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| 1 | Holocene palynological records and their responses to the controversies of climate system in the Shiyang River drainage basin显示文摘The Shiyang River drainage basin is located in the northwest margin of the Asian monsoon region. Previous studies reached different conclusions about Holocene climatic changes in the basin. Some studies suggested the Holocene climatic changes were mainly controlled by the Asian monsoon and that the climate was relatively humid during the early Holocene (11.6-7.1 cal ka BP). Other studies found the mid-Holocene Climatic Optimum (7.0-5.0 cal ka BP), and this climate condition was similar to the Holocene westerly wind pattern in arid Central Asia. The modern climate is affected by the Asian monsoon and westerly wind in the drainage basin, and the Holocene climatic records showed two different Holocene climatic patterns-a westerly wind pattern and monsoonal pattern. However, it remains unclear what caused the two different Holocene climatic patterns to co-exist in the region. The palynological records are the main evidence for the Holocene climatic changes in the basin. This paper focuses on palynological records for different parts of the drainage basin. Among them, QTH02, QTL-03 and Sanjiaocheng records are located in the terminal lake, and the Hongshuihe record is located in the middle reaches of the basin. In the terminal lake, the palynological records of QTH02 and QTL-03 are similar, but the Sanjiaocheng record differs. The difference is mainly affected by the variable pollen assemblages in the different locations of the lake basin. From comparison and synthesis of the four palynological records, we concluded that the millennial-scale Holocene climatic changes were affected by the combined effects of the Asian monsoon and westerly wind in the drainage basin, which show the complicated Holocene climatic pattern in the northwest margin of the Asian monsoon. | LI Yu WANG NaiAng LI ZhuoLun ZHANG HuaAn | 2011 | Chinese Science Bulletin2011，56，6： | 18 |
| 2 | Purification and characterization of a novel immunomodulatory protein from the medicinal mushroom Trametes versicolor显示文摘Bioactive proteins represent an important group of functional agents in medicinal mushrooms.Trametes versicolor(L.) Lloyd is a mushroom frequently used in traditional Chinese medicine for its anti-tumor and immunomodulatory activities.A new immunomodulatory protein from T.versicolor,named TVC,was purified by ammonium sulfate precipitation,ion-exchange chromatography and gel filtration chromatography.Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of the purified protein revealed a single band with a molecular weight of 15.0 kD.Native polyacrylamide gel analysis revealed a band at 30 kD,indicating that TVC exists in solution as a homodimer.Isoelectric focusing showed that TVC was an acidic protein with an isoelectric point of 4.0.TVC was found to lack carbohydrate modifications(based on periodic acid/Schiff staining) and it does not agglutinate mouse red blood cells,suggesting that TVC is not a lectin-like protein.Biological activity assays dem-onstrated that TVC can enhance the proliferation of splenocytes,while it has no stimulatory effects on CD4+and CD8+T cells. TVC markedly increases the proliferation of human peripheral blood lymphocytes in a dose-dependent manner and enhances the production of both nitric oxide and tumor necrosis factor-alpha by lipopolysaccharide-induced murine macrophages.The results indicate that TVC is an immunostimulant that can boost immune response.Comparison of the N-terminal amino acid residues and mass spectrometry results with the protein database revealed no homologous proteins. | LI Feng WEN HuaAn ZHANG YongJie AN Min LIU XingZhong | 2011 | Science China(Life Sciences)2011，54，4： | 11 |
| 3 | From Green Super Rice to green agriculture:Reaping the promise of functional genomics research显示文摘Producing sufficient food with finite resources to feed the growing global population while having a smaller impact on the environment has always been a great challenge.Here,we review the concept and practices of Green Super Rice(GSR)that have led to a paradigm shift in goals for crop genetic improvement and models of food production for promoting sustainable agriculture.The momentous achievements and global deliveries of GSR have been fueled by the integration of abundant genetic resources,functional gene discoveries,and innovative breeding techniques with precise gene and whole-genome selection and efficient agronomic management to promote resource-saving,environmentally friendly crop production systems.We also provide perspectives on new horizons in genomic breeding technologies geared toward delivering green and nutritious crop varieties to further enhance the development of green agricul-ture and better nourish the world population. | Sibin Yu Jauhar Ali Shaochuan Zhou Guangjun Ren Huaan Xie Jianlong Xu Xinqiao Yu Fasong Zhou Shaobing Peng Liangyong Ma Dingyang Yuan Zefu Li Dazhou Chen Ruifeng Zheng Zhigang Zhao Chengcai Chu Aiqing You Yu Wei Susong Zhu Qiongyao Gu Guangcun He Shigui Li Guifu Liu Changhua Liu Chaopu Zhang Jinghua Xiao Lijun Luo Zhikang Li Qifa Zhang | 2022 | Molecular Plant2022，15，1： | 6 |
