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| 1 | Pluripotent stem cells induced from mouse neural stem cells and small intestinal epithelial cells by small molecule compounds显示文摘最近,我们报导了一条化学途径从老鼠成纤维细胞产生 pluripotent 干细胞。然而,是否化学上导致了 pluripotent 干细胞(CiPSCs ) ,能从要示威的另外的房间类型遗体被导出。用系跟踪,这里,我们首先从成纤维细胞验证 CiPSCs 的产生。下次,我们证明从外胚层的神经干细胞(NSC ) 和从内胚叶的小肠的上皮的房间(IEC ) 能是化学上 reprogrammed 进 pluripotent 干细胞。CiPSCs 源于 NSC 和 IEC 类似于老鼠处于增长率,全球基因表示侧面, epigenetic 地位,自强和区别能力的胚胎的干细胞,和 germline 传播才能。有趣地, pluripotency 基因 Sall4 从不同房间类型,和一样的核心在化学 reprogramming 过程在起始的阶段被表示小分子为 reprogramming 被要求,在从这些多样的房间类型位于化学 reprogramming 下面的分子的机制建议保存。我们的分析也证明这些小分子的使用应该被调整从不同房间类型满足 reprogramming 的要求。一起,这些调查结果证明那条完整的化学 reprogramming 途径能在不同织物起源的房间被使用并且建议化学 reprogramming 是有要延长到更起始的类型的潜力的有希望的策略。 | Junqing Ye Jian Ge Xu Zhang Lin Cheng Zhengyuan Zhang Shan He Yuping Wang Hua Lin Weifeng Yang Junfang Liu Yang Zhao Hongkui Deng | 2016 | Cell Research2016，26，1： | 19 |
| 2 | Variety distribution pattern and climatic potential productivity of spring maize in Northeast China under climate change显示文摘This study was based on the daily meteorological data of 101 meteorological stations from 1971 to 2000 and the 0.25°×0.25° grid data from 1951 to 2100 simulated by RegCM3 under the future A1B climatic scenario published by National Climate Center,in combination with the demand of climatic condition for maize growth in Northeast China.The trajectory of agricultural climatic resources and the effects of climate change on variety distribution and climatic potential productivity of spring maize in Northeast China under future climate change were analyzed.The main agro-climatic resource factors include:the initial date daily average temperature stably passing 10℃(≥10℃),the first frost date,the days of growing period,the ≥10℃ accumulated temperature,and the total radiation and precipitation in the growing period.The results showed that:(1) in the coming 100 years,the first date of ≥10℃ would be significantly advanced,and the first frost date would be delayed.The days of growing period would be extended,the ≥10℃ accumulated temperature and the total radiation would be significantly increased.However,no significant change was found in precipitation.(2) Due to the climate change,the early-maturing varieties will be gradually replaced by late-maturing varieties in Northeast China,and the planting boundaries of several maize varieties would be extended northward and eastward.(3) There would be a significant change in the climatic potential productivity of maize in Northeast China with the high-value gradually moving towards northeast.(4) It was an effective way to increase the climatic potential productivity of maize by appropriate adjustment of sowing date. | YUAN Bin GUO JlanPing YE MingZhu ZHAO JunFang | 2012 | Chinese Science Bulletin2012，57，26： | 16 |
| 3 | I-IBV life cycle is restricted in mouse hepatocytes .~xpressing human NTCP显示文摘 | Hanjie Li Qiuyu Zhuang Yuze Wang Tianyi'ng Zhang Jinghua Zhao Yali Zhang Junfang Zhang Yi Lin Quan Yuan Ningshao Xia Jiahuai Han | 2014 | Cellular & Molecular Immunology2014，11，2： | 14 |
| 4 | Fields experiments in North China show no decrease in winter wheat yields with night temperature increased by 2.0-2.5°C显示文摘The trends of daily maximum and minimum temperature in global warming indicated that the daily minimum temperature (Tmin) has risen more than twice as fast as the daily maximum temperature (Tmax) during the 20th century. Most researchers have focused on how the crops respond to daily mean temperature, whereas few controlled experiments were carried out to investigate how the crops respond to the Tmin rise. In particular, no experiment research has reported on how crops respond to the higher night