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| 1 | The secretion profile of mesenchymal stem cells and potential applications in treating human diseases显示文摘Mesenchymal stromal/stem cells(MSCs)possess multi-lineage differentiation and self-renewal potentials.MSCs-based therapies have been widely utilized for the treatment of diverse inflammatory diseases,due to the potent immunoregulatory functions of MSCs.An increasing body of evidence indicates that MSCs exert their therapeutic effects largely through their paracrine actions.Growth factors,cytokines,chemokines,extracellular matrix components,and metabolic products were all found to be functional molecules of MSCs in various therapeutic paradigms.These secretory factors contribute to immune modulation,tissue remodeling,and cellular homeostasis during regeneration.In this review,we summarize and discuss recent advances in our understanding of the secretory behavior of MSCs and the intracellular communication that accounts for their potential in treating human diseases. | Yuyi Han Jianxin Yang Jiankai Fang Yipeng Zhou Eleonora Candi Jihong Wang Dong Hua Changshun Shao Yufang Shi | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 6 |
| 2 | Plasmonic Refractive Index Sensors Based on One-and Two-Dimensional Gold Grating on a Gold Film显示文摘In this paper,we propose two kinds of composite structures based on the one-and two-dimensional(1D&2D)gold grating on a gold film for plasmonic refractive index sensing.The resonance modes and sensing characteristics of the composite structures are numerically simulated by the finite-difference time-domain method.The composite structure of the 1D gold semi-cylinder grating and gold film is analyzed first,and the optimized parameters of the grating period are obtained.The sensitivity and figure of merit(FOM)can reach 660 RIU/nm and 169 RIU-1,respectively.Then,we replace the 1D grating with the 2D gold semi-sphere particles array and find that the 2D grating composite structure can excite strong surface plasmon resonance intensity in a wider period range.The sensitivity and FOM of the improved composite structure can reach 985 RIU/nm and 298 RIU-1,respectively.At last,the comparison results of the sensing performance of the two structures are discussed.The proposed structures can be used for bio-chemical refractive index sensing. | Jiankai ZHU Xiangxian WANG Yuan WU Yingwen SU Tianxu JIA Hua YANG Liping ZHANG Yunping QI Xiaolei WEN | 2020 | Photonic Sensors2020，10，4： | 1 |
| 3 | Laser Additive Manufacturing of Bio-inspired Metallic Structures显示文摘High-performance/multifunctional metallic components primarily determine the service performance of equip-ment applied in the aerospace,aviation,and automobile industries.Organisms have developed structures with specific properties over millions of years of natural evolution,thereby providing inspiration for the design of high-performance structures to satisfy the increasing demands of modern industries.From the perspective of manufacturing,the ability of conventional processing technologies is inadequate for fabricating these complex structural configurations.By contrast,laser additive manufacturing(AM)is an effective method for fabricating complex metallic bio-inspired structures owing to its layer-by-layer deposition advantage.Herein,recent devel-opments in the laser AM of bio-inspired cellular,plate,and truss structures,as well as the materials used in laser AM for bio-inspired printing are briefly reviewed.The organisms being imitated include butterfly,Norway spruce,mantis shrimp,beetle,and water spider,which expand the diversity of multifunctional structures for laser AM.The mechanical properties and functions of laser-AM-processed bio-inspired structures are discussed.Additionally,the challenges,possible outcomes,and directions of utilizing laser AM technology to fabricate high-performance/multifunctional metallic bio-inspired structures in the future are outlined. | Jiankai Yang Dongdong Gu Kaijie Lin Yicha Zhang Meng Guo Luhao Yuan Han Zhang Hongmei Zhang | 2022 | Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers)2022，1，1： | 1 |
