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| 1 | Spatial gradient distributions of thermal shock-induced damage to granite显示文摘In this study,we attempted to investigate the spatial gradient distributions of thermal shock-induced damage to granite with respect to associated deterioration mechanisms.First,thermal shock experiments were conducted on granite specimens by slowly preheating the specimens to high temperatures,followed by rapid cooling in tap water.Then,the spatial gradient distributions of thermal shock-induced damage were investigated by computed tomography(CT)and image analysis techniques.Finally,the influence of the preheating temperature on the spatial gradients of the damage was discussed.The results show that the thermal shock induced by rapid cooling can cause more damage to granite than that induced by slow cooling.The thermal shock induced by rapid cooling can cause spatial gradient distributions of the damage to granite.The damage near the specimen surface was at a maximum,while the damage inside the specimen was at a minimum.In addition,the preheating temperature can significantly influence the spatial gradient distributions of the thermal shock-induced damage.The spatial gradient distribution of damage increased as the preheating temperature increased and then decreased significantly over 600C.When the preheating temperature was sufficiently high(e.g.800C),the gradient can be ignored. | Lifeng Fan Jingwei Gao Xiuli Du Zhijun Wu | 2020 | Journal of Rock Mechanics and Geotechnical Engineering2020，12，5： | 11 |
| 2 | An in vivo study of the biodistribution of gold nanoparticles after intervaginal space injection in the tarsal tunnel显示文摘金 nanoparticles (AuNPs ) 的 biodistribution 是仔细与毒物学的效果有关并且因为他们的潜在的申请,担心大。与为液体运输的新奇解剖、组织学的结构的发现,然而,内在的机制包含了在在里面 AuNPs 的 vivo 运输和 biodistribution 要求进一步深入的调查。在当前的学习,在腱,容器,和神经纤维的一个焦点的点可以最佳地与另外的遥远的结缔组织连接的地方,我们在跗骨的隧道在 intervaginal 空间注射(ISI ) 以后在老鼠调查了 10-nm AuNPs 的 biodistribution。AuNPs 的静脉内的注射(IVI ) 用作控制。血和机关与诱导地联合的血浆团 spectrometry (ICPMS ) 为 Au 分发的定量分析在注射以后在 5, 15,和 30 min 并且在 1, 4, 12,和 24 h 被收集。IVI 和 ISI 产出显著地不同的结果:在在 ISI 以后的血的 AuNP 内容在 IVI 以后是比那低得多的;在肺,心,和肠是类似的;并且在皮和肌肉是更高的。这些调查结果被 AuNP 内容和相对机关 AuNP 分发比例的比率支持。我们表明的结果一快,直接并且发行量无关的 AuNP 器官运输小径,它可以改进我们生理、病理学的 biodistribution 的理解在生物系统处理。而且,这些结果提供新奇卓见进在里面 vivo 运输和 AuNPs 的 biodistribution,它可以导致新奇、有效治疗学并且管理策略。 | Xiaoli Shi Yuting Zhu Wenda Hua Yinglu Ji Qing Ha Xinxiao Han Yang Liu Jingwei Gao Qiang Zhang Sidi Liu Keli Ren Xiaochun Wu Hongyi Li Dong Han | 2016 | Nano Research2016，9，7： | 7 |
| 3 | Pantograph-catenary electrical contact system of high-speed railways:recent progress,challenges,and outlooks显示文摘As the unique power entrance,the pantograph-catenary electrical contact system maintains the efficiency and reliability of power transmission for the high-speed train.Along with the fast development of high-speed railways all over the world,some commercialized lines are built for covering the remote places under harsh environment,especially in China;these environmental elements including wind,sand,rain,thunder,ice and snow need to be considered during the design of the pantograph-catenary system.The pantograph-catenary system includes the pantograph,the contact wire and the interface—pantograph slide.As the key component,this pantograph slide plays a critical role in reliable power transmission under dynamic condition.The fundamental material characteristics of the pantograph slide and contact wire such as electrical conductivity,impact resistance,wear resistance,etc.,directly determine the sliding electrical contact performance of the pantograph-catenary system;meanwhile,different detection methods of the pantograph-catenary system are crucial for the reliability of service and maintenance.In addition,the challenges brought from extreme operational conditions are discussed,taking the Sichuan-Tibet Railway currently under construction as a special example with the high-altitude climate.The outlook for developing the ultra-high-speed train equipped with the novel pantograph-catenary system which can address the harsher operational environment is also involved.This paper has provided a comprehensive review of the high-speed railway pantograph-catenary systems,including its progress,challenges,outlooks in the history and future. | Guangning Wu Keliang Dong Zhilei Xu Song Xiao Wenfu Wei Huan Chen Jie Li Zhanglin Huang Jingwei Li Guoqiang Gao Guozheng Kang Chuanjun Tu Xingyi Huang | 2022 | Railway Engineering Science2022，30，4： | 5 |
