Factors that impact health-related quality of life in adults with celiac disease:A multicenter study

查看全文 作　　者：F [1]Casellas;L [2]Rodrigo;J López [3]Vivancos;S [2]Riestra;C [2]Pantiga;JS [4]Baudet;F [5]Junquera;V Puig [5]Diví;C [6]Abadia;M [6]Papo;J [7]Gelabert;JR [1]Malagelada

机构地区：[1]Digestive System Research Unit, Hospital Universitari Vall d' Hebron, Barcelona, Spain;[2]Digestive System Research Unit, Hospital Central de Asturias, Oviedo, Spain;[3]Digestive System Research Unit, Internal Medicine Department, Hospital General de Catalunya, Barcelona, Spain;[4]Digestive System Research Unit, Hospital Virgen de la Candelaria, Santa Cruz de Tenerife, Spain;[5]Digestive System Research Unit, Corporació Parc Taulí, Sabadell, Spain;[6]Digestive System Research Unit, Hospital Joan ⅩⅩⅢ, Tarragona, Spain;[7]Digestive System Research Unit, Hospital Verge del Toro, Menorca, Spain

出　　处：《World Journal of Gastroenterology》索引2008年第14卷第1期,共7页

摘　　要：AIM: To evaluate the factors involved in the impairment of health-related quality of life (HRQOL) in patients with celiac disease.METHODS: A multicenter, cross-sectional prospective study was performed in patients with celiac disease who completed two HRQOL questionnaires: the gastrointestinal quality of life index (GIQLI) and the EuroQol-5D (EQ).RESULTS: Three hundred and forty patients (163 controlled with a gluten-free diet, and 177 newly diagnosed with a normal diet) were included. The GIQLI score was significantly better in patients on a gluten-free diet (GFD) than in non-treated patients on their usual diet, both in terms of the overall score (3.3 vs 2.7, respectively; P < 0.001), as well as on the individual questionnaire dimensions. Both the preference value of the EQ as the visual analogue scale were significantly better in treated than in non-treated patients (0.93 vs 0.72 P < 0.001 and 80 vs 70 P < 0.001, respectively). Variables significantly associated with a worse HRQOL score were female gender, failure to adhere to a GFD, and symptomatic status.CONCLUSION: In untreated celiac disease, the most important factors that influence patient perception of health are the presence of symptoms and a normal diet. HRQOL improves to levels similar to those described in the general population in celiac disease patients well controlled with a GFD. 关键词：乳糜泻成年人慢性营养不良健康情况生存质量

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Factors that impact health-related quality of life in adults with celiac disease:A multicenter study

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