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| 1 | Ag nanoparticles sensitize IR-induced killing of cancer cells显示文摘 | Ruizhi Xu Jun Ma Xinchen Sun ZhongpingChen Xiaoli Jiang Zhirui auo Lan Huang YangLi Meng Wang Changling Wang Jiwei Liu XuFan Jiayu Gu Xi Chen Yu Zhang Ning Gu | 2009 | Cell Research2009，19，8： | 11 |
| 2 | ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer显示文摘The Serine-Glycien-One-Carbon(SGOC)pathway is pivotal in multiple anabolic processes.Expression levels of SGOC genes are deregulated under tumoeigenic condltions,suggesting panicipation of oncogenes in deregulating the SGOC biosynthetic pathway.However,the underlying mechanism remains elusive.Here,we identifed that Interleukin enfiarccer-binding factor 3(ILF3)is overexpressed in primary CRC patient specimens and correlates with poor progroosis.ILF3 is critical in regulating the SGOC pathway by directly regulating the mRNA stability of SGOC genes,thereby increasing SGOC genes expression and facilitating tumor growth.Mehhanktic studies showed that the EGF-MIEK-ERK pathway nnediates ILF3 phosphorylation,which hin ders E3 ligase speckle-type POZ protein(SPOP)-mediated poly-ubiquitination and degradation of ILF3.Sign iftca ntly,combination of SGOC inhibitor and the anti-EGFR monoclonal antibody cetuximab can hinder the growth of patient-derived xenografts that sustain high ERK-ILF3 levels.Taken together,deregutation of ILF3 via the EGF-ERK signaling plays an important role in systemic serine metabolic reprogramming and confers a predilection toward CRC development.Our findings indicate that clinical evaluation of SCOC inhibitor is warranted for CRC patients with ILF3 overexpression. | Kai Li Jian-lin Wu Baifu Qin Zongmin Fan Qin Tang Weisi Lu Haipeng Zhang Fan Xing Manqi Meng Shaomin Zou Wenxia Wei Honglei Chen Jian Cai Huaiming Wang Hui Zhang Jiayue Cai Ling Fang Xiqing Bian Chuangqi Chen Ping Lan Bart Ghesquiere Lekun Fang Mong-Hong Lee | 2020 | Cell Research2020，30，2： | 6 |
| 3 | Post-Synthetic and In Situ Vacancy Repairing of Iron Hexacyanoferrate Toward Highly Stable Cathodes for Sodium-Ion Batteries显示文摘Iron hexacyanoferrate(FeHCF)is a promising cathode material for sodium-ion batteries.However,FeHCF always suffers from a poor cycling stability,which is closely related to the abundant vacancy defects in its framework.Herein,post-synthetic and in-situ vacancy repairing strategies are proposed for the synthesis of highquality FeHCF in a highly concentrated Na_(4)Fe(CN)_(6) solution.Both the post-synthetic and in-situ vacancy repaired FeHCF products(FeHCF-P and FeHCF-I)show the significant decrease in the number of vacancy defects and the reinforced structure,which can suppress the side reactions and activate the capacity from low-spin Fe in FeHCF.In particular,FeHCF-P delivers a reversible discharge capacity of 131 mAh g^(−1) at 1 C and remains 109 mAh g^(−1) after 500 cycles,with a capacity retention of 83%.FeHCF-I can deliver a high discharge capacity of 158.5 mAh g^(−1) at 1 C.Even at 10 C,the FeHCF-I electrode still maintains a discharge specific capacity of 103 mAh g^(−1) and retains 75% after 800 cycles.This work provides a new vacancy repairing strategy for the solution synthesis of high-quality FeHCF. | Min Wan Rui Zeng Jingtao Meng Zexiao Cheng Weilun Chen Jiayu Peng Wuxing Zhang Yunhui Huang | 2022 | Nano-Micro Letters2022，14，1： | 3 |
| 4 | Current sustained delivery strategies for the design of local neurotrophic factors in treatment of neurological disorders显示文摘Although therapeutic potential of neurotrophic factors(NTFs)has been well recognized for over two decades,attempts to translate that potential to the clinic have been disappointing,largely due to significant obstacles in delivery,including inadequate protein dose/kinetics released at target sites.Considerable efforts have been made to improve the therapeutic performance of NTFs.This articles reviews recent developments in localized delivery systems of NTFs for the neurological disorders treatments with a main focus on sustained delivery strategies.Different non-covalent binding approaches have been employed to immobilize proteins in hydrogels,microspheres,electrospun nanofibers,and their combined systems,which serve