| 4 | Cancer metabolism and tumor microenvironment:fostering each other?显示文摘The changes associated with malignancy are not only in cancer cells but also in environment in which cancer cells live.Metabolic reprogramming supports tumor cells’high demand of biogenesis for their rapid proliferation,and helps tumor cells to survive under certain genetic or environmental stresses.Emerging evidence suggests that metabolic alteration is ultimately and tightly associated with genetic changes,in particular the dysregulation of key oncogenic and tumor suppressive signaling pathways.Cancer cells activate HIF signaling even in the presence of oxygen and in the absence of growth factor stimulation.This cancer metabolic phenotype,described firstly by German physiologist Otto Warburg,ensures enhanced glycolytic metabolism for the biosynthesis of macromolecules.The conception of metabolite signaling,i.e.,metabolites are regulators of cell signaling,provides novel insights into how reactive oxygen species(ROS)and other metabolites deregulation may regulate redox homeostasis,epigenetics,and proliferation of cancer cells.Moreover,the unveiling of noncanonical functions of metabolic enzymes,such as the moonlighting functions of phosphoglycerate kinase 1(PGK1),reassures the importance of metabolism in cancer development.The metabolic,microRNAs,and ncRNAs alterations in cancer cells can be sorted and delivered either to intercellular matrix or to cancer adjacent cells to shape cancer microenvironment via media such as exosome.Among them,cancer microenvironmental cells are immune cells which exert profound effects on cancer cells.Understanding of all these processes is a prerequisite for the development of a more effective strategy to contain cancers. | Yiyuan Yuan Huimin Li Wang Pu Leilei Chen Dong Guo Hongfei Jiang Bo He Siyuan Qin Kui Wang Na Li Jingwei Feng Jing Wen Shipeng Cheng Yaguang Zhang Weiwei Yang Dan Ye Zhimin Lu Canhua Huang Jun Mei Hua-Feng Zhang Ping Gao Peng Jiang Shicheng Su Bing Sun Shi-Min Zhao | 2022 | Science China(Life Sciences)2022，65，2： | 5 |
| 5 | Genome-wide identification of RNA editing in seven porcine tissues by matched DNA and RNA high-throughput sequencing显示文摘Background: RNA editing is a co/posttranscriptional modification mechanism that increases the diversity of transcripts, with potential functional consequences. The advent of next-generation sequencing technologies has enabled the identification of RNA edits at unprecedented throughput and resolution. However, our knowledge of RNA editing in swine is still limited.Results: Here, we utilized RES-Scanner to identify RNA editing sites in the brain, subcutaneous fat, heart, liver,muscle, lung and ovary in three 180-day-old Large White gilts based on matched strand-specific RNA sequencing and whole-genome resequencing datasets. In total, we identified 74863 editing sites, and 92.1% of these sites caused adenosine-to-guanosine(A-to-G) conversion. Most A-to-G sites were located in noncoding regions and generally had low editing levels. In total, 151 A-to-G sites were detected in coding regions(CDS), including 94 sites that could lead to nonsynonymous amino acid changes. We provide further evidence supporting a previous observation that pig transcriptomes are highly editable at PRE-1 elements. The number of A-to-G editing sites ranged from 4155(muscle) to 25001(brain) across the seven tissues. The expression levels of the ADAR enzymes could explain some but not all of this variation across tissues. The functional analysis of the genes with tissuespecific editing sites in each tissue revealed that RNA editing might play important roles in tissue