|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Liutex (vortex) core definition and automatic identification for turbulence vortex structures显示文摘As a milestone research in vortex identification(VI),the physical quantity of Liutex,including its forms of scalar,vector and tensor,was systematically explored and rigorously obtained as the third-generation(3G)of the vortex definition and identification methods distinguished from the first generation(1G)by vorticity and the second generation(2G)by the vortex identification(VI)criteria solely dependent on the velocity gradient tensor eigenvalues.Based on these findings,the vortex-core lines were abstracted from the well-defined Liutex,and for the first time,were automatically generated and massively visualized using computer.The distinctive characteristics of these vortex cores with the intriguing threshold-independency make them be the uniquely appropriate entity to represent and to depict the vortex structures in turbulence.The letter made use of the DNS data for the natural transition in a zero-pressure gradient flat-plate(Type-A turbulent boundary layer(TBL))and the fully-developed turbulence in a square annular duct(Type-B TBL)to demonstrate the vortex structure represented by the vortex-core lines.The 3G VI approach based on the vortex-core lines is capable of profoundly uncovering the vortex natures.Moreover,the capability of automatically identifying the vortex cores and massively visualizing the large number of vortex-core behaviors in a transient way will enable the fluid-mechanics and other related-science communities to step into a new era to explore the intrinsic natures of the centennial puzzle of turbulence and other vortex-related phenomena in future. | Hongyi Xu Xiao-shu Cai Chaoqun Liu | 2019 | Journal of Hydrodynamics2019，31，5： | 21 |
| 2 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 3 | Liutex theoretical system and six core elements of vortex identification显示文摘The third-generation vortex identification method of Liutex(previously called Rortex)was introduced by the team led by Prof.Chaoqun Liu from University of Texas at Arlington to mathematically extract the rigid rotation part from the fluid motion,and thus to define and visualize vortices.Unlike the vorticity-based first generation and the scalar-valued second generation,Q,λ2,Δandλci methods for example,the Liutex vector provides a unique,mathematical and systematic way to define vortices and visualize vortical structures from multiple perspectives without ambiguity.In this article,we summarize the recent developments of the Liutex framework and discuss the Liutex theoretical system including its existence,uniqueness,stability,Galilean invariance,locality and globality,decomposition in tensor and vector forms,Liutex similarity in turbulence,and multiple Liutex-based vortex visualization methods including Liutex lines,Liutex magnitude iso-surfaces,Liutex-Ωmethod,and Liutex core line method,etc..Thereafter,the six core elements of vortex identification,including(1)absolute strength,(2)relative strength,(3)local rotational axis,(4)vortex rotation axes,(5)vortex core size,(6)vortex boundary,are used as touchstones against which the Liutex vortex identification system is examined.It is demonstrated with illustrative examples that the Liutex system is able to give complete and precise information of all six core elements in contrast to the failure and inaccuracy of the first and second-generation methods.The important concept that vorticity cannot represent vortex and the superiority of the Liutex system over previous methods are reiterated and stated in appropriate places throughout the paper.Finally,the article concludes with future perspectives,especially the application of the Liutex system in studying turbulence mechanisms encouraged by the discovery of Liutex similarity law.As a newly defined physical quantity,Liutex may open a door for quantified vortex and turbulence research including Liutex(vortex)dynamics and lead the community out of the shadow of turbulence research which traditionally relies on observations,graphics,assumptions,hypotheses,and other qualitative analyses.An optimistic projection is that the Liutex system could be critical to investigation of the vortex dynamics in applications from hydrodynamics,aerodynamics,oceanography,meteorology,etc.and to research of the generation,sustenance,modelling and controlling of turbulence. | Yi-qian Wang Yi-sheng Gao Hongyi Xu Xiang-rui Dong Jian-ming Liu Wen-qian Xu Meng-long Chen Chaoqun Liu | 2020 | Journal of Hydrodynamics2020，32，2： | 17 |
