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| 1 | A distributed measurement method for in-situ soil moisture content by using carbon-fiber heated cable显示文摘Moisture content is a fundamental physical index that quantifies soil property and is closely associated with the hydrological,ecological and engineering behaviors of soil.To measure in-situ soil moisture contents,a distributed measurement system for in-situ soil moisture content(SM-DTS) is introduced.The system is based on carbon-fiber heated cable(CKHC) technology that has been developed to enhance the measuring accuracy of in-situ soil moisture content.Using CFHC technique,a temperature characteristic value(T_t) can be defined from temperature-time curves.A relationship among T_t,soil thermal impedance coefficient and soil moisture content is then established in laboratory.The feasibility of the SM-DTS technology to provide distributed measurements of in-situ soil moisture content is verified through field tests.The research reported herein indicates that the proposed SM-DTS is capable of measuring in-situ soil moisture content over long distances and large areas. | Dingfeng Cao Bin Shi Honghu Zhu Guangqing Wei Shen-En Chen Junfan Yan | 2015 | Journal of Rock Mechanics and Geotechnical Engineering2015，7，6： | 10 |
| 2 | Microglia accumulation and activation after subarachnoid hemorrhage显示文摘Subarachnoid hemorrhage(SAH) is a severe cerebrovascular disease accounting for a significant portion of young patients with stroke with high morbidity and mortality(van Gijn et al., 2007). Secondary brain injury resulting from neuroinflammation is considered to be a key pathological process(Zheng and Wong, 2017). Microglia, the resident immune cells of the brain, are implicated in numerous neurological diseases, such as Alzheimer's disease。 | Junfan Chen George Kwok Chu Wong | 2021 | Neural Regeneration Research2021，16，8： | 4 |
| 3 | Microglia activation,classification and microglia-mediated neuroinflammatory modulators in subarachnoid hemorrhage显示文摘Subarachnoid hemorrhage is a devastating disease with significant mortality and morbidity,despite advances in treating cerebral aneurysms.There has been recent progress in the intensive care management and monitoring of patients with subarachnoid hemorrhage,but the results remain unsatisfactory.Microglia,the resident immune cells of the brain,are increasingly recognized as playing a significant role in neurological diseases,including subarachnoid hemorrhage.In early brain injury following subarachnoid hemorrhage,microglial activation and neuroinflammation have been implicated in the development of disease complications and recovery.To understand the disease processes following subarachnoid hemorrhage,it is important to focus on the modulators of microglial activation and the pro-inflammatory/anti-inflammatory cytokines and chemokines.In this review,we summarize research on the modulators of microglia-mediated inflammation in subarachnoid hemorrhage,including transcriptome changes and the neuroinflammatory signaling pathways.We also describe the latest developments in single-cell transcriptomics for microglia and summarize advances that have been made in the transcriptome-based classification of microglia and the implications for microglial activation and neuroinflammation. | Junfan Chen Zhiyuan Vera Zheng Gang Lu Wai Yee Chan Yisen Zhang George Kwok Chu Wong | 2022 | Neural Regeneration Research2022，17，7： | 3 |
| 4 | Novel role of STAT3 in microglia-dependent neuroinflammation after experimental subarachnoid haemorrhage显示文摘Background and purpose Signal transducer and activator of transcription 3(STAT3)may contribute to the proinflammation in the central nervous system diseases by modulating the microglial responses.Thus,this study was intended to investigate the effect of STAT3 on microglia-dependent neuroinflammation and functional outcome after experimental subarachnoid haemorrhage(SAH).Methods The SAH model was established by endovascular perforation in the mouse.Real-time PCR(RtPCR)and western blot were used to examine the dynamic STAT3 signalling pathway responses after SAH.To clarify the role of the STAT3 signalling pathway in the microglia-dependent neuroinflammation after SAH,the microglia-specific STAT3 knockout(KO)mice were generated by the Cre-LoxP system.The neurological functions were assessed by Catwalk and Morris water maze tests.Neuronal loss after SAH was determined by immunohistochemistry staining.Microglial polarisation status after STAT3 KO was then examined by RtPCR and immunofluorescence.Results The STAT3 and Janus kinase-signal transducer 2 activated immediately with the upregulation and phosphorylation after SAH.Downstream factors and related mediators altered dynamically and accordingly.Microglial STAT3 deletion ameliorated the neurological impairment and alleviated the early neuronal loss after SAH.To investigate the underlying mechanism,we examined the microglial reaction after STAT3 KO.STAT3 deletion reversed the increase of microglia after SAH.Loss of STAT3 triggered the early morphological changes of microglia and primed microglia from M1 to M2 polarisation.Functionally,microglial STAT3 deletion suppressed the SAH-induced proinflammation and promoted the anti-inflammation in the early phase.Conclusions STAT3 is closely related to the microglial polarisation transition and modulation of microglia-dependent neuroinflammation.Microglial STAT3 deletion improved neurological function and neuronal survival probably through promoting M2 polarisation and anti-inflammatory responses after SAH.STAT3 may serve as a promising therapeutic target to alleviate early brain injury after SAH. | Zhiyuan Vera Zheng Junfan Chen Hao Lyu Sin Yu Erica Lam Gang Lu Wai Yee Chan George K C Wong | 2022 | Stroke & Vascular Neurology2022，7，1： | 3 |
