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| 1 | Broadband achromatic metalens in terahertz regime显示文摘Achromatic focusing is essential for broadband operation, which has recently been realised from visible to infrared wavelengths using a metasurface. Similarly, multi-terahertz functional devices can be encoded in a desired metasurface phase profile. However, metalenses suffer from larger chromatic aberrations because of the intrinsic dispersion of each unit element. Here, we propose an achromatic metalens with C-shaped unit elements working from 0.3 to 0.8 THz with a bandwidth of approximately 91% over the centre frequency. The designed metalens possesses a high working efficiency of more than 68% at the peak and a relatively high numerical aperture of 0.385. We further demonstrate the robustness of our Cshaped metalens, considering lateral shape deformations and deviations in the etching depth. Our metalens design opens an avenue for future applications of terahertz meta-devices in spectroscopy, time-offlight tomography and hyperspectral imaging systems. | Qingqing Cheng Meilin Ma Dong Yu Zhixiong Shen Jingya Xie Juncheng Wang Nianxi Xu Hanming Guo Wei Hu Shuming Wang Tao Li Songlin Zhuang | 2019 | Science Bulletin2019，64，20： | 16 |
| 2 | rMVP: A Memory-efficient, Visualization-enhanced, and Parallel-accelerated Tool for Genome-wide Association Study显示文摘Along with the develoipment of high-throughput sequencing technologies,both sample size and SNP number are increasing rapidly in genome-wide association studies(GWAS),and the associated computation is more challenging than ever.Here,we present a memory-efficient,visualization-enhanced,and parallel-accelerated R package called“r MVP”to address the need for improved GWAS computation.r MVP can 1)effectively process large GWAS data,2)rapidly evaluate population structure,3)efficiently estimate variance components by Efficient Mixed-Model Association e Xpedited(EMMAX),Factored Spectrally Transformed Linear Mixed Models(Fa ST-LMM),and Haseman-Elston(HE)regression algorithms,4)implement parallel-accelerated association tests of markers using general linear model(GLM),mixed linear model(MLM),and fixed and random model circulating probability unification(Farm CPU)methods,5)compute fast with a globally efficient design in the GWAS processes,and 6)generate various visualizations of GWASrelated information.Accelerated by block matrix multiplication strategy and multiple threads,the association test methods embedded in r MVP are significantly faster than PLINK,GEMMA,and Farm CPU_pkg.r MVP is freely available at http://gffzz188fe103f8f1460aswvwn6xkuvpq96woc.ffgz.tsg.suse.edu.cn/xiaolei-lab/r MVP. | Lilin Yin Haohao Zhang Zhenshuang Tang Jingya Xu Dong Yin Zhiwu Zhang Xiaohui Yuan Mengjin Zhu Shuhong Zhao Xinyun Li Xiaolei Liu | 2021 | Genomics, Proteomics & Bioinformatics2021，19，4： | 12 |
| 3 | Nerve Growth Factor Prevents the Apoptosis-associated Increase in Acetylcholinesterase Activity after Hydrogen Peroxide Treatment by Activating Akt显示文摘Acetylcholinesterase (疼痛) 被认为玩结果显示出的重要角色 duringapoptosis.Our 那 H_2O_2 导致了疼痛活动,功能的标记 inapoptosis,象 neuronal 一样 PC 12 房间的增加。谷胱甘肽,涉及细胞的氧化还原作用动态平衡,禁止了疼痛活动的增加,建议在这个过程的那个反应的氧种类(ROS ) 千盐湖钥匙角色。进一步的调查证明疼痛的举起在 Akt,从进 cytosol 的线粒体的细胞色素 c 的版本,和 caspase 家庭成员的激活的降级以后被观察。神经生长因素(NGF ) 什么时候是在场的,与 Akt 水平,疼痛的举起,细胞色素 c 散开,以及 apoptosis 的维护,显著地在对待 H_2O_2 的 PC12 细胞被稀释。然而, wortmannin, PI3K/Aktpathway 的一个禁止者,加速了 apoptosis 并且增加了疼痛活动。过去表示 ofconstitutively 激活 Akt,它是 NGF receptorTrkA,推迟的 mitochondrial 倒塌和疼痛活动的禁止的举起的一个下游的发信号元素。因此, NGF preventedapoptosis 和由激活 Akt 小径并且稳定线粒体的功能的疼痛活动的举起。 | Hua JIANG~(1,3) Jingya ZHANG~(1,3) Hui ZHU~(1,3) Hong LI~2 and Xuejun ZHANG~1 ~1Laboratory of Molecular Cell Biology,Institute of Biochemistry and Cell Biology,Shangha Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China ~2DEFEMA,Faculté de Medecine et de Pharmacie,University of Rouen,Rouen 76821,France ~3Graduate school of the Chinese Academy of Sciences,Beijing 100080,China | 2007 | Acta Biochimica et Biophysica Sinica2007，39，1： | 9 |
