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| 1 | Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis显示文摘Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells may be a potential strategy for cancer therapy.Therefore,ferroptosis-inducing drugs are attracting more attention for cancer treatment.Here,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum Lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer cells.Subsequently,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH depletion.The ferroptosis inhibitors Fer-1 and Lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell death.Furthermore,we demonstrated that Ca^(2+)/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing ferroptosis.Taken together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca^(2+)/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment. | Peng Chen Qibiao Wu Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming Zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 42 |
| 2 | Ambient air quality trends and driving factor analysis in Beijing, 1983–2007显示文摘The rapid development in Beijing, the capital of China, has resulted in serious air pollution problems. Meanwhile great efforts have been made to improve the air quality, especially since 1998. The variation in air quality under the interaction of pollution and control in this mega city has attracted much attention. We analyzed the changes in ambient air quality in Beijing since the 1980's using the Daniel trend test based on data from long-term monitoring stations. The results showed that different pollutants displayed three trends: a decreasing trend, an increasing trend and a flat trend. SO2, dustfall, B[a]P, NO2 and PM10 fit decreasing trend pattern, while NOx showed an increasing trend, and CO, ozone pollution, total suspended particulate (TSP), as well as Pb fit the flat trend. The cause of the general air pollution in Beijing has changed from being predominantly related to coal burning to mixed traffic exhaust and coal burning related pollution. Seasonally, the pollution level is typically higher during the heating season from November to the following March. The interaction between pollution sources change and implementation of air pollution control measures was the main driving factor that caused the variation in air quality. Changes of industrial structure and improved energy effciency, the use of clean energy and preferred use of clean coal, reduction in pollution sources, and implementation of advanced environmental standards have all contributed to the reduction in air pollution, particularly since 1998. | Ju Zhang Zhiyun Ouyang Hong Miao Xiaoke Wang | 2011 | Journal of Environmental Sciences2011，23，12： | 22 |
| 3 | Inhibition of RhoA/Rho-kinase pathway suppresses the expression of extracellular matrix induced by CTGF or TGF-β in ARPE-19显示文摘AIM:To investigate the role of Rho-associated protein kinase (ROCK) inhibitor, Y27632, in mediating the production of extracellular matrix (ECM) components including fibronectin, matrix metallo-proteinase-2 (MMP-2) and type I collagen as induced by connective tissue growth factor(CTGF) or transforming growth factor-β (TGF-β) in a human retinal pigment epithelial cell line, ARPE-19. METHODS:The effect of Y27632 on the CTGF or TGF-β induced phenotype in ARPE-19 cells was measured with immunocytochemistry as the change in F-actin. ARPE-19 cells were treated with CTGF (1, 10, 100ng/mL)and TGF-β (10ng/mL) in serum free media, and analyzed for fibronectin, laminin, and MMP-2 and type I collagen by RT-qPCR and immunocytochemistry. Cells were also pretreated with an ROCK inhibitor, Y27632, to analyze the signaling contributing to ECM production. ·RESULTS:Treatment of ARPE-19 cells in culture with TGF-β or CTGF induced an ECM change from a cobblestone morphology to a more elongated swirl pattern