|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | Extra-wide bandwidth via complementary exchange resonance and dielectric polarization of sandwiched FeNi@SnO_(2)nanosheets for electromagnetic wave absorption显示文摘Advanced electromagnetic(EM)wave absorbers with wide bandwidth is crucial to avoid EM interference and radiation,while achieving compensatio nal attenuation at different frequencies is challe nging.Herein,two-dimensional(2 D)sandwiched FeNi@SnO_(2)have been designed,for which SnO_(2)nanosheets provide numerous heterogeneous nucleation sites for the growth of dispersive FeNi nanoparticles with reduced size.The SnO_(2)exhibits dipole polarization at 21.45 GHz with a width of~4.00 GHz,while the FeNi nanoparticles induce excha nge resonance at 18.13 GHz(~6.00 GHz width)and interfacial polarization at15.97 GHz(~6.00 GHz width).Such complementary attenuation mechanisms give rise to an impressive ultra-wide effective absorption bandwidth of 11.70 GHz with strong absorption of-49.1 dB at a small thickness of 1.75 mm.Not only superior EM wave absorption is achieved in this work,it also provides a versatile strategy to integrate different loss mechanisms in the design of EM wave absorbers with extra-wide bandwidth. | Huipeng Lv Chen Wu Faxiang Qin Huaxin Peng Mi Yan | 2021 | Journal of Materials Science & Technology2021，，31： | 4 |
| 3 | Band-tailored van der Waals heterostructure for multilevel memory and artificial synapse显示文摘Two-dimensional(2D)van der Waals heterostructure(vdWH)-based floating gate devices show great potential for next-generation nonvolatile and multilevel data storage memory.However,high program voltage induced substantial energy consumption,which is one of the primary concerns,hinders their applications in lowenergy-consumption artificial synapses for neuromorphic computing.In this study,we demonstrate a three-terminal floating gate device based on the vdWH of tin disulfide(SnS2),hexagonal boron nitride(h-BN),and few-layer graphene.The large electron affinity of SnS2 facilitates a significant reduction in the program voltage of the device by lowering the hole-injection barrier across h-BN.Our floating gate device,as a nonvolatile multilevel electronic memory,exhibits large on/off current ratio(105),good retention(over 104 s),and robust endurance(over 1000 cycles).Moreover,it can function as an artificial synapse to emulate basic synaptic functions.Further,low energy consumption down to7 picojoule(pJ)can be achieved owing to the small program voltage.High linearity(<1)and conductance ratio(80)in long-term potentiation and depression(LTP/LTD)further contribute to the high pattern recognition accuracy(90%)in artificial neural network simulation.The proposed device with attentive band engineering can promote the future development of energy-efficient memory and neuromorphic devices. | Yanan Wang Yue Zheng Jing Gao Tengyu Jin Enlong Li Xu Lian Xuan Pan Cheng Han Huipeng Chen Wei Chen | 2021 | InfoMat2021，3，8： | 3 |
| 4 | RNA interference-mediated silencing of vATPase subunits A and E affect survival and development of the 28-spotted ladybeetle,Henosepilachna vigintioctopunctata显示文摘RNA interference(RNAi)has emerged as a powerful tool for developing novel management strategies for controlling insect pests.The 28-spotted ladybeetle,Henosepilachna vigintioctopunctata is one of the most important pests attacking solanaceous plants in Asia.In this study,the potential of dietary RNAi to manage H.vigintioctopunctata was investigated using both in vitro synthesized and bacterially expressed double-stranded RNAs(dsRNAs)of HvvATPase A and HvvATPase E.The expression levels of HvvATPase A and HvvATPase E were higher in Malpighian tubules than in other tissue types.The silencing of HvvATPase A and HvvATPase E led to significant mortality in H.vigintioctopunctata larvae.In addition,the ingestion of HvvATPase A and HvvATPase E significantly deterred feeding behavior and subsequently arrested the development of H.vigintioctopunctata.Notably,the