| 4 | Analyzing electrostatic modulation of signal transduction efficiency in MoS_(2) nanoelectromechanical resonators with interferometric readout显示文摘Optical interferometry is a highly sensitive method for detecting the miniscule resonant motion in two-dimensional(2D)nanoelectromechanical systems(NEMS).However,the technique to control the interferometry signal strength has not been fully understood.In this work,we present analytical modeling of an effective method for tuning motion-to-signal responsivity in interferometric detection of 2D molybdenum disulfide(MoS_(2))NEMS resonators.We show that the responsivity can be tuned very efficiently,all the way from maximum to 0,by varying the vacuum gap underneath the 2D membrane electrostatically.We further show that the gate voltage corresponding to 0 responsivity,which means no motion signal can be detected,varies with the MoS_(2)thickness,diameter,pre-strain,and initial vacuum gap.Our findings provide an important guideline for optimizing measurement conditions when detecting motion in 2D NEMS structures using laser interferometry. | Jiankai ZHU Pengcheng ZHANG Rui YANG Zenghui WANG | 2022 | Science China(Information Sciences)2022，65，2： | 0 |
| 5 | Effect of Different Calcination Temperatures on the Structure and Properties of Zirconium-Based Coating Layer Modified Cathode Material Li_(1.2)Mn_(0.54)Ni_(0.13)Co_(0.13)O_(2)显示文摘Lithium-rich manganese-based oxides have the advantages of high discharge specific capacity, so they are potential candidates for advanced lithium battery cathode materials. However, they also have drawbacks to be solved such as serious irreversible loss of capacity and voltage decay in the cycling process. Surface coating method was used in this paper to modify the lithium-rich manganese-based oxide(LRMO,Li_(1.2)Mn_(0.54)Ni_(0.13)Co_(0.13)O_(2)) to improve its electrochemical properties. Zirconium-based compounds coated LRMO materials(ZBC@LRMO) were obtained via the reaction of lithium hydroxide with zirconium n-butanol and subsequent thermal treatment at different temperatures. The results of X-ray diffraction and transmission electron microscopy confirm that the crystal structure and composition of the ZBC coating layer vary with the calcination temperature. The coating layer obtained at 600 ℃ is composed of tetragonal ZrO_(2) and Li_(2)ZrO_(3). The ZBC@LRMO sample with tetragonal ZrO =2 and Li_(2)ZrO_(3) composite exhibits the best electrochemical performance: the discharge capacity of ZBC@LRMO can reach 296 mAh g^(-1) at 0.1 C and 120 mAh g^(-1) at high rate of 5 C. | Zijun Liao Jiankai Kang Qi Luo Caifeng Pan Jiangdong Chen Xiaolong Mo Hanbo Zou Wei Yang Shengzhou Chen | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，6： | 0 |
| 6 | Electrically Actuated Shape Recovery of NiTi Components Processed by Laser Powder Bed Fusion after Regulating the Dimensional Accuracy and Phase Transformation Behavior显示文摘To develop self-recovery intelligent components based on resistance heating and obtain satisfactory performance in practical applications,this study optimized the forming quality,dimensional accuracy,and phase transformation temperatures of Nickel-titanium(NiTi)alloys by controlling the process parameters.The tensile properties and shape-memory effects of the NiTi alloys prepared using the optimized process were clarified.The relationship between the change in temperature and the shape recovery process of the deformed structure under electrical excitation was investigated.The results show that the suitable processing window for ensuring the forming quality without noticeable distortion and macro cracks depends on the laser parameters.In both the X and Y directions,the measured dimensions increased with an increase in laser power and first decreased and then stabilized with an increase in scanning speed.The XRD results showed that all the as-built samples consisted of B2 austenite and B19’martensite phases and Ni3Ti.Mechanical tests suggested that excellent tensile properties with a tensile strength of 753.28 MPa and elongation of 6.81%could be obtained under the optimal parameters of 250 W and 1200 mm/s.An excellent shape-recovery rate of 88.23%was achieved under the optimal parameters.Subsequently,chiral lattice structures were successfully fabricated by laser powder bed fusion(LPBF)under the optimal parameters,and a shape-recovery rate of 96.7%was achieved under electrical actuation for a structure with a pre-compressed strain of 20%.This study also found that the temperatures at the grasp regions were always higher than those at other positions because of the generation of contact resistance at the grasp regions.This facilitates the rapid recovery of the structure at the grasp regions,which has important implications for the design iteration of NiTi smart components. | Luhao Yuan Dongdong Gu Kaijie Lin He Liu Jianfeng Sun Jiankai Yang Xin Liu Wei Chen Yingjie Song | 2022 | Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers)2022，1，4： | 0 |