as depots for sustained local release of NTFs.The challenges associated with current NTFs delivery systems and how these systems can be applied to neurological diseases and disorders have been discussed in the review.In conclusion,optimal delivery systems for NTFs will be needed for reliable and meaningful clinical benefits;ideally,delivering a time and dose-controlled release of bioactive multiNTFs at different individual optimal kinetics to achieve multi-functions in target tissues is significant preferred. | Hongzhuo Liu Yanyan Zhou Shichao Chen Meng Bu Jiayu Xin Sanming Li | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，5： | 2 |
| 5 | A study of the meteor ological causes of a prolonged and severe haze episode in January 2013 over central-eastern China显示文摘 | WANG Hong XU Jiayu ZHANG Meng | 2014 | Atmospheric Environment2014，98，： | 1 |
| 6 | Flexible ternary carbon black/Bi_(2)Te_(3) based alloy/polylactic acid thermoelectric composites fabricated by additive manufacturing显示文摘Flexible ternary carbon black/Bi_(2)Te_(3) based alloy/polylactic acid(CB/BTBA/PLA)composites were fabricated by additive manufacturing and their thermoelectric properties were investigated from 300 K to 360 K.At 300 K,as the mass ratios of BTBAs in the composites increased from 38.5% to 71.4%,both the electrical conductivity and Seebeck coefficient of the composites increased from 5.8 S/cm to 13.3 S/cm,and from 60.2 mV/K to 119.9 mV/K,respectively,and the thermal conductivity slightly increased from 0.15 W m^(-1)K^(-1) to 0.25 W m^(-1)K^(-1),as a result,the ZT value of the composites increased from 0.004 to 0.023.As the temperature increased from 300 K to 360 K,the electrical conductivity of all the composites slightly decreased,while the thermal conductivity slowly increased,and a highest ZT value of 0.024 was achieved for the composites with 71.4% BTBAs at 320 K.Unlike traditional sterolithography,fused deposition modeling,selective laser melting,etc.,this additive manufacturing process can directly print the solutions which contain inorganic fillers and polymer matrixes into almost any designed intricate geometries of thermoelectric composites,therefore this process has great potential to be used for fabrication of flexible polymer based thermoelectric composites and devices. | Yong Du Jiageng Chen Qiufeng Meng Jiayue Xu Biplab Paul Per Eklund | 2020 | Journal of Materiomics2020，6，2： | 1 |
| 7 | Unmodified methodologies in target discovery for small molecule drugs:A rising star显示文摘Target discovery,involving target identification and validation,is the prerequisite for drug discovery and screening.Novel methodologies and technologies for the precise discovery and confirmation of drug targets are powerful tools in understanding the disease,looking for a drug and elucidating the mechanism of drug treatment.Among the common target identification and confirmation methods,the modified method is time-consuming and laborious,which may reduce or change the activity of natural products.The unmodified methods developed in recent years without chemical modification have gradually become an important means of studying drug targets.A wide range of unmodified approaches have been reported,introducing and analyzing the recent emerging methodologies and technologies.This review highlights the advantages and limitations of these methods for the application of drug target discovery and presents an overview of their contributions to the target discovery of small molecule drugs.The application and future development trends of methodologies in target discovery are also prospected to provide a reference for drug target research. | Jiayue Tang Meng Ou Qiuling Zheng Ya Ding | 2022 | Chinese Chemical Letters2022，33，12： | 1 |