temperature, which was the main trend in the climate warming. Taking winter wheat as the test crop, we investigated how the winter wheat growth and yields responded to the higher night temperature. In the field experiments, infrared heaters were used to increase higher night temperature (HNT) by about 2.5°C in contrast to the normal night temperature (CK) in two whole growth durations of winter wheat in 2008-2009 and 2009-2010 in North China. The results indicated that, compared to the CK treatment, winter wheat yield did not decline in HNT treatment, which increased temperatures by 2.0 2.5°C in both Warmer year (WY) and Colder year (CY). Furthermore, winter wheat yield in CY increased significantly in HNT treatment. HNT treatment in CY could significantly promote tillering and increase the effective panicles, which increased grain yield significantly (by more than 30% compared with CK). HNT treatment in CY contributed to an increase in the effective panicles and Kernels significantly, although making a significant reduction in 1000-grain weight, but did not lead to the yield decline. Under the HNT treatment, the whole growth duration of the winter wheat was shortened and the phenological dates were earlier except for the beginning of overwintering; the beginnings of the overwintering phase were postponed substantially and the ends of the overwintering phase were ahead of date compared to CK, which shortened the duration of overwintering considerably. We draw on our own studies to show examples of higher night temperature impact on winter wheat in a relatively cold year and relatively warm year in North China. Our results refer to winter wheat in North China, not all main winter wheat producing regions, in Huang-Huai and Southwest of China. Some uncertainties of our predictions derive from fast progress in crop breeding, the variability of climate, and the role of adaptive actions in the future. As expected, the adaptation measures should be considered to cope with the impacts of global warming on crops, and further research and assessments should be conducted. | FANG ShiBo TAN KaiYan REN SanXue ZHANG XinShi ZHAO JunFang | 2012 | Science China Earth Sciences2012，55，6： | 13 |
| 5 | Feasibility and value of quantitative dynamic contrast enhancement MR imaging in the evaluation of sinonasal tumors显示文摘 | Xian Junfang Du Huarui Wang Xinyan Yan Fei Zhang Zhengyu Hao Hui Zhao Bo Tong Yajian Zhang Jue Han Demin | 2014 | Chinese Medical Journal2014，，12： | 13 |
| 6 | Two-photon-excited near-infrared emissive carbon dotsas multifunctional agents for fluorescence imaging andphotothermal therapy显示文摘C dots (CDs) have shown great potential in bioimaging and phototherapy.However, it is challenging to manipulate their fluorescent properties andtherapeutic efficacy to satisfy the requirements for clinic applications. In thisstudy, we prepared S, Se-codoped CDs via a hydrothermal method anddemonstrated that the doping resulted in excitation wavelength-independentnear-infrared (NIR) emissions of the CDs, with peaks at 731 and 820 nm.Significantly, the CDs exhibited a photothermal conversion efficiency of -58.2%,which is the highest reported value for C nanostructures and is comparable tothat of Au nanostructures. Moreover, the CDs had a large two-photon absorptioncross section (-30,045 GM), which allowed NIR emissions and the photothermalconversion of the CDs through the two-photon excitation (TPE) mechanism. Invitro and in vivo tests suggested that CDs can function as new multi functionalphototheranostic agents for the TPE fluorescence imaging and photothermaltheraov of cancer cells. | Minhuan Lan Shaojing Zhao Zhenyu Zhang Li Yan Liang Guo Guangle Niu Jinfeng Zhang Junfang Zhao Hongyan Zhang Pengfei Wang Guangyu Zhu Chun-Sing Lee Wenjun Zhang | 2017 | Nano Research2017，10，9： | 9 |