| 4 | A newly Found Biotite Syenogranite in the Huangshaping Polymetallic Deposit, South China: Insights into Cu Mineralization显示文摘The W-Sn-Mo-Cu-Pb-Zn polymetallic mineralization in the Huangshaping Deposit is associated with different types of Jurassic granitic intrusions such as quartz porphyry, granophyre and granite porphyry. In this study, we carried out detailed mineralogical, petrological, geochemical, zircon U-Pb geochronological and Hf isotopic studies on a newly found, Cu-mineralization-related finegrained biotite syenogranite at Huangshaping. This syenogranite is mainly composed of quartz(40%), K-feldspar(30%), plagioclase(15%) and biotite(5%), enriching in SiO_2(75.58 wt.%–76.02 wt.%), K_2O(5.24 wt.%–5.78 wt.%), Al_2O_3(12.23 wt.%–12.46 wt.%), Rb(405 ppm–504 ppm), U(18.5 ppm–40.7 ppm), Th(47 ppm–52.3 ppm), Nb(49.6 ppm–57.5 ppm), and Cu(54 ppm–288 ppm) whereas depleting in P_2O_5(0.01 wt.%), TiO_2(0.05 wt.%–0.06 wt.%), Ba(5 ppm–13.1 ppm), Sr(6.8 ppm–23.9 ppm) and Eu(0.04 ppm–0.05 ppm), with A1-type alkaline granite characteristics. Magmatic and hydrothermal zircons were separated from a Cu-mineralized syenogranite sample and yielded the 206 Pb/238 U concordant ages of 156.5±1.8 and 154.4±2.9 Ma, representing the intrusive age of the pluton and probable Cu-mineralization time at the Huangshaping Deposit, respectively. Zircon Hf isotopes suggest a crust-derived(partial melting of Paleoproterozoic basement) magma for the syenogranite, with some degree of crust-mantle interaction. We infer that the syenogranite is a transitional phase between the granophyre and the granite porphyry, not only contributed greatly to the Cu mineralization but also provided W-Sn polymetallic ore-forming metals for the Huangshaping Deposit. | Weicheng Jiang Huan Li Jinghua Wu Zhekai Zhou Hua Kong Jingya Cao | 2018 | Journal of Earth Science2018，29，3： | 7 |
| 5 | Diterpenoid UDP-Glycosyltransferases from Chinese Sweet Tea and Ashitaba Complete the Biosynthesis of Rubusoside显示文摘 | Yuwei Sun Zhuo Chen Jianxu Li Jianhua Li Huajun LV Jingya Yang Weiwei Li Dingan Xie Zhiqiang Xiong Peng Zhang Yong Wang | 2018 | Molecular Plant2018，11，10： | 7 |
| 6 | Recent Advances in Space-Deployable Structures in China显示文摘Deployable space structure technology is an approach used in building spacecraft,especially when realizing deployment and folding functions.Once in orbit,the structures are released from the fairing,deployed,and positioned.With the development of communication,remote-sensing,and navigation satellites,space-deployable structures have become cutting-edge research topics in space science and technology.This paper summarizes the current research status and development trend of spacedeployable structures in China,including large space mesh antennas,space solar arrays,and deployable structures and mechanisms for deep-space exploration.Critical technologies of space-deployable structures are addressed from the perspectives of deployable mechanisms,cable-membrane form-finding,dynamic analysis,reliable environmental adaptability analysis,and validation.Finally,future technology developments and trends are elucidated in the fields of mesh antennas,solar arrays,deployable mechanisms,and on-orbit adjustment,assembly,and construction. | Xiaofei Ma Tuanjie Li Jingya Ma Zhiyi Wang Chuang Shi Shikun Zheng Qifeng Cui Xiao Li Fan Liu Hongwei Guo Liwu Liu Zuowei Wang Yang Li | 2022 | Engineering2022，，10： | 6 |
| 7 | Multicell power allocation method based on game theory for inter-cell interference coordination显示文摘As a new technology, coordinated multipoint (CoMP) transmission is included in LTE-Advanced study item. Moreover, the network architecture in LTE-Advanced system is modified to take into account coordinated transmission. Under this background, a novel power allocation game model is established to mitigate inter-cell interference with cellular coordination. In the light of cellular cooperation relationship and centralized control in eNodeB, the power allocation in each served antenna unit aims to make signal to interference plus noise ratio (SINR) balanced among inter-cells. Through the proposed power allocation game algorithm, the users' SINR can reach the Nash equilibrium, making it feasible to reduce the co-frequency interference by decreasing the transmitted power. Numerical results show that the proposed power allocation algorithm improves the throughput both in cell-center and cell-edge. Moreover, the blocking rate in cell-edge is reduced too. | ZHANG Hui XU XiaoDong LI JingYa TAO XiaoFeng ZHANG Ping SVENSSON Tommy BOTELLA Carmen | 2009 | Science in China(Series F)2009，52，12： | 5 |