| 8 | Dynamic landscape mapping of humoral immunity to SARS-CoY-2 identifies non-structural protein antibodies associated with the survival of critical COVID-19 patients显示文摘A comprehensive analysis of the humoral immune response to the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is essential in understanding COVID-19 pathogenesis and developing antibody-based diagnostics and therapy.In this work,we performed a longitudinal analysis of antibody responses to SARS-CoV-2 proteins in 104 serum samples from 49 critical COVID-19 patients using a peptide-based SARS-CoV-2 proteome microarray.Our data show that the binding epitopes of IgM and IgG antibodies differ across SARS-CoV-2 proteins and even within the same protein. | Linlin Cheng Xiaomei Zhang Yu Chen Dan Wang Dong Zhang Songxin Yan Hongye Wang Meng Xiao Te Liang Haolong Li Meng Xu Xin Hou jiayu Dai Xian Wu Mingyuan Li Minya Lu Dong Wu Ran Tian Jing Zhao Yan Zhang Wei Cao Jinglan Wang Xiaowei Yan Xiang Zhou Zhengyin Liu Yingchun Xu Fuchu He Yongzhe Li Xiaobo Yu Shuyang Zhang | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 1 |
| 9 | Kinetics process for structure-engineered integrated gradient porous paper-based supercapacitors with boosted electrochemical performance显示文摘Due to their rich and adjustable porous network structure,paper-based functional materials have become a research hotspot in the field of energy storage.However,reasonably designing and making full use of the rich pore structure of paper-based materials to improve the electrochemical performance of paper-based energy storage devices still faces many challenges.Herein,we propose a structure engineering technique to develop a conductive integrated gradient porous paper-based(CIGPP)supercapacitor,and the kinetics process for the influence of gradient holes on the electrochemical performance of the CIGPP is investigated through experimental tests and COMSOL simulations.All results indicate that the gradient holes endow the CIGPP with an enhanced electrochemical performance.Specifically,the CIGPP shows a significant improvement in the specific capacitance,displays rich frequency response characteristics for electrolyte ions,and exhibits a good rate performance.Also,the CIGPP supercapacitor exhibits a low self-discharge and maintains a stable electrochemical performance in different electrolyte environments because of gradient holes.More importantly,when the CIGPP is used as a substrate to fabricate a CIGPP-PANI hybrid,it still maintains good electrochemical properties.In addition,the CIGPP supercapacitor also shows excellent stability and sensitivity for monitoring human motion and deaf-mute voicing,showing potential application prospects.This study provides a reference and feasible way for the design of structure-engineered integrated paper-based energy storage devices with outstanding comprehensive electrochemical performance. | Chuanyin Xiong Yongkang Zhang Jiayu Xu Weihua Dang Xuhui Sun Meng An Yonghao Ni Junjie Mao | 2023 | Nano Research2023，16，7： | 1 |
| 10 | BMP4 preserves the developmental potential of mESCs through Ube2s-and Chmp4b-mediated chromosomal stability safeguarding显示文摘Chemically defined medium is widely used for culturing mouse embryonic stem cells(mESCs),in which N2B27 works as a substitution for serum,and GSK3βand MEK inhibitors(2i)help to promote ground-state pluripo-tency.However,recent studies suggested that MEKi might cause irreversible defects that compromise the developmental potential of mESCs.Here,we demon-strated the deficient bone morphogenetic protein(BMP)signal in the chemically defined condition is one of the main causes for the impaired pluripotency.Mechanisti-cally,activating the BMP signal pathway by BMP4 could safeguard the chromosomal integrity and proliferation capacity of mESCs through regulating downstream tar-gets Ube2s and Chmp4b.More importantly,BMP4 pro-motes a distinct in vivo developmental potential and a long-term pluripotency preservation.Besides,the pluripotent improvements driven by BMP4 are superior to those by attenuating MEK suppression.Taken together,our study shows appropriate activation of BMP signal is essential for regulating functional pluripotency and reveals that BMP4 should be applied in the serum-free culture system. | Mingzhu Wang Kun Zhao Meng Liu Mengting Wang Zhibin Qiao Shanru Yi Yonghua Jiang Xiaochen Kou Yanhong Zhao Jiqing Yin Tianming Li Hong Wang Cizhong Jiang Shaorong Gao Jiayu Chen | 2022 | Protein & Cell2022，13，8： | 0 |