| 4 | Cerebral small vessel disease or intracranial large vessel atherosclerosis may carry different risk for future strokes显示文摘Background The effect of cerebral small vessel disease(CSVD)and intracranial arterial stenosis(ICAS)on stroke outcomes remains unclear.Methods Data of 1045 patients with minor stroke or transient ischaemic attack(TIA)were obtained from 45 sites of the Clopidogrel in High-Risk Patients with Acute Non-disabling Cerebrovascular Events(CHANCE)trial.We assessed the associations of burdens of CSVD and ICAS with new strokes and bleeding events using multivariate Cox regression models and those with modified Rankin Scale(mRS)scores using ordinal logistic regression models.Results Among the 1045 patients,CSVD was present in 830 cases(79.4%)and ICAS in 460(44.0%).Patients with>1 ICAS segment showed the highest risk of new strokes(HR 2.03,95%CI 1.15 to 3.56,p=0.01).No association between CSVD and the occurrence of new strokes was found.The presence of severe CSVD(common OR(cOR)2.01,95%CI 1.40 to 2.89,p<0.001)and>1 ICAS segment(cOR 2.15,95%CI 1.57 to 2.93,p<0.001)was associated with higher mRS scores.Severe CSVD(HR 10.70,95%CI 1.16 to 99.04,p=0.04),but not ICAS,was associated with a higher risk of bleeding events.Six-point modified CSVD score improved the predictive power for bleeding events and disability.Interpretation CSVD is associated with more disability and bleeding events,and ICAS is associated with an increased risk of stroke and disability in patients with minor stroke and TIA at 3 months.CSVD and ICAS may represent different vascular pathologies and play distinct roles in stroke outcomes. | Huimin Chen Yuesong Pan Lixia Zong Jing Jing Xia Meng Yuyuan Xu Hongyi Yan Xingquan Zhao Liping Liu Hao Li S Claiborne Johnston Yongjun Wang Yilong Wang | 2020 | Stroke & Vascular Neurology2020，5，2： | 13 |
| 5 | Composition, origin and weathering process of surface sediment in Kumtagh Desert, Northwest China显示文摘Kumtagh 沙漠是在中国的八最大的沙漠之一,但是因为存取的困难,以前糟糕调查我们的学科交差的学习。在这份报纸, 33 件代表性的表面沉积样品从在实验室荒芜、分析的 Kumtagh 被收集获得重矿物质部件和 geochemical 元素内容。结果证明重矿物质的各种各样的类型在这些样品是在场的,与绿帘石和角闪石的高水平。Si 和艾尔收起化学作文的大部分。与上面的大陆人外壳(UCC ) 的 geochemical 元素的平均作文相比,除了 Si 和 Ca,所有元素被弄空到某个度;Fe, Mg, Ca, P, Ti 和 Mn 在他们的内容有高关联系数。矿物质和 Kumtagh 荒芜的沉积的 geochemical 作文在 Altyn Tagh 山脉和 Taklamakan 沙漠的附近与 Altyn Tagh 山脉,和冲积/洪水的扇子的表面沉积的岩石的有类似,显示 Kumtagh 荒芜的沉积的一主要来源位于 Altyn Tagh 山脉。在 Aqik 山谷和 Shule 河的更低的活动范围的冲积沉积物和湖沉积是容易的被侵蚀并且搬运由强壮在东北弯屈进 Kumtagh 沙漠,形成沙漠的另一来源扔。一张 A-CN-K 第三的图证明由 Na 和 K 的损失捱过的弱度化学药品发生在这些沉积,而 A-CNK-FM 第三的图建议 Fe 和 Mg 经历了重要化学区别。物理捱过过程为 mafic 矿物质在好粒子引起容易的侵蚀和丰富,这样粗糙的荒芜的沙粒子能相对在 Fe 和 Mg 被弄空。在经历不太化学的捱过的干旱区域的沉积的矿物质和 geochemical 作文被物理捱过主要影响。 | XU Zhiwei LU Huayu ZHAO Cunfa WANG Xianyan SU Zhizhu WANG Zhenting LIU Hongyi WANG Lixin LU Qi | 2011 | Journal of Geographical Sciences2011，21，6： | 13 |
| 6 | Association of elevated hs-CRP and multiple infarctions with outcomes of minor stroke or TIA: subgroup analysis of CHANCE randomised clinical trial显示文摘Background and purpose The relationship of high-sensitive C-reactive protein(hs-CRP)levels and infarction numbers with the prognosis of stroke is uncertain.This study evaluated the association of different hs-CRP levels and infarction numbers with the prognosis of acute minor ischaemic stroke or transient ischaemic attack(TIA).Methods A subset of 807 patients with both hs-CRP measurement and baseline MRI was included from the Clopidogrel in High-risk Patients with Acute Non-disabling Cerebrovascular Events trial.The primary efficacy outcome was the occurrence of an ischaemic stroke at the 1-year follow-up.Infarction numbers were classified as multiple acute infarctions(MAIs),single acute infarction and no acute