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| 1 | Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling:Influence of smoking显示文摘瞄准:为了调查一个模糊逻辑模型是否能预言肤色,表面的癌症(CRC ) 风险由在世袭 non-polyposis 肤色吸表面的癌症(HNPCC ) 病人产生了。方法:从 Creighton 大学世袭癌症研究所登记的 340 个 HNPCC 失配修理(MMR ) 变化搬运人为当模特儿被选择。年龄依赖者曲线被产生阐明开发 CRC 的概率上的在基因变化(hMLH1 或 hMSH2 ) 之间的联合效果,性,和吸烟地位。结果:在男 hMSH2 变化搬运人的吸烟显著地增加的 CRC 风险(P <
0.05 ) 。hMLH1 变化为男性相对 hMSH2 变化搬运人扩充了 CRC 风险(P <
0.05 ) 。男性们非为 hMLH1 比女性有 CRC 的显著地更高的风险吸烟者(P <
0.05 ) , hMLH1 吸烟者(P <
0.1 ) 并且 hMSH2 吸烟者(P <
0.1 ) 。以在在男性的 hMSH2 的一种剂量依赖者方式的吸烟支持的 CRC (P <
0.05 ) 。有 hMSH2 变化的女性和与 hMLH1 组一起的两性仅仅在广泛的吸烟历史以后表明了吸烟效果(P <
0.05 ) 。结论:由在 HNPCC 病人吸烟的 CRC 提升依赖于基因变化,性和年龄。这些数据证明模糊建模可以启用临床的风险分数的明确的表达,从而允许 CRC 预防策略的 individualization。 | Rhonda M Brand David D Jones Henry T Lynch Randall E Brand Patrice Watson Ramesh Ashwathnayaran Hemant K Roy | 2006 | World Journal of Gastroenterology2006，12，28： | 5 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | Plant disease resistance genes显示文摘 | Hammond-Kosack K E Jone J D | 1997 | Annu Rev Plant Physiol Plant Mol Biol1997，48，： | 2 |
| 4 | Interactions between crop residue and soil organic matter quality and the functional diversity of soil microbial communities显示文摘 | BENDING G D TURNER M K JONES J E | 2002 | Soil Boil Biochem2002，34，： | 1 |
| 5 | Low-copy plasmids can perform as weU as or better than high-copy plasmids for metabolic engineering of bacteria 显示文摘 | Jones K L Kim S W Keasling J D | 2000 | Metabolic Engineering2000，2，： | 1 |
| 6 | Persistent organic pollutants (POPs):state of the science显示文摘 | Jones K C Voogt P D | 1999 | Environ Pollut1999，100，123： | 1 |
| 7 | Remote detection of rhizomania in sugar beets 显示文摘 | Steddom K Heidel G Jones D | 2003 | Phytopathology2003，93，： | 1 |
| 8 | Determination of pesticides in soil samples by supercritical fluid chromatography-atmospheric pressure chemical ionisation mass spectrometric detection显示文摘 | Dost K Jones D C Auerbach R | 2000 | Analyst2000，125，10： | 1 |
| 9 | Effects of crude protein content,degradability and energy concentration of the diet on growth and carcass characteristics of market Iambs fed high concentrate diets 显示文摘 | Beauchemin K A McCeland L A Jones D | 1995 | Can J Anita Sci1995，75，： | 1 |
| 10 | Nicotinic acetycholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection 显示文摘 | BUCKINGHAM S D JONES A K BROWN L A | 2009 | Pharmacol Rev2009，61，1： | 1 |
| 11 | The vascular biology of nitric oxide and its role in atherosclerosis 显示文摘 | LLOYD JONES D M BLOCH K D | 1996 | Annu Rev Med1996，47，： | 1 |
| 12 | Perisylvian language networks of the human brain显示文摘 | Catani M Jones D K Ffytche D H | 2005 | Ann Neurol2005，57，1： | 1 |
| 13 | Occurrences and fates of hydroxylated polybrominated diphenyl ethers in marine sedi- ments in relation to trophodynamies显示文摘 | ZHANG K WAN Y JONES P D | 2012 | Environmental Science & Technology2012，46，4： | 1 |
| 14 | Reliance on decision aids: an examination of auditors' assessment of management fraud 显示文摘 | Eining M M Jones D R Loebbecke J K | 1997 | Auditing: A Journal of Practice and Theory1997，16，2： | 1 |
| 15 | Radiosensitization of MDA-MB-231 breast tumor cells by adenovirus-mediated overexpression of a fragment of the XRCC4 protein 显示文摘 | JONES K R GEWIRTZ D A YANNONE S M | 2005 | Mol Cancer Ther2005，4，10： | 1 |
| 16 | Efficacy and tolerability of antipical antipsychotics for schizophrenia: A Meta analysis including paliperidone extended release 显示文摘 | NICHOLL D JONES M TRAKAS K | 2008 | Schizophr Res2008，102，2： | 1 |
| 17 | Winter survival of transgenic al falfa overexpressing superoxide dismutase显示文摘 | Bowley S R Jones K S | 1999 | Plant Physiol1999，119，： | 1 |
| 18 | Disease progress, yield loss, and control of Xanthomonas fragariae on strawberry plants 显示文摘 | Roberts P D Jones J B Chandler C K | 1997 | Plant Disease1997，81，8： | 1 |
| 19 | Idiopathic and diabetic gastroparesis显示文摘 | O'Donovan D Feinle- Bisset C Jones K | 2003 | Curr Treat Options Gastroenterol2003，6，： | 1 |
| 20 | Global biomonitoring of perfluorinated organics 显示文摘 | Giesy J P Kannan K Jones P D | 2001 | Scientific World Journal2001，1，11： | 1 |
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