function.Specifically, more pathways showed significant enrichment in the fat and liver than in other tissues, while no pathway was enriched in the muscle.Conclusions: This study identified a total of 74863 nonredundant RNA editing sites in seven tissues and revealed the potential importance of RNA editing in tissue function. Our findings largely extend the porcine editome and enhance our understanding of RNA editing in swine. | Yuebo Zhang Longchao Zhang Jingwei Yue Xia Wei Ligang Wang Xin Liu Hongmei Gao Xinhua Hou Fuping Zhao Hua Yan Lixian Wang | 2019 | Journal of Animal Science and Biotechnology2019，10，2： | 4 |
| 6 | Phase boundary engineering of metal-organic-framework-derived carbonaceous nickel selenides for sodium-ion batteries显示文摘Nano Research volume 13,pages2289–2298(2020)Cite this article 347 Accesses 1 Altmetric Metrics details Abstract Sodium-ion batteries(SIBs)are promising power sources due to the low cost and abundance of battery-grade sodium resources,while practical SIBs suffer from intrinsically sluggish diffusion kinetics and severe volume changes of electrode materials.Metal-organic framework(MOFs)derived carbonaceous metal compound offer promising applications in electrode materials due to their tailorable composition,nanostructure,chemical and physical properties.Here,we fabricated hierarchical MOF-derived carbonaceous nickel selenides with bi-phase composition for enhanced sodium storage capability.As MOF formation time increases,the pyrolyzed and selenized products gradually transform from a single-phase Ni3Se4 into bi-phase NiSex then single-phase NiSe2,with concomitant morphological evolution from solid spheres into hierarchical urchin-like yolk-shell structures.As SIBs anodes,bi-phase NiSex@C/CNT-10h(10 h of hydrothermal synthesis time)exhibits a high specific capacity of 387.1 mAh/g at 0.1 A/g,long cycling stability of 306.3 mAh/g at a moderately high current density of 1 A/g after 2,000 cycles.Computational simulation further proves the lattice mismatch at the phase boundary facilitates more interstitial space for sodium storage.Our understanding of the phase boundary engineering of transformed MOFs and their morphological evolution is conducive to fabricate novel composites/hybrids for applications in batteries,catalysis,sensors,and environmental remediation. | Shiyao Lu Hu Wu Jingwei Hou Limin Liu Jiao Li Chris J.Harris Cheng-Yen Lao Yuzheng Guo Kai Xi Shujiang Ding Guoxin Gao Anthony K.Cheetham R.Vasant Kumar | 2020 | Nano Research2020，13，8： | 4 |
| 7 | Synergistic inhibitory effect of wogonin and low-dose paclitaxel on gastric cancer cells and tumor xenografts显示文摘Objective:To investigate the synergistic inhibitory effects of wogonin(WOG)and chemotherapeutic drugs on growth of gastric cancer cells and tumor xenografts.Methods:The IC50 values of WOG,cisplatin(CDDP)and paclitaxel(PTX)in four gastric cancer cell lines were determined by MTS assay.Hoechst staining and the median effect method of Chou-Talalay were used to assess the apoptosis of cells and the interaction of two drugs,respectively.BGC-823-derived xenografts in nude mice were established to investigate the effects of WOG combined with chemotherapeutic drugs in vivo.Results:WOG,CDDP and PTX inhibited the growth of BGC-823,MGC-803,MKN-45 and HGC-27 gastric cancer cells in a dose-dependent manner.WOG combined with CDDP or PTX synergistically inhibited the growth of all gastric cancer cell lines in vitro.In BGC-823,MGC-803,HGC-27 and MKN-45 cell lines,synergisms between WOG and PTX were shown when the fraction affected(Fa)values were<0.45,<0.90,<0.85 and<0.60.While WOG and CDDP had a synergistic inhibitory effect when the Fa values were>0,>0,>0.65 and>0.10.From the results of in vivo experiments using tumor xenografts,WOG and low-dose PTX showed better efficacy than either drug alone.The inhibitory percentages of tumor weight were 61.58%,20.29%,and 22.28%for the combination,WOG-alone,and low-dose PTX-alone groups,respectively.Notably,WOG combined with CDDP displayed very high toxicity.Conclusions:A synergistic inhibitory effect on growth was observed when WOG was combined with low-dose PTX in gastric cancer cells and tumor xenografts.These findings provide evidence for the design of a clinical trial to test the combination of WOG with low-dose PTX in human gastric cancer. | Tingting Wang Jing Gao Jingwei Yu Lin Shen | 2013 | Chinese Journal of Cancer Research2013，25，5： | 3 |