| 7 | The Application of CO2-EOR in Ultra-Low Permeability Reservoir显示文摘 | Bo Chi Min Li Xue Wang Zhaoyong Li Lifang Wu Shuyan Sun Jiankai Wang Yangxin Su Guinan Yang | 2014 | Journal of Earth Science and Engineering2014，4，5： | 0 |
| 8 | Cultivation of gut microorganisms of the marine ascidian Halocynthia roretzi reveals their potential roles in the environmental adaptation of their host显示文摘It has long been known that abundant symbiotic bacteria exist in the tunic and gut of marine ascidians,and that these play crucial roles in host development,physiological metabolism,and environmental adaptation.However,the identity,roles and functions of these symbiotic bacteria are known for only a few strains.In this study,we isolated and cultivated 263 strains of microorganisms from the intestine of the marine ascidian Halocynthia roretzi through a combination of aerobic and anaerobic culture approaches.Most cultivated species,both aerobic and anaerobic,from ascidian stool samples belonged to the genus Bacillus based on 16S rDNA sequencing identification and phylogenetic assays.The distribution of cultured bacteria varied with seasonal changes in environmental conditions.To explore the functions of cultured bacteria,we screened out a strain of Serratia sp.whose extracts showed high antibacterial activity against aquatic pathogens.These findings revealed the potential roles of gut microorganisms in ascidian defense and environmental adaptation,thus providing insights into the interaction and co-evolution between gut bacteria and their hosts. | Yang Yang Yuting Zhu Haiming Liu Jiankai Wei Haiyan Yu Bo Dong | 2022 | Marine Life Science & Technology2022，4，2： | 0 |
| 9 | Compressive mechanical properties and shape memory effect of NiTi gradient lattice structures fabricated by laser powder bed fusion显示文摘Laser additive manufacturing (AM) of lattice structures with light weight, excellent impact resistance, and energy absorption performance is receiving considerable attention in aerospace, transportation, and mechanical equipment application fields. In this study, we designed four gradient lattice structures (GLSs) using the topology optimization method, including the unidirectional GLS, the bi-directional increasing GLS, the bi-directional decreasing GLS and the none-GLS. All GLSs were manufactureed by laser powder bed fusion (LPBF). The uniaxial compression tests and finite element analysis were conducted to investigate the influence of gradient distribution features on deformation modes and energy absorption performance of GLSs. The results showed that, compared with the 45° shear fracture characteristic of the none-GLS, the unidirectional GLS, the bi-directional increasing GLS and the bi-directional decreasing GLS had the characteristics of the layer-by-layer fracture, showing considerably improved energy absorption capacity. The bi-directional increasing GLS showed a unique combination of shear fracture and layer-by-layer fracture, having the optimal energy absorption performance with energy absorption and specific energy absorption of 235.6 J and 9.5 J g-1 at 0.5 strain, respectively. Combined with the shape memory effect of NiTi alloy, multiple compression-heat recovery experiments were carried out to verify the shape memory function of LPBF-processed NiTi GLSs. These findings have potential value for the future design of GLSs and the realization of shape memory function of NiTi components through laser AM. | Wei Chen Dongdong Gu Jiankai Yang Qin Yang Jie Chen Xianfeng Shen | 2022 | International Journal of Extreme Manufacturing2022，4，4： | 0 |