| 4 | Two classes of QC-LDPC cycle codes approaching Gallager lower bound显示文摘Dear editor,Many research results show that, for equivalent bit length, short nonbinary LDPC codes outperform binary LDPC codes by about 1 dB(1–3)Moreover, nonbinary LDPC codes have lower errorfloor, fast iterative decoding convergence, and strong ability of correcting burst errors. But the roadblock to their application is the high decoding complexity. Recently, significant studies on the low-complexity decoding algorithms of nonbinaryLDPC codes have been done [4]. | Hengzhou XU Huaan LI Mengmeng XU Dan FENG Hai ZHU | 2019 | Science China(Information Sciences)2019，62，10： | 2 |
| 5 | Radiofrequency Ablation Versus Antiarrhythmic Medication for Treatment of Ventricular Premature Beats From the Right Ventricular Outflow Tract: Prospective Randomized Study显示文摘 | Zhiyu Ling Zengzhang Liu Li Su Vadim Zipunnikov Jinjin Wu Huaan Du Kamsang Woo Shaojie Chen Bin Zhong Xianbin Lan Jinqi Fan Yanping Xu Weijie Chen Yuehui Yin Saman Nazarian Bernhard Zrenner | 2014 | Circulation: Arrhythmia and Electrophysiology2014，，2： | 1 |
| 6 | Gradual daylength sensing coupled with optimum cropping modes enhances multi-latitude adaptation of rice and maize显示文摘To expand crop planting areas,reestablishment of crop latitude adaptation based on genetic variation in photoperiodic genes can be performed,but it is quite time consuming.By contrast,a crop variety that already exhibits multi-latitude adaptation has the potential to increase its planting areas to be more widely and quickly available.However,the importance and potential of multi-latitude adaptation of crop varieties have not been systematically described.Here,combining daylength-sensing data with the cropping system of elite rice and maize varieties,we found that varieties with gradual daylength sensing coupled with optimum cropping modes have an enhanced capacity for multi-latitude adaptation in China.Furthermore,this multi-latitude adaptation expanded their planting areas and indirectly improved China’s nationwide rice and maize unit yield.Thus,coupling the daylength-sensing process with optimum cropping modes to enhance latitude adaptability of excellent varieties represents an exciting approach for deploying crop varieties with the potential to expand their planting areas and quickly improve nationwide crop unit yield in developing countries. | Xiaoying Wang Jiupan Han Rui Li Leilei Qiu Cheng Zhang Ming Lu Rongyu Huang Xiangfeng Wang Jianfu Zhang Huaan Xie Shigui Li Xi Huang Xinhao Ouyang | 2023 | Plant Communications2023，4，1： | 1 |
| 7 | Direct and reverse overwrite processes in perpendicular recording显示文摘 | Li Shaoping Zhang Huaan | 2006 | IEEE Transactions on Magnetics2006，42，2： | 1 |
| 8 | Direct and reverse overwrite processes in perpendicular recording显示文摘 | Li Shaoping Zhang Huaan | 2006 | IEEE Transactions on Magnetics2006，42，2： | 1 |
| 9 | Medical micro-and nanomotors in the body显示文摘Attributed to the miniaturized body size and active mobility,micro-and nanomotors(MNMs)have demonstrated tremendous potential for medical applications.However,from bench to bedside,massive efforts are needed to address critical issues,such as cost-effective fabrication,on-demand integration of multiple functions,biocompatibility,biodegradability,controlled propulsion and in vivo navigation.Herein,we summarize the advances of biomedical MNMs reported in the past two decades,with particular emphasis on the design,fabrication,propulsion,navigation,and the abilities of biological barriers penetration,biosensing,diagnosis,minimally invasive surgery and targeted cargo delivery.Future perspectives and challenges are discussed as well.This review can lay the foundation for the future direction of medical MNMs,pushing one step forward on the road to achieving practical theranostics using MNMs. | Huaan Li Fei Peng Xiaohui Yan Chun Mao Xing Ma Daniela A.Wilson Qiang He Yingfeng Tu | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 0 |
| 10 | Bladder microenvironment actuated proteomotors with ammonia amplification for enhanced cancer treatment显示文摘Enzyme-driven micro/nanomotors consuming in situ chemical fuels have attracted lots of attention for biomedical applications.However,motor systems composed by organism-derived organics that maximize the therapeutic efficacy of enzymatic products remain challenging.Herein,swimming proteomotors based on biocompatible urease and human serum albumin are constructed for enhanced antitumor therapy via active motion and ammonia amplification.By decomposing urea into carbon dioxide and ammonia,the designed proteomotors are endowed with self-propulsive capability,which leads to improved internalization and enhanced penetration in vitro.As a glutamine synthetase inhibitor,the loaded L-methionine sulfoximine further prevents the conversion of toxic ammonia into non-toxic glutamine in both tumor and stromal cells,resulting in local ammonia amplification.After intravesical instillation,the proteomotors achieve longer bladder retention and thus significantly inhibit the growth of orthotopic bladder tumor in vivo without adverse effects.We envision that the as-developed swimming proteomotors with amplification of the product toxicity may be a potential platform for active cancer treatment. | Hao Tian Juanfeng Ou Yong Wang Jia Sun Junbin Gao Yicheng Ye Ruotian Zhang Bin Chen Fei Wang Weichang Huang Huaan Li Lu Liu Chuxiao Shao Zhili Xu Fei Peng Yingfeng Tu | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 0 |
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