| 8 | The five major autoimmune diseases increase the risk of cancer:epidemiological data froma large-scale cohort study in China显示文摘Background:Cancer incidence and mortality have received critical attention during the long-term management of morbidities in patients with autoimmune diseases(AIDs).This study aimed to investigate and compare the risk of cancer associated with five major AIDs in a large-scale Chinese cohort.Methods:A total of 8,120 AID patients consecutively admitted to a national tertiary referral center in China were included and followed-up for 38,726.55 patient-years,including those with systemic lupus erythematosus(SLE),rheumatoid arthritis(RA),Sjoren’s syndrome(SS),systemic scleroderma(SSc),and idiopathic inflammatory myositis(IIM).Demographic data,cancer incidence,predilecting sites and cancer onset time were recorded and compared among the five AIDs.Results:Four hundred and thirty(5.3%)patients developed cancer.Their median agewas 57.5 years and AID durationwas 79.8 months.The estimated total standardized incidence ratio(SIR)of cancer in AIDs patients was 3.37,with the highest SIR observed in IIM(4.31),followed by RA(3.99),SSc(3.77),SS(2.88)and SLE(2.58).The increased SIR of cancers in AID patients showed a female predominance(female vs.male:3.59 vs.2.77)and younger patient involvement(age<50 vs.≥50 years:4.88 vs.3.04).Patientswith SLE had increased SIRs for developing hematologic malignancies and solid tumors located in the urinary bladder,corpus uteri and cervix uteri.Patients with SS had a significantly high SIR for developing non-Hodgkin’s lymphoma.Within 3 years of IIM diagnosis,74.6%of the patients developed cancer and they had a high risk of ovarian cancer.RA was associated with a wide distribution of scancers,including non-Hodgkin’s lymphoma,gynecologic,urinary tract,thyroid gland and lung cancers.SSc patients had increased SIRs for developing cervical uterine,lung,and breast cancers.Conclusion:Patients with five major AIDs in China had an increased risk of developing cancer,with a predominance in women and younger patients,although cancer incidence,predilection sites and cancer onset time may vary greatly in each AID entity. | Ziyue Zhou Huazhen Liu Yiying Yang Jingya Zhou Lidan Zhao Hua Chen Yunyun Fei Wen Zhang Mengtao Li Yan Zhao Xiaofeng Zeng Fengchun Zhang Huaxia Yang Xuan Zhang | 2022 | Cancer Communications2022，42，5： | 4 |
| 9 | DMP1 prevents osteocyte alterations,FGF23 elevation and left ventricular hypertrophy in mice with chronic kidney disease显示文摘During chronic kidney disease (CKD),alterations in bone and mineral metabolism include increased production of the hormone fibroblast growth factor 23 (FGF23) that may contribute to cardiovascular mortality.The osteocyte protein dentin matrix protein 1 (DMP1) reduces FGF23 and enhances bone mineralization,but its effects in CKD are unknown.We tested the hypothesis that DMP1 supplementation in CKD would improve bone health,prevent FGF23 elevations and minimize consequent adverse cardiovascular outcomes.We investigated DMP1 regulation and effects in wild-type (WT) mice and the Col4a3^-/- mouse model of CKD.Col4a3^-/- mice demonstrated impaired kidney function,reduced bone DMP1 expression,reduced bone mass,altered osteocyte morphology and connectivity,increased osteocyte apoptosis,increased serum FGF23,hyperphosphatemia,left ventricular hypertrophy (LVH),and reduced survival.Genetic or pharmacological supplementation of DMP1 in Col4a3^-/- mice prevented osteocyte apoptosis,preserved osteocyte networks,corrected bone mass,partially lowered FGF23 levels by attenuating NFAT-induced FGF23 transcription,and further increased serum phosphate.Despite impaired kidney function and worsened hyperphosphatemia,DMP1 prevented development of LVH and improved Col4a3^-/- survival.Our data suggest that CKD reduces DMP1 expression,whereas its restoration represents a potential therapeutic approach to lower FGF23 and improve bone and cardiac health in CKD. | Corey Dussold Claire Gerber Samantha White Xueyan Wang Lixin Qi Connor Francis Maralee Capella Guillaume Courbon Jingya Wang Chaoyuan Li Jian Q. Feng Tamara Isakova Myles Wolf Valentin David Aline Martin | 2019 | Bone Research2019，7，2： | 4 |