| 8 | The landscape of chromatin accessibility in skeletal muscle during embryonic development in pigs显示文摘Background:The development of skeletal muscle in pigs during the embryonic stage is precisely regulated by transcriptional mechanisms,which depend on chromatin accessibility.However,how chromatin accessibility plays a regulatory role during embryonic skeletal muscle development in pigs has not been reported.To gain insight into the landscape of chromatin accessibility and the associated genome-wide transcriptome during embryonic muscle development,we performed ATAC-seq and RNA-seq analyses of skeletal muscle from pig embryos at 45,70 and 100 days post coitus(dpc).Results:In total,21,638,35,447 and 60,181 unique regions(or peaks)were found across the embryos at 45 dpc(LW45),70 dpc(LW70)and 100 dpc(LW100),respectively.More than 91%of the peaks were annotated within−1 kb to 100 bp of transcription start sites(TSSs).First,widespread increases in specific accessible chromatin regions(ACRs)from embryos at 45 to 100 dpc suggested that the regulatory mechanisms became increasingly complicated during embryonic development.Second,the findings from integrated ATAC-seq and RNA-seq analyses showed that not only the numbers but also the intensities of ACRs could control the expression of associated genes.Moreover,the motif screening of stage-specific ACRs revealed some transcription factors that regulate muscle developmentrelated genes,such as MyoG,Mef2c,and Mef2d.Several potential transcriptional repressors,including E2F6,OTX2 and CTCF,were identified among the genes that exhibited different regulation trends between the ATAC-seq and RNA-seq data.Conclusions:This work indicates that chromatin accessibility plays an important regulatory role in the embryonic muscle development of pigs and regulates the temporal and spatial expression patterns of key genes in muscle development by influencing the binding of transcription factors.Our results contribute to a better understanding of the regulatory dynamics of genes involved in pig embryonic skeletal muscle development. | Jingwei Yue Xinhua Hou Xin Liu Ligang Wang Hongmei Gao Fuping Zhao Lijun Shi Liangyu Shi Hua Yan Tianyu Deng Jianfei Gong Lixian Wang Longchao Zhang | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 2 |
| 9 | SMND-309, a novel derivative of salvianolic acid B, protects rat brains ischemia and reperfusion injury by targeting the JAK2/STAT3 pathway显示文摘 | Haibo Zhu Libo Zou Jingwei Tian Guangying Du Yubai Gao | 2013 | European Journal of Pharmacology (-)2013，，1： | 1 |
| 10 | Serum levels of TUBB3 correlate with clinical outcome in Chinese patients with advanced gastric cancer receiving first-line paclitaxel plus capecitabine显示文摘 | Jingwei Yu Jing Gao Zhihao Lu Yilin Li Lin Shen | 2012 | Medical Oncology2012，，5： | 1 |
| 11 | Spatially distributed damage in sandstone under stress-freeze-thaw coupling conditions显示文摘In the present study,we tried to understand the spatially distributed damage in sandstone samples under the coupled stress-freeze-thaw(SFT)conditions.Firstly,uniaxial compressive stresses(i.e.0 MPa,10 MPa,20 MPa,and 25 MPa)were applied to the samples,and then freeze-thaw(FT)cycles(0,8,16,and 24)were performed on the uniaxially stressed samples to realize the SFT coupling.Next,real-time CT scanning was conducted to observe the induced damage.The total porosity was introduced to quantitatively evaluate the damage degree.The local porosity variation,with the distance from the center of the sandstone sample,was analyzed to understand the spatial distribution of damage.Finally,the coupling effects of SFT on the damage gradient were discussed.The results indicate that the porosity rises with FT