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| 1 | Surgical treatment of hepatocellular carcinoma with severe intratumoral arterioportal shunt显示文摘We report a case of hepatocellular carcinoma (HCC) that caused a severe arterioportal shunt (APS). A 49-year-old man was admitted to hospital due to esophagogastric variceal hemorrhage and HCC, and underwent endoscopic variceal ligation (EVL) and endoscopic injection sclerotherapy (EIS). He was then referred to our hospital. Abdominal computed tomography revealed a lowdensity lesion in the posterior segment of the liver and an intratumoral APS, which caused portal hypertension. Although the patient underwent EVL, EIS, Hassab’s operation, and transcatheter arterial embolization for APS, he vomited blood due to rupture of esophagogastric varices. Right hepatectomy was performed for the treatment of HCC and APS, although the indocyanine green retention value at 15 min after intravenous injection was poor (30%). The patient’s postoperative course was uneventful. Eventually, APS disappeared and the esophagogastric varices improved. | Hiromichi Ishii Teruhisa Sonoyama Shingo Nakashima Hiroyuki Nagata Atsushi Shiozaki Yoshiaki Kuriu Hisashi Ikoma Masayoshi Nakanishi Daisuke Ichikawa Hitoshi Fujiwara Kazuma Okamoto Toshiya Ochiai Yukihito Kokuba Chohei Sakakura Eigo Otsuji | 2010 | World Journal of Gastroenterology2010，16，25： | 11 |
| 2 | Soluble ST2 protein inhibits LPS stimulation on monocyte-derived dendritic cells显示文摘ST2 蛋白质是 ST2L 蛋白质的可溶的拼接变体,它是为 interleukin-33 (IL-33 ) 的受体。以前,我们报导可溶的 ST2 在 monocytic 房间压制了 lipopolysaccharide (LPS ) 和 cytokine 生产的信号 transduction。到调查这禁止的效果是否发生在树枝状的房间,它是在天生、适应的免疫的关键播放器,人的导出单核白血球的树枝状的房间在 LPS 刺激前与可溶的 ST2 蛋白质被预先对待。尽管可溶的 ST2 没稀释树枝状的房间的导致 LPS 的成熟,有可溶的 ST2 的预告的处理压制了 cytokine 生产并且禁止了 LPS 发信号。而且,天真的 T 房间的增长被可溶的 ST2 显著地禁止预告的处理。IL-33 在不成熟的导出单核白血球的树枝状的房间的 cytokine 生产上有小效果。而且,可溶的 ST2 蛋白质被使内在化进树枝状的房间,建议那可溶的 ST2 蛋白质由除 IL-33 的隐遁以外的不在经典中的机制行动。 | Akihisa Nagata Naoki Takezako Hiroyuki Tamemoto Hiromi Ohto-Ozaki SatoshiOhta Shin-ichi Tominaga Ken Yanagisawa | 2012 | Cellular & Molecular Immunology2012，9，5： | 4 |
| 3 | Randomized study of lafutidine vs lansoprazole in patients with mild gastroesophageal reflux disease显示文摘AIM: To compare the clinical efficacy of the secondgeneration H2 RA lafutidine with that of lansoprazole in Japanese patients with mild gastroesophageal reflux disease(GERD). METHODS: Patients with symptoms of GERD and a diagnosis of grade A reflux esophagitis(according to the Los Angeles classification) were randomized to receive lafutidine(10 mg, twice daily) or lansoprazole(30 mg, once daily) for an initial 8 wk, followed by maintenance treatment comprising half-doses of the assigned drug for 24 wk. The primary endpoint was the frequency and severity of heartburn during initial and maintenance treatment. The secondary endpoints were the sum score of questions 2 and 3 in the Gastrointestinal Symptom Rating Scale(GSRS), and the satisfaction score.RESULTS: Between April 2012 and March 2013, a total of 53 patients were enrolled, of whom 24 and 29 received lafutidine and