indicating a mesenchymal phenotype. RT-qPCR analysis and different gene expression analysis demonstrated an upregulation in expression of genes associated with cytoskeletal structure and motility. CTGFor TGF-β significantly increased expression of fibronectin mRNA (P =0.006, P =0.003 respectively), laminin mRNA (P =0.006, P =0.005), MMP-2 mRNA (P =0.006, P =0.001), COL1A1 mRNA (P =0.001, P =0.001), COL1A2 mRNA (P = 0.001, P =0.001). Preincubation of ARPE-19 with Y27632 (10mmol/L) significantly prevented CTGF or TGF-β induced fibronectin (P=0.005, P=0.003 respectively), MMP-2 (P = 0.003, P =0.002), COL1A1 (P =0.006, P =0.003), and COL1A2 (P =0.006, P =0.004) gene expression, but not laminin (P =0.375, P =0.516). CONCLUSION:Our study demonstrated that both TGF-β and CTGF upregulate the expression of ECM components including fibronectin, laminin, MMP-2 and type I collagen by activating the RhoA/ROCK signaling pathway. During this process, ARPE-19 cells were shown to change from an epithelial to a mesenchymal phenotype in vitro. Y27632, a ROCK inhibitor, inhibited the transcription of fibronectin, MMP-2 and type I collagen, but not laminin. The data from our work suggest a role for CTGF as a profibrotic mediator. Inhibiting the RhoA/ROCK pathway represents a potential target to prevent the fibrosis of retinal pigment epithelial (RPE) cells. This might lead to a novel therapeutic approach to preventing the onset of early proliferative vitreoretinopathy(PVR). | Jing Zhu Duy Nguyen Hong Ouyang Xiao-Hui Zhang Xiao-Ming Chen Kang Zhang | 2013 | International Journal of Ophthalmology(English edition)2013，6，1： | 21 |
| 4 | Petrogenesis of Late Cretaceous Jiangla'angzong I-Type Granite in Central Lhasa Terrane, Tibet, China: Constraints from Whole-Rock Geochemistry, Zircon U-Pb Geochronology, and Sr-Nd-Pb-Hf Isotopes显示文摘The Jiangla'angzong granite in the northern part of the Central Lhasa Terrane is composed of syenogranite and adamellite. LA-ICP-MS zircon U-Pb analyses suggest that syenogranite has a weighted mean ^(206) Pb/^(238) U age of 86±1 Ma(mean square weighted deviation=0.37), which is in accordance with the muscovite Ar-Ar age(85±1 Ma) of Cu-Au ore-bearing skarns and the zircon U-Pb age(84±1 Ma) of adamellite. This suggests that the Jiangla'angzong magmatism and Cu–Au mineralization events took place during the Late Cretaceous. The granite contains hornblende, biotite, and pyroxene, and does not contain Al-bearing minerals, such as muscovite, cordierite, and garnet. It has high contents of SiO_2(65.10–70.91 wt%), K_2O(3.44–5.17 wt%), and total K_2O+Na_2O(7.13–8.15 wt%), and moderate contents of A_(12)O_3(14.14–16.45 wt%) and CaO(2.33–4.11 wt%), with a Reitman index(σ43) of 2.18 to 2.33, and A/CNK values of 0.88 to 1.02. The P_2O_5 contents show a negative correlation with SiO_2, whereas Pb contents show a positive correlation with SiO_2. Th and Y contents are relatively low and show a negative correlation with the Rb contents. These characteristics suggest that the Jiangla'angzong granite is a high K calc–alkaline metaluminous I–type granite. It is enriched in light rare earth elements(LREE) and large ion lithofile elements(LILE), and depleted in heavy rare earth elements(HREE) and high field strength elements(HFSE), with LREE/HREE ratios of 11.7 to 18.1. The granite has negative Eu anomalies of 0.58 to 0.94 without obvious Ce anomalies(δCe=1.00–1.04). The relatively low initial 87 Sr/86 Sr ratios of 0.7106 to 0.7179, positive εHf(t) values of 1.0 to 4.1, and two-stage Hf model ages(TDM2) ranging from 889 Ma to 1082 Ma, These geochemical features indicate that the granite derived from a juvenile crust. The(^(143) Nd/^(144) Nd)_t values from the Jiangla'angzong granite range from 0.5121 to 0.5123, its εNd(t) values range from-10.17 to-6.10, its(^(206) Pb/^(204) Pb)_t values range from 18.683 to 18.746, its(^(207) Pb/^(204) Pb)_t values range from 15.695 to 15.700, and its(^(208) Pb/^(204) Pb)_t values range from 39.012 to 39.071. These data indicate that the granite was formed by melting of the upper crust with the addition of some mantle materials. We propose that the Jiangla'angzong granite was formed during the postcollision extension of the Qiangtang and Lhasa terranes. | LIU Hong LI Guangming HUANG Hanxiao CAO Huawen YUAN Qian LI Yingxu OUYANG Yuan LAN Shuangshuang LU Menghong YAN Guoqiang | 2018 | Acta Geologica Sinica(English Edition)2018，92，4： | 20 |