| 10 | Antimicrobial Chlorinated Carbazole Alkaloids from the Sponge-Associated Actinomycete Streptomyces diacarni LHW51701显示文摘Four new chlorinated carbazole alkaloids,chlocarbazomycins(CCBs)A-D,were isolated from sponge associated bacterium Streptomyces diacarni LHW51701.Their structures were elucidated via spectroscopic techniques(including HRESIMS,ID&2D NMR),and X-ray crystallographic analysis.Structurally,the 4-chloro coupled with 3-methoxyl substituents in the tricycle nucleus of CCBs A-D and the A/-methoxyl group of CCB-D are rare in naturally occurred tricyclic carbazole alkaloids.Moreover,CCBs A-D do not bear the typical Cl poro-alkyl and C2 meto-methyl side chains of bacterial tricycle carbazoles,suggesting a novel mechanism of aromatic ring formation in biosynthesis.The biological evaluation showed that CCB-C possessed inhibitory activities against pathogenic microorganisms including methicillin-resistant Staphylococcus aureus(MRSA),Mycobacterium smegmatis,Bacillus mycoides,and Candida albicans. | Yijia Cheng Nannan Chen Jing Li Jun-Cheng Su Jingya Yang Cui-Xian Zhang Hou-Wen Lin Yongjun Zhou | 2021 | Chinese Journal of Chemistry2021，39，5： | 3 |
| 11 | Berry syndrome: a rare cardiac malformation with extra-cardiac findings显示文摘Dear Editor,Berry syndrome is a rare combination of congenital cardiac malformations characterized by four abnormal features;namely,an aortopulmonary window(APW),aortic origin of the right pulmonary artery,hypoplasia or interruption of the aortic arch,with an intact ventricular septum.The disease was first reported by Berry in 1982,who estimated the incidence within the population with congenital cardiac malformations to be 0.046%(Berry et al.,1982).Until recently, | Jingya Li Ya Yang Xiaomin Duan Lanzhong Jin Lin Zheng Xin Zhang Haiyan Wei Yan Sun Xiaolin Zhang Pei Li Jiao Yang Ning Ma Fangyun Wang | 2017 | Science China(Life Sciences)2017，60，7： | 3 |
| 12 | Nuclear UHRF1 is a gate-keeper of cellular AMPK activity and function显示文摘The AMP-activated protein kinase(AMPK)is a central regulator of energy homeostasis.Although much has been learned on how low energy status and glucose starvation activate AMPK,how AMPK activity is properly controlled in vivo is still poorly understood.Here we report that UHRF1,an epigenetic regulator highly expressed in proliferating and cancer cells,interacts with AMPK and serves to suppress AMPK activity under both basal and stressed conditions.As a nuclear protein,UHRF1 promotes AMPK nuclear retention and strongly suppresses nuclear AMPK activity toward substrates H2B and EZH2.Importantly,we demonstrate that UHRF1 also robustly inhibits AMPK activity in the cytoplasm compartment,most likely as a consequence of AMPK nucleocytoplasmic shuttling.Mechanistically,we found that UHRF1 has no obvious effect on AMPK activation by upstream kinases LKB1 and CAMKK2 but inhibits AMPK activity by acting as a bridging factor targeting phosphatase PP2A to dephosphorylate AMPK.Hepatic overexpression of UHRF1 showed profound effects on glucose and lipid metabolism in wild-type mice but not in those with the liver-specific knockout of AMPKα1/α2,whereas knockdown of UHRF1 in adipose tissue led to AMPK activation and reduced sizes of adipocytes and lipogenic activity,highlighting the physiological significance of this regulation in glucose and lipid metabolism.Thus,our study identifies UHRF1 as a novel AMPK gate-keeper with critical roles in cellular metabolism. | Xiang Xu Guangjin Ding Caizhi Liu Yuhan Ding Xiaoxin Chen Xiaoli Huang Chen-Song Zhang Shanxin Lu Yunpeng Zhang Yuanyong Huang Zhaosu Chen Wei Wei Lujian Liao Shu-Hai Lin Jingya Li Wei Liu Jiwen Li Sheng-Cai Lin Xinran Ma Jiemin Wong | 2022 | Cell Research2022，32，1： | 3 |
