008，14，1： | 2 |
| 3 | Numerical atomic orbitals for linear-waling calculations 显示文摘 | Junquera J Paz O Sanchez-Portal D | 2001 | Phys Rev B2001，64，23： | 1 |
| 4 | A multicenter,randomized,clinical trial of hormonal therapy in the prevention of rebleeding from gastrointestinal angiodysplasia显示文摘 | Junquera F Feu F Papo M | | 0，，5： | 1 |
| 5 | Value of bibliometric analysis for research policy :a case study of spanish research into in- novation and technology management显示文摘 | B JUNQUERA M MITRE | 2007 | Scientometrics2007，71，3： | 1 |
| 6 | Non-sebaceous lymphadenoma of the parotid gland:immunohistochemical study and DNA ploidy analysis显示文摘 | Gallego L Junquera L Fresno M F | 2009 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2009，107，4： | 1 |
| 7 | Mandibular condyle fractures: Determinants of treatment and outcome 显示文摘 | Villarreal PM Monje F Junquera LM | 2004 | J Oral Maxillofac Surg2004，62，2： | 1 |
| 8 | Expression of metalloproteases and their inhibitors by tumor and stromal cells in ductal carcinoma in situ of the breast and their relationship with microinvasive events显示文摘 | GONZLEZ L O GONZLEZ REYES S JUNQUERA S | 2010 | J Cancer Res Clin Oncol2010，136，9： | 1 |
| 9 | Long-lasting prevention against blowfly strike using the insect growth regulator dieyclanil显示文摘 | BOWEN F L FISARA P JUNQUERA P | 1999 | Aust Vet J1999，77，7： | 1 |
| 10 | A multicenter,randomized,clinical trial of hormonal therapy in the prevention of rebleeding from gastrointestinal angiodysplasia显示文摘 | Junquera F Feu F Papo M | | Gastroenterology0，，： | 1 |
| 11 | A Multicenter, Randomized, Clinical Trial of Hormonal Therapy in the Prevention of Rebleeding From Gastrointestinal Angiodysplasia显示文摘 | Félix Junquera Faust Feu Michel Papo Sebastián Videla José Ramón Armengol Josep Mar??a Bordas Esteban Saperas Josep M. Piqué Juan-Ramón Malagelada | 2001 | Gastroenterology2001，，5： | 1 |
| 12 | Expression of androgen receptor and two androgen-induced proteins(apolipoprotein D and pepsinogen C) in ductal carcinoma in situ of the breast显示文摘 | Gonzalez L O Corte M D Junquera S | 2007 | Histopathology2007，50，7： | 1 |
| 13 | Behavior of tricyclic antidepressants in aqueous solution:Self-aggregation and association with β-cyclodextrin显示文摘 | JUNQUERA E ROMERO J C AICART E | 2001 | Langmuir2001，17，： | 1 |
| 14 | R-AIIyl Nickel( 11 ) complexes with chelating N-Heteroeyclic carbenes:synthesis, structural characterization and catalytic activity显示文摘 | JUNQUERA B L PETRA C M VALERGA P | 2012 | Organometallics2012，31，6： | 1 |
| 15 | Ferro- electricity and tetragonality in uhrathin PbTiO3 films显示文摘 | Lichtensteiger C Triscone J M Junquera J | 2005 | Physical Review Letters2005，94，04： | 1 |
| 16 | Citizens' attitude to reuse of municipal solid waste:a practical application显示文摘 | Junquera B Delbrio J A Muniz M | 2001 | Resources conservation and recycling2001，33，1： | 1 |
| 17 | Critical thickness for ferroelectricity in perovskite ultrathin films 显示文摘 | JUNQUERA J GHOSEZ P | 2003 | Nature2003，422，： | 1 |
| 18 | Mandibular condyle fractures:determinants of treatment and outcome 显示文摘 | Villarreal PM Monje F Junquera LM | 2004 | J Oral Maxillofac Surg2004，62，2： | 1 |
| 19 | Managers' Profile in Environmental Strategy:A Review of the Literature显示文摘 | Femández E Junquera B Ordiz M | | 0，，05： | 1 |
| 20 | Merkel cell carcinoma: our experience in this rare pathology 显示文摘 | Rosado P Junquera L Vivanco B | 2011 | Med Oral Patol Oral Cir Bucal2011，16，6： | 1 |
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