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| 1 | Comparison of Pb(Ⅱ) and Cd(Ⅱ) micro-interfacial adsorption on fine sediment in the Pearl River Basin, China显示文摘The complex micro-interfacial interaction theories of heavy metal ions such as Pb(Ⅱ)and Cd(Ⅱ)adsorption on fine sediment in aqueous solution were not systematically investigated.The aim of this work was to reflect the micro-interfacial adsorption characteristics.Sediment samples were collected from an estuary.The Isothermal and kinetics adsorption experiment were done to acquire the data.Isothermal,kinetics,film diffusion and intraparticle diffusion models were adopted to fit the adsorption experimental data.The results indicated that the Langmuir,Freundlich and Temkin models were suitable for analyzing the isothermal experimental data.The maximum adsorption capacities of Pb(Ⅱ)and Cd(Ⅱ)on the sediment were 1.1377 and 0.9821 mg·g-1,respectively.The qm and KL of the Langmuir model,Kf and nF of the Freundlich model,and b and A of the Temkin model all exhibited a power function relationship with the initial adsorbate concentration.The pseudo-second-order model provided a better fit for the experimental kinetics data compared with the fit of the pseudo-first-order and Elovich models.The pseudo-second-order parameters k2 and qe of Pb(Ⅱ)and qe of Cd(Ⅱ)both had a power function relationship with adsorption time,additionally,the k2 of Cd(Ⅱ)had an exponential function relationship with adsorption time.The liquid-film diffusion parameters kfd of Pb(Ⅱ)and Cd(Ⅱ)were 0.0569 and 0.1806 min1,respectively.The intraparticle diffusion parameter kid values of Pb(Ⅱ)and Cd(Ⅱ)were 0.0055 mg$g1$min1/2 and 0.0049 mg$g1$min1/2,respectively.The physical significance of the model parameters showed that Pb(Ⅱ)adsorption on sediment was stronger than Cd(Ⅱ).The results of this study provided a theoretical reference for the micro-interfacial mechanism of heavy metal ion adsorption on sediment. | Qunsheng Fang Zhihe Chen Jianpeng Zheng Zhihua Zhu | 2021 | International Journal of Sediment Research2021，36，3： | 5 |
| 2 | First stirling-type cryocooler reaching lambda point of ~4He(2.17K) and its prospect in Chinese HUBS satellite project显示文摘The issue of 'missing baryons” is always an unsolved mystery in galaxy cosmology, and an important reason for the great uncertainty of the galaxies' formation and evolution. To find the 'missing' baryons, extra high-resolution spectral observation and imaging of the soft X-ray band (<1 kev) is required. However, the existing observation methods cannot meet this requirement. Therefore, Tsinghua University leads and proposes the Chinese 'Hot Universe Baryon Surveyor (HUBS)' satellite program. | Jue Wang Changzhao Pan Tong Zhang Kaiqi Luo Xiaotong Xi Xianlin Wu Jianpeng Zheng Liubiao Chen Junjie Wang Yuan Zhou Hai Jin Wei Cui | 2019 | Science Bulletin2019，64，4： | 3 |
| 3 | A novel cryogenic insulation system of hollow glass microspheres and self-evaporation vapor-cooled shield for liquid hydrogen storage显示文摘Liquid hydrogen(LH2)attracts widespread attention because of its highest energy storage density.However,evaporation loss is a serious problem in LH2 storage due to the low boiling point(20 K).Efficient insulation technology is an important issue in the study of LH2 storage.Hollow glass microspheres(HGMs)is a potential promising thermal insulation material because of its low apparent thermal conductivity,fast installation(Compared with multi-layer insulation,it can be injected in a short time.),and easy maintenance.A novel cryogenic insulation system consisting of HGMs and a selfevaporating vapor-cooled shield(VCS)is proposed for storage of LH2.A thermodynamic model has been established to analyze the coupled heat transfer characteristics of HGMs and VCS in the composite insulation system.The results show that the combination of HGMs and VCS can effectively reduce heat flux into the LH2 tank.With the increase of VCS number from 1 to 3,the minimum heat flux through HGMs decreases by 57.36%,65.29%,and 68.21%,respectively.Another significant advantage of HGMs is that their thermal insulation properties are not sensitive to ambient vacuum change.When ambient vacuum rises from 10^-3 Pa to 1 Pa,the heat flux into the LH2 tank increases by approximately 20%.When the vacuum rises from 10^-3 Pa to 100 Pa,the combination of VCS and HGMs reduces the heat flux into the tank by 58.08%-69.84% compared with pure HGMs. | Jianpeng ZHENG Liubiao CHEN Ping WANG Jingjie ZHANG Junjie WANG Yuan ZHOU | 2020 | Frontiers in Energy2020，14，3： | 3 |
