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| 1 | A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone显示文摘Transforming growth factor-β(TGF-β)and bone morphogenetic protein(BMP)play important roles in bone metabolism.Smad ubiquitination regulatory factors(Smurfs)regulate TGF-β/BMP signaling via ubiquitination,resulting in degradation of signaling molecules to prevent excessive activation of TGF-β/BMP signaling.Though Smurf2 has been shown to negatively regulate TGF-β/Smad signaling,its involvement in BMP/Smad signaling in bone metabolism has not been thoroughly investigated.In the present study,we sought to evaluate the role of Smurf2 in BMP/Smad signaling in bone metabolism.Absorbable collagen sponges containing 3μg of recombinant human BMP2(rhBMP2)were implanted in the dorsal muscle pouches of wild type(WT)and Smurf2−/−mice.The rhBMP2-induced ectopic bone in Smurf2−/−mice showed greater bone mass,higher mineral apposition and bone formation rates,and greater osteoblast numbers than the ectopic bone in WT mice.In WT mice,the ectopic bone consisted of a thin discontinuous outer cortical shell and scant inner trabecular bone.In contrast,in Smurf2−/−mice,the induced bone consisted of a thick,continuous outer cortical shell and abundant inner trabecular bone.Additionally,rhBMP2-stimulated bone marrow stromal cells(BMSCs)from Smurf2−/−mice showed increased osteogenic differentiation.Smurf2 induced the ubiquitination of Smad1/5.BMP/Smad signaling was enhanced in Smurf2−/−BMSCs stimulated with rhBMP2,and the inhibition of BMP/Smad signaling suppressed osteogenic differentiation of these BMSCs.These findings demonstrate that Smurf2 negatively regulates BMP/Smad signaling,thereby identifying a new regulatory mechanism in bone metabolism. | Junichi Kushioka Takashi Kaito Rintaro Okada Hiroyuki Ishiguro Zeynep Bal Joe Kodama Ryota Chijimatsu Melanie Pye Masahiro Narimatsu Jeffrey LWrana Yasumichi Inoue Hiroko Ninomiya Shin Yamamoto Takashi Saitou Hideki Yoshikawa Takeshi Imamura | 2020 | Bone Research2020，8，4： | 6 |
| 2 | Sclerosing epithelioid fibrosarcoma of the liver infiltrating the inferior vena cava显示文摘Sclerosing epithelioid fibrosarcoma (SEF) is a rare and distinct variant of fibrosarcoma, composed of epithelioid tumor cells arranged in strands, nests, cords, or sheets embedded within a sclerotic collagenous matrix. We report a 39-year-old man with SEF of the liver, which infiltrated the inferior vena cava (IVC). The SEF of the liver was successfully resected, and the infiltrated IVC was also removed together with the liver tumor. Histopathological examination of the tumor showed typical histopathology of SEF. Immunohistochemically, the tumor was positive for vimentin. Recurrence was noted 7 mo after surgery. After chemotherapy, the recurrent tumor was resected surgically, and histopathological examination showed similar findingsto those of the primary tumor. To our knowledge, this is the first report of SEF of the liver with tumor invasion of the IVC. | Yoshito Tomimaru Hiroaki Nagano Shigeru Marubashi Shogo Kobayashi Hidetoshi Eguchi Yutaka Takeda Masahiro Tanemura Toru Kitagawa Koji Umeshita Nobuyuki Hashimoto Hideki Yoshikawa Kenichi Wakasa Yuichiro Doki Masaki Mori | 2009 | World Journal of Gastroenterology2009，15，33： | 5 |
| 3 | Acta Biomat:开发出可促进机体神经组织再生的新型网格纤维结构显示文摘近日。一项刊登在国际杂志Acta Biomaterialia上的研究报告中。来自日本大阪大学的研究人员通过研究开发出了一种网格结构。其能够被缠绕在损伤的周围神经组织上来帮助促进损伤神经的再生并且恢复其功能。 | Koji Suzuki Hiroyuki Tanaka Mitsuhiro Ebara Koichiro Uto Hozo Matsuoka Shunsuke Nishimoto Kiyoshi Okada Tsuyoshi Murase Hideki Yoshikawa | 2017 | 现代生物医学进展2017，17，18： | 4 |
| 4 | IL-6 negatively regulates osteoblast differentiation through the SHP2/MEK2 and SHP2/Akt2 pathways in vitro显示文摘 | Shoichi Kaneshiro Kosuke Ebina Kenrin Shi Chikahisa Higuchi Makoto Hirao Michio Okamoto Kota Koizumi Tokimitsu Morimoto Hideki Yoshikawa Jun Hashimoto | 2014 | Journal of Bone and Mineral Metabolism2014，，4： | 2 |
| 5 | Usefulness of enhanced recovery after surgery protocol as compared with conventional perioperative care in gastric surgery显示文摘 | Takanobu Yamada Tsutomu Hayashi Haruhiko Cho Takaki Yoshikawa Hideki Taniguchi Ryoji Fukushima Akira Tsuburaya | 2012 | Gastric Cancer2012，，1： | 1 |