| 5 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 6 | Evaluation of Circulating Endometrial Cells as a Biomarker for Endometriosis显示文摘 | Ying Chen Hong-Lan Zhu Zhe-Wen Tang Kuang Hong Neoh Dong-Fang Ouyang Heng Cui Hong-Yan Cheng Rui-Qiong Ma Xue Ye Ray P. S. Han Xiao-Hong Chang | 2017 | Chinese Medical Journal2017，，19： | 10 |
| 7 | Carbon Materials Reinforced Aluminum Composites:A Review显示文摘Carbon materials, including carbon fibers, graphite, diamond, carbon foams, carbon nanotubes, and graphene, are attractive reinforcements for aluminum matrix composites due to their excellent mechanical and/or physical properties as well as light weight. Carbon materials reinforced aluminum(C/Al) composites are promising materials in many areas such as aerospace, thermal management, and automobile. However, there are still some challenging problems that need to be resolved,such as interfacial reactions, low wettability, and anisotropic properties. These problems have limited the use of these composites. This review mainly focuses on the categories, fabrication processes, existing problems and solutions, coatings and interfaces, challenges and opportunities of C/Al composites so as to provide a useful reference for future research. | Yu Huang Qiubao Ouyang Di Zhang Jing Zhu Ruixiang Li Hong Yu | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，5： | 8 |
| 8 | Application of pole-zero cancellation circuit in nuclear signal filtering and shaping algorithm显示文摘In radiation measurement and digital nuclear spectrum systems,traditional nuclear signal processing circuits in nuclear electronics have been gradually replaced by digital algorithm modules with the application of highperformance programmable hardware logic devices(such as FPGA or DSP).Referring to the digital realization method of inverse RC integral circuit systems,the function of the pole-zero cancellation(PZC)circuit was analyzed,a new modified cascade equivalent model of PZC was established,and the time-domain digital PZC(DPZC)recursive algorithm was derived in detail in this study.Two parameters kIand k_(D)are included in the new algorithm,where kIshould match the exponential decay time constant of the input signal to realize the pole-zero compensation,while the decay time constant of the output signal can be changed with the adjustable parameter k_(D)(which is larger than the decay time constant of the input signal).Based on the new DPZC algorithm module,two trapezoidal(triangular)shaping filters were designed and implemented.The amplitude–frequency characteristics of the output signal of the proposed trapezoidal shaping algorithm and the convolution trapezoidal shaping algorithm were compared,with fixed peaking time.The results show that the trapezoidal shaping algorithm based on DPZC can better suppress high-frequency noise.Finally,based on the Na I(Tl)scintillator(u75 mm×75 mm)detector and^(137)Cs source,the effect of the k_(D)value on the energy resolution of the DPZC trapezoidal(triangular)shaping algorithm was studied.The experimental results show that,with an increase in k_(D),the energy resolution of the system improved and reached the maximum when k_(D)was greater than 10,and the optimal energy resolution of the system was 7.72%. | Huai-Ping Wang Jian-Bin Zhou Xiao-Ping Ouyang Xian-Guo Tuo Xu Hong Yi Liu Jie Yu You-Xian Jin | 2021 | Nuclear Science and Techniques2021，32，8： | 7 |