| 4 | Immune response triggered by the ablation of hepatocellular carcinoma with nanosecond pulsed electric field显示文摘Nanosecond pulsed electric field(nsPEF)is a novel,nonthermal,and minimally invasive modality that can ablate solid tumors by inducing apoptosis.Recent animal experiments show that nsPEF can induce the immunogenic cell death of hepatocellular carcinoma(HCC)and stimulate the host’s immune response to kill residual tumor cells and decrease distant metastatic tumors.nsPEF-induced immunity is of great clinical importance because the nonthermal ablation may enhance the immune memory,which can prevent HCC recurrence and metastasis.This review summarized the most advanced research on the effect of nsPEF.The possible mechanisms of how locoregional nsPEF ablation enhances the systemic anticancer immune responses were illustrated.nsPEF stimulates the host immune system to boost stimulation and prevail suppression.Also,nsPEF increases the dendritic cell loading and inhibits the regulatory responses,thereby improving immune stimulation and limiting immunosuppression in HCC-bearing hosts.Therefore,nsPEF has excellent potential for HCC treatment. | Jianpeng Liu Xinhua Chen Shusen Zheng | 2021 | Frontiers of Medicine2021，15，2： | 2 |
| 5 | Dynamics of Anchor Last Deployment of Submersible Buoy System显示文摘Submersible buoy systems are widely used for oceanographic research,ocean engineering and coastal defense.Severe sea environment has obvious effects on the dynamics of submersible buoy systems.Huge tension can occur and may cause the snap of cables,especially during the deployment period.This paper studies the deployment dynamics of submersible buoy systems with numerical and experimental methods.By applying the lumped mass approach,a three-dimensional multi-body model of submersible buoy system is developed considering the hydrodynamic force,tension force and impact force between components of submersible buoy system and seabed.Numerical integration method is used to solve the differential equations.The simulation output includes tension force,trajectory,profile and dropping location and impact force of submersible buoys.In addition,the deployment experiment of a simplified submersible buoy model was carried out.The profile and different nodes' velocities of the submersible buoy are obtained.By comparing the results of the two methods,it is found that the numerical model well simulates the actual process and conditions of the experiment.The simulation results agree well with the results of the experiment such as gravity anchor's location and velocities of different nodes of the submersible buoy.The study results will help to understand the conditions of submersible buoy's deployment,operation and recovery,and can be used to guide the design and optimization of the system. | ZHENG Zhongqiang XU Jianpeng HUANG Peng WANG Lei YANG Xiaoguang CHANG Zongyu | 2016 | Journal of Ocean University of China2016，15，1： | 1 |
| 6 | Inhibition of glypican-3 expression via RNA interference influencesthe growth and invasive ability of the MHCC97-H human hepatocellular carcinomacell line显示文摘 | Jian Ruan Feiye Liu Xiaohua Chen Peng Zhao Ning Su Guozhu Xie Jianpeng Chen Dayong Zheng Rongcheng Luo | 2011 | International Journal of Molecular Medicine2011，，4： | 1 |
| 7 | Reduced functional connectivity in early-stage drug-naive Parkinson’s disease: a resting-state fMRI study显示文摘 | ChunYan Luo Wei Song Qin Chen ZhenZhen Zheng Ke Chen Bei Cao Jing Yang JianPeng Li XiaoQi Huang QiYong Gong Hui-Fang Shang | 2014 | Neurobiology of Aging2014，，2： | 1 |
| 8 | Impact of hepatitis B vaccination among children in Guangdong Province, China显示文摘 | Jianpeng Xiao Jikai Zhang Chenggang Wu Xiaoping Shao Guowen Peng Zhiqiang Peng Wenjun Ma Yonghui Zhang Huizhen Zheng | 2012 | International Journal of Infectious Diseases2012，，9： | 1 |