| 10 | Biosynthesis and Immunological Evaluation of a Dual-Antigen Nanoconjugate Vaccine Against Brucella melitensis显示文摘Brucellosis,caused by Brucella,is one of the most common zoonosis.However,there is still no vaccine for human use.Although some live attenuated vaccines have been approved for animals,the protection effect is not ideal.In this study,we developed a dual-antigen nanoconjugate vaccine containing both polysaccharide and protein antigens against Brucella.First,the antigenic polysaccharide was covalently coupled to the outer membrane protein Omp19 using protein glycan coupling technology,and then it was successfully loaded on a nano-carrier through the SpyTag/SpyCatcher system.After confirming the efficient immune activation and safety performance of the dual-antigen nanoconjugate vaccine,the potent serum antibody response against the two antigens and remarkable protective effect in non-lethal and lethal Brucella infection models were further demonstrated through different routes of administration.These results indicated that the dual-antigen nanoconjugate vaccine enhanced both T helper 1 cell(Th1)and Th2 immune responses and protected mice from Brucella infection.Furthermore,we found that this protective effect was maintained for at least 18 weeks.To our knowledge,this is the first Brucella vaccine bearing diverse antigens,including a protein and polysaccharide,on a single nanoparticle.Thus,we also present an attractive technology for co-delivery of different types of antigens using a strategy applicable to other vaccines against infectious diseases. | Jing Huang Yufei Wang Kangfeng Wang Shulei Li Peng Sun Yan Guo Jiankai Liu Ruifu Yang Ming Zeng Chao Pan Hengliang Wang Li Zhu | 2023 | Engineering2023，，10： | 0 |
| 11 | Technical pathways of dual carbon control in China’s buildings sector显示文摘Reducing carbon emissions in the buildings sector is of great significance to the realization of China’s carbon peak and neutrality goals.By analyzing factors influencing buildings carbon emissions at the operational stage,this paper applies the China Building Carbon Emission Model(CBCEM)to make medium and long-term forecasts of China’s building operation carbon emissions,discussing the goals and realization paths of China’s dual carbon goals in the buildings sector.The results show that building operation carbon emissions,according to the current development model in the buildings sector,will peak in 2038-2040 with a peak carbon emission of about 3.15 billion tons of CO_(2);however,by 2060,carbon emissions will still be 2.72 billion tons of CO_(2),falling short of China’s dual carbon goals.The carbon saving effects of three scenarios,namely clean grid priority,building photovoltaic priority and energy efficiency enhancement priority,were measured and shown to be significant in all three scenarios,but the building photovoltaic priority and energy efficiency enhancement priority scenarios were superior in comparison. | Wei Xu Deyu Sun Jiankai Dong Shuai Huang Shuo Yang | 2022 | Carbon Neutrality2022，1，1： | 0 |
| 12 | Multitarget tracking control algorithm under local information selection interaction mechanism显示文摘This study focuses on the problem of multitarget tracking.To address the existing problems of current tracking algorithms,as manifested by the time consumption of subgroup separation and the uneven group size of unmanned aerial vehicles(UAVs)for target tracking,a multitarget tracking control algorithm under local information selection interaction is proposed.First,on the basis of location,number,and perceived target information of neighboring UAVs,a temporary leader selection strategy is designed to realize the local follow-up movement of UAVs when the UAVs cannot fully perceive the target.Second,in combination with the basic rules of cluster movement and target information perception factors,distributed control equations are designed to achieve a rapid gathering of UAVs and consistent tracking of multiple targets.Lastly,the simulation experiments are conducted in two-and three-dimensional spaces.Under a certain number of UAVs,clustering speed of the proposed algorithm is less than 3 s,and the equal probability of the UAV subgroup size after group separation is over 78%. | Jiehong Wu Jinghui Yang Weijun Zhang Jiankai Zuo | 2021 | Intelligent and Converged Networks2021，2，2： | 0 |
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