| 11 | A de novo missense mutation in MPP2 confers an increased risk of Vogt–Koyanagi–Harada disease as shown by trio-based whole-exome sequencing显示文摘Vogt–Koyanagi–Harada(VKH)disease is a leading cause of blindness in young and middle-aged people.However,the etiology of VKH disease remains unclear.Here,we performed the first trio-based whole-exome sequencing study,which enrolled 25 VKH patients and 50 controls,followed by a study of 2081 VKH patients from a Han Chinese population to uncover detrimental mutations.A total of 15 de novo mutations in VKH patients were identified,with one of the most important being the membrane palmitoylated protein 2(MPP2)p.K315N(MPP2-N315)mutation.The MPP2-N315 mutation was highly deleterious according to bioinformatic predictions.Additionally,this mutation appears rare,being absent from the 1000 Genome Project and Genome Aggregation Database,and it is highly conserved in 10 species,including humans and mice.Subsequent studies showed that pathological phenotypes and retinal vascular leakage were aggravated in MPP2-N315 mutation knock-in or MPP2-N315 adeno-associated virus-treated mice with experimental autoimmune uveitis(EAU).In vitro,we used clustered regularly interspaced short palindromic repeats(CRISPR‒Cas9)gene editing technology to delete intrinsic MPP2 before overexpressing wild-type MPP2 or MPP2-N315.Levels of cytokines,such as IL-1β,IL-17E,and vascular endothelial growth factor A,were increased,and barrier function was destroyed in the MPP2-N315 mutant ARPE19 cells.Mechanistically,the MPP2-N315 mutation had a stronger ability to directly bind to ANXA2 than MPP2-K315,as shown by LC‒MS/MS and Co-IP,and resulted in activation of the ERK3/IL-17E pathway.Overall,our results demonstrated that the MPP2-K315N mutation may increase susceptibility to VKH disease. | Xianyang Liu Jiayu Meng Xingyun Liao Yusen Liu Qian Zhou Zongren Xu Shuming Yin Qingfeng Cao Guannan Su Siyuan He Wanqian Li Xiaotang Wang Guoqing Wang Dali Li Peizeng Yang Shengping Hou | 2023 | Cellular & Molecular Immunology2023，20，11： | 0 |
| 12 | Time-domain and Frequency-domain Analyses of PETT Oscillation in Press Pack IGBTs显示文摘Plasma extraction transit time(PETT)oscillation might appear in IGBT devices,which is harmful to the electromagnetic compatibility(EMC)of a renewable energy system.To eliminate this oscillation,its frequency-domain characteristics in wire-bonded IGBT devices have been extensively studied.However,the time-domain analysis of PETT oscillation,especially in Press Pack IGBT(PPI)devices,has not attracted enough attention yet.In this paper,PETT oscillations with multi-chips in PPI devices are systematically investigated by experiments.It is first reported there are multiple resonant oscillations at the tail period when multi-chips turn off.Oscillations overlap in the time domain waveforms,which lead PETT oscillation to be more serious in multi-chips.Then,PETT oscillation is divided into three different feedback states for the first time.For the IGBT chip in the PETT oscillation,its physical based model and behavior model are proposed,which further form the equivalent circuit as the two-port network.Moreover,it is indicated that only parallel resonances can lead to PETT oscillation,which is consistent with experiment results. | Jiayu Fan Xiang Cui Xinling Tang Cheng Peng Zhibin Zhao Xiangrui Meng Xuebao Li Zhong Chen | 2023 | CSEE Journal of Power and Energy Systems2023，9，2： | 0 |
| 13 | Control of lupus activity during pregnancy via the engagement of IgG sialylation:novel crosstalk between IgG sialylation and pDC functions显示文摘Immunoglobulin(IgG)glycosylation affects the effector functions of IgG in a myriad of biological processes and has been closely associated with numerous autoimmune diseases,including systemic lupus erythematosus(SLE),thus underlining the pathogenic role of glycosylation aberration in autoimmunity.This study aims to explore the relationship between IgG sialylation patterns and lupus pregnancy.Relative to that in serum samples from the control cohort,IgG sialylation level was aberrantly downregulated in serum samples from the SLE cohort at four stages(from preconception to the third trimester of pregnancy)and was significantly associated with lupus activity and fetal loss during lupus pregnancy.The type I interferon signature of pregnant patients with SLE was negatively correlated with the level of IgG sialylation.The lack of sialylation dampened the ability of IgG