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| 1 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 2 | 针对患者利益的机器学习和人工智能研究:在透明性、可重复性、伦理和有效性等方面的20个关键问题显示文摘机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、对潜在伦理问题的探究,以及对有效性的明确验证。这些问题的存在有许多原因,其中最重要的一点(为此我们提供了初步解决方案)就是当前缺乏针对ML和AI的最佳实践指南。我们认为从事研究的跨学科团队和应用ML/AI影响健康的项目,将因解决有关透明度、可重复性、伦理和有效性(TREE)的一系列问题而受益。这里提出的20个关键问题为研究团队提供了一个研究设计、实施和报告框架;帮助编辑和同行评审专家评估文献的贡献;让患者、临床医生和政策制定者评估新发现可能会给患者带来的获益。 | Sebastian Vollmer Bilal A Mateen Gergo Bohner Franz J Kirdly Rayid Ghani Pall Jonsson Sarah Cumbers Adrian Jonas Katherine S L McAllister Puja Myles David Granger Mark Birse Richard Branson Karel G M Moons Gary S Collins John P A Chris Holmes Harry Hemingwayp 李峰(译) 徐磊(校) 赵邑(校) | 2020 | 英国医学杂志中文版2020，23，9： | 5 |
| 3 | 心房颤动——当今面临的挑战显示文摘在过去数年里,临床和科撞方面对心房颤动(房颤)的关注明显增加,有关这一论题的出版物数量迅速、稳定的增长就是证明。虽然已有一些新方法治疗遮一心律失常一但大多数房颤患者仍然不得不忍受这一心律失常,包括其不良后果和症状,房颤无疑是虽迫切需要有更好治疗方法的一种心律失常。为了达到这一目的,就需要更深刻地认识房颤的机制.以便开发直接影响这一基础病理生理机制的治疗措施。 | Olsson SB Hansson A Hedin E Holm M Ingemansson M Johansson R Meurling C Pehrson S Roijer A Yuan S 方丕华 | 1997 | 中华心律失常学杂志1997，1，1： | 3 |
| 4 | IL 28 B genotype is not useful for predicting treatment outcome in A sian chronic hepatitis B patients treated with pegylated interferon‐α显示文摘 | Jacinta A Holmes Tin Nguyen Dilip Ratnam Neel M Heerasing Jane V Tehan Sara Bonanzinga Anouk Dev Sally Bell Stephen Pianko Robert Chen Kumar Visvanathan Rachel Hammond David Iser Ferry Rusli William Sievert Paul V Desmond D Scott Bowden Alexander J Thomps | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 5 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet . 2013 (9867)2013，，9867： | 2 |
| 6 | Polymer Supported Chromium Porpbyrin as Catalyst for Polycarbonate Formation in Supercritical Carbon Dioxide显示文摘 | Stamp L M Mang S A Holmes A B | 2001 | Chem Commun2001，30，： | 1 |
| 7 | Benchmarking Attribute Selection Techniques for Discrete Class Data Mining显示文摘 | Hall M A Holms G | 2003 | IEEE Transactions on Knowledge and Data Engineering2003，15，6： | 1 |
| 8 | The quantity and quality of physiealaetivity among those trying to lose weight 显示文摘 | Gordon P M Heath G W Holmes A | 2000 | American Journal of Preventive Medicine2000，18，1： | 1 |
| 9 | Pivotal role of connec- tive tissue growth factor in lung fibrosis显示文摘 | Ponticos M Holmes A M Shi-Wen X | 2009 | Arthritis& Rheum2009，60，7： | 1 |
| 10 | Double-strand break repair in yeast requires both leading and lagging strand DNA polymerases显示文摘 | Holmes A M Haber J E | 1999 | Cell1999，96，： | 1 |
| 11 | Mutations in the extra sex combs and enhancer of Polycomb genes increase homologous recombination in somatic cells of Drosophila melanogaster显示文摘 | Holmes A M Weedmark K A Gloor G B | 2006 | Genetics2006，172，4： | 1 |
| 12 | Fractionation and separation of human salivary proteins by pH-gradient ion exchange and reversed phase chromatography coupled to mass spectrometry 显示文摘 | Pepaj M A Holm B Fleckenstein | 2006 | J Sep Sci2006，29，4： | 1 |
| 13 | Prevalence esti- mates and health-related correlates of cognitive impairment from a probability sample of community-residing Latino elders显示文摘 | Ramirez M Teresi J A Holmes D etal | 2007 | J Aging Health2007，19，4： | 1 |
| 14 | Staphylococcus aureus isolates carrying Panton-Valentine leukocidin genes in England Wales:frequency,characterization and association with clinical disease显示文摘 | Holmes A Ganner M McGuane S | 2005 | J Clin Microbiol2005，43，5： | 1 |
| 15 | Evidence for best veterinary practice: clinical veterinary research显示文摘 | Holmes M A | 2007 | J Vet Intern Med2007，21，： | 1 |
| 16 | 1997 Volvo Award winner in biomechanical studies, Kinematic behavior of the porcine lum- bar spine:a chronic lesion model显示文摘 | Kaigle A M Holm S H Hansson T H | 1997 | Spine1997，22，24： | 1 |
| 17 | Microelastohydrodynamic lubrication of coated cylinders using coupled differential deflection method显示文摘 | Elsharkawy A A Holmes M J A Evans H P | 2006 | IMechE2006，，： | 1 |
| 18 | Land surface temper- ature from KA band (37 GHz) passive microwave observations 显示文摘 | Holmes T R H De Jeu R A M Owe M | 2009 | Journal of Geophysical Research-Atmospheres2009，，13： | 1 |
| 19 | Avian reovirus crC protein contain a putative fusion sequence and induces fu- sionwhen expressed in mammalian cells 显示文摘 | Theophilos M B Huang J A Holmes I | 1995 | Virology1995，208，： | 1 |
| 20 | Risk factors for acute leukemia in children : a review显示文摘 | Belson M Kingsley B Holmes A | 2007 | Environ Health Perspect2007，115，1： | 1 |
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