| 7 | Simulating Net Carbon Budget of Forest Ecosystems and Its Response to Climate Change in Northeastern China Using Improved FORCCHN显示文摘As dominant biomes,forests play an important and indispensable role in adjusting the global carbon balance under climate change.Therefore,there are scientific and political implications in investigating the carbon budget of forest ecosystems and its response to climate change.Here we synthesized the most recent research progresses on the carbon cycle in terrestrial ecosystems,and applied an individual-based forest ecosystem carbon budget model for China(FORCCHN) to simulate the dynamics of the carbon fluxes of forest ecosystems in the northeastern China.The FORCCHN model was further improved and applied through adding variables and modules of precipitation(rainfall and snowfall) interception by tree crown,understory plants and litter.The results showed that the optimized FORCCHN model had a good performance in simulating the carbon budget of forest ecosystems in the northeastern China.From 1981 to 2002,the forests played a positive role in absorbing carbon dioxide.However,the capability of forest carbon sequestration had been gradually declining during the the same period.As for the average spatial distri-bution of net carbon budget,a majority of the regions were carbon sinks.Several scattered areas in the Heilongjiang Province and the Liaoning Province were identified as carbon sources.The net carbon budget was apparently more sensitive to an increase of air temperature than change of precipitation. | ZHAO Junfang YAN Xiaodong JIA Gensuo | 2012 | Chinese Geographical Science2012，22，1： | 6 |
| 8 | Audiological evaluation in Chinese patients with mitochondrial encephalomyopathies显示文摘 | Liu Yuhe Xue Junfang Zhao Danhua Chen Li Yuan Yun Wang Zhaoxia | 2014 | Chinese Medical Journal2014，，12： | 6 |
| 9 | Impacts of future climate change on agroclimatic resources in Northeast China显示文摘在这研究,空间分发和在东北中国的农业热和降水资源的变化趋势被分析在这个区域在 agroclimatic 资源上探索未来气候变化的影响。这研究基于输出从为从 2005 ~ 2099 的东北中国的地区性的气候模型系统的气象学的数据,在低、高的放射的强迫情形 RCP4.5 (低排放情形) 和 RCP8.5 (高排放情形) 下面是在 IPCC AR5 求婚了。在基线情形下面的模型产量,和 RCP4.5 和 RCP8.5 情形从 1961 ~ 2010 在东北中国从 91 个气象学的车站与观察数据被吸收执行分析。结果显示那:(1 ) 到北方的来自南方的温度减少的空间分发,和温度被投射在所有区域增加,特别在一种高排放情形下面。在基线情形下面的平均年度温度是 7.70 整灭牥瑡牵 ? 癥湥獴椠 ? 桃湩 ? 畤楲杮ㄠ吗?? | CHU Zheng GUO Jianping ZHAO Junfang | 2017 | Journal of Geographical Sciences2017，27，9： | 3 |
| 10 | Hepatitis C and Alcohol Exacerbate Liver Injury by Suppression of FOXO3显示文摘 | Batbayar Tumurbaatar Irina Tikhanovich Zhuan Li Jinyu Ren Robert Ralston Sudhakiranmayi Kuravi Roosevelt Campbell Gaurav Chaturvedi Ting-Ting Huang Jie Zhao Junfang Hao Maura O’Neil Steven A. Weinman | 2013 | The American Journal of Pathology2013，，6： | 2 |
| 11 | Temporal-spatial distributions of road silt loadings and fugitive road dust emissions in Beijing from 2019 to 2020显示文摘Road silt loading(sL)is an important parameter in the fugitive road dust(FRD)emissions.In this study,the improved Testing Re-entrained Aerosol Kinetic Emissions from Roads(TRAKER)combined with the AP-42 method was firstly developed to quickly measure and estimate the sLs of paved roads in Beijing,China.The annual average sLs in Beijing was 0.59±0.31 g/m^(2)in 2020,and decreased by 22.4%compared with that in 2019.The seasonal variations of sLs followed the order of spring>winter>summer>autumn in the two years.The seasonal mean road sLs on the same type road in the four seasons presented a decline trend from^(2)019 to 2020,especially on the Expressway,decreasing 47.4%-72.7%.The road sLs on the different type roads in the same season followed the order of Major arterial∼Minor