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| 1 | A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone显示文摘Transforming growth factor-β(TGF-β)and bone morphogenetic protein(BMP)play important roles in bone metabolism.Smad ubiquitination regulatory factors(Smurfs)regulate TGF-β/BMP signaling via ubiquitination,resulting in degradation of signaling molecules to prevent excessive activation of TGF-β/BMP signaling.Though Smurf2 has been shown to negatively regulate TGF-β/Smad signaling,its involvement in BMP/Smad signaling in bone metabolism has not been thoroughly investigated.In the present study,we sought to evaluate the role of Smurf2 in BMP/Smad signaling in bone metabolism.Absorbable collagen sponges containing 3μg of recombinant human BMP2(rhBMP2)were implanted in the dorsal muscle pouches of wild type(WT)and Smurf2−/−mice.The rhBMP2-induced ectopic bone in Smurf2−/−mice showed greater bone mass,higher mineral apposition and bone formation rates,and greater osteoblast numbers than the ectopic bone in WT mice.In WT mice,the ectopic bone consisted of a thin discontinuous outer cortical shell and scant inner trabecular bone.In contrast,in Smurf2−/−mice,the induced bone consisted of a thick,continuous outer cortical shell and abundant inner trabecular bone.Additionally,rhBMP2-stimulated bone marrow stromal cells(BMSCs)from Smurf2−/−mice showed increased osteogenic differentiation.Smurf2 induced the ubiquitination of Smad1/5.BMP/Smad signaling was enhanced in Smurf2−/−BMSCs stimulated with rhBMP2,and the inhibition of BMP/Smad signaling suppressed osteogenic differentiation of these BMSCs.These findings demonstrate that Smurf2 negatively regulates BMP/Smad signaling,thereby identifying a new regulatory mechanism in bone metabolism. | Junichi Kushioka Takashi Kaito Rintaro Okada Hiroyuki Ishiguro Zeynep Bal Joe Kodama Ryota Chijimatsu Melanie Pye Masahiro Narimatsu Jeffrey LWrana Yasumichi Inoue Hiroko Ninomiya Shin Yamamoto Takashi Saitou Hideki Yoshikawa Takeshi Imamura | 2020 | Bone Research2020，8，4： | 6 |
| 2 | Nuclear corepressor 1 expression predicts response to first-line endocrine therapy for breast cancer patients on relapse显示文摘背景雌激素受体 alpha (嗯一)是最重要的内分泌的治疗应答预言者因为有对内分泌的治疗的反应的预言的胸 cancer.The 精确性的女人被认为被包含雌激素受体 coregulatory 蛋白质和串音在之间影响嗯并且另外的生长发信号因素的 networks.Nuclear corepressor 1 ( NCOR1 )是学习客观的抄写 repressor.The 是在蛋白质 le 调查 NCOR1 | ZHANG Zhen-huan Hiroko Yamashita Tatsuya Toyama Yutaka Yamamoto Teru Kawasoe Mutsuko lbusuki Saori Tomita Hiroshi Sugiura Shunzo Kobayashi Yoshitaka Fujii Hirotaka Iwase | 2009 | Chinese Medical Journal2009，，15： | 4 |
| 3 | Effects of dexmedetomidine on mortality rate and inflammatory responses to endotoxin-induced shock in rats显示文摘 | Takumi Taniguchi Yoko Kidani Hiroko Kanakura Yasuhiko Takemoto Ken Yamamoto | 2004 | Critical Care Medicine2004，，6： | 3 |
| 4 | Stability of the DMF-Protected Au Nanoclusters: Photochemical, Dispersion, and Thermal Properties 显示文摘 | Hideya Kawasaki Hiroko Yamamoto | 2010 | Langmuir2010，26，8： | 1 |
| 5 | Up-Regulation of Calcineurin Aβ mRNA in the Alzheimer’s Disease Brain: Assessment by cDNA Microarray显示文摘 | Ryuji Hata Makoto Masumura Hiroyasu Akatsu Feng Li Hiroko Fujita Yasuo Nagai Takayuki Yamamoto Hidechika Okada Kenji Kosaka Masahiro Sakanaka Tohru Sawada | 2001 | Biochemical and Biophysical Research Communications2001，，2： | 1 |