infarction(NAI).The association between different hs-CRP levels with different infarction numbers and the risk of any outcome was analysed using multivariable Cox regression models.Results Among the 807 patients,84(10.4%)patients had a recurrent ischaemic stroke within 1 year.After adjustment for conventional confounding factors,patients with both elevated hs-CRP levels and MAIs were associated with approximately 4.7-fold of risk of ischaemic stroke within 1 year(16.7% vs 3.5%,HR 4.68,95% CI 1.54 to 14.23,p=0.007),compared with those with non-elevated hs-CRP levels and NAI.Similar results were observed for the composite events.Conclusions Combined elevated hs-CRP levels and MAIs may increase 1-year stroke risk stratification efficiency in patients with minor ischaemic stroke or TIA compared with using those markers alone,which indicated that the combination of inflammatory and imaging markers might improve the effectiveness of risk stratification concerning minor ischaemic stroke or TIA. | Guangyao Wang Jing Jing Jiejie Li Yuesong Pan Hongyi Yan Xia Meng Xingquan Zhao Liping Liu Hao Li David Z Wang Yongjun Wang Yilong Wang | 2021 | Stroke & Vascular Neurology2021，6，1： | 11 |
| 7 | Endovascular treatment with or without intravenous alteplase for acute ischaemic stroke due to basilar artery occlusion显示文摘Background and purpose It remains controversial if endovascular treatment(EVT)can improve the outcome of patients with acute basilar artery occlusion(BAO).This study aims to compare the functional outcomes between EVT with and without intravenous thrombolysis(IVT)first in patients who had acute ischaemic stroke(AIS)due to BAO.Methods Patients who had AIS with BAO who underwent EVT within 24 hours of onset were enrolled in this multicentre cohort study,and the efficacy and safety were compared between IVT+EVT and direct EVT.The primary outcome was 90-day functional independence.All outcomes were assessed with adjusted OR(aOR)from the multivariable logistic regression.In addition,a meta-analysis was performed on all recently published pivotal studies on functional independence after EVT in patients with BAO.Results Of 310 enrolled patients with BAO,241(78%)were treated with direct EVT and 69(22%)with IVT+EVT.Direct EVT was associated with a worse functional outcome(aOR,0.46(95%CI 0.24 to 0.85),p=0.01).IVT+EVT was associated with a lower percentage of patients who needed≥3 passes of stent retriever(10.14%vs 20.75%).The meta-analysis regression revealed a potential positive correlation between bridging with IVT first and functional independence(r=0.14(95%CI 0.05 to 0.24),p<0.01).Conclusions This study showed that compared with direct EVT,EVT with IVT first was associated with better functional outcomes in patients with BAO treated within 24 hours of onset.The meta-analysis demonstrated similar favourable efficacy of IVT first followed by EVT in patients with BAO. | Ximing Nie David Wang Yuehua Pu Yufei Wei Qixuan Lu Hongyi Yan Xin Liu Lina Zheng Jingyi Liu Xinxuan Yang Yarong Ding Dacheng Liu Wanying Duan Zhe Zhang Zhonghua Yang Miao Wen Weibin Gu Xinyi Hou Xinyi Leng Yuesong Pan Zhongrong Miao Liping Liu | 2022 | Stroke & Vascular Neurology2022，7，3： | 10 |
| 8 | Allele-aware chromosome-level genome assembly of Artemisia annua reveals the correlation between ADS expansion and artemisinin yield显示文摘Artemisia annua is the major natural source of artemisinin,an anti-malarial medicine commonly used worldwide.Here,we present chromosome-level haploid maps for two A.annua strains with different artemisinin contents to explore the relationships between genomic organization and artemisinin production.High-fidelity sequencing,optical mapping,and chromatin conformation capture sequencing were used to assemble the heterogeneous and repetitive genome and resolve the haplotypes of A.annua.Approximately 5o,ooo genes were annotated for each haplotype genome,and a triplication event that occurred approximately 58.12million years ago was examined for the first time in this species.A total of 3,903,467-5,193,414 variants(SNPs,indels,and structural variants)were identified in the 1.5-Gb genome