cycles,and the applied stresses can accelerate the increase in porosity.The damage increases exponentially with the distance from the center of the sample.The damage presents a spatial gradient distribution,not the commonly used uniform distribution in various studies.The damage gradient increases with FT cycles,and the increasing rate in damage gradient decreases at uniaxial stress of 0 MPa and 10 MPa first,but the increasing rate in damage gradient increases with FT cycles then at stress increasing to 20 MPa. | Lifeng Fan Yiding Fan Yan Xi Jingwei Gao | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，6： | 1 |
| 12 | Effects of coarse and fine aggregates on long-term mechanical properties of sea sand recycled aggregate concrete显示文摘Typical effects of coarse and fine aggregates on the long-term properties of sea sand recycled aggregate concrete(SSRAC)are analyzed by a series of axial compression tests.Two different types of fine(coarse)aggregates are considered:sea sand and river sand(natural and recycled coarse aggregates).Variations in SSRAC properties at different ages are investigated.A novel test system is developed via axial compression experiments and the digital image correlation method to obtain the deformation field and crack development of concrete.Supportive results show that the compressive strength of SSRAC increase with decreasing recycled coarse aggregate replacement percentage and increasing sea sand chloride ion content.The elastic modulus of SSRAC increases with age.However,the Poisson’s ratio reduces after 2 years.Typical axial stress-strain curves of SSRAC vary with age.Generally,the effect of coarse aggregates on the axial deformation of SSRAC is clear;however,the deformation differences between coarse aggregate and cement mortar reduce by adopting sea sand.The aggregate type changes the crack characteristics and propagation of SSRAC.Finally,an analytical expression is suggested to construct the long-term stress-strain curve of SSRAC. | Jingwei YlNG Yijie HUANG Xu GAO Xibo QI Yuedong SUN | 2021 | Frontiers of Structural and Civil Engineering2021，15，3： | 1 |
| 13 | Giant neurogenic tumors of mediastinum: report of two cases and literature review显示文摘Neurogenic tumors are commonly found in the mediastinum, especially in the posterior mediastinum or in the chest wall, neurogenic tumors may reach large size before becoming symptomatic. If the neurogenic tumor occupied more than half size of the chest wall accompanied by mediastinal shift, tracheal compression, or superior vena reflux disorder, it may be called giant intrathoracic neurogenic tumors. Giant intrathoracic neurogenic tumors are relatively rare. Most of intrathoracic neurogenic tumors were benign or low-grade malignant tumors in nature. Complete surgical excision should be the rule for these patients. We report two cases of giant neurogenic tumors, and study the clinical manifestations, diagnostic methods, surgical management, and prognosis in the light of the most important published data. | Jingwei Wang Jidong Yan Shuhua Ren Yu Guo Yang Gao Lijun Zhou | 2013 | Chinese Journal of Cancer Research2013，25，2： | 1 |
| 14 | In situ assembly of fibrinogen/hyaluronic acid hydrogel via knob-hole interaction for 3D cellular engineering显示文摘Hyaluronic acid(HA)-based hydrogels have applied widely for biomedical applications due to its biocompatibility and biodegradability.However,the use of initiators or crosslinkers during the hydrogel formation may cause cytotoxicity and thereby impair the biocompatibility.Inspired by the crosslinking mechanism of fibrin gel,a novel HA-based hydrogel was developed via the in situ supramolecular assembly based on knob-hole interactions between fibrinogen and knob-grafted HA(knob-g-HA)in this study.The knob-grafted HA was synthesized by coupling knob peptides(GPRPAAC,a mimic peptide of fibrin knob A)to HA via Michael addition.Then the translucent fibrinogen/knob-g-HA hydrogels were prepared by simply mixing the solutions of knob-g-HA and fibrinogen at the knob/hole ratio of 1.2.The rheological behaviors of the