| 13 | Characterization on the formation of porosity and tensile properties prediction in die casting Mg alloys显示文摘The 3D visualization of the porosity in high-pressure die casting(HPDC)Mg alloys AZ91D and Mg4Ce2Al0.5Mn(EA42)was investigated by X-ray computed tomography.It was demonstrated that the volumetric porosity at the near-gate location for alloy EA42 was significantly higher than that far from the gate location.This difference resulted from the low valid time during intensified casting pressure conditions.Specimens of alloy EA42 exhibited a narrow pore distribution in the side view(~0.5 mm)compared to the wide distribution(~1.8 mm)of alloy AZ91D,which was mainly attributed to the formation mechanism of the defect band.The formation of microporosity in the defect band of alloy EA42 was inhibited because of the significant latent heat released by a large amount of the Al11Ce3phase segregated in the defect band during solidification.Additionally,an effective estimator(Z-Propagation)was introduced,which is proposed to predict the projected area fraction of the porosity(f)involved during tensile failure with better effectiveness compared with traditional methods based on the actual fractured surface.By coupling the Z-Propagation method with the critical local strain model,the logarithmic fracture strain and true fracture stress of the specimens were predicted within 3.03%and 1.65%of the absolute value of the average relative error(AARE),respectively. | Zixin Li Dejiang Li Wenke Zhou Bo Hu Xingfeng Zhao Jingya Wang Ming Qin Jiangkun Xu Xiaoqin Zeng | 2022 | Journal of Magnesium and Alloys2022，10，7： | 2 |
| 14 | Enrichment factors of movable hydrocarbons in lacustrine shale oil and exploration potential of shale oil in Gulong Sag,Songliao Basin,NE China显示文摘The geological characteristics and production practices of the major middle-and high-maturity shale oil exploration areas in China are analyzed.Combined with laboratory results,it is clear that three essential conditions,i.e.economic initial production,commercial cumulative oil production of single well,and large-scale recoverable reserves confirmed by the testing production,determine whether the continental shale oil can be put into large-scale commercial development.The quantity and quality of movable hydrocarbons are confirmed to be crucial to economic development of shale oil,and focuses in evaluation of shale oil enrichment area/interval.The evaluation indexes of movable hydrocarbon enrichment include:(1)the material basis for forming retained hydrocarbon,including TOC>2%(preferentially 3%-4%),and typeⅠ-Ⅱkerogens;(2)the mobility of retained hydrocarbon,which is closely related to the hydrocarbon composition and flow behaviors of light/heavy components,and can be evaluated from the perspectives of thermal maturity(Ro),gas-oil ratio(GOR),crude oil density,quality of hydrocarbon components,preservation conditions;and(3)the reservoir characteristics associated with the engineering reconstruction,including the main pore throat distribution zone,reservoir physical properties(including fractures),lamellation feature and diagenetic stage,etc.Accordingly,13 evaluation indexes in three categories and their reference values are established.The evaluation indicates that the light shale oil zones in the Gulong Sag of Songliao Basin have the most favorable enrichment conditions of movable hydrocarbons,followed by light oil and black oil zones,containing 20.8×10^(8) t light oil resources in reservoirs with R_(0)>1.2%,pressure coefficient greater than 1.4,effective porosity greater than 6%,crude oil density less than 0.82 g/cm^(3),and GOR>100 m/m^(3).The shale oil in the Gulong Sag can be explored and developed separately by the categories(resource sweet spot,engineering sweet spot,and tight oil sweet spot)depending on shale oil flowability.The Gulong Sag is the most promising area to achieve large-scale breakthrough and production of continental shale oil in China. | ZHAO Wenzhi BIAN Congsheng LI Yongxin ZHANG Jinyou HE Kun LIU Wei ZHANG Bin LEI Zhengdong LIU Chang ZHANG Jingya GUAN Ming LIU Shijul | 2023 | Petroleum Exploration and Development2023，50，3： | 2 |
