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| 1 | s Early-onset in Major Depression a Predictor of Specific Clinical Features with More Impaired Social Function?显示文摘Background: Early-onset major depressive disorder (MDD) (EOD) is often particularly malignant due to its special clinical features, accompanying impaired social function, protracted recovery time, and frequent recurrence. This study aimed to observe the effects of age onset on clinical characteristics and social function in MDD patients in Asia. Methods: In total, 547 out-patients aged 18-5 years who were from 13 study sites in five Asian countries were included. These patients had MDD diagnose according to the Diagnostic and Statistical Manual of Mental Disorders, 4^th Edition criteria. Clinical features and social function were assessed using Symptom Checklist-90-revised (SCL-90-R) and Sheehan Disability Scale (SDS). Quality of life was assessed by a 36-item Short-form Health Survey (SF-36). Analyses were performed using a continuous or dichotomous (cut-off: 30 years) age-of-onset indicator. Results: Early-onset MDD (EOD, 〈30 years) was associated with longer illness (P - 0.003), unmarried status (P 〈 0.001), higher neuroticism (P 〈 0.002) based on the SCL-90-R, and more limited social function and mental health (P = 0.006, P = 0.007) based on the SF-36 and SDS. The impairment of social function and clinical severity were more prominent at in-patients with younger onset ages. Special clinical features and more impaired social function and quality of life were associated with EOD, as in western studies. Conclusions: EOD often follows higher levels of neuroticism. Age of onset of MDD may be a predictor of clinical features and impaired social function, allowing earlier diagnosis and treatment. | Yan-Hong Liu Lin Chen Yun-Ai Su Yi-Ru Fang Manit Srisurapanont Jin Pyo Hong Ahmad Hatim Hong Choon Chua Dianne Bautista Tian-Mei Si | 2015 | Chinese Medical Journal2015，，6： | 5 |
| 2 | Whole-genome,transcriptome,and methylome analyses provide insights into the evolution of platycoside biosynthesis in Platycodon grandiflorus,a medicinal plant显示文摘Triterpenoid saponins(TSs)are common plant defense phytochemicals with potential pharmaceutical properties.Platycodon grandiflorus(Campanulaceae)has been traditionally used to treat bronchitis and asthma in East Asia.The oleanane-type TSs,platycosides,are a major component of the P.grandiflorus root extract.Recent studies show that platycosides exhibit anti-inflammatory,antiobesity,anticancer,antiviral,and antiallergy properties.However,the evolutionary history of platycoside biosynthesis genes remains unknown.In this study,we sequenced the genome of P.grandiflorus and investigated the genes involved in platycoside biosynthesis.The draft genome of P.grandiflorus is 680.1 Mb long and contains 40,017 protein-coding genes.Genomic analysis revealed that the CYP716 family genes play a major role in platycoside oxidation.The CYP716 gene family of P.grandiflorus was much larger than that of other Asterid species.Orthologous gene annotation also revealed the expansion ofβ-amyrin synthases(bASs)in P.grandiflorus,which was confirmed by tissue-specific gene expression.In these expanded gene families,we identified key genes showing preferential expression in roots and association with platycoside biosynthesis.In addition,wholegenome bisulfite sequencing showed that CYP716 and bAS genes are hypomethylated in