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| 1 | Clinical Progression of Incidental, Asymptomatic Lesions Discovered During Culprit Vessel Coronary Intervention显示文摘 | Ruchira Glaser Faith Selzer David P. Faxon Warren K. Laskey Howard A. Cohen James Slater Katherine M. Detre Robert L. Wilensky | 2005 | Circulation2005，，2： | 4 |
| 2 | Early surgery in Crohn's disease a benefit in selected cases显示文摘AIM: To compare the outcomes of a cohort of Crohn's disease(CD) patients undergoing early surgery(ES) to those undergoing initial medical therapy(IMT).METHODS: We performed a review of a prospective database CD patients managed at a single tertiary institution. Inclusion criteria were all patients with ileal or ileocolonic CD between 1995-2014. Patients with incomplete data, isolated colonic or perianal CD were excluded. Primary endpoints included the need for, and time to subsequent surgery. Secondary endpoints included the number and duration of hospital admissions, and medical therapy. RESULTS: Forty-two patients underwent ES and 115 underwent IMT. The operative intervention rate at 5 years in the ES group was 14.2% vs IMT 31.3%(HR = 0.41, 95%CI: 0.23-0.72, P = 0.041). The ES group had fewer hospital admissions per patient [median 1 vs 3(P = 0.012)] and fewer patients required anti-TNF therapy than IMT(33.3% vs 57%, P = 0.003). A subgroup analysis of 62 IMT patients who had undergone surgery were compared to ES patients, and showed similar 5 year(from index surgery) re-operation rates 16.1% vs 14.3%. In this subset, a significant difference was still found in median number of hospital admissions favouring ES, 1 vs 2(P = 0.002).CONCLUSION: Our data supports other recent studies suggesting that patients with ileocolonic CD may have a more benign disease course if undergoing early surgical intervention, with fewer admissions to hospital and atrend to reduced overall operation rates. | Vinna An Lauren Cohen Matthew Lawrence Michelle Thomas Jane Andrews James Moore | 2016 | World Journal of Gastrointestinal Surgery2016，8，7： | 3 |
| 3 | Cardiovascular Function and Treatment in β-Thalassemia Major: A Consensus Statement From the American Heart Association显示文摘 | Dudley J. Pennell James E. Udelson Andrew E. Arai Biykem Bozkurt Alan R. Cohen Renzo Galanello Timothy M. Hoffman Michael S. Kiernan Stamatios Lerakis Antonio Piga John B. Porter John Malcolm Walker John Wood | 2013 | Circulation2013，，3： | 3 |
| 4 | Induction and Maintenance Therapy With Infliximab for Children With Moderate to Severe Ulcerative Colitis显示文摘 | Jeffrey Hyams Lakshmi Damaraju Marion Blank Jewel Johanns Cynthia Guzzo Harland S. Winter Subra Kugathasan Stanley Cohen James Markowitz Johanna C. Escher Gigi Veereman–Wauters Wallace Crandall Robert Baldassano Anne Griffiths | 2012 | Clinical Gastroenterology and Hepatology2012，，4： | 3 |
| 5 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 6 | Tolerance: Is It Worth the Risk?显示文摘 | James D. Eason Ari J. Cohen Satheesh Nair Teresita Alcantera George E. Loss | 2005 | Transplantation2005，，9： | 2 |