| 9 | New innovations in pavement materials and engineering:A review on pavement engineering research 2021显示文摘Sustainable and resilient pavement infrastructure is critical for current economic and environmental challenges.In the past 10 years,the pavement infrastructure strongly supports the rapid development of the global social economy.New theories,new methods,new technologies and new materials related to pavement engineering are emerging.Deterioration of pavement infrastructure is a typical multi-physics problem.Because of actual coupled behaviors of traffic and environmental conditions,predictions of pavement service life become more and more complicated and require a deep knowledge of pavement material analysis.In order to summarize the current and determine the future research of pavement engineering,Journal of Traffic and Transportation Engineering(English Edition)has launched a review paper on the topic of'New innovations in pavement materials and engineering:A review on pavement engineering research 2021'.Based on the joint-effort of 43 scholars from 24 well-known universities in highway engineering,this review paper systematically analyzes the research status and future development direction of 5 major fields of pavement engineering in the world.The content includes asphalt binder performance and modeling,mixture performance and modeling of pavement materials,multi-scale mechanics,green and sustainable pavement,and intelligent pavement.Overall,this review paper is able to provide references and insights for researchers and engineers in the field of pavement engineering. | JTTE Editorial Office Jiaqi Chen Hancheng Dan Yongjie Ding Yangming Gao Meng Guo Shuaicheng Guo Bingye Han Bin Hong Yue Hou Chichun Hu Jing Hu Ju Huyan Jiwang Jiang Wei Jiang Cheng Li Pengfei Liu Yu Liu Zhuangzhuang Liu Guoyang Lu Jian Ouyang Xin Qu Dongya Ren Chao Wang Chaohui Wang Dawei Wang Di Wang Hainian Wang Haopeng Wang Yue Xiao Chao Xing Huining Xu Yu Yan Xu Yang Lingyun You Zhanping You Bin Yu Huayang Yu Huanan Yu Henglong Zhang Jizhe Zhang Changhong Zhou Changjun Zhou Xingyi Zhu | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，6： | 7 |
| 10 | Centralized isolation of Helicobacter pylori from multiple centers and transport condition influences显示文摘AIM:To evaluate the efficacy of centralized culture and possible influencing factors.METHODS:From January 2010 to July 2012,66452 patients with suspected Helicobacter pylori(H.pylori) infection from 26 hospitals in Zhejiang and Jiangsu Provinces in China underwent gastrointestinal endoscopy.Gastric mucosal biopsies were taken from the antrum for culture.These biopsies were transported under natural environmental temperature to the central laboratory in Hangzhou city and divided into three groups based on their transport time:5,24 and 48 h.The culture results were reported after 72 h and the positive culture rates were analyzed by a χ2 test.An additional 5736 biopsies from H.pylori-positive patients(5646 rapid urease test-positive and 90 14C-urease breath test-positive) were also cultured for quality control in the central laboratory setting.RESULTS:The positive culture rate was 31.66%(21036/66452) for the patient samples and 71.72%(4114/5736) for the H.pylori-positive quality control specimens.In the 5 h transport group,the positiveculture rate was 30.99%(3865/12471),and 32.84%(14960/45553) in the 24 h transport group.In contrast,the positive culture rate declined significantly in the 48 h transport group(26.25%; P < 0.001).During transportation,the average natural temperature increased from 4.67 to 29.14℃,while the positive culture rate declined from 36.67%(1462/3987) to 24.12%(1799/7459).When the temperature exceeded 24℃,the positive culture rate