during pairwise comparison between haplotypes,consistent with the high heterozygosity of this species.Genomic analyses revealed a correlation between artemisinin concents and the copy number of amorpha-4,11-dienes ynthasegenes.This correlation was further confirmed by resequencing of 36A.annua samples with varied artemisinin contents.Circular consensus sequencing of transcripts facilitated the detection of paralog expression.Collectively,our study provides chromosome-level allele-aware genome assemblies for two A.annua strains and new insights into the biosynthesis of artemisinin and its regulation,which will contribute to conquering malaria worldwide. | Baosheng Liao Xiaofeng Shen Li Xiang Shuai Guo Shiyu Chen Ying Meng Yu Liang Dandan Ding Junqi Bai Dong Zhang Tomasz Czechowski Yi Li Hui Yao Tingyu Mai Caroline Howard Chao Sun Haitao Liu Jiushi Liu Jin Pei Jihai Gao Jigang Wang Xiaohui Qiu Zhihai Huang Hongyi Li Ling Yuan Jianhe Wei lan Graham Jiang Xu Boli Zhang Shilin Chen | 2022 | Molecular Plant2022，15，8： | 9 |
| 9 | An in vivo study of the biodistribution of gold nanoparticles after intervaginal space injection in the tarsal tunnel显示文摘金 nanoparticles (AuNPs ) 的 biodistribution 是仔细与毒物学的效果有关并且因为他们的潜在的申请,担心大。与为液体运输的新奇解剖、组织学的结构的发现,然而,内在的机制包含了在在里面 AuNPs 的 vivo 运输和 biodistribution 要求进一步深入的调查。在当前的学习,在腱,容器,和神经纤维的一个焦点的点可以最佳地与另外的遥远的结缔组织连接的地方,我们在跗骨的隧道在 intervaginal 空间注射(ISI ) 以后在老鼠调查了 10-nm AuNPs 的 biodistribution。AuNPs 的静脉内的注射(IVI ) 用作控制。血和机关与诱导地联合的血浆团 spectrometry (ICPMS ) 为 Au 分发的定量分析在注射以后在 5, 15,和 30 min 并且在 1, 4, 12,和 24 h 被收集。IVI 和 ISI 产出显著地不同的结果:在在 ISI 以后的血的 AuNP 内容在 IVI 以后是比那低得多的;在肺,心,和肠是类似的;并且在皮和肌肉是更高的。这些调查结果被 AuNP 内容和相对机关 AuNP 分发比例的比率支持。我们表明的结果一快,直接并且发行量无关的 AuNP 器官运输小径,它可以改进我们生理、病理学的 biodistribution 的理解在生物系统处理。而且,这些结果提供新奇卓见进在里面 vivo 运输和 AuNPs 的 biodistribution,它可以导致新奇、有效治疗学并且管理策略。 | Xiaoli Shi Yuting Zhu Wenda Hua Yinglu Ji Qing Ha Xinxiao Han Yang Liu Jingwei Gao Qiang Zhang Sidi Liu Keli Ren Xiaochun Wu Hongyi Li Dong Han | 2016 | Nano Research2016，9，7： | 7 |
| 10 | Genetics and Molecular Marker Identification of a Resistance to Glomerella Leaf Spot in Apple显示文摘Apple Glomerella leaf spot(GLS) is a destructive fungal disease that damages apple leaves during the summer in China.Breeding new diseaseresistant varieties is considered to be the best way of controlling GLS.A genetic study of resistance to Glomerella leaf spot(GLS) in apple was conducted by using four F_1 hybrid groups(‘Fuji' בGolden Delicious',‘Golden Delicious' בFuji',‘Gala' בFuji',and ‘Fuji' בQF-2') generated from two highly resistant varieties or selections,‘Fuji' and ‘QF-2',and two highly susceptible varieties,‘Golden Delicious' and ‘Gala'.The results showed that the separation ratios of resistant plants to the susceptible ones in the four F_1 hybrid groups were statistically consistent with the theoretical ratios of 1:1,1:1,0:1,and 1:0.Comprehensive analysis enabled us to generate the following conclusions:GLS resistance in apple may be controlled by a single recessive gene.The genotype of the resistant plants was rr,whereas the genotypes of the susceptible ones were RR and Rr.By using ‘Golden Delicious' בFuji' F_1 hybrid groups and the bulked segregation analysis(BSA) method,the marker S0506206-243 bp associated with disease resistance character to GLS was identified through screening 500 SSR primers encompassing the entire apple genome with even coverage,and the genetic distance between the marker and the GLS resistance gene was 9.8 cM. | LIU Yuanxia LI Baohua WANG Caihong LIU Chunxiao KONG Xianghua ZHU Jun DAI Hongyi | 2016 | Horticultural Plant Journal2016，2，3： | 6 |