| 5 | Entire or mero- morphic functions sharing one value显示文摘 | ZHANG XIAOYU CHEN JUNFAN LIN WEICHUAN | 2008 | Computers & Mathematics with Applications2008，56，： | 1 |
| 6 | Entire or meromorphic functions sharing one value 显示文摘 | ZHANG Xiaoyu CHEN Junfan LIN Weichuan | 2008 | Comput Math Ap- pl2008，56，： | 1 |
| 7 | Entire or meromorphic functions sharing one value 显示文摘 | ZHANG Xiaoyu CHEN Junfan LIN Weichuan | 2008 | Comput Math Appl2008，56，7： | 1 |
| 8 | Exploratory study of highly susceptible to SARS-CoV-2 populations显示文摘The coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is threatening public health.The human angiotensin-converting enzyme 2(ACE2)has a remarkably high affinity binding to SARS-CoV-2.This study explored whether certain populations,including obese and cancer patients,are susceptible to SARS-CoV-2.The expression pattern of ACE2 in normal and tumor tissues of cancer patients was compared by the search for network database and re-analysis of pubic data.The level of ACE2 expression in normal adipose tissue was higher than that in normal lung tissue,which indicated the adipose tissue might be vulnerable to SARS-CoV-2;the levels of ACE2 expressed by adipocytes and adipose progenitor cells were similar between non-obese individuals and obese individuals(BMI>29),but obese individuals have more adiposes so as to increase the number of ACE2-expressing cells;the expression of ACE2 in tumor tissues posed by five different types of cancers increased significantly compared with that in adjacent tissues.Therefore,we proposed the following hypothesis:the obese individuals and five types of cancer patients might have a higher risk of SARS-CoV-2 infection,which might become the target population of SARS-CoV-2 infection in the future. | Xiaodong Jia Chengliang Yin Shanshan Lu Yan Chen Qingyan Liu Junfan Bai Lei Zhi Yinying Lu | 2022 | Life Research2022，5，3： | 0 |
| 9 | Uniqueness of Meromorphic Solutions for a Class of Complex Linear Differential-Difference Equations显示文摘In this paper,we mainly study the uniqueness of transcendental meromorphic solutions for a class of complex linear differential-difference equations.Specially,suppose that f(z)is a finite order transcendental meromorphic solution of complex linear differential-difference equation:W_(1)(z)f'(z+1)+W_(2)(z)f(z)=W_(3)(z),where W_(1)(z),W_(2)(z),W_(3)(z) are nonzero meromorphic functions,with their orders of growth being less than one,such that W_(1)(z)+W_(2)(z)■0.If f(z) and a meromorphic function g(z) share 0,1,∞ CM,then either f(z)≡g(z) or f(z)+g(z)≡f(z)g(z) or f^(2)(z)(g(z)-1)^(2)+g^(2)(z)(f(z)-1)^(2)≡f(z)g(z)(f(z)g(z)-1) or there exists a polynomial φ(z)=az+b_(0) such that ■ where a(≠0),a_(0),b_(0) are constants with e^(a_(0))≠e^(b_(0)). | Hongjin LIN Junfan CHEN Shuqing LIN | 2022 | Journal of Mathematical Research with Applications2022，42，4： | 0 |
| 10 | Neuropeptide S mainly from Kolliker-Fuse nucleus promotes wakefulness through activation of cognate receptor-neurons in the paraventricular thalamus显示文摘Neuropeptide S(NPS)is a neuromodulator that concentratively expressed in the Kolliker Fuse nucleus(KF)and pericoerulear area(Peri-LC)in mice.NPS and its receptor(NPSR)system participates multiple biological effects.The paraventricular thalamus(PVT),a newly identified area that critical for wakefulness,highly expressed NPSR suggesting that NPS NPSR system may be involved in the regulation of sleep-waking states through PVT.The present study was undertaken to investigate effects of NPS on the sleep-waking states through PVT. | Shao Yufeng Cai Chenchen Chen Yunong Ren Yanli Lu Guijuan Xie Junfan Hou Yiping | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 11 | RSPSSL:A novel high-fidelity Raman spectral preprocessing scheme to enhance biomedical applications and chemical resolution visualization显示文摘Raman spectroscopy has tremendous potential for material analysis with its molecular fingerprinting capability in many branches of science and technology.It is also an emerging omics technique for metabolic profiling to shape precision medicine.However,precisely attributing vibration peaks coupled with specific environmental,instrumental,and specimen noise is problematic.Intelligent Raman spectral preprocessing to remove statistical bias noise and sample-related errors should provide a powerful tool for valuable information extraction.Here,we propose a novel Raman spectral preprocessing scheme based on self-supervised learning(RSPSSL)with high capacity and spectral fidelity.It can preprocess arbitrary Raman spectra without further training at a speed of~1900 spectra per second without human interference.The experimental data preprocessing trial demonstrated its excellent capacity and signal fidelity with an 88%reduction in root mean square error and a 60%reduction in infinite norm({L}_{{\infty}})compared to established techniques.With this advantage,it remarkably enhanced various biomedical applications with a 400%accuracy elevation(ΔAUC)in cancer diagnosis,an average 38%(few-shot)and 242%accuracy improvement in paraquat concentration prediction,and unsealed the chemical resolution of biomedical hyperspectral images,especially in the spectral fingerprint region.It precisely preprocessed various Raman spectra from different spectroscopy devices,laboratories,and diverse applications.This scheme will enable biomedical mechanism screening with the label-free volumetric molecular imaging tool on organism and disease metabolomics profiling with a scenario of high throughput,cross-device,various analyte complexity,and diverse applications. | Jiaqi Hu Gina Jinna Chen Chenlong Xue Pei Liang Yanqun Xiang Chuanlun Zhang Xiaokeng Chi Guoying Liu Yanfang Ye Dongyu Cui De Zhang Xiaojun yu Hong Dang Wen Zhang Junfan Chen Quan Tang Penglai Guo Ho-Pui Ho Yuchao Li Longqing Cong Perry Ping Shum | 2024 | Light(Science & Applications)2024，13，2： | 0 |
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