| 7 | Do medical students studying in the United Kingdom have an adequate factual knowledge of basic life support?显示文摘BACKGROUND: Healthcare professionals have a duty to maintain basic life support(BLS) skills. This study aims to evaluate medical students' factual knowledge of BLS and the training they receive.METHODS: A cross-sectional, closed-response questionnaire was distributed to the fi rst-and fourth-year students studying at institutions in the United Kingdom. The paper questionnaire sought to quantify respondent's previous BLS training, factual knowledge of the BLS algorithm using five multiple choice questions(MCQs), and valuate their desire for further BLS training. Students received 1 point for each correctly identifi ed answer to the 5 MCQ's.RESULTS: A total of 3,732 complete responses were received from 21 medical schools. Eighty percent(n=2,999) of students completed a BLS course as part of their undergraduate medical studies. There was a signifi cant difference(P<0.001) in the percentage of the fourth-year students selecting the correct answer in all the MCQ's compared to the fi rst-year students except in identifyingthe correct depth of compressions required during CPR(P=0.095). Overall 10.3%(95% CI 9.9% to 10.7%) of respondents correctly identified the answer to 5 MCQ's on BLS: 9% of the first-year students(n=194) and 12% of the fourth-year students(n=190). On an institutional level the proportion of students answering all MCQ's correctly ranged from 2% to 54% at different universities. Eighty-one percent of students(n=3,031) wished for more BLS training in their curriculum.CONCLUSION: Factual knowledge of BLS is poor among medical students in the UK. There is a disparity in standards of knowledge across institutions and respondents indicating that they would like more training. | Robert D.Willmore Damjan Veljanoski Feray Ozdes Bethan Stephens James Mooney Seamus G.Crumley Arpan Doshi Philippa Davies Shreya Badhrinarayanan Emily Day Kristian Tattam April Wilson Nathan Crang Lorna Green Craig A.Mounsey Howell Fu Joseph Williams Michelle S.D'souza Dhanya Sebastian Liam A.Mcgiveron Matthew G.Percy James Cohen Imogen J.John Alice Lethbridge Imogen Watkins Omar Amin Mubasher A.Qamar John Gerrard Hanrahan Emily Cramond-Wong | 2019 | World Journal of Emergency Medicine2019，10，2： | 2 |
| 8 | Acidosis, oxygen, and interference with mitochondrial permeability transition pore formation in the early minutes of reperfusion are critical to postconditioning’s success显示文摘 | Michael V. Cohen MD Xi-Ming Yang James M. Downey | 2008 | Basic Research in Cardiology2008，，5： | 2 |
| 9 | Bidirectional effect of Wnt signaling antagonist DKK1 on the modulation of anthrax toxin uptake显示文摘LRP6,a co-receptor for the morphogen Wnt,aids endocytosis of anthrax complexes.Here we report that Dickkopf1(DKK1)protein,a secreted LRP6 ligand and antagonist,is also a modulator of anthrax toxin sensitivity.shRNA-mediated gene silencing or TALEN-mediated gene knockout of DKK1 reduced sensitivity of cells to PA-dependent hybrid toxins.However,unlike the solely inhibitory effect on Wnt signaling,the effects of DKK1 overexpression on anthrax toxicity were bidirectional,depending on its endogenous expression and cell context.Fluorescence microscopy and biochemical analyses showed that DKK1 facilitates internalization of anthrax toxins and their receptors,an event mediated by DKK1-LRP6-Kremen2 complex.Monoclonal antibodies against DKK1 provided dose-dependent protection to macrophages from killing by anthrax lethal toxin(LT).Our discovery that DKK1 forms ternary structure with LRP6 and Kremen2 in promoting PA-mediated toxin internalization provides a paradigm for bacterial exploitation of mechanisms that host cells use to internalize signaling proteins. | QIAN LiLi CAI ChangZu YUAN PengFei JEONG Sun-Young YANG XiaoZhou DEALMEIDA Venita ERNST James COSTA Michael COHEN Stanley N. WEI WenSheng | 2014 | Science China(Life Sciences)2014，57，5： | 2 |