fibrinogen/knob-g-HA hydrogels with the fibrinogen concentrations of 50,100 and 200 mg/mL were evaluated,and it was found that the dynamic storage moduli(G0)were higher than the loss moduli(G00)over the whole frequency range for all the groups.The SEM results showed that fibrinogen/knob-g-HA hydrogels presented the heterogeneous mesh-like structures which were different from the honeycomb-like structures of fibrinogen/MA-HA hydrogels.Correspondingly,a higher swelling ratio was obtained in the groups of fibrinogen/knob-g-HA hydrogel.Finally,the cytocompatibility of fibrinogen/knob-g-HA hydrogels was proved by live/dead stainings and MTT assays in the 293T cells encapsulation test.All these results highlight the biological potential of the fibrinogen/knob-g-HA hydrogels for 3D cellular engineering. | Shengjie Huang Chunfen Wang Jingwei Xu Lie Ma Changyou Gao | 2017 | Bioactive Materials2017，2，4： | 1 |
| 15 | Consensus of discrete-time second-order agents with time-varying topology and time-varying delays显示文摘 | Yanping Gao Jingwei Ma Min Zuo Tongqiang Jiang Junping Du | 2012 | Journal of the Franklin Institute2012，，8： | 1 |
| 16 | A slippery hydrogel coating with durable oil-repellent property and self-regeneration capacity显示文摘Traditional lubricant impregnated surfaces usually required fluorinated lubricants to achieve slippery oil repellency, but the lubricants infused were expensive and toxic and also suffered from limited stability because of their migrating, evaporating, and leaking during use. Herein, to address this issue, we fabricated a durably fluorine-free slippery oil-repellent hydrogel coating using water as the lubricant. Due to its enhanced water-binding affinity, water could wet the hydrogel completely and form a hydrated-water layer on the surface. The hydrated water layer could act as a lubricant to repel foreign oils, which allowed the hydrogel to display slippery oil-repellency in air, exhibit superoleophobicity underwater, and resist oil fouling upon oil immersion.The hydrogel kept its oil-repellent properties after mechanical tests as well as thermal and freezing treatments,demonstrating its durability. Thanks to its moisture absorption, the water lubricant layer could self-regenerate upon the lubricated water layer depletion through exposure to a humid environment. Exploiting it is water-attracting and oil repellency, the hydrogel coating was demonstrated as a versatile platform for oil/water separation, polymer/water separation, drag-reduction, and antifogging. | XU Ting GAO ZhongShuai LI FangChao MIAO Gan JIA YuYu MIAO Xiao ZHU XiaoTao LU JingWei WANG Bo SONG YuanMing REN GuiNa LI XiangMing | 2022 | Science China(Technological Sciences)2022，65，8： | 0 |
| 17 | Efficient Computation of Scattering from Targets with Negative Impedance Surface显示文摘Current surface integral equations used for computing scattering from targets with negative impedance boundary condition(IBC)are not efficient.A modified surface dual integral equation(M-SDIE)for targets with negative IBC is presented.A pure imaginary number is used to balance the formulations.It is proved that the M-SDIE is accurate and efficient with three numerical examples.The first numerical example shows that the M-SDIE is accurate compared with Mie.The second example shows that the presented SIE is efficient.In the third example,a missile head is selected to present the computing power of the M-SDIE.All the examples show that the M-SDIE is an efficient algorithm for negative IBC. | Jingwei Hao Hongwei Gao Xinqing Sheng | 2017 | Journal of Beijing Institute of Technology2017，26，1： | 0 |