| 11 | Design of Environmental Monitoring and Control System for Large-scale Pig House with Fermentation Bed显示文摘The design and assembly of environmental monitoring and control system for large-scale pig house with fermentation bed helped to solve the problem of environmental automatic control in piggery.The sensors would monitor the temperature,humidity,light,wind direction,wind speed,CO2,NH3and other parameters.On-line real-time data collection was achieved.The expert system was constructed to control the temperature in piggery below 30℃,to control the air and mattress humidities higher than 65%.Under the conditions of different season or different wind speed,even in day and night,the control actuators were different.The actuators included fanning wet curtain,lighting,micro spraying,spraying,propeller fan,electric aluminum alloy shutter and spraying systems on the roof.The actuators were integrated,and they control the piggery environment simultaneously.The system also designed the remote video monitor interface,parameter-monitoring curved interface and operation interface,which provided a good man-machine interface. | Bo LIU Huiyong ZHENG Yingzhi LIN Shengbing LIU Hongyi ZHENG Chunzhong YOU Huai SHI Jianglin LAN Zhaolong LI Jianyang TANG Qinlou HUANG | 2015 | Agricultural Science & Technology2015，16，2： | 6 |
| 12 | Effects of inorganic arsenic on growth and microcystin production of a Microcystis strain isolated from an algal bloom in Dianchi Lake,China显示文摘Our previous data have shown that inorganic arsenic concentrations were high in Dianchi Lake,China,where Microcystis blooms often occur.To explore the relationship between arsenic and the growth of Microcystis,the effects of arsenite[As(III)]and arsenate[As(V)]on the growth and toxin production of M.aeruginosa strain FACHB 905 were tested.Results showed that M.aeruginosa FACHB 905 was tolerant to inorganic arsenic and its growth was not inhibited when the concentration of As(III)was below 10-5 mol L-1 or that of As(V)below 10-3 mol L-1.Total microcystin production was stimulated in the presence of 10-7 mol L-1 As(III)and the response of this M.aeruginosa strain to As(III)seemed to be a typical inverted U-shaped hormesis.The content increase of microcystin-LR per cell indicated that the toxicity was enhanced as M.aeruginosa FACHB 905 was exposed to As(V).Considering the relatively high concentration of inorganic arsenic in Dianchi Lake(139μg L-1 in epilimnetic water),the origin of the M.aeruginosa strain,inorganic arsenic favors survival of M.aeruginosa FACHB 905 and may stimulate its microcystin production and cellular toxicity. | GONG Yan AO HongYi LIU BiBo WEN Sheng WANG Zhi HU DingJing ZHANG XingZhong SONG LiRong LIU JianTong | 2011 | Chinese Science Bulletin2011，56，22： | 6 |
| 13 | An Overview of Finite/Fixed-Time Control and Its Application in Engineering Systems显示文摘The finite/fixed-time stabilization and tracking control is currently a hot field in various systems since the faster convergence can be obtained. By contrast to the asymptotic stability,the finite-time stability possesses the better control performance and disturbance rejection property. Different from the finite-time stability, the fixed-time stability has a faster convergence speed and the upper bound of the settling time can be estimated. Moreover, the convergent time does not rely on the initial information.This work aims at presenting an overview of the finite/fixed-time stabilization and tracking control and its applications in engineering systems. Firstly, several fundamental definitions on the finite/fixed-time stability are recalled. Then, the research results on the finite/fixed-time stabilization and tracking control are reviewed in detail and categorized via diverse input signal structures and engineering applications. Finally, some challenging problems needed to be solved are presented. | Yang Liu Hongyi Li Zongyu Zuo Xiaodi Li Renquan Lu | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，12： | 6 |
| 14 | Effect of Different Calcium Levels on Growth,Yield and Fruit Quality of Tomatoes in Substrate Culture显示文摘Tomato seedlings were grown in substrate culture with pots. The formulation of Holland Greenhouse Horticulture Research Institute was used(as CK) and the effects of different Ca concentrations(LCa, CK and HCa)on growth, yield, and fruit quality(protein, Vitamin C, nitrates, organic acid and soluble sugar) of tomato were studied keeping concentrations of other nutrients unchanged in the nutrient solution. The results showed that parameters related to the growth of tomato(plant height and Stem diameter), changes of tomato yield per plant and quality of tomato