decreased significantly,especially in the 48 h transport group(23.17%).CONCLUSION:Transportation of specimens within 24 h and below 24℃ is reasonable and acceptable for centralized culture of multicenter H.pylori samples. | Ya-Nan Gong You-Ming Li Ning-Min Yang Hong-Zhang Li Feng Guo Lang Lin Qun-Ying Wang Jia-Kun Zhang Zi-Zhong Ji Ji-Bo Mao Jun-Liang Mao Zheng-Chao Shi Wu-Heng Tang Xin-Jian Zhu Wei Shao Xiao-Feng Zhang Xing-Hua Wang Yue-Feng Tong Mi-Zu Jiang Guang-Lan Chen Zhi-Yong Wang Hui-Min Tu Guo-Fa Jiang Jian-Sheng Wu Xu-Peng Chen Qiu-Long Ding Hong Ouyang Feng-Zhe Jin Yan-Li Xu Jian-Zhong Zhang | 2015 | World Journal of Gastroenterology2015，21，3： | 6 |
| 11 | Dendrite-accelerated thermal runaway mechanisms of lithium metal pouch batteries显示文摘High-energy-density lithium metal batteries(LMBs)are widely accepted as promising next-generation energy storage systems.However,the safety features of practical LMBs are rarely explored quantitatively.Herein,the thermal runaway behaviors of a 3.26 Ah(343 Wh kg^(−1))Li|LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2)pouch cell in the whole life cycle are quantitatively investigated by extended volume-accelerating rate calorimetry and differential scanning calorimetry.By thermal failure analyses on pristine cell with fresh Li metal,activated cell with once plated dendrites,and 20-cycled cell with large quantities of dendrites and dead Li,dendrite-accelerated thermal runaway mechanisms including reaction sequence and heat release contribution are reached.Suppressing dendrite growth and reducing the reactivity between Li metal anode and electrolyte at high temperature are effective strategies to enhance the safety performance of LMBs.These findings can largely enhance the understanding on the thermal runaway behaviors of Li metal pouch cells in practical working conditions. | Xiang-Qun Xu Xin-Bing Cheng Feng-Ni Jiang Shi-Jie Yang Dongsheng Ren Peng Shi HungJen Hsu Hong Yuan Jia-Qi Huang Minggao Ouyang Qiang Zhang | 2022 | SusMat2022，2，4： | 6 |
| 12 | Molecular Weight Controllable Degradation of Laminaria japonica Polysaccharides and Its Antioxidant Properties显示文摘In this study, molecular weight controllable degradation of algal Laminaria japonica polysaccharides(LPS) was investigated by ultrasound combined with hydrogen peroxide. Three main factors, i.e., ultrasonic power(A), ultrasonic time(B), and H_2O_2 concentration(C) were chosen for optimizing parameters by employing three-factors, three-levels BBD. The influence of degradation on structure change and antioxidant activities was also investigated. A second-order polynomial equation including molecular weight(Y) of Laminaria japonica polysaccharides and each variable parameter, i.e., ultrasonic power(A), ultrasonic time(B), and H_2O_2 concentration(C), was established: Y=20718.67-4273.13A-4000.38B-1438.75C+2333.25AB+1511.00AC+873.00BC+2838.29A^2 + 2490.79B^2+873.04C^2. The equation regression coefficient value(R^2 = 0.969) indicated that this equation was valid. The value of the adjusted determination coefficient(adjusted R^2 = 0.914) also confirmed that the model was highly significant. The results of selected experimental degradation conditions matched with the predicted value. FT-IR spectra revealed that the structures of LPS before and after degradation were not significantly changed. Antioxidant activities of LPS revealed that low Mws possessed stronger inhibitory than the original polysaccharides. The scavenging effects on superoxide radicals was the highest when IC50 of crude LPS was 4.92 mg mL^(-1) and IC50 of Mw 18.576 KDa was 1.02 mg mL^(-1), which was fourfold higher than initial polysaccharide. | ZHA Shenghua ZHAO Qingsheng ZHAO Bing OUYANG Jie MO Jianling CHEN Jinjin CAO Lili ZHANG Hong | 2016 | Journal of Ocean University of China2016，15，4： | 4 |