| 9 | Turning weak into strong: on the CTAB-induced active surface growth显示文摘Discovering new methods and principles in the inequivalent growth of equivalent facets is of great significance for going beyond symmetrical nanocrystals and for out-of-box exploration. In this work, we demonstrate that a middle ground exists between the traditional weak ligands and the strong ligands with unusual growth modes. By modifying the seed concentration during the growth of pentagonal Au nanorods, the typical weak ligand cetyltrimethylammonium bromide(CTAB) is made strong, leading to notches of restricted growth and even the active surface growth mode. In-depth investigation in the link between growth kinetics and ligand packing reveals the principle of their interplay —— that the on-off dynamics of the ligands only allows for a certain limit of materials deposition rate. Beyond this limit, the growth materials build up and are then diverted elsewhere, leading to inequivalent growth. The fact that a freshly grown surface has few ligands promotes the active surface growth, focusing the growth materials onto a few sites. We believe that the knowhow of interfering ligand packing via growth kinetics would offer a powerful tool of synthetic control, where the facet-and curvature-dependent ligand packing is expected to be useful synthetic handles. | Yonglong Zheng Jianpeng Zong Ting Xiang Quan Ren Dongmeng Su Yuhua Feng Yawen Wang Hongyu Chen | 2022 | Science China Chemistry2022，65，7： | 0 |
| 10 | Qianjin Wenwu decoction suppresses renal interstitial fibrosis by enhancing the degradation of extracellular matrix in mice with unilateral ureteral obstruction显示文摘Diabetic kidney disease(DKD)is the most common complication of diabetes mellitus(DM).Qianjin Wenwu decoction(QWD),a well-known traditional Korean medicine,has been used for the treatment of DKD,with satisfactory therapeutic effects.This study was designed to investigate the active components and mechanisms of action of QWD in the treatment of DKD.The results demonstrated that a total of 13 active components in five types were found in QwD,including flavonoids,flavonoid glycosides,phenylpropionic acids,saponins,coumarins,and lignins.Two key proteins,TGF-β1 and TIMP-1,were identified as the target proteins through molecular docking.Furthermore,QWD significantly suppressed Scr and BUN levels which increased after unilateral ureteral obstruction(UUO).Hematoxylin&eosin(H&E)and Masson staining results demonstrated that QWD significantly alleviated renal interstitial fibrosis in UUO mice.We also found that QWD promoted ECM degradation by regulating MMP-9/TIMP-1 homeostasis to improve renal tubulointerstitial fibrosis and interfere with the expression and activity of TGF-βl in DKD treatment.These findings explain the underlying mechanism of QWD for the treatment of DKD,and also provide methodological reference for investigating the mechanism of traditional medicine in the treatment of DKD. | JIN Chengshan WU Xiaotian YOU Yue WANG Yuing WU Jing ZUO Along ZHENG Yan GUO Jianpeng | 2023 | Chinese Journal of Natural Medicines2023，21，4： | 0 |
| 11 | In vivo imaging of the neuronal response to spinal cord injury:a narrative review显示文摘Deciphering the neuronal response to injury in the spinal cord is essential for exploring treatment strategies for spinal cord injury(SCI).However,this subject has been neglected in part because appropriate tools are lacking.Emerging in vivo imaging and labeling methods offer great potential for observing dynamic neural processes in the central nervous system in conditions of health and disease.This review first discusses in vivo imaging of the mouse spinal cord with a focus on the latest imaging techniques,and then analyzes the dynamic biological response of spinal cord sensory and motor neurons to SCI.We then summarize and compare the techniques behind these studies and clarify the advantages of in vivo imaging compared with traditional neuroscience examinations.Finally,we identify the challenges and possible solutions for spinal cord neuron imaging. | Junhao Deng Chang Sun Ying Zheng Jianpeng Gao Xiang Cui Yu Wang Licheng Zhang Peifu Tang | 2024 | Neural Regeneration Research2024，19，4： | 0 |