arterial∼Branch road>Express road,and Township road∼Country highway>Provincial highway∼National highway.The emission intensities of PM10 and PM_(2.5)from FRD in Beijing in 2020 were lower than those in 2019.The PM10 and PM_(2.5)emission intensities at the four planning areas in the two years all presented the order of the capital functional core area>the urban functional expansion area>the urban development new area>the ecological conservation and development area.The annual emissions of PM10 and PM_(2.5)from FRD in Beijing in 2020 were 74,886 ton and 18,118 ton,respectively,decreasing by∼33.3%compared with those in 2019. | Haibin Wang Lihui Han Tingting Li Song Qu Yuncheng Zhao Shoubin Fan Tong Chen Haoran Cui Junfang Liu | 2023 | Journal of Environmental Sciences2023，，10： | 1 |
| 12 | Inhibitor tolerance and bioethanol fermentability of levoglucosan-utilizing Escherichia coli were enhanced by overexpression of stress-responsive gene ycfR:The proteomics-guided metabolic engineering显示文摘Pretreatment of lignocellulosic biomass is crucial for the release of biofermentable sugars for biofuels production,which could greatly alleviate the burgeoning environment and energy crisis caused by the massive usage of traditional fossil fuels.Pyrolysis is a cost-saving pretreatment process that can readily decompose biomass into levoglucosan,a promising anhydrosugar;however,many undesired toxic compounds inhibitory to downstream microbial fermentation are also generated during the pyrolysis,immensely impeding the bioconversion of levoglucosan-containing pyrolysate.Here,we took the first insight into the proteomic responses of a levoglucosan-utilizing and ethanol-producing Escherichia coli to three representative biomass-derived inhibitors,identifying large amounts of differentially expressed proteins(DEPs)that could guide the downstream metabolic engineering for the development of inhibitor-resistant strains.Fifteen up-and eight down-regulated DEPs were further identified as the biomarker stress-responsive proteins candidate for cellular tolerance to multiple inhibitors.Among these biomarker proteins,YcfR exhibiting the highest expression fold-change level was chosen as the target of overexpression to validate proteomics results and develop robust strains with enhanced inhibitor tolerance and fermentation performance.Finally,based on four plasmid-borne genes encoding the levoglucosan kinase,pyruvate decarboxylase,alcohol dehydrogenase,and protein YcfR,a new recombinant strain E.coli LGE-ycfR was successfully created,showing much higher acetic acid-,furfural-,and phenol-tolerance levels compared to the control without overexpression of ycfR.The specific growth rate,final cell density,ethanol concentration,ethanol productivity,and levoglucosan consumption rate of the recombinant were also remarkably improved.From the proteomics-guided metabolic engineering and phenotypic observations,we for the first time corroborated that YcfR is a stress-induced protein responsive to multiple biomass-derived inhibitors,and also developed an inhibitors-resistant strain that could produce bioethanol from levoglucosan in the presence of inhibitors of relatively high concentration.The newly developed E.coli LGE-ycfR strain that could eliminate the commonly-used costly detoxicification processes,is of great potential for the in situ cost-effective bioethanol production from the biomass-derived pyrolytic substrates. | Dongdong Chang Zia Ul Islam Junfang Zheng Jie Zhao Xiaoyong Cui Zhisheng Yu | 2021 | Synthetic and Systems Biotechnology2021，6，4： | 1 |
| 13 | Multiple symmetric positive solutions to a new kind of four point boundary value problem显示文摘 | Junfang Zhao Chunmei Miao Weigao Ge | 2009 | Nonlinear Analysis2009，71，12： | 1 |