| 15 | Interest rate liberalization and pass-through of monetary policy rate to bank lending rates in China显示文摘We examine whether the effectiveness of the monetary policy rate transmission differs before and after interest rate liberalization in China using the autoregressive distributed lag (ARDL) bound test and an error correction model (ECM). The results show that after liberalization the mark-up is lower, and both the Iong-run and shortrun interest rate pass-through has become faster and more complete. We attribute our findings to the ongoing reforms of China's banking system, which has improved the competitiveness of Chinese commercial banks. | Jingya Li Ming-Hua Liu | 2019 | Frontiers of Business Research in China2019，13，2： | 2 |
| 16 | Enhanced catalysis of ultrasmall Au-MoS_2 clusters against reactive oxygen species for radiation protection显示文摘Ionizing radiation produces excessive reactive oxygen species(ROS) which impose detrimental effects on biological systems. Thus, it is important to explore clinically safe and efficacious radioprotection agents to scavenge ROS and reduce the risks of radiotherapy. Recently, emerging catalytic nanomaterials such as sulfide nanomaterials have shown capability of clearing ROS in vivo by unique electron transfers between atoms, but their catalytic activities are yet suboptimal. As such, there is an unmet need to improve catalytic properties for stronger antioxidant activities and radiation protection. Herein, we prepared ultrasmall Au-MoS_2 clusters(~2.5 nm) and they showed enhanced catalytic properties via gold intercalation facilitating increased active sites and synergistic effects. Electrocatalysis results revealed that the catalytic activity of Au-MoS_2 towards H2O_2 was superior to ultrasmall MoS_2 without Au. As a result, we found that improving the electrocatalytic property of Au-MoS_2 can effectively enhance corresponding antioxidant activities and radioprotection effects in vivo. In addition, Au-MoS_2 also showed significant radioprotection in vitro and dramatically reduced the excess of radiation-induced adverse ROS. It also rescued radiation-induced DNA damages and protected the bone marrow hematopoietic system from ionizing radiation. | Peixian Bian Jinxuan Zhang Junying Wang Jiang Yang Jingya Wang Haile Liu Yuanming Sun Meixian Li Xiao-Dong Zhang | 2018 | Science Bulletin2018，63，14： | 2 |
| 17 | Structure-Mediated Excitation of Air Plasma and Silicon Plasma Expansion in Femtosecond Laser Pulses Ablation显示文摘Femtosecond laser-induced surface structures upon multiple pulses irradiation are strongly correlated with the pulse number,which in turn signifcantly afects successive laser-material interactions.By recording the dynamics of femtosecond laser ablation of silicon using time-resolved shadowgraphy,here we present direct visualization of the excitation of air plasma induced by the refected laser during the second pulse irradiation.Te interaction of the air plasma and silicon plasma is found to enhance the shockwave expansion induced by silicon ablation in the longitudinal direction,showing anisotropic expansion dynamics in diferent directions.We further demonstrate the vanishing of air plasma as the pulse number increases because of the generation of a rough surface without light focusing ability.In the scenario,the interaction of air plasma and silicon plasma disappears;the expansion of the silicon plasma and shockwave restores its original characteristic that is dominated by the laser-material coupling.Te results show that the excitation of air plasma and the laser-material coupling involved in laser-induced plasma and shockwave expansion are structure mediated and dependent on the pulse number,which is of fundamental importance for deep insight into the nature of laser-material interactions during multiple pulses ablation. | Qingsong Wang Lan Jiang Jingya Sun Changji Pan Weina Han Guoyan Wang Feifei Wang Kaihu Zhang Ming Li Yongfeng Lu | 2018 | Research2018，，1： | 2 |