to suppress the functions of plasmacytoid dendritic cells(pDCs).RNA-seq analysis further revealed that the expression of genes associated with the spleen tyrosine kinase(SYK)signaling pathway significantly differed between IgG-and deSia-IgG-treated pDCs.This finding was confirmed by the attenuation of the ability to phosphorylate SYK and BLNK in deSia-IgG.Finally,the coculture of pDCs isolated from pregnant patients with SLE with IgG/deSia-IgG demonstrated the sialylation-dependent anti-inflammatory function of IgG.Our findings suggested that IgG influences lupus activity through regulating pDCs function via the modulation of the SYK pathway in a sialic acid-dependent manner. | You Wang Sihan Lin Jiayue Wu Meng Jiang Jianhua Lin Yu Zhang Huihua Ding Haibo Zhou Nan Shen Wen Di | 2023 | Frontiers of Medicine2023，17，3： | 0 |
| 14 | Reducing CO_(2)emissions from the rebalancing operation of the bike-sharing system in Beijing显示文摘With the development of the bike-sharing system(BSS)and the introduction of green and low carbon development,the environmental impacts of BSS had received increasing attention in recent years.However,the emissions from the rebalancing of BSS,where fossil-fueled vehicles are commonly used,are usually neglected,which goes against the idea of green travel in a sharing economy.Previous studies on the bike-sharing rebalancing problem(BRP),which is considered NP-hard,have mainly focused on algorithm innovation instead of improving the solution model,thereby hindering the application of many existing models in large-scale BRP.This study then proposes a method for optimizing the CO_(2)emissions from BRP and takes the BSS of Beijing as a demonstration.We initially analyze the spatial and temporal characteristics of BSS,especially the flow between districts,and find that each district can be independently rebalanced.Afterward,we develop a rebalancing optimization model based on a partitioning strategy to avoid deciding the number of bikes being loaded or unloaded at each parking node.We then employ the tabu search algorithm to solve the model.Results show that(i)due to over launch and lack of planning in rebalancing,the BSS in Beijing shows great potential for optimization,such as by reducing the number of vehicle routes,CO_(2)emissions,and unmet demands;(ii)the CO_(2)emissions of BSS in Beijing can be reduced by 57.5%by forming balanced parking nodes at the end of the day and decreasing the repetition of vehicle routes and the loads of vehicles;and(iii)the launch amounts of bikes in specific districts,such as Shijingshan and Mentougou,should be increased. | Meng QIN Jiayu WANG Wei-Ming CHEN Ke WANG | 2023 | Frontiers of Engineering Management2023，10，2： | 0 |
| 15 | A cell marker-based clustering strategy(cmCluster)for precise cell type identification of scRNA-seq data显示文摘Background:The precise and efficient analysis of single-cell transcriptome data provides powerful support for studying the diversity of cell functions at the single-cell level.The most important and challenging steps are cell clustering and recognition of cell populations.While the precision of clustering and annotation are considered separately in most current studies,it is worth attempting to develop an extensive and flexible strategy to balance clustering accuracy and biological explanation comprehensively.Methods:The cell marker-based clustering strategy(cmCluster),which is a modified Louvain clustering method,aims to search the optimal clusters through genetic algorithm(GA)and grid search based on the cell type annotation results.Results:By applying cmCluster on a set of single-cell transcriptome data,the results showed that it was beneficial for the recognition of cell populations and explanation of biological function even on the occasion of incomplete cell type information or multiple data resources.In addition,cmCluster also produced clear boundaries and appropriate subtypes with potential marker genes.The relevant code is available in GitHub website(huangyuwei301/cmCluster).Conclusions:We speculate that cmCluster provides researchers effective screening strategies to improve the accuracy of subsequent biological analysis,reduce artificial bias,and facilitate the comparison and analysis of multiple studies. | Yuwei Huang Huidan Chang Xiaoyi Chen Jiayue Meng Mengyao Han Tao Huang Liyun Yuan Guoqing Zhang | 2023 | Quantitative Biology2023，11，2： | 0 |