lansoprazole, respectively. After 8 wk, the frequency and severity of heartburn was significantly reduced in both groups. However, lafutidine was significantly inferior to lansoprazole with regard to the severity of heartburn during initial and maintenance treatment(P = 0.016). The sum score of questions 2 and 3 in the GSRS, and satisfaction scores were also significantly worse in the lafutidine group than the lansoprazole group(P = 0.0068 and P = 0.0048, respectively).CONCLUSION: The clinical efficacy of lafutidine was inferior to that of lansoprazole, even in Japanese patients with mild GERD. | Ryuta Takenaka Hiroyuki Okada Seiji Kawano Yoshinori Komazawa Fumiya Yoshinaga Shinji Nagata Masafumi Inoue Hirohisa Komatsu Seiji Onogawa Yoshinori Kushiyama Shinichi Mukai Hiroko Todo Hideharu Okanobu Noriaki Manabe Shinji Tanaka Ken Haruma Yoshikazu Kinoshita | 2016 | World Journal of Gastroenterology2016，22，23： | 2 |
| 4 | 辣椒SSR标记的开发和高密度遗传连锁图谱的构建显示文摘为了方便辣椒的标记辅助育种和遗传分析,我们利用辣椒基因组富集文库和公共数据库辣椒的cDNA序列,从中开发了一批非冗余的、具有2~3个碱基基序的SSR(simple sequence repeat)标记。SSR富集文库由三种限制性内切酶(AluI、HaeⅢ、RsaI)和两种生物素标记的寡核苷酸探针b(GA)15和b(CA)15共同构建而成。从6528个克隆开发了1736个基因组SSR标记,从13003个序列中获得了1344个cDNA序列来源的SSR标记。利用自交系K9-11和MZC-180的种内杂交种(K9-11×MZC-180)获得了双单倍体分离群体,并用于遗传作图。将597个标记定位到该连锁图上,其中包括265个新开发的SSR标记。将该遗传图谱命名为KL-DH,它包括12个连锁群,覆盖了2028cM的遗传距离,标记间的平均距离少于4cM。将KL-DH图谱的框架结构与已发表的COSⅡ图谱进行了比较,并利用番茄的基因组序列来整合两个图谱。COSⅡ图谱是由C.frutescens×C.annuum种间杂种的F2分离群体构建而成。本研究所建立的种内杂交KL-DH图谱和种间杂交COSⅡ图谱在图谱长度和标记分布上比较相似,表明KL-DH图谱几乎覆盖了整个辣椒基因组。 | Toru Sugita Yukari Semi Hiromasa Sawada Yumi Utoyama Yuko Hosomi Eri Yoshimoto Yuki Maehata Hiroyuki Fukuoka Ryutaro Nagata Akio Ohyama 高凌云 孔秋生 | 2013 | 辣椒杂志2013，，2： | 2 |
| 5 | Why is the coexistence of gastric cancer and duodenal ulcer rare? Examination of factors related to both gastric cancer and duodenal ulcer显示文摘 | Hideyuki Ubukata Hiroyuki Nagata Takanobu Tabuchi Satoru Konishi Teruhiko Kasuga Takafumi Tabuchi | 2011 | Gastric Cancer2011，，1： | 2 |
| 6 | Thermodynamic stability of γ-aluminum oxynitride显示文摘 | WATARU Nakao HIROYUKI Fukuyama KAZUHIRO Nagata | 2003 | Journal of the Electrochemical Society2003，150，2： | 1 |
| 7 | Intraductal polypoid growth variant of pancreatic acinar cell carcinoma metastasizing to the intrahepatic bile duct 6 years after surgery: A case report and literature review显示文摘 | Shigenori Nagata Miki Tomoeda Chiaki Kubo Hidenori Yoshizawa Michiko Yuki Masanori Kitamura Akemi Takenaka Hiroyuki Uehara Kazuhiro Katayama Katsuyuki Nakanishi Hidenori Takahashi Hiroaki Ohigashi Osamu Ishikawa Yasuhiko Tomita | 2012 | Pancreatology2012，，： | 1 |
| 8 | Simultaneous determination of residual fourteen kinds of beta-lactam and macrolide antibiotics in bovine muscles by high-performance liquid chromatography with a diode array detector显示文摘 | Nagata Tomoko Ashizawa Eiichi Hashimoto Hiroyuki | 2004 | Journal of the Food Hygienic Society of Japan2004，45，3： | 1 |
| 9 | Localized small-bowel infarction caused by Aspergillus during chemotherapy for acute myeloid leukemia: Report of a case显示文摘 | Megumu Enjoji Shunroh Ohtsukasa Hiroto Nagano Moriyuki Matsuki Yasuyuki Kawachi Akane Kurisu Hiroshi Maruyama Manabu Kusakabe Kaoru Nagata Hiroyuki Hamaguchi Kazuhiro Taki | 2008 | Surgery Today2008，，5： | 1 |