| 6 | Plasma interleukin (IL)-18 (interferon-γ-inducing factor) and other inflammatory cytokines in patients with gouty arthritis and monosodium urate monohydrate crystal-induced secretion of IL-18显示文摘 | Taku Inokuchi Yuji Moriwaki Hiroko Tsutsui Asako Yamamoto Sumio Takahashi Zenta Tsutsumi Tuneyoshi Ka Kenji Nakanishi Tetsuya Yamamoto | 2005 | Cytokine2005，，1： | 1 |
| 7 | Metallothionein Genes in the Nematode Caenorhabditis elegans and Metal Inducibility in Mammalian Culture Cells显示文摘Genomic DNAs of metallothionein Ⅰ and Ⅱ in Caenorhabditis elegans (CeMT-Ⅰand CeMT-Ⅱ) were isolated by YAC library/polytene filter hybridization followed by subcloning of corresponding cosmid clones. Both genes are mapped at chromosome V. Although the similarities of 5’-flanking regions and coding regions have shown only 55-58%, the introns are split at the same position in both genes, indicating that these two genes are originally from the same gene. While several metal responsive elements are conserved among eukaryotes, only one metal responsive element was found in the promoter region in CeMT-Ⅱ and not in CeMT-Ⅰ. Indced, neither of 5’-flanking regions of CeMT-Ⅰ nor CeMT-Ⅱ connected to chloramphenicol acetyltransferase reporter gene is responsive to heavy metals in mammalian culture cells by transient transfection analysis. These results would suggest that the metal regulatory factors in C.elegans might be different from those conserved in invertebrates and vertebrates, although the MTs in C elegans revealed the similarities to mammalian MTs in several | FUMIHIKO KUGAWA HIROKO YAMAMOTO SHIGEHIRO OSADA MASATADA AOKI MASAYOSHI IMAGAWA AND TSUTOMU NISHIHARA (College of Pharmacy, Nihon University, 7-7-1 Narashino-dai, Funabashi,Chiba 274 and Faculty of Pharmaceutical Sciences, Osaka University,1-6 Yama | 1994 | Biomedical and Environmental Sciences1994，7，3： | 1 |
| 8 | Lime-nitrogen application affects nitrification, denitrification, and N 2 O emission in an acidic tea soil显示文摘 | Akinori Yamamoto Hiroko Akiyama Takuji Naokawa Yasuhiro Miyazaki Yusuke Honda Yukimasa Sano Yasuhiro Nakajima Kazuyuki Yagi | 2014 | Biology and Fertility of Soils2014，，1： | 1 |
| 9 | Stable Transfection of GM1 Synthase Gene into GM1-Deficient NG108-15 Cells, CR-72 Cells, Rescues the Responsiveness of TRK-Neurotrophin Receptor to Its Ligand, NGF显示文摘 | Tatsuro Mutoh Tadanori Hamano Shigeaki Yano Hiroshi Koga Hiroko Yamamoto Koichi Furukawa Robert W. Ledeen | 2002 | Neurochemical Research (-)2002，，7： | 1 |
| 10 | Polymorphisms of the TNF gene and the TNF receptor superfamily member 1B gene are associated with susceptibility to ulcerative colitis and Crohn’s disease, respectively显示文摘 | Hiroko Sashio Kazuo Tamura Reiko Ito Yoshihiro Yamamoto Hiroko Bamba Tadashi Kosaka Shin Fukui Koji Sawada Yoshihiro Fukuda Kazutami Tamura Masamichi Satomi Takashi Shimoyama Jun-ichi Furuyama | 2002 | Immunogenetics2002，，12： | 1 |
| 11 | Cellular and molecular mechanisms of dietary regulation on rat intestinal H + /peptide transporter PepT1显示文摘 | Toshiyuki Shiraga Ken-Ichi Miyamoto Hiroko Tanaka Hironori Yamamoto Yutaka Taketani Kyoko Morita Ikumi Tamai Akira Tsuji Eiji Takeda | 1999 | Gastroenterology1999，，2： | 1 |