| 16 | Eco-friendly glucose assisted structurally simplified high-efficiency tin-lead mixed perovskite solar cells显示文摘Achieving highly-efficient and stable perovskite solar cells(PSCs) with a simplified structure remains challenging, despite the tremendous potential for reducing preparation cost and facile processability by removing hole transport layer(HTL). In this work, eco-friendly glucose(Gl) as an interface modifier for HTL-free narrow bandgap tin-lead(Sn-Pb) PSCs is proposed. Gl not only enhances the wettability of the indium tin oxide to promote perovskite heterogeneous nucleation on substrate, but also realizes defect passivation by interacting with uncoordinated Pb^(2+) and Sn^(2+) in perovskite films. As a result, the quality of the perovskite films has been significantly improved, accompanied by reduced defects of bottom interface and optimized energy level structure of device, leading to an efficiency increase and a less nonradiative voltage loss of 0.102 V(for a bandgap of ~1.26 eV). Consequently, the optimized PSC delivers an unprecedented efficiency over 21% with high open-circuit voltage and enhanced stability, outperforming the control device. This work demonstrates a cost-effective approach to develop simplified structure high efficiency HTL-free Sn-Pb PSC. | Jiayu You Hongyu Bian Meng Wang Xinghong Cai Chunmei Li Guangdong Zhou Hao Lu Changxiang Fang Jia Huang Yanqing Yao Cunyun Xu Qunliang Song | 2023 | Journal of Energy Chemistry2023，，10： | 0 |
| 17 | Strain‑Induced Surface Interface Dual Polarization Constructs PML‑Cu/Bi_(12)O_(17)Br_(2) High‑Density Active Sites for CO_(2) Photoreduction显示文摘The insufficient active sites and slow interfacial charge trans-fer of photocatalysts restrict the efficiency of CO_(2) photoreduction.The synchronized modulation of the above key issues is demanding and chal-lenging.Herein,strain-induced strategy is developed to construct the Bi–O-bonded interface in Cu porphyrin-based monoatomic layer(PML-Cu)and Bi_(12)O_(17)Br_(2)(BOB),which triggers the surface interface dual polarization of PML-Cu/BOB(PBOB).In this multi-step polarization,the built-in electric field formed between the interfaces induces the electron transfer from con-duction band(CB)of BOB to CB of PML-Cu and suppresses its reverse migration.Moreover,the surface polarization of PML-Cu further promotes the electron converge in Cu atoms.The introduction of PML-Cu endows a high density of dispersed Cu active sites on the surface of PBOB,significantly promoting the adsorption and activation of CO_(2) and CO desorption.The conversion rate of CO_(2) photoreduction to CO for PBOB can reach 584.3μmol g-1,which is 7.83 times higher than BOB and 20.01 times than PML-Cu.This work offers valuable insights into multi-step polarization regulation and active site design for catalysts. | Yi Zhang Fangyu Guo Jun Di Keke Wang Molly Meng‑Jung Li Jiayu Dai Yuanbin She Jiexiang Xia Huaming Li | 2024 | Nano-Micro Letters2024，16，5： | 0 |
| 18 | Microenvironmental effects on growth response of Pinus massoniana to climate at its northern boundary in the Tongbai Mountains,Central China显示文摘The Tongbai Mountains is an ecologically sensi-tive region and the northern boundary of Pinus massoniana Lamb.To analyze the effect of different microenvironments on tree growth response to climate factors,we developed standard chronologies for earlywood width(EWW),late-wood width(LWW),and total ring width(TRW)of P.massoniana at two sampling sites on slopes with different orientations,then analyzed characteristics of the chronolo-gies and their correlations with climate variables from five stations in the region and with a regional normalized differ-ence vegetation index(NDVI).Statistical results showed that the TRW/EWW/LWW chronology consistency and charac-teristics(mean sensitivity,signal to noise ratio,expressed population signal)for trees growing on the southeastern slope were much higher than for trees on the northeastern slope.Correlations indicated that temperature in current March and August has a significant positive