P.grandiflorus,suggesting that epigenetic modification of these two gene families affects platycoside biosynthesis.Thus whole-genome,transcriptome,and methylome data of P.grandiflorus provide novel insights into the regulation of platycoside biosynthesis by CYP716 and bAS gene families. | Jungeun Kim Sang-Ho Kang Sin-Gi Park Tae-Jin Yang Yi Lee Ok Tae Kim Oksung Chung Jungho Lee Jae-Pil Choi Soo-Jin Kwon Keunpyo Lee Byoung-Ohg Ahn Dong Jin Lee Seung-il Yoo In-Gang Shin Yurry Um Dae Young Lee Geum-Soog Kim Chang Pyo Hong Jong Bhak Chang-Kug Kim | 2020 | Horticulture Research2020，7，1： | 2 |
| 3 | Adding adefovir vs. switching to entecavir for lamivudine‐resistant chronic hepatitis B ( ACE study): a 2‐year follow‐up randomized controlled trial显示文摘 | Hyung Joon Yim Yeon Seok Seo Eileen L. Yoon Chang Wook Kim Chang Don Lee Sang Hoon Park Myung Seok Lee Choong Kee Park Hee Bok Chae Moon Young Kim Soon Koo Baik Yun Soo Kim Ju Hyun Kim Jung Il Lee Jin Woo Lee Sun Pyo Hong Soon Ho Um | 2013 | Liver Int2013，，2： | 2 |
| 4 | An approach to the dyeing of polyester fiber using indigo and its extended wash fastness properties 显示文摘 | SON Young A HONG Jin Pyo KIM Tae Kyung | 2004 | Dyes and Pigments2004，，61： | 1 |
| 5 | Adefovir and Lamivudine Combination Therapy in Patients with Entecavir-Resistant Chronic Hepatitis B: Antiviral Responses and Evolution of Mutations显示文摘 | Yim Hyung Joon Lee Hyun Jung Suh Sang Jun Seo Yeon Seok Kim Chang Wook Lee Chang Don Park Sang Hoon Lee Myung Seok Park Choong Kee Chae Hee Bok Kim Moon Young Baik Soon Koo Kim Yun Soo Kim Ju Hyun Lee Jung Il Lee Jin Woo Hong Sun Pyo Um | 2014 | Intervirology2014，，5： | 1 |
| 6 | An approach to the dyeing of polyester fiber using indigo and its extended wash fastness properties 显示文摘 | Son Young A Hong Jin Pyo Kim Tae Kyung | 2004 | Dyes and Pigments2004，61，： | 1 |
| 7 | Combination of ginsenoside Rg3 with docetaxel enhances the susceptibility of prostate cancer cells via inhibition of NF-κB显示文摘 | Sun Mi Kim So Yong Lee Jin Suk Cho Seung Mo Son Sang Sook Choi Yeo Pyo Yun Hwan Soo Yoo Do Young Yoon Ki-Wan Oh Sang Bae Han Jin Tae Hong | 2009 | European Journal of Pharmacology2009，，1： | 1 |
| 8 | Indigo adsorption properties to polyester fibers of different levels of fineness 显示文摘 | Son Young A Lim Hyeong Tae Hong Jin Pyo | 2005 | Dyes and Pigments2005，65，： | 1 |
| 9 | HCV core protein induces hepatic lipid accumulation by activating SREBP1 and PPARγ显示文摘 | Kook Hwan Kim Sung Pyo Hong KyeongJin Kim Min Jung Park Kwang Jin Kim JaeHun Cheong | 2007 | Biochemical and Biophysical Research Communications2007，，4： | 1 |
| 10 | Neuronal differentiation of embryonic midbrain cells by upregulation of peroxisome proliferator-activated receptor-gamma via the JNK-dependent pathway显示文摘 | Ki Sook Park Rhee Da Lee Sun-Kyung Kang Soon Young Han Kui Lae Park Ki Hwa Yang Youn Sook Song Hye Ji Park Yoot Mo Lee Yeo Pyo Yun Ki Wan Oh Dae Joong Kim Young Won Yun Se Jin Hwang Sung Eun Lee Jin Tae Hong | 2004 | Experimental Cell Research2004，，2： | 1 |