bacterially expressed dsRNAs consistently caused higher mortality in larvae and adults.Finally,the nontarget effects of the dsRNAs of H.vigintioctopunctata on the predatory ladybeetle Propylaea japonica were evaluated.P.japonica 1st instar larvae were administered vATPase A and vATPase E dsRNAs from H.vigintioctopunctata and P.japonica under the worst-case scenario,in which dsGFP served as negative control.There were significant effects of dsHvvATPase A on P.japonica at the transcriptional level but not at the organismal level,whereas dsHvvATPase E did not effect P.japonica at either the transcriptional or the organismal level.Collectively,the results of the study suggest that HvvATPase A and HvvATPase E can act as novel molecular targets for the control of H.vigintioctopunctata. | Wei Guo Mujuan Guo Chunxiao Yang Zhuoqi Liu Shimin Chen Jing Lu Baoli Qiu Youjun Zhang Xuguo Zhou Huipeng Pan | 2021 | Insect Science2021，28，6： | 3 |
| 5 | In situ monitoring of the structural change of microemulsions in simulated gastrointestinal conditions by SAXS and FRET显示文摘Microemulsions are promising drug delivery systems for the oral administration of poorly watersoluble drugs. However, the evolution of microemulsions in the gastrointestinal tract is still poorly characterized,especially the structural change of microemulsions under the effect of lipase and mucus. To better understand the fate of microemulsions in the gastrointestinal tract, we applied small-angle X-ray scattering(SAXS) and fluorescence resonance energy transfer(FRET) to monitor the structural change of microemulsions under the effect of lipolysis and mucus. First, the effect of lipolysis on microemulsions was studied by SAXS, which found the generation of liquid crystalline phases. Meanwhile, FRET spectra indicated micelles with smaller particle sizes were generated during lipolysis, which could be affected by CaCl_2, bile salts and lecithin. Then, the effect of mucus on the structural change of lipolysed microemulsions was studied. The results of SAXS and FRET indicated that the liquid crystalline phases disappeared, and more micelles were generated. In summary, we studied the structural change of microemulsions in simulated gastrointestinal conditions by SAXS and FRET, and successfully monitored the appearance and disappearance of the liquid crystalline phases and micelles. | Xia Lv Shuguang Zhang Huipeng Ma Peipei Dong Xiaodong Ma Ming Xu Yan Tian Zeyao Tang Jinyong Peng Haibo Chen Jianbin Zhang | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 2 |
| 6 | A New Indicator for Global Food Security Assessment: Harvested Area Rather Than Cropland Area显示文摘Cropland area has long been used as a key indicator of food security.However,grain yield is not solely controlled by the area of the cropland.Therefore,we proposed a new indicator to assess food security.Results show that from 1992 to 2004,the global cropland area increased by 840200 km^(2)(99.4%),but the grain yield increased only by 310 million t(29.1%);and from 2004 to 2015,the cropland area decreased by 39000 km^(2)(4.64%),but the grain yield increased by 370 million t(70.84%).This result showed that grain yield was not linearly correlated with cropland area,and delimiting the threshold of cropland protection may not guarantee food security.Combined with further correlation analysis,we found that the increase in the global grain yield was more closely related to the harvested area(R^(2)=0.94),which indicated that the harvested area is a more scientific and accurate indicator than cropland area in terms of guaranteeing food security.Therefore,if governments want to ensure the food security,they should choose a new and more accurate indicator:harvested area rather than cropland area. | SONG Fengjiao WANG Shijie BAI Xiaoyong WU Luhua WANG Jinfeng LI Chaojun CHEN Huan LUO Xuling XI Huipeng ZHANG Sirui LUO Guofeng YAN Mengqi ZHEN Qingqing | 2022 | Chinese Geographical Science2022，32，2： | 2 |