fruits were the highest when the plants were grown at 20% Ca treatments. In the second study, increased EC concentrations of nutrient solution resulted in stronger plants with improved yields and quality. Four different concentration gradients of nutrient solution treatment were designed based on the results of the first research stage(EC=1.5, 2.5, 3.5, 4.5 m S/cm, respectively). The single tomato plant had the highest production which is 2 268.994 g/plant, when the nutrient solution strength was at EC=1.5 m S cm, whereas they have the best fruit quality when the solution strength at EC 4.5 m S/cm. This suggests the need for wide popularization of the nutrient solution formula in large areas to improve the tomato production. | Jing FENG Ruiping LIU Hongyi LUO | 2015 | Agricultural Science & Technology2015，16，8： | 6 |
| 15 | An Analytical Method for Calculating the Shielding Effectiveness of an Enclosure with an Oblique Rectangular Aperture显示文摘An efficient analytical method is proposed to calculate the Shielding effectiveness(SE)of an enclosure with an oblique rectangular aperture.This enclosure was first decomposed into two ones with horizontal rectangular apertures through mirror image and Green function theories.The SE of each decomposed enclosure was calculated by the Robinson’s method.The relationship between the SE of the original cavity and those of the decomposed ones was also derived analytically.The SE of the original cavity could be directly obtained from this analytical relationship.The accuracy of the proposed method was validated with measurements and the Transmission line matrix(TLM)solver.The results show that the efficiency was largely improved compared with the TLM solver. | SU Donglin LIU Hongyi YANG Shunchuan ZHAO Zihua SUI Donghai | 2019 | Chinese Journal of Electronics2019，28，4： | 5 |
| 16 | Artificial intelligence and big data facilitated targeted drug discovery显示文摘Different kinds of biological databases publicly available nowadays provide us a goldmine of multidiscipline big data.The Cancer Genome Atlas is a cancer database including detailed information of many patients with cancer.DrugBank is a database including detailed information of approved,investigational and withdrawn drugs,as well as other nutraceutical and metabolite structures.PubChem is a chemical compound database including all commercially available compounds as well as other synthesisable compounds.Protein Data Bank is a crystal structure database including X-ray,cryo-EM and nuclear magnetic resonance protein three-dimensional structures as well as their ligands.On the other hand,artificial intelligence(AI)is playing an important role in the drug discovery progress.The integration of such big data and AI is making a great difference in the discovery of novel targeted drug.In this review,we focus on the currently available advanced methods for the discovery of highly effective lead compounds with great absorption,distribution,metabolism,excretion and toxicity properties. | Benquan Liu Huiqin He Hongyi Luo Tingting Zhang Jingwei Jiang | 2019 | Stroke & Vascular Neurology2019，4，4： | 5 |
| 17 | A nanoporous oxide interlayer makes a better Pt catalyst on a metallic substrate: Nanoflowers on a nanotube bed显示文摘改进在铂催化剂和钛底层之间的接触, TiO 的层 < 潜水艇 class= “ a-plus-plus ” > 2 个 nanotube 数组在由脉搏电极淀积扔磅 nanoflowers 前被综合了。在 electrocatalytic 活动的戏剧的改进(3 ????????????? | Hongyi Li Jinshu Wang Man Liu Hong Wang Penglei Su JunshuWu Ju Li | 2014 | Nano Research2014，7，7： | 5 |
| 18 | Limitation of fault-sealing and its control on hydrocarbon accumulation——An example from the Laoyemiao Oilfi eld of the Nanpu Sag显示文摘Based on previous studies on the internal structures of fault belts, the fault belts in the Laoyemiao Oilfi eld of the Nanpu Sag can be divided into three units, a crushed zone, an upper induced fracture zone and a lower induced fracture zone according to the log response characteristics. The upper induced fracture zone is characterized by the development of pervasive fractures and has a poor sealing or non-sealing capability. It therefore can act as pathways for hydrocarbon migration. The lower induced