| 13 | Simultaneous determination of metronidazole and tinidazole in plasma by using HPLC-DAD coupled with second-order calibration显示文摘A method using HPLC-DAD coupled with second-order calibration was developed to simultaneously determine metronidazole and tinidazole in plasma samples in this paper.The second-order calibration method based on APTLD(alternating penalty trilinear decomposition) algorithm was proposed to analyze the three-way HPLC-DAD data from both standard and prediction samples, which makes it possible that calibration can be performed even in the presence of unknown interferences with a simple and green chromatographic condition and short analysis time.The results showed that good recoveries were obtained although the chromatographic and spectral profiles of the analytes of interest as well as background were partially overlapped with each other in plasma samples. | Li Qun Ouyang Hai Long Wu Ya Juan Liu Jian Yue Wang Yong Jie Yu Hong Yan Zou Ru Qin Yu | 2010 | Chinese Chemical Letters2010，21，10： | 4 |
| 14 | Biomarkers for hepatocellular carcinoma based on body fluids and feces显示文摘Novel non-/minimally-invasive and effective approaches are urgently needed to supplement and improve current strategies for diagnosis and management of hepatocellular carcinoma(HCC).Overwhelming evidence from published studies on HCC has documented that multiple molecular biomarkers detected in body fluids and feces can be utilized in early-diagnosis,predicting responses to specific therapies,evaluating prognosis before or after therapy,as well as serving as novel therapeutic targets.Detection and analysis of proteins,metabolites,circulating nucleic acids,circulating tumor cells,and extracellular vesicles in body fluids(e.g.,blood and urine)and gut microbiota(e.g.,in feces)have excellent capabilities to improve different aspects of management of HCC.Numerous studies have been devoted in identifying more promising candidate biomarkers and therapeutic targets for diagnosis,treatment,and monitoring responses of HCC to conventional therapies,most of which may improve diagnosis and management of HCC in the future.This review aimed to summarize recent advances in utilizing these biomarkers in HCC and discuss their clinical significance. | Ming-Cheng Guan Wei Ouyang Ming-Da Wang Lei Liang Na Li Ting-Ting Fu Feng Shen Wan-Yee Lau Qiu-Ran Xu Dong-Sheng Huang Hong Zhu Tian Yang | 2021 | World Journal of Gastrointestinal Oncology2021，13，5： | 4 |
| 15 | Effect of Support on Catalytic Performance of Photothermal Fischer-Tropsch Synthesis to Produce Lower Olefins over FesC2-based Catalysts显示文摘Photothermal Fischer-Tropsch synthesis(FTS)has been extensively studied,but few reports were focused on systematically exploring the influence of support on catalytic performance.Herein,a series of Fe5C2-based catalysts with different supports was fabricated via a one-step wet-chemical method for photothermal conversion of syngas to lower olefins.Under light irradiation,the optimized FesC2/a-Al2O3 catalyst demonstrated remarkable photothermal FTS activity,delivering selectivity to lower olefins of 50.3%with a CO conversion rate of 52.5%.Characterization studies using X-ray diffraction and Mossbauer spectroscopy analysis revealed that the active catalyst mainly contained FesC2 nanoparticles on a-AbO3 support.It was found that the weak interaction between active phase and a-AhO3 could promote the formation of FesC2,which contributed to the high selectivity to lower olefins. | LI Yuan LI Ruizhe LI Zhenhua WEI Weiqin OUYANG Shuxin YUAN Hong ZHANG Tierui | 2020 | Chemical Research in Chinese Universities2020，36，6： | 3 |