| 10 | Clinicopathological Features of Serrated Adenocarcinoma Defined by Makinen in Dukes’ B Colorectal Carcinoma显示文摘 | Shida Yosuke Fujimori Takahiro Tanaka Hiroyuki Fujimori Yukari Kimura Ryusuke Ueda Hirofumi Ichikawa Kazuhito Tomita Shigeki Nagata Hitoshi Kubota Keiichi Tsubaki Masahiro Kato Hiroyuki Yao Takashi Sugai Tamotsu Sugihara Kenichi Ohkura Yas | 2012 | Pathobiology2012，，4： | 1 |
| 11 | An Organic Acid-Induced Sigmoidal Release System for Oral Controlled-Release Preparations显示文摘 | Shinji Narisawa Minako Nagata Chieko Danyoshi Hiroyuki Yoshino Kazuo Murata Yoshiyuki Hirakawa Kazuo Noda | 1994 | Pharmaceutical Research1994，，1： | 1 |
| 12 | Development of simple sequence repeat markers and construction of a high-density linkage map of Capsicum annuum显示文摘 | Toru Sugita Yukari Semi Hiromasa Sawada Yumi Utoyama Yuko Hosomi Eri Yoshimoto Yuki Maehata Hiroyuki Fukuoka Ryutaro Nagata Akio Ohyama | 2013 | Molecular Breeding2013，，4： | 1 |
| 13 | Mechanisms of Pig- iron Making from Magnetite Ore Pellets Containing Coal at Low Temperature 显示文摘 | Kazuhiro NAGATA Rie KOJIMA Taiehi MURAKAMI Masahiro SUSA Hiroyuki FUKUYAMA | 2001 | ISIJ Internation2001，41，11： | 1 |
| 14 | Mechanisms of pig-iron making from magnetite ore pellets containing coal at low temperature 显示文摘 | Kazuhiro Nagata Rie Kojima Taichi Murakami Masahiro Susa Hiroyuki Fukuyama | 2001 | ISIJ International2001，41，11： | 1 |
| 15 | Renal disease in the elderly and the very elderly Japanese: analysis of the Japan Renal Biopsy Registry (J-RBR)显示文摘 | Hitoshi Yokoyama Hitoshi Sugiyama Hiroshi Sato Takashi Taguchi Michio Nagata Seiichi Matsuo Hirofumi Makino Tsuyoshi Watanabe Takao Saito Yutaka Kiyohara Shinichi Nishi Hiroyuki Iida Kunio Morozumi Atsushi Fukatsu Tamaki Sasaki Kazuhiko Tsuruya Yukimasa K | 2012 | Clinical and Experimental Nephrology2012，，6： | 1 |
| 16 | Liquid chromatographic detection of fumonisins in rice seed显示文摘 | Masayo KushirojReiko Nagata Hiroyuki Nakagawa | 2008 | Rep Natl Food Res Inst2008，，72： | 1 |
| 17 | Phase diagram cuspidine (3CaO · 2SiO2 · CaF2)-CaF2显示文摘 | Takashi Watanabe Hiroyuki Fukuyama Kazuhiro Nagata Masahiro Susa | 2000 | Metallurgical and Materials Transactions B2000，，6： | 1 |
| 18 | Solid-state reaction kinetics of the system CaO-FeO显示文摘 | Hiroyuki Fukuyama Md Khalid Kazuhiro Nagata | 2002 | Metall Mater Trans B2002，33，2： | 1 |
| 19 | Stability of Cuspidine (3CaO · 2SiO2 · CaF2 ) and Phase Relations in the CaO- SiO2-CaF2 System 显示文摘 | Watanabe Takashi Fukuyama Hiroyuki Nagata Kazuhiro | 2002 | ISIJ International2002，42，5： | 1 |
| 20 | Rapid decrease of intracellular pH associated with inhibition of Na+/H+exchanger precedes apoptotic events in the MNK45 and MNK74 gastric cancer celllines treated with 2-aminophenoxazine-3-one显示文摘 | Hiroyuki Nagata Xiao-Fang Che Keisuke Miyazawa Akio Tomoda Masato Konishi Hideyuki Ubukata Takafumi Tabuchi | 2011 | Oncology Reports2011，，2： | 1 |
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