| 18 | Mechanism analysis of solvent selectivity and energy-saving optimization in vapor recompression-assisted extractive distillation for separation of binary azeotrope显示文摘Octane and p-xylene are common components in crude gasoline,so their separation process is very important in petroleum industry.The azeotrope and near azeotrope are often separated by extractive distillation in industry,which can realize the recovery and utilization of resources.In this work,the vapor–liquid equilibrium experiment was used to obtain the vapor–liquid equilibrium properties of the difficult separation system,and on this basis,the solvent extraction mechanism was studied.The mechanism of solvent separation plays a guiding role in selecting suitable solvents for industrial separation.The interaction energy,bond length and charge density distribution of p-xylene with solvent are calculated by quantum chemistry method.The quantum chemistry calculation results and experiment results showed that N-formylmorpholine is the best solvent among the alternative solvents in the work.This work provides an effective and complete solvent screening process from phase equilibrium experiments to quantum chemical calculation.An extractive distillation simulation process with N-formylmorpholine as solvent is designed to separate octane and p-xylene.In addition,the feasibility and effectiveness of the intensified vapor recompression assisted extraction distillation are also discussed.In the extractive distillation process,the vapor recompression-assisted extraction distillation process is globally optimal.Compared with basic process,the total annual cost can be reduced by 43.2%.This study provides theoretical guidance for extractive distillation separation technology and solvent selection. | Xiaomin Qiu Yuanyuan Shen Zhengkun Hou Qi Wang Zhaoyou Zhu Yinglong Wang Jingwei Yang Jun Gao | 2022 | Chinese Journal of Chemical Engineering2022，35，6： | 0 |
| 19 | Organic Passivation of Deep Defects in Cu(In,Ga)Se_(2) Film for Geometry-Simplified Compound Solar Cells显示文摘Diverse defects in copper indium gallium diselenide solar cells cause nonradiative recombination losses and impair device performance.Here,an organic passivation scheme for surface and grain boundary defects is reported,which employs an organic passivation agent to infiltrate the copper indium gallium diselenide thin films.A transparent conductive passivating(TCP)film is then developed by incorporating metal nanowires into the organic polymer and used in solar cells.The TCP films have a transmittance of more than 90%in the visible and nearinfrared spectra and a sheet resistance of~10.5Ω/sq.This leads to improvements in the open-circuit voltage and the efficiency of the organic passivated solar cells compared with control cells and paves the way for novel approaches to copper indium gallium diselenide defect passivation and possibly other compound solar cells. | Jingwei Chen Xuan Chang Jianxin Guo Qing Gao Xuning Zhang Chenxu Liu Xueliang Yang Xin Zhou Bingbing Chen Feng Li Jianming Wang Xiaobing Yan Dengyuan Song Han Li Benjamin S.Flavel Shufang Wang Jianhui Chen | 2023 | Research2023，，4： | 0 |
| 20 | Highly expressed SERCA2 triggers tumor cell autophagy and is a druggable vulnerability in triple-negative breast cancer显示文摘Chemoresistance remains a major obstacle to successful treatment of triple negative breast cancer(TNBC).Identification of druggable vulnerabilities is an important aim for TNBC therapy.Here,we report that SERCA2 expression correlates with TNBC progression in human patients,which promotes TNBC cell proliferation,migration and chemoresistance.Mechanistically,SERCA2 interacts with LC3B via LIR motif,facilitating WIPI2-independent autophagosome formation to induce autophagy.Autophagy-mediated SERCA2 degradation induces SERCA2 transactivation through a Ca^(2+)/CaMKK/CREB-1 feedback.Moreover,we found that SERCA2-targeting small molecule RL71 enhances SERCA2-LC3B interaction and induces excessive autophagic cell death.The increase in SERCA2 expression predisposes TNBC cells to RL71-induced autophagic cell death in vitro and in vivo.This study elucidates a mechanism by which TNBC cells maintain their high autophagy activity to induce chemoresistance,and suggests increased SERCA2 expression as a druggable vulnerability for TNBC. | Minmin Fan Jian Gao Lin Zhou Wenwen Xue Yixuan Wang Jingwei Chen Wuhao Li Ying Yu Bo Liu Yan Shen Qiang Xu | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 0 |
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