| 7 | Non-isothermal Crystallization of PET/PLA Blends显示文摘 | Huipeng Chen Marek Pyda Peggy Cebe | 2009 | Thermoehimiea Aeta2009，492，： | 1 |
| 8 | Virus infection of a weed increases vector attraction to and vector fitness on the weed 显示文摘 | Chen Gong Pan Huipeng Xie Wen | 2013 | Scientific Reports2013，3，： | 1 |
| 9 | Non-isothermal crystallization of PET / PLA blends显示文摘 | Chen Huipeng Pyda Marek Cebe Peggy | 2009 | Thermochimica Acta2009，492，： | 1 |
| 10 | A comparative study between China and IHRA for the vehicle-pedestrian impact 显示文摘 | CHEN Huipeng FU Lianxue ZHENG Heyue | 2009 | SAE International Journal of Passenger Cars-Mechanical Systems2009，2，1： | 1 |
| 11 | Determination and correlation solubility of m-phenylenediamine in (methanol, ethanol, acetonitrile and water) and their binary solvents from 278.15 K to 313.15 K显示文摘In this study, the solubility of m-phenylenediamine in four pure solvents(methanol, ethanol, acetonitrile and water) and three binary solvent(methanol + water),(ethanol + water) and(acetonitrile + water) systems were determined in the temperature ranging from 278.15 K to 313.15 K by using the gravimetric method under atmospheric pressure. In the temperature range of 278.15 K to 313.15 K, the mole fraction solubility values of m-phenylenediamine in water, methanol, ethanol, and acetonitrile are 0.0093–0.1533, 0.1668–0.5589,0.1072–0.5356, and 0.1717–0.6438, respectively. At constant temperature and solvent composition, the mole fraction solubility of o-phenylenediamine in four pure solvents was increased as the following order:water b ethanol b methanol b acetonitrile;and in the three binary solvent mixtures could be ranked as follows:(ethanol + water) b(methanol + water) b(acetonitrile + water). The relationship between the experimental temperature and the solubility of m-phenylenediamine was revealed as follows: the solubility of mphenylenediamine in pure and binary solvents could be increased with the increase of temperature. The experimental values were correlated with the Jouyban–Acree model, van’t Hoff–Jouyban–Acree model, modified Apelblat–Jouyban–Acree model, Sun model and Ma model. The standard dissolution enthalpy, standard dissolution entropy and the Gibbs energy were calculated based on the experimental solubility data. In the binary solvent mixtures, the dissolution of m-phenylenediamine could be an endothermic process. The solubility data,correlation equations and thermodynamic property obtained from this study would be invoked as basic data and models regarding the purification and crystallization process of m-phenylenediamine. | Pengbao Lian Huipeng Zhao Jianlong Wang Lizhen Chen Yong Xiang Qinghua Ren | 2019 | Chinese Journal of Chemical Engineering2019，27，5： | 1 |
| 12 | Non-isothermal Crystallization of PET/ PLA Blends显示文摘 | Huipeng Chen | 2009 | Thermochimica Acta2009，492，： | 1 |
| 13 | Chain confinement in electrospun nanofibers of PET with carbon nanotubes 显示文摘 | Huipeng Chen Zhen Liu Peggy Cebe | 2009 | Polymer2009，50，： | 1 |
| 14 | A comparative study between China and IHRA for the vehicle-pedestrian impact 显示文摘 | CHEN Huipeng FU Lianxue ZHENG Heyue | 2009 | SAE Int''l J Passenger Cars-Mechanical Systems2009，2，1： | 1 |
| 15 | Flexible multi-level quasi-volatile memory based on organic vertical transistor显示文摘Driven by important megatrends such as cloud computing,artificial intelligence,and the Internet of Things,as a device used to store programs and data in computing systems,memory is struggling to catch up with the explosive growth of data and bandwidth requirements in the system.However,the storage wair between non-volatile memory and volatile memory retards the further improvement of modern memory computing systems.Herein,a quasi-volatile transistor memory based on organic polymer/perovskite quantum dot blend was fabricated using the vertical transistor configuration.Contributing to vertical structure and appropriate doping ratio of blend film,the quasi-volatile memory device displayed 1,560 times longer data retention time(>100 s)with