| 12 | The targeting of anionized polyvinylpyrrolidone to the renal system显示文摘 | Hiroshi Kodaira Yasuo Tsutsumi Yasuo Yoshioka Haruhiko Kamada Yoshihisa Kaneda Yoko Yamamoto Shin-ichi Tsunoda Takayuki Okamoto Yohei Mukai Hiroko Shibata Shinsaku Nakagawa Tadanori Mayumi | 2003 | Biomaterials2003，，18： | 1 |
| 13 | Neutrophil Extracellular Traps Mediate a Host Defense Response to Human Immunodeficiency Virus-1显示文摘 | Tatsuya Saitoh Jun Komano Yasunori Saitoh Takuma Misawa Michihiro Takahama Tatsuya Kozaki Takuya Uehata Hidenori Iwasaki Hiroko Omori Shoji Yamaoka Naoki Yamamoto Shizuo Akira | 2012 | Cell Host & Microbe2012，，： | 1 |
| 14 | Nonredundant Roles of Sema4A in the Immune System: Defective T Cell Priming and Th1/Th2 Regulation in Sema4A-Deficient Mice显示文摘 | Atsushi Kumanogoh Takashi Shikina Kazuhiro Suzuki Satoshi Uematsu Kazunori Yukawa Shin-Ichiro Kashiwamura Hiroko Tsutsui Midori Yamamoto Hyota Takamatsu Elizabeth P. Ko-Mitamura Noriko Takegahara Satoko Marukawa Isao Ishida Hiroshi Morishita Durbaka V.R. | 2005 | Immunity2005，，： | 1 |
| 15 | Pharmacological inhibition of the Hedgehog pathway prevents human rhabdomyosarcomacell growth显示文摘 | Naoya Kawabata Kosei Ijiri Yasuhiro Ishidou Takuya Yamamoto Hiroko Nagao Satoshi Nagano Shingo Maeda Setsuro Komiya Takao Setoguchi | 2011 | International Journal of Oncology2011，，4： | 1 |
| 16 | Mucosal cutting biopsy technique for histological diagnosis of suspected gastrointestinal stromal tumors of the stomach显示文摘 | Mikinori Kataoka Takashi Kawai Kenji Yagi Hiroko Sugimoto Kei Yamamoto Yasutaka Hayama Masaya Nonaka Takaya Aoki Masakatsu Fukuzawa Mari Fukuzawa Takao Itoi Fuminori Moriyasu | 2012 | Digestive Endoscopy2012，，3： | 1 |
| 17 | Single Center Experience of Cell‐Free and Concentrated Ascites Reinfusion Therapy in Malignancy Related Ascites显示文摘 | Tetsuya Ito Norio Hanafusa Mieko Fukui Hiroko Yamamoto Yasuyuki Watanabe Eisei Noiri Satoru Iwase Kiyoshi Miyagawa Toshiro Fujita Masaomi Nangaku | 2014 | Ther Apher Dial2014，，1： | 1 |
| 18 | Differentiation of embryonic stem cells into hepatocytes: Biological functions and therapeutic application显示文摘 | Hanako Yamamoto Gary Quinn Akira Asari Hiroko Yamanokuchi Takumi Teratani Masaaki Terada Takahiro Ochiya | 2003 | Hepatology2003，，5： | 1 |
| 19 | Cilostazol for prevention of secondary stroke (CSPS 2): an aspirin-controlled, double-blind, randomised non-inferiority trial显示文摘 | Yukito Shinohara Yasuo Katayama Shinichiro Uchiyama Takenori Yamaguchi Shunnosuke Handa Kempei Matsuoka Yasuo Ohashi Norio Tanahashi Hiroko Yamamoto Chokoh Genka Yasuhisa Kitagawa Hideo Kusuoka Katsuya Nishimaru Motoo Tsushima Yukihiro Koretsune Tohru Saw | 2010 | Lancet Neurology2010，，10： | 1 |
| 20 | Metabolomic profiling of lung and prostate tumor tissues by capillary electrophoresis time-of-flight mass spectrometry显示文摘 | Kenjiro Kami Tamaki Fujimori Hajime Sato Mutsuko Sato Hiroyuki Yamamoto Yoshiaki Ohashi Naoyuki Sugiyama Yasushi Ishihama Hiroko Onozuka Atsushi Ochiai Hiroyasu Esumi Tomoyoshi Soga Masaru Tomita | 2013 | Metabolomics2013，，2： | 1 |
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