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| 1 | Genomic insights into the ESBL and MCR-l-producing ST648 Escherichia coli with multi-drug resistance显示文摘多粘菌素由 multidrug 抵抗的克否定的病原体对严重感染充当避难处的一根最终的线。这个常规想法被活动 colistin 抵抗基因(mcr-1 ) 的最近的发现戏剧性地质问在食物动物和世界范围的人是流行的。更重要地, mcr-1 基因被发现与另外的抗菌素抵抗基因 co 局部性,提起可能性与平底锅药抵抗超级臭虫正在出现。然而,很少在 mcr-1-positive 的染色体上被报导细菌的主人水库。这里,我们报导三个人定序的染色体 mcr-1-positive Escherichia coli (E15004, E15015 和 E15017 ) 孤立并且通过细菌的比较 genomics 的分析定义一般特征。和顺序打字的进一步的 genomic 采矿允许我们阐明 MCR-1-carrying E。coli E15017 属于顺序类型 ST648 和 coproduces 扩大光谱的 -lactamase (ESBL ) 。给 ST648 与任何一个新德里 metallo 为伙伴所知的事实 -- lactamase 1 或 ESBL,我们的结果与 multidrug 电阻作为流行克隆加亮 ST648 的可能性。 | Huimin Zhang Christopher H. Seward Zuowei Wu Huiyan Ye Youjun Feng | 2016 | Science Bulletin2016，61，11： | 4 |
| 2 | Fabrication of TiO 2 /ZnO composite nanofibers by electrospinning and their photocatalytic property显示文摘 | Ruilai Liu Huiyan Ye Xiaopeng Xiong Haiqing Liu | 2010 | Materials Chemistry and Physics2010，，3： | 2 |
| 3 | A medical image 3 D recon- struction method based on improved MC and MT algorithms 显示文摘 | Huiyan Jiang Ye Zhang Yudong Zhao | 2009 | Industrial Electronics and Applications2009，，2527： | 1 |
| 4 | Practical identity-based aggregate signature scheme from bilinear maps 显示文摘 | Wang Zhu Chen Huiyan Ye Dingfeng | 2008 | Journal of Shanghai Jiaotong University: English Edition2008，13，6： | 1 |
| 5 | Suppression of cell pyroptosis by omeprazole through PDE4-mediated autophagy in gastric epithelial cells显示文摘Helicobacter pylori is a risk factor for the development of peptic ulcers with autophagy dysfunction.Omeprazole was widely known as the first-line regimen for H.pylori-associated gastritis.Objectives:The objective of this work was to assess the role of omeprazole on cell pyroptosis and autophagy.Methods:The clinical samples were collected.Quantitative polymerase chain reaction,western blotting,enzyme linked immunosorbent assay,and immunofluorescence(IF)analysis were conducted to reveal the mechanism of omeprazole on cell pyroptosis and autophagy.Results:The results revealed that omeprazole could decrease cell pyroptosis,which was attributed to the downregulation of cleaved caspase-1 expression,resulting in the inhibition of gasdermin E and interleukin-18/1βmaturation and secretion as well as the resolution of inflammation.Mechanistically,omeprazole treatment led to drastic downregulation of mammalian target of rapamycin(mTOR)activity was observed in BGC823 cells,leading to enhanced autophagy characterized by increased LC3II expression,which further reduced cell pyroptosis.This omeprazole-mediated phenomenon was enhanced after phosphodiesterase-4(PDE4)inhibitor dipyridamole(DIP)treatment.In addition,activation of mTOR by MHY1485 could rescue the suppression of cell pyroptosis induced by omeprazole.Most importantly,IF analysis suggested that phosphorylation of mTOR and PDE4 activity and caspase-1 were enhanced in H.pylori-infected gastric mucosa.Conclusion:These findings indicate that omeprazole suppresses cell pyroptosis through PDE4-mediated autophagy in gastric epithelial cells,and DIP enhanced the omeprazole-mediated inhibition of cell pyroptosis,implying that DIP is an alternative combined therapy strategy in improving the treatment of patients with H.pylori infection. | LIPING YE HUIYAN SUN XINHUA LIANG WENXU PAN LI XIANG WENJUN DU LANLAN GENG WANFU XU SITANG GONG | 2023 | BIOCELL2023，47，12： | 0 |
| 6 | A new glimpse of FadR-DNA crosstalk revealed by deep dissection of the E. coil FadR regulatory protein显示文摘 | Yongchang Zhang | 2014 | Protein & Cell2014，5，12： | 0 |
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