| 11 | Regenerative potential of mouse embryonic stem cell-derived PDGFRα+ cardiac lineage committed cells in infarcted myocardium显示文摘BACKGROUND Pluripotent stem cell-derived cardiomyocytes(CMs) have become one of the most attractive cellular resources for cell-based therapy to rescue damaged cardiac tissue.AIM We investigated the regenerative potential of mouse embryonic stem cell(ESC)-derived platelet-derived growth factor receptor-α(PDGFRα)+ cardiac lineagecommitted cells(CLCs), which have a proliferative capacity but are in a morphologically and functionally immature state compared with differentiated CMs.METHODSWe induced mouse ESCs into PDGFRα+ CLCs and αMHC+ CMs using a combination of the small molecule cyclosporin A, the rho-associated coiled-coil kinase inhibitor Y27632, the antioxidant Trolox, and the ALK5 inhibitor EW7197.We implanted PDGFRα+ CLCs and differentiated αMHC+ CMs into a myocardial infarction(MI) murine model and performed functional analysis using transthoracic echocardiography(TTE) and histologic analysis.RESULTS Compared with the untreated MI hearts, the anterior and septal regional wall motion and systolic functional parameters were notably and similarly improved in the MI hearts implanted with PDGFRα+ CLCs and αMHC+ CMs based on TTE.In histologic analysis, the untreated MI hearts contained a thinner ventricular wall than did the controls, while the ventricular walls of MI hearts implanted with PDGFRα+ CLCs and αMHC+ CMs were similarly thicker compared with that of the untreated MI hearts. Furthermore, implanted PDGFRα+ CLCs aligned and integrated with host CMs and were mostly differentiated into α-actinin+ CMs,and they did not convert into CD31+ endothelial cells or αSMA+ mural cells.CONCLUSION PDGFRα+ CLCs from mouse ESCs exhibiting proliferative capacity showed a regenerative effect in infarcted myocardium. Therefore, mouse ESC-derived PDGFRα+ CLCs may represent a potential cellular resource for cardiac regeneration. | Seon Pyo Hong Sukhyun Song Seungjoo Lee Hyeonju Jo Hyoung Kyu Kim Jin Han Jae-Hyeong Park Sung Woo Cho | 2019 | World Journal of Stem Cells2019，11，1： | 1 |
| 12 | An approach to the dyeing of polyester fiber using indigo and its extended wash fastness properties显示文摘 | Son Young A Hong Jin Pyo Kim Tae Kyung | 2004 | Dyes and Pigments2004，61，： | 1 |
| 13 | Characteristics and prevalence of intrapulmonary shunt detected by contrast echocardiography with harmonic imaging in liver transplant candidates显示文摘 | Byung Jin Kim Sang-Chol Lee Seung Woo Park Moon-Suk Choi Kwang Cheol Koh Seung Woon Paik Sang Hoon Lee Kyung Pyo Hong Jeong Euy Park Jung Don Seo | 2004 | The American Journal of Cardiology2004，，4： | 1 |
| 14 | A Phase II Study of Synchronous Three-Dimensional Conformal Boost to the Gross Tumor Volume for Patients With Unresectable Stage III Non–Small-Cell Lung Cancer: Results of Korean Radiation Oncology Group 0301 Study显示文摘 | Kwan Ho Cho Sung Ja Ahn Hong Ryull Pyo Kyu-Sik Kim Young-Chul Kim Sung Ho Moon Ji-Youn Han Heung Tae Kim Woong Sub Koom Jin Soo Lee | 2009 | International Journal of Radiation Oncology Biology Physics2009，，5： | 1 |
| 15 | Green Tea (-)-Epigallocatechin-3-Gallate Inhibits [beta]-Amyloid-Induced Cognitive Dysfunction through Modification of Secretase Activity via Inhibition of ERK and NF-[kappa]B Pathways in Mice1,2显示文摘 | Lee Jae Woong Lee Yong Kyoung Ban Jung Ok Ha Tae Youl Yun Yeo Pyo Han Sang Bae Oh Ki Wan Hong Jin Tae | 2009 | The Journal of Nutrition2009，，10： | 1 |
| 16 | Inhibitory effect of green tea extract on β-amyloid-induced PC12 cell death by inhibition of the activation of NF-κB and ERK/p38 MAP kinase pathway through antioxidant mechanisms显示文摘 | Sun Young Lee Jae Woong Lee Heesoon Lee Han Soo Yoo Yeo Pyo Yun Ki Wan Oh Tae Youl Ha Jin Tae Hong | 2005 | Molecular Brain Research2005，，1： | 1 |
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