| 12 | Discovering metabolic vulnerability using spatially resolved metabolomics for antitumor small molecule-drug conjugates development as a precise cancer therapy strategy显示文摘Against tumor-dependent metabolic vulnerability is an attractive strategy for tumor-targeted therapy.However,metabolic inhibitors are limited by the drug resistance of cancerous cells due to their metabolic plasticity and heterogeneity.Herein,choline metabolism was discovered by spatially resolved metabolomics analysis as metabolic vulnerability which is highly active in different cancer types,and a choline-modified strategy for small molecule-drug conjugates(SMDCs)design was developed to fool tumor cells into indiscriminately taking in choline-modified chemotherapy drugs for targeted cancer therapy,instead of directly inhibiting choline metabolism.As a proof-of-concept,choline-modified SMDCs were designed,screened,and investigated for their druggability in vitro and in vivo.This strategy improved tumor targeting,preserved tumor inhibition and reduced toxicity of paclitaxel,through targeted drug delivery to tumor by highly expressed choline transporters,and site-specific release by carboxylesterase.This study expands the strategy of targeting metabolic vulnerability and provides new ideas of developing SMDCs for precise cancer therapy. | Xiangyi Wang Jin Zhang Kailu Zheng Qianqian Du Guocai Wang Jianpeng Huang Yanhe Zhou Yan Li Hongtao Jin Jiuming He | 2023 | Journal of Pharmaceutical Analysis2023，13，7： | 0 |
| 13 | MOF-derived Se doped MnS/Ti_(3)C_(2)T_(x) as cathode and Zn-Ti_(3)C_(2)T_(x) membrane as anode for rocking-chair zinc-ion battery显示文摘Mn-based zinc ion battery has the advantages of low cost and high performance,which makes it the promising energy storage system.However,the poor conductivity and the agglomeration in the synthesis process of manganese-based materials restrict the performance of batteries.Herein,the Se-doped MnS/Ti_(3)C_(2)T_(x)(Se-MnS/Ti_(3)C_(2)T_(x))composite material derived from Mn-based metal-organic framework is reported.Electrochemical tests show that Se-doped could generate S defects and enhance the electrochemical activity of MnS.At the same time,the introduction of Ti_(3)C_(2)T_(x) substrate is conducive to exposing more sulfur defects and improving the utilization rate of defects.In the mechanism study,it is found that Se-MnS/Ti_(3)C_(2)T_(x) is transformed into S/Se co-doped Mn3O_(4) at the first charge,which innovatively elucidated the behavior of S/Se during activation.In the electrochemical performance test,the specific capacity can reach 74.7 mAh·g^(-1) at 5.0 A·g^(-1).In addition,the Zn-Ti_(3)C_(2)T_(x) membrane electrode is prepared by vacuum filtration as the zinc-poor anode,which is assembled into the rocking chair full battery to avoid dendrite growth and exhibit excellent rate performance.The addition of Zn2+weakens the electrostatic repulsion between the interlayers of MXene,and the formation of the folded morphology aids the penetration of the electrolyte.At 1.0 A·g^(-1),the capacity can reach 50.6 mAh·g^(-1).This work is helpful to promote the research and development of the reaction mechanism of manganese based rocking chair batteries. | Kaisheng Sun Zemao Xiao Yunfei Shen Heng Lv Jianpeng Zhu Jianxiang Pang Yang Zheng Wenwen Kong Long Chen | 2024 | Nano Research2024，17，4： | 0 |
| 14 | A Prediction Method for △f_0F_(2min) of a Single Station From Interplanetary Parameters Based on Statistical Study显示文摘Using 86 CME-interplanetary shock events,the correlation between the peak values of (a) the solar wind parameters(B_z,E_y,P_(dyn)) and the geomagnetic indices(SYM-H,ASY-H,Kp), (b) the coupling functions(Borovsky,Akasofu,Newell) and the geomagnetic indices,(c) the solar wind parameters/coupling functions/geomagnetic indices and the ionospheric parameter(Δf_0F_(2min)), are investigated.The statistical results show that in group(a),B_(z min) and SYM-H_(min) have the best correlation,that in group(b),the best correlation is between the peak values of Akasofu function (A_(min)) and SYM-H_(min),and that in group(c),the best correlation is between K_(pmax) andΔf_0F_(2min). Based on the statistical results,a method for predicting f_0F_2 of a single station is attempted to be set up.The input is modified B_(z min) and the outputs are SYM-H_(min) andΔf_0F_(2min).Then 25 CME-IPS events that caused geomagnetic storms in 1998 and 2009 are used to check the prediction method. The results show that our method can be used to predict SYM-H_(min) andΔf_0F_(2min). | LI Zheng WEI Fengsi FENG Xueshang GUO Jianpeng XU Xiaojun | 2012 | 空间科学学报2012，32，3： | 0 |
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