| 14 | Study on the adsorption of Neutral Red from aqueous solution onto halloysite nanotubes显示文摘 | Peng Luo Yafei Zhao Bing Zhang Jindun Liu Yong Yang Junfang Liu | 2009 | Water Research2009，，： | 1 |
| 15 | Integrated Metabolite and Gene Expression Profiles Identify Lipid Biomarkers Associated With Progression of Hepatocellular Carcinoma and Patient Outcomes显示文摘 | Anuradha Budhu Stephanie Roessler Xuelian Zhao Zhipeng Yu Marshonna Forgues Junfang Ji Edward Karoly Lun–Xiu Qin Qing–Hai Ye Hu–Liang Jia Jia Fan Hui–Chuan Sun Zhao–You Tang Xin Wei Wang | 2013 | Gastroenterology2013，，5： | 1 |
| 16 | Performance of aerobic rice varieties under irrigated conditions in North China显示文摘 | B.A.M. Bouman Xiaoguang Yang Huaqi Wang Zhimin Wang Junfang Zhao Bin Chen | 2005 | Field Crops Research2005，，1： | 1 |
| 17 | Imaging and histopathological findings of lacrimal sac lymphoma显示文摘 | Guo Pengde Yan Fei Tian Cheng Zhao Pengfei Wang Zhenchang Xian Junfang | 2014 | Chinese Medical Journal2014，，1： | 1 |
| 18 | Quantum Statistical Entropy of Black Hole显示文摘 | Zhao Ren Zhang Junfang Zhang Lichun | 2002 | General Relativity and Gravitation2002，，12： | 1 |
| 19 | Microwave induced in-situ formation of SiC nano wires on SiCNO ceramic aerogels with excellent electromagnetic wave absorption performance显示文摘Electromagnetic absorption(EMA)materials with light weight and harsh environmental robustness are highly desired and crucially important in the stealth of high-speed vehicles.However,meeting these two requirements is always a great challenge,which excluded the most attractive lightweight candidates,such as carbon-based materials.In this study,SiC_(nw)-reinfbrced SiCNO(SiC_(nw)/SiCNO)composite aerogels were fabricated through the in-situ growth of SiC_(nw) in polymer-derived SiCNO ceramic aerogels by using catalyst-assisted microwave heating at ultra-low temperature and in short time.The phase composition,microstructure,and EMA property of the SiC_(nw)/SiCNO composite aerogels were systematically investigated.The results indicated that the morphology and phase composition of SiC_(nw)/SiCNO composite aerogels can be regulated easily by varying the microwave treatment temperature.The composite aerogels show excellent EMA property with minimum reflection loss of -23.9 dB@13.8 GHz,-26.5 dB@10.9 GHz,and -20.4 dB@14.5 GHz and the corresponding effective bandwidth of 5.2 GHz,3.2 GHz,and 4.8 GHz at 2.0 mm thickness for microwave treatment at 600℃,800℃,and 1000℃,respectively,which is much better than that of SiCN ceramic aerogels.The superior EMA performance is mainly attributed to the improved impedance matching,multireflection,multi-interfacial polarization,and micro current caused by migration of hopping electrons. | Keke YUAN Daoyang HAN Junfang LIANG Wanyu ZHAO Mingliang LI Biao ZHAO Wen LIU Hongxia LU Hailong WANG Hongliang XU Gang SHAO Rui ZHANG | 2021 | Journal of Advanced Ceramics2021，10，5： | 1 |
| 20 | Protective effects of Achyranthes bidentata polypeptides on retinal ganglion cells post-optic nerve crush in rats显示文摘Achyranthes bidentata polypeptides(ABPP) have been reported to inhibit apoptosis of retinal ganglion cells(RGCs).The present study investigated the protective effects of ABPP on RGCs in a rat model of optic nerve injury.With prolonged injury time,RGC densities were gradually decreased.ABPP(5 μg) significantly increased RGC densities and upregulated growth associated protein 43 expression in rats with optic nerve injury.Results demonstrate that ABPP can protect RGCs and promote axonal growth after optic nerve crush. | Nan Hu Qi Zhao Fangling Zhang Junfang Zhang Xiaosong Gu | 2011 | Neural Regeneration Research2011，6，15： | 0 |
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