fracture zone consists of fewer fractures and has limited sealing capability. The crushed zone has a good sealing capability comparable to mudstone and can thus prevent lateral migration of fluid. Through physical modeling and comparing laboratory data with calculated data of oil column heights of traps sealed by faults, it is concluded that the fault-sealing capability for oil and gas is limited. When the oil column height reaches a threshold, oil will spill over from the top of reservoir along the lower induced fracture zone under the action of buoyancy, and the size of reservoir will remain unchanged. Analysis of the formation mechanisms of the fault-sealed reservoirs in the Nanpu Sag indicated that the charging sequence of oil and gas in the reservoir was from lower formation to upper formation, with the fault playing an important role in oil and gas accumulation. The hydrocarbon potential in reverse fault-sealed traps is much better than that in the consequent fault-sealed traps. The reverse fault-sealed traps are favorable and preferred exploration targets. | Jiang Zhenxue Dong Yuexia Li Hongyi Liu Luofu Liu Guangdi Li Xiaoying | 2008 | Petroleum Science2008，5，4： | 4 |
| 19 | Targeting folate receptorβpositive tumor-associated macrophages in lung cancer with a folate-modified liposomal complex显示文摘Tumor-associated macrophages(TAMs)facilitate cancer progression by promoting tumor invasion,angiogenesis,metastasis,inflammatory responses,and immunosuppression.Folate receptorβ(FRβ)is overexpressed in TAMs.However,the clinical significance of FRβ-positive macrophages in lung cancer remains poorly understood.In this study,we verified that FRβoverexpression in lung cancer TAMs was associated with poor prognosis.We utilized a folate-modified lipoplex comprising a folatemodified liposome(F-PLP)delivering a BIM-S plasmid to target both lung cancer cells and FRβ-positive macrophages in the tumor microenvironment.Transfection of LL/2 cells and MH-S cells with F-PLP/pBIM induced cell apoptosis.Injection of F-PLP/pBIM into LL/2 and A549 lung cancer models significantly depleted FRβ-positive macrophages and reduced tumor growth.Treatment of tumor-bearing mice with F-PLP/pBIM significantly inhibited tumor growth in vivo by inducing tumor cell and macrophage apoptosis,reducing tumor proliferation,and inhibiting tumor angiogenesis.In addition,a preliminary safety evaluation demonstrated a good safety profile of F-PLP/pBIM as a gene therapy administered intravenously.This work describes a novel application of lipoplexes in lung cancer targeted therapy that influences the tumor microenvironment by targeting TAMs. | Yan Tie Heng Zheng Zhiyao He Jingyun Yang Bin Shao Li Liu Min Luo Xia Yuan Yu Liu Xiangxian Zhang Hongyi Li Min Wu Xiawei Wei | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 20 | Optimization of broadband omnidirectional antireflection coatings for solar cells显示文摘Broadband and omnidirectional antireflection coating is generally an effective way to improve solar cell efficiency, because the destructive interference between the reflected and incident light can maximize the light transmission into the absorption layer. In this paper, we report the incident quantum efficiency ηin, not incident energy or power, as the evaluation function by the ant colony algorithm optimization method, which is a swarm-based optimization method. Also, SPCTRL2 is proposed to be incorporated for accurate optimization because the solar irradiance on a receiver plane is dependent on position, season, and time. Cities of Quito, Beijing and Moscow are selected for two-and three-layer antireflective coating optimization over λ = [300,1100] nm and θ = [0°, 90°]. The ηin increases by 0.26%, 1.37% and 4.24% for the above 3 cities, respectively, compared with that calculated by other rigorous optimization algorithms methods, which is further verified by the effect of position and time dependent solar spectrum on the antireflective coating design. | Xia Guo Qiaoli Liu Huijun Tian Ben Li Hongyi Zhou Chong Li Anqi Hu Xiaoying He | 2019 | Journal of Semiconductors2019，40，3： | 4 |
您所在的机构暂未开通此部分的功能，请联系管理员