effect on TRW/EWW/LWW formation,and the effect on the northeastern slope was weaker than on the southeastern slope.Compared to temperature,precipitation has more complicated effects on tree growth,but the effect on the northeastern slope was also generally weaker than on the southeastern slope.Step-wise linear regression analyses showed that temperature in August was the main limiting factor at the two sampling sites.Similarly,the response of tree growth on the southeast-ern slope as determined by the NDVI is better than on the northeastern slope,and the TRW/EWW/LWW chronologies for the southeastern slope explained over 50%of the total NDVI variances in June.Overall,the results indicate that the difference in the climate response of P.massoniana at two sampling sites is clearly caused by differences in the microenvironment,and such differences should be properly considered in future studies of forest dynamics and climate reconstructions. | Jianfeng Peng Jiayue Cui Jinbao Li Meng Peng Yongtao Ma Xiaoxu Wei Jinkuan Li Xuan Li Yamen Liu Jiaxin Li | 2024 | Journal of Forestry Research2024，35，1： | 0 |
| 19 | NIR-Ⅱ photothermal therapy for effective tumor eradication enhanced by heterogeneous nanorods with dual catalytic activities显示文摘Rational design and exploitation of nanomaterials with superior treatment properties for suitable indications is a way out to relieve cost constraint of therapy and solve the unsatisfactory efficacy for cancer patients.In this work,we propose a greatly facile approach to produce heterogeneous Pd-Au nanorods(Pd-Au NRs)that solve the current bottleneck problems of photothermal thermal therapy(PTT)as well as completely eliminate tumors in animal models without toxic side effects.Depositing Pd clusters on both tips of Au NRs offers Pd-Au NRs three novel functions,i.e.,the extension of the absorption into NIR-Ⅱ region,the activation of prodrug of 5-fluorouracil(5-Fu)via the bioorthogonal reaction,and the peroxidase-mimic activity to produce·OH.The heterogeneous nanorods showed a high and stable photothermal conversion efficiency(52.07%)in a safer NIR-Ⅱ irradiation region(1,064 nm),which not only eliminate most of tumor cells at only one dose of the irradiation for 5 min but also improve the in situ conversion of 5-fluoro-1-propargyluracil and H2O2 into active 5-Fu and·OH to eradicate residual tumors for inhibiting tumor metastasis.This dual catalytic activity-synergistic mechanism of PTT demonstrates the importance of material design in solving current bottleneck problem of tumor therapy. | Linghua Zhang Wenjie Wang Meng Ou Xiaoxiao Huang Yu Ma Jiayue Tang Ting Hou Sheng Zhang Li Yin Huan Chen Yanglong Hou Ya Ding | 2022 | Nano Research2022，15，5： | 0 |
| 20 | Low temperature one-pot synthesis of 1,1-diethoxyethane from ethanol on Bi/BiCeO_(x)with strong metal-support interactions显示文摘The direct conversion of ethanol to 1,1-diethoxyethane(DEE)through one-pot dehydrogenation-acetalization has attracted broad interest from both academia and industry.Based on thermodynamics,the oxidative dehydrogenation of alcohol to acetaldehyde requires high temperature to activate oxygen to realize the C-H cleavage,while the acetalization of acetaldehyde with ethanol is exothermic reversible reaction favorable at low temperature.The mismatching of the reaction condition for the two consecutive steps makes it a great challenge to achieve both high ethanol conversion and high DEE selectivity.This work reports a highly efficient bi-functional catalysis by Bi/BiCeO_(x)for one-pot oxidative dehydrogenation-acetalization route from ethanol to DEE under 150℃and ambient pressure,affording a selectivity of 98.5%±0.5%to DEE at an ethanol conversion of 87.0%±1.0%.An efficient tandem catalysis has been achieved on the interfacial Bi^(δ)+-Ov-Ce^(III)sites in Bi/BiCeO_(x)established by strong metal-support interaction,in which Biδ+-Ov-sites contribute to the oxidative dehydrogenation of ethanol at mild temperature,and-Ov-CeIII sites to the subsequent acetalization between the generated acetaldehyde and ethanol. | Zhe An Jiayu Liu Meng Cao Jian Zhang Yanru Zhu Hongyan Song Xu Xiang Jing He | 2023 | Nano Research2023，16，3： | 0 |
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