respect to the dynamic random access memory and fast data programming speed(20 ps)in which was far more quickly than that of other organic non-volatile memories to fill the gap between volatile and non-volatile memories.Moreover,the device retention characteristics could be further promoted under the photoelectric synergistic stimulation,which also provided the possibility to reduce electric writing condition.Furthermore,the quasi-volatile memory device showed good electrical performance under bending conditions.This work provides a simple solution to fabricate multi-level quasi-volatile memory,which opens up a whole new avenue of'universal memory'and lays a solid foundation for low power and flexible random access memory devices. | Huihuang Yang Qian Yang Lihua He Xiaomin Wu Changsong Gao Xianghong Zhang Liuting Shan Huipeng Chen Tailiang Guo | 2022 | Nano Research2022，15，1： | 0 |
| 16 | Four genetic loci affecting swine lung lesions identified by whole-genome sequencing-based association studies显示文摘Dear Editor,Lung disease is a serious concern in humans and domestic animals.Huge economic losses are caused by enzootic pneumonia in the swine industry worldwide(Maes et al.,2018).The lung can be easily invaded by environmental pathogens,resulting in lung diseases usually accompanied by lung lesions. | Xinkai Tong Tao Huang Mingpeng Zhang Jiaqi Chen Zhou Zhang Jingquan Li Huipeng Du Ziqi Ling Zhongzi Wu Bin Yang Shijun Xiao Huashui Ai | 2021 | Science China(Life Sciences)2021，64，9： | 0 |
| 17 | From Small Scale Guerrilla Warfare to a Wide Range of Army Operations the Development Direction of Software Production and Education显示文摘 | Lei Xu Huipeng Chen Hongwei Liu Yanhang Zhang Qing Wang | 2018 | 国际计算机前沿大会会议论文集2018，，2： | 0 |
| 18 | Application of Project Management in Undergraduates' Innovation Experiment Teaching显示文摘 | Qing Wang Huipeng Chen Hongwei Liu Lei Xu Yanhang Zhang | 2018 | 国际计算机前沿大会会议论文集2018，，2： | 0 |
| 19 | Exploration of C Language Practical Teaching Method Based on Project Learning显示文摘This paper proposes a practical teaching approach in C programing language based on project learning.Having performing experimental teaching in class,this approach obtains pretty good teaching results,although it presents some flaws.This paper briefs the process of teaching,analyses the problems which are found during teaching and provides the solutions accordingly. | Huipeng Chen Yingtao Zhang Songbo Liu | 2016 | 国际计算机前沿大会会议论文集2016，，2： | 0 |
| 20 | Relationship between a function of the northward pressure gradient and the Pacific Equatorial Undercurrent显示文摘The Equatorial Undercurrent(EUC) plays an important role in ocean circulation and global climate change. Near the equator, as the Coriolis parameter goes to 0, equatorial currents cannot be described by geostrophy in which the pressure gradient force term is balanced by the Coriolis force term. Many previous studies focus on the relationships between the EUC and El Ni?o-Southern Oscillation(ENSO), the thermocline, sea surface topography, the distribution of equatorial wind stress and other atmosphere-ocean factors. However, little attention has been paid to the northward pressure gradient(NGT), which may also be important to the EUC. The pressure can be regarded as a complex nonlinear function of terms including temperature, salinity and density.This study attempts to reveal the connection between a function of the northward pressure gradient(FNP) and the EUC. The connection is derived from primitive equations, by simplifying the equations with using scaling analysis, and shows that the beta effect may be the main reason why the FNP is important to the EUC. The vertical structure of the EUC can be partially described by the FNP. The NGT has an obvious influence on the EUC while the eastward pressure gradient has a relatively smaller effect. | CHEN Xuan ZHENG Chongwei WU Hui YOU Xiaobao LI Xunqiang WANG Huipeng | 2018 | Acta Oceanologica Sinica2018，37，9： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员