| 16 | Enhancing bifunctionality of CoN nanowires by Mn doping for long-lasting Zn-air batteries显示文摘Tailoring the nanostructure and composition of transition metal nitrides is highly important for their use as potent low-cost electrocatalysts. Cobalt nitride(CoN) exhibits strong catalytic activity for oxygen evolution reaction(OER). However, its poor catalytic efficiency for oxygen reduction reaction(ORR) hinders its application in rechargeable zinc-air batteries(ZABs) as the air cathode. In this work, we deploy the effective strategy of Mn doping to improve both OER and ORR activity of CoN nanowires as the cathode material for ZAB. Theoretical calculation predicts that moderate Mn doping in cobalt nitride results in a downshift of the d-band center and reduces the adsorption energy of reaction intermediates. With ~10 at% Mn dopants, stronger catalysis activities for both OER and ORR are achieved compared to pure CoN nanowires. Subsequently, both aqueous and flexible quasi-solid-state ZABs are constructed using the Mn-doped CoN nanowires array as additive-free air cathode. Both types of devices present large open circuit potential, high power density and long-cycle stability. This work pushes forward the progress in developing cost-effective ZABs. | Yongqi Zhang Bo Ouyang Guankui Long Hua Tan Zhe Wang Zheng Zhang Weibo Gao Rajdeep Singh Rawat Hong Jin Fan | 2020 | Science China Chemistry2020，63，7： | 3 |
| 17 | REE Geochemistry of VMS and SEDEX Ores in China显示文摘REE ratios and patterns for massive pyrite ore and massive cuprous pyrite ore ofthe Baiyinchang orefield are quite similar to those for quartz keratophyritic tuff and quartzalbitophyre of the same orefield. However, massive cuprous pyrite ore of the Ashele Cu-Zn de-posit is similar to basalt-diabase of the same district in REE geochemistry. Comparison of theChinese VMS ores with those from Rio Tinto, Spain and Que River, Australia, in REEgeochemistry has been made. REE ratios and patterns of bedded-massive and massive ores ofthe Changba-Lijiagou Zn-Pb deposit, the second largest SEDEX deposit in China are similarto those of their host rocks, the Qinling shales of Devonian age and the Changba adamellite.The three types of ore and their host rocks of the Dongshengmiao pyrite (pyrrhotite)-Zn-Pbdeposit have parallel REE ratios and patterns. | Song Xuexin Xu Qingsheng Guo Yuemin Mao Xueying and Ouyang Hong Institute of Mineral Deposits, Chinese Academy of Geological Sciences, Beijing Institute of High Energy Physics, Chinese Academy of Sinices, Beijing | 1997 | Acta Geologica Sinica(English Edition)1997，71，3： | 3 |
| 18 | Gaussian shaper for nuclear pulses based on multilevel cascade convolution显示文摘For nuclear measurements,it is necessary to obtain accurate information from nuclear pulses,which should be obtained by first shaping the pulses outputted by the detectors.However,commonly used pulse-shaping algorithms have certain problems.For example,certain pulse-shaping algorithms have long dead-times in high-counting-rate environments or are difficult to achieve in digital systems.Gaussian signals are widely used in analog nuclear instruments owing to their symmetry and completeness.A Gaussian signal is usually implemented by using a multilevel S–K filter in series or in parallel.It is difficult to construct a real-time digital Gaussian filter for the complex Gaussian filtering algorithm.Based on the multilevel cascade convolution,a pulse-shaping algorithm for double exponential signals is proposed in this study,which,in addition to double exponential signals,allows more complex output signal models to be used in the new algorithm.The proposed algorithm can be used in high-counting-rate environments and has been implemented in an FPGA with fewer multipliers than those required in other traditional Gaussian pulse-shaping algorithms.The offline processing results indicated that the average peak base width of the output-shaped pulses obtained using the proposed algorithm was reduced compared with that obtained using the traditional Gaussian pulse-shaping algorithm.Experimental results also demonstrated that signal-to-noise ratios and energy resolutions were improved,particularly for pulses with a low energy.The energy resolution was improved by 0.1–0.2%while improving the counting rate. | Min Wang Jian‑Bin Zhou Xiao‑Ping Ouyang Ying‑Jie Ma Xu Hong | 2022 | Nuclear Science and Techniques2022，33，12： | 3 |