| 6 | Adenovirus-mediated gene transfer of adiponectin reduces the severity of collagen-induced arthritis in mice显示文摘 | Kosuke Ebina Kazuya Oshima Morihiro Matsuda Atsunori Fukuhara Kazuhisa Maeda Shinji Kihara Jun Hashimoto Takahiro Ochi Nirmal K. Banda Hideki Yoshikawa Iichiro Shimomura | 2008 | Biochemical and Biophysical Research Communications2008，，2： | 1 |
| 7 | Alendronate treatment for hip osteoarthritis: prospective randomized 2-year trial显示文摘 | Takashi Nishii Satoru Tamura Toshiyuki Shiomi Hideki Yoshikawa Nobuhiko Sugano | 2013 | Clinical Rheumatology2013，，12： | 1 |
| 8 | Repeated vertebrobasilar thromboembolism in a patient with severe upper cervical instability because of rheumatoid arthritis显示文摘 | Kazuya Oshima Hironobu Sakaura Motoki Iwasaki Akio Nakura Ryutaro Fujii Hideki Yoshikawa | 2011 | The Spine Journal2011，，2： | 1 |
| 9 | Comparison of Fit and Fill Between Anatomic Stem and Straight Tapered Stem Using Virtual Implantation on the ORTHODOC Workstation显示文摘 | Keiji Haraguchi Nobuhiko Sugano Takashi Nishii Tsuyoshi Koyama Shunsaku Nishihara Hideki Yoshikawa Takahiro Ochi | 2001 | Computer Aided Surgery2001，，5： | 1 |
| 10 | Interconnected porous hydroxyapatite ceramics for bone tissue engineering显示文摘 | Hideki Yoshikawa Noriyuki Tamai Tsuyoshi Murase | 2009 | J R Soc Interface2009，6，6： | 1 |
| 11 | Matrix extracellular phosphoglycoprotein (MEPE) is highly expressed in osteocytes in human bone显示文摘 | Akihide Nampei Jun Hashimoto Kenji Hayashida Hideki Tsuboi Kenrin Shi Isamu Tsuji Hideaki Miyashita Takao Yamada Naomichi Matsukawa Masayuki Matsumoto Shigeto Morimoto Toshio Ogihara Takahiro Ochi Hideki Yoshikawa | 2004 | Journal of Bone and Mineral Metabolism2004，，3： | 1 |
| 12 | Second-look arthroscopy of anterior cruciate ligament grafts with multistranded hamstring tendons显示文摘 | Yukiyoshi Toritsuka Konsei Shino Shuji Horibe Tomoki Mitsuoka Masayuki Hamada Ken Nakata Norimasa Nakamura Hideki Yoshikawa | 2004 | Arthroscopy: The Journal of Arthroscopic and Related Surgery2004，，： | 1 |
| 13 | Comparison of adenosine triphosphate, microbiological load, and residual protein as indicators for assessing the cleanliness of flexible gastrointestinal endoseopes显示文摘 | Ryo Fushimi Masaki Takashina Hideki Yoshikawa | 2012 | Ameriean Journal of Infection Control2012，41，2： | 1 |
| 14 | Cartilage repair using an in vitro generated scaffold-free tissue-engineered construct derived from porcine synovial mesenchymal stem cells显示文摘 | Wataru Ando Kosuke Tateishi David A. Hart Daisuke Katakai Yoshinari Tanaka Ken Nakata Jun Hashimoto Hiromichi Fujie Konsei Shino Hideki Yoshikawa Norimasa Nakamura | 2007 | Biomaterials2007，，36： | 1 |
| 15 | Y-40138, a multiple cytokine production modulator, protects against d -galactosamine and lipopolysaccharide-induced hepatitis显示文摘 | Tetsuko Fukuda Akira Mogami Hideki Tanaka Tsutomu Yoshikawa Masao Hisadome Hirotsugu Komatsu | 2006 | Life Sciences2006，，9： | 1 |
| 16 | Surgery With Vascular Reconstruction for Soft-Tissue Sarcomas in the Inguinal Region: Oncologic and Functional Outcomes显示文摘 | Makoto Emori Kenichiro Hamada Shinsuke Omori Susumu Joyama Yasuhiko Tomita Nobuyuki Hashimoto Hiroshi Takami Norifumi Naka Hideki Yoshikawa Nobuhito Araki | 2012 | Annals of Vascular Surgery2012，，5： | 1 |
| 17 | Bone morphogenetic proteins in bone tumors显示文摘 | Hideki Yoshikawa Takanobu Nakase Akira Myoui | 2004 | J Orthop Sci2004，9，3： | 1 |
| 18 | Granular cell tumor of the subcutis: CT and MRI findings显示文摘 | I. Kudawara Takafumi Ueda Hideki Yoshikawa | 1999 | Skeletal Radiology1999，，2： | 1 |
| 19 | Five-Year Results of Metal-on-Metal Resurfacing Arthroplasty in Asian Patients显示文摘 | Takashi Nishii Nobuhiko Sugano Hidenobu Miki Masaki Takao Tsuyoshi Koyama Hideki Yoshikawa | 2007 | The Journal of Arthroplasty2007，，： | 1 |
| 20 | Bone tissue engineering with bone marrow-derived stromal cells integrated with concentrated growth factor in Rattus norvegicus calvaria defect model显示文摘 | Hirotsugu Honda Noriyuki Tamai Norifumi Naka Hideki Yoshikawa Akira Myoui | 2013 | Journal of Artificial Organs2013，，3： | 1 |
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