| 18 | Traditional Chinese Medicine guidelines for coronavirus disease 2019显示文摘OBJECTIVE:To summarize the evidence from Traditional Chinese Medicine(TCM)practice in the treatment of coronavirus disease 2019(COVID-19)and provide timely clinical practice guidance.METHODS:The guidelines were developed in accordance with the World Health Organization rapid guideline process.The evidence on TCM for COVID-19 from published guidelines,direct and indirect published clinical evidence,first hand clinical data,and expert experience and consensus were collected.The grading of recommendations assessment,development and evaluation(GRADE)method was used to grade the evidence and make the recommendations.RESULTS:Based on the available evidence,the guidelines recommended 17 Chinese medicines for COVID-19:2 Chinese herbal granules,7 Chinese patent medicines,and 8 Chinese herbal injections.CONCLUSION:As the literature search was conducted on March,any subsequent versions of these guidelines require an up-to-date literature review.We hope that the evidence summary in these guidelines will be helpful in global efforts to address COVID-19. | Liang Ning Ma Yanfang Wang Jingya Li Huizhen Wang Xiaohui Jiao Liwen Liu Bin Ma Yan Zhao Chen Luo Xufei Zhao Siya Lu Meng Cao Jin Hu Wenpin Zhang Hairong Liu Guoxiu Lu Cheng Liu Mengyu Li Li Han Xuejie Liu Yuqi Wang Liying Zhao Xueyao Wei Dongfeng Bai Jing Sun Mingyu Yang Yong Wu Xiaodan Chen Yaolong Shi Nannan Wang Yanping Wang Yongyan | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 2 |
| 19 | Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia显示文摘Hepatic cholesterol accumulation is an important contributor to hypercholesterolemia,which results in atherosclerosis and cardiovascular disease(CVD).ATP-citrate lyase(ACLY)is a key lipogenic enzyme that converts cytosolic citrate derived from tricarboxylic acid cycle(TCA cycle)to acetyl-CoA in the cytoplasm.Therefore,ACLY represents a link between mitochondria oxidative phosphorylation and cytosolic de novo lipogenesis.In this study,we developed the small molecule 326E with an enedioic acid structural moiety as a novel ACLY inhibitor,and its CoA-conjugated form 326E-CoA inhibited ACLY activity with an IC_(50)=5.31±1.2μmol/L in vitro.326E treatment reduced de novo lipogenesis,and increased cholesterol efflux in vitro and in vivo.326E was rapidly absorbed after oral administration,exhibited a higher blood exposure than that of the approved ACLY inhibitor bempedoic acid(BA)used for hypercholesterolemia.Chronic 326E treatment in hamsters and rhesus monkeys resulted in remarkable improvement of hyperlipidemia.Once daily oral administration of 326E for 24 weeks prevented the occurrence of atherosclerosis in ApoE^(-/-)mice to a greater extent than that of BA treatment.Taken together,our data suggest that inhibition of ACLY by 326E represents a promising strategy for the treatment of hypercholesterolemia. | Zhifu Xie Mei Zhang Qian Song Long Cheng Xinwen Zhang Gaolei Song Xinyu Sun Min Gu Chendong Zhou Yangming Zhang Kexin Zhu Jianpeng Yin Xiaoyan Chen Jingya Li Fajun Nan | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 1 |
| 20 | Molten salt as ultrastrong polar solvent enables the most straightforward pyrolysis towards highly efficient and stable single-atom electrocatalyst显示文摘Currently,pyrolysis as the most widely used method still has some key issues not well resolved for synthesis of carbon-supported single-atom catalysts(C-SACs),e.g.,the sintering of metal atoms at high temperature as well as the high cost and complicated preparations of precursors.In this report,molten salts are demonstrated to be marvellous medium for preparation of C-SACs by pyrolysis of small molecular precursors(ionic liquid).The ultrastrong polarity on one hand establishes robust interaction with precursor and enables better carbonization,resulting in largely enhanced yield.On the other hand,the aggregation of metal atoms is effectively refrained while no nanoparticle or cluster is formed.By this strategy,a C-SAC with atomically dispersed Fe-N_(4) sites and a high specific area over 2000 m^(2) g^(-1) is obtained,which illustrates high ORR activity in both acid and alkaline media.Moreover,this SAC exhibits superior methanol tolerance and stability after acid soaking at 85℃ for 48 h.It is believed that the molten-salts-assisted pyrolysis can be developed into a routine strategy as it not only can largely simply the synthesis of C-SACs,but also can be extended to prepare other types of SACs. | Nannan Li Wei Liu Chao Zhu Ce Hao Jingya Guo Hongyu Jing Jinwen Hu Cuncun Xin Danyang Wu Yantao Shi | 2021 | Journal of Energy Chemistry2021，30，3： | 1 |
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