| 19 | Loss of FOXC1 contributes to the corneal epithelial fate switch and pathogenesis显示文摘Forkhead box C1(FOXC1)is required for neural crest and ocular development,and mutations in FOXC1 lead to inherited Axenfeld-Rieger syndrome.Here,we find that FOXC1 and paired box 6(PAX6)are co-expressed in the human limbus and central corneal epithelium.Deficiency of FOXC1 and alternation in epithelial features occur in patients with corneal ulcers.FOXC1 governs the fate of the corneal epithelium by directly binding to lineage-specific open promoters or enhancers marked by H3K4me2.FOXC1 depletion not only activates the keratinization pathway and reprograms corneal epithelial cells into skin-like epithelial cells,but also disrupts the collagen metabolic process and interferon signaling pathways.Loss of interferon regulatory factor 1 and PAX6 induced by FOXC1 dysfunction is linked to the corneal ulcer.Collectively,our results reveal a FOXC1.mediated regulatory network responsible for corneal epithelial homeostasis and provide a potential therapeutic target for corneal ulcer. | Mingsen Li Liqiong Zhu Jiafeng Liu Huaxing Huang Huizhen Guo Li Wang Lingyu Li Sijie Gu Jieying Tan Jing Zhong Bowen Wang Zhen Mao Yong Fan Chunqiao Liu Jin Yuan Hong Ouyang | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 2 |
| 20 | Alpha-fetoprotein,protein induced by vitamin K absence or antagonist-Ⅱ,lens culinaris agglutinin-reactive fraction of alpha-fetoprotein alone and in combination for early detection of hepatocellular carcinoma from nonalcoholic fatty liver disease:A multicenter analysis显示文摘Background:Current surveillance strategies for hepatocellular carcinoma(HCC)among patients with non-alcoholic fatty liver disease(NAFLD)are insufficient.This study aimed to investigate the diagnostic perfor-mance of alpha-fetoprotein(AFP),protein induced by vitamin K absence or antagonist-Ⅱ(PIVKA-Ⅱ),lens culinaris agglutinin-reactive fraction of AFP(AFP-L3),and their combinations in HCC underlying NAFLD patients.Methods:Serologic AFP,AFP-L3,and PIVKA-Ⅱ levels in NAFLD patients with and without HCC were mea-sured.By receiver operating characteristic(ROC)analyses,the area under the curve(AUC),sensitivity,and specificity were obtained to evaluate the diagnostic accuracy of each biomarker and their combinations.Results:This study was conducted on 139 patients with NAFLD-HCC and 345 NAFLD controls.The eleva-tion of these three biomarkers was observed in patients with NAFLD-HCC compared to those in NAFLD controls(all P<0.001).When they were analyzed individually,PIVKA-Ⅱ showed the best performance in diagnosing any-stage HCC with an AUC of 0.869,followed by AFP(0.763;vs.PIVKA-Ⅱ,P<0.001)and AFP-L3(0.689;vs.PIVKA-II,P<0.001).When they were analyzed in combination,AFP+PIVKA-Ⅱ yielded the highest AUC(0.906),followed by AFP+PIVKA-II+AFP-L3(0.904;vs.AFP+PIVKA-Ⅱ,P=0.086),PIVKA-Ⅱ+AFP-L3(0.881;vs.AFP+PIVKA-II,P<0.001),and AFP+AFP-L3(0.759;vs.AFP+PIVKA-II,P<0.001).Similar findings were obtained in the subgroup with early-stage NAFLD-HCC,as well as the non-cirrhotic subgroup.Conclusions:These data validated the better diagnostic ability of PIVKA-II than AFP or AFP-L3 alone for diagnosing any-stage HCC among patients with NAFLD,and the combination of AFP+PIVKA-II signifi-cantly improved the diagnostic accuracy of NAFLD-HCC. | Ming-Cheng Guan Wei Ouyang Si-Yu Liu Li-Yang Sun Wei-Yue Chen Xiang-Min Tong Hong Zhu Tian Yang | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，6： | 2 |
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