| 10 | AGA Institute Review of Endoscopic Sedation显示文摘 | Lawrence B. Cohen Mark H. DeLegge James Aisenberg Joel V. Brill John M. Inadomi Michael L. Kochman Joseph D. Piorkowski | 2007 | Gastroenterology2007，，2： | 2 |
| 11 | Potential of Blood Eosinophils, Eosinophil-Derived Neurotoxin, and Eotaxin-3 as Biomarkers of Eosinophilic Esophagitis显示文摘 | Michael R. Konikoff Carine Blanchard Cassie Kirby Bridget K. Buckmeier Mitchell B. Cohen James E. Heubi Philip E. Putnam Marc E. Rothenberg | 2006 | Clinical Gastroenterology and Hepatology2006，，： | 1 |
| 12 | Percutaneous Coronary Intervention in the Current Era Compared With 1985–1986: The National Heart, Lung, and Blood Institute Registries显示文摘 | David O. Williams Richard Holubkov Wanlin Yeh Martial G. Bourassa Mahdi Al-Bassam Peter C. Block Paul Coady Howard Cohen Michael Cowley Gerald Dorros David Faxon David R. Holmes Alice Jacobs Sheryl F. Kelsey Spencer B. King Richard Myler James Slater Vlad | 2000 | Circulation: Journal of the American Heart Association2000，，24： | 1 |
| 13 | A practical guide to assessment of ventricular diastolic function using doppler echocardiography显示文摘 | Gerald I. Cohen Joseph F. Pietrolungo James D. Thomas Allan L. Klein | 1996 | Journal of the American College of Cardiology1996，，7： | 1 |
| 14 | An evaluation of the president' s emergency plan for AIDS relief effect on health systems strengthening in Sub-Saharan Africa显示文摘 | Robert L Cohen Yuanzhang Li Russell Giese James D Mancuso | 2013 | Epidemiology and Prevention2013，62，4： | 1 |
| 15 | Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch显示文摘 | Paul Cohen Julia D. Levy Yingying Zhang Andrea Frontini Dmitriy P. Kolodin Katrin J. Svensson James C. Lo Xing Zeng Li Ye Melin J. Khandekar Jun Wu Subhadra C. Gunawardana Alexander S. Banks Jo?o Paulo G. Camporez Michael J. Jurczak Shingo Kajimura David | 2013 | Cell2013，，： | 1 |
| 16 | Practice Parameters for the Management of Hemorrhoids (Revised)显示文摘 | Peter Cataldo M.D. C. Neal Ellis M.D. Sharon Gregorcyk M.D. Neil Hyman M.D. W. Donald Buie M.D. James Church M.D. Jeffrey Cohen M.D. Phillip Fleshner M.D. John Kilkenny M.D. Clifford Ko M.D. David Levien M.D. Richard Nelson M.D. Graham Newstead M.D. Charl | 2005 | Diseases of the Colon & Rectum2005，，2： | 1 |
| 17 | Practice Parameters for Colon Cancer显示文摘 | Daniel Otchy Neil H. Hyman Clifford Simmang Thomas Anthony Donald W. Buie Peter Cataldo James Church Jeffrey Cohen Frederick Dentsman Neal C. Ellis John W. Kilkenny Clifford Ko Richard Moore Charles Orsay Ronald Place Janice Rafferty Jan Rakinic Paul Savo | 2004 | Diseases of the Colon & Rectum2004，，： | 1 |
| 18 | Surface roughness and friction coefficient in peened friction stir welded 2195 aluminum alloy 显示文摘 | Omar Hatamleh James Smith Donald Cohen | 2009 | Applied Surface Science2009，255，： | 1 |
| 19 | Cognitive function in morbidly obese individuals with and without binge eating disorder显示文摘 | Rachel Galioto Mary Beth Spitznagel Gladys Strain Michael Devlin Ronald Cohen Robert Paul Ross D. Crosby James E. Mitchell John Gunstad | 2012 | Comprehensive Psychiatry2012，，5： | 1 |
| 20 | Assessing the impact of temperature on grape phenolic metabolism显示文摘 | Seth D. Cohen Julie M. Tarara James A. Kennedy | 2007 | Analytica Chimica Acta2007，，1： | 1 |
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