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| 1 | BRIEF ARTICLE New reduced volume preparation regimen in colon capsule endoscopy显示文摘AIM:To evaluate the effectiveness of our proposed bowel preparation method for colon capsule endoscopy.METHODS:A pilot,multicenter,randomized controlled trial compared our proposed 'reduced volume method'(group A) with the 'conventional volume method'(group B) preparation regimens.Group A did not drink polyethylene glycol electrolyte lavage solution(PEGELS) the day before the capsule procedure,while group B drank 2 L.During the procedure day,groups A and B drank 2 L and 1 L of PEG-ELS,respectively,and swallowed the colon capsule(PillCam COLON capsule).Two hours later the first booster of 100 g magnesium citrate mixed with 900 mL water was administered to both groups,and the second booster was administered six hours post capsule ingestion as long as the capsule had not been excreted by that time.Capsule videos were reviewed for grading of cleansing level,RESULTS:Sixty-four subjects were enrolled,with results from 60 analyzed.Groups A and B included 31 and 29 subjects,respectively.Twenty-nine(94%) subjects in group A and 25(86%) subjects in group B had adequate bowel preparation(ns).Twenty-two(71%) of the 31 subjects in group A excreted the capsule within its battery life compared to 16(55%) of the 29 subjects in group B(ns).Of the remaining 22 subjects whose capsules were not excreted within the battery life,all of the capsules reached the left side colon before they stopped functioning.A single adverse event was reported in one subject who had mild symptoms of nausea and vomiting one hour after starting to drink PEG-ELS,due to ingesting the PEG-ELS faster than recommended.CONCLUSION:Our proposed reduced volume bowel preparation method for colon capsule without PEG-ELS during the days before the procedure was as effective as the conventional volume method. | Yasuo Kakugawa Yutaka Saito Shoichi Saito Kenji Watanabe Naoki Ohmiya Mitsuyuki Murano Shiro Oka Tetsuo Arakawa Hidemi Goto Kazuhide Higuchi Shinji Tanaka Hideki Ishikawa Hisao Tajiri | 2012 | World Journal of Gastroenterology2012，18，17： | 8 |
| 2 | 有为决定早阶段的区分的胃的癌的扩展区域的 NBI 的在我的 DL 的实用性显示文摘 AIM: To investigate whether magnifying endoscopy with narrow band imaging (ME-NBI) is useful for evaluating the area of superficial, depressed- or flat-type differentiated adenocarcinoma of the stomach. METHODS: This procedure was performed in Saitama Medical University International Medical Center, Japanese Red Cross Kumamoto Hospital and Kitakyushu Municipal Medical Center. The subjects were 31 patients in whom biopsy findings, from superficial, depressed- or flat-type gastric lesion, suggested differentiated adenocarcinoma in the above 3 hospitals between January and December 2009. Biopsy was performed on the lesion and non-lesion sides of a boundary (imaginary boundary) visualized on ME-NBI. The results were pathologically investigated. We evaluated the accuracy of estimating a demarcation line (DL) on ME-NBI in comparison with biopsy findings as a gold standard. RESULTS: The DL that could be recognized at 2 points on the orifice and anal sides of each lesion during ME-NBI was consistent with the pathological findings in 22 patients with 0-Ⅱc lesions, 7 with 0-Ⅱb lesions, and 2 with 0-Ⅱb + Ⅱc lesions, showing an accuracy of 100%. CONCLUSION: The results suggest the usefulness of ME-NBI for evaluating the area of superficial, depressed- and flat-type differentiated adenocarcinoma of the stomach. | Kouichi Nonaka Masaaki Namoto Hideki Kitada Michio Shimizu Yasutoshi Ochiai Osamu Togawa Masamitsu Nakao Makoto Nishimura Keiko Ishikawa Shin Arai Hiroto Kita | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，8： | 6 |
| 3 | Magnifying Narrowband Imaging Is More Accurate Than Conventional White-Light Imaging in Diagnosis of Gastric Mucosal Cancer显示文摘 | Yasumasa Ezoe Manabu Muto Noriya Uedo Hisashi Doyama Kenshi Yao Ichiro Oda Kazuhiro Kaneko Yoshiro Kawahara Chizu Yokoi Yasushi Sugiura Hideki Ishikawa Yoji Takeuchi Yoshibumi Kaneko Yutaka Saito | 2011 | Gastroenterology2011，，6： | 4 |
| 4 | Real-world efficacy of daclatasvir and asunaprevir with respect to resistance-associated substitutions显示文摘AIM To investigate daclatasvir(DCV) and asunaprevir(ASV) efficacy in hepatitis C(HCV) patients, with respect to resistance-associated substitutions(RASs).METHODS A total of 392 HCV-infected patients from multiple centers were included in this study. We evaluated their clinical courses and sustained virologic responses(SVR) according to pretreatment factors(gender, age, history of interferon-based regimens, platelet counts, level of viremia, pretreatment NA5A:L31, and Y93 substitutions). We also analyzed the pretreatment and post-treatment major RASs of NS3:D168, NS5A:L31 and Y93 substitutions using a direct-sequencing method in 17 patients who were unable to achieve SVR at 12 wk after treatment completion(SVR12).RESULTS The overall SVR12 rate was 88.3%. Thirty-one patients discontinued treatment before 24 wk because of adverse events, 23 of whom achieved SVR12. There were no significant differences in SVR12 rates with respect to gender, age, history of interferon-based regimens, and platelet counts. The SVR12 rate in patients with viral loads of ≥ 6.0 log IU/m L was significantly lower than those with viral loads of < 6.0 log IU/m L(P < 0.001). The SVR12 rate in patients with Y93 substitution-positive was significantly lower than those with Y93 substitution-negative(P < 0.001). The L31 substitution-positive group showed a lower SVR12 rate than the L31 substitution-negative group, but the difference was not statistically significant. Seventeen patients who did not achieve SVR12 and had available pretreatment and post-treatment sera had additional RASs in NS3:D168, NS5:L31, and Y93 substitution at treatment failure.CONCLUSION Combination of DCV and ASV is associated with a high SVR rate. Baseline RASs should be thoroughly assessed to avoid additional RASs after treatment failure. | Hideki Fujii Atsushi Umemura Taichiro Nishikawa Kanji Yamaguchi Michihisa Moriguchi Hideki Nakamura Kohichiroh Yasui Masahito Minami Saiyu Tanaka Hiroki Ishikawa Hiroyuki Kimura Shiro Takami Yasuyuki Nagao Toshihide Shima Yoshito Itoh | 2017 | World Journal of Hepatology2017，9，25： | 3 |
| 5 | Nature of white opaque substance in gastric epithelial neoplasia as visualized by magnifying endoscopy with narrow‐band imaging显示文摘 | Kenshi Yao Akinori Iwashita Masami Nambu Hiroshi Tanabe Takashi Nagahama Shinichiro Maki Hideki Ishikawa Toshiyuki Matsui Munechika Enjoji | 2012 | Digestive Endoscopy2012，，6： | 2 |
| 6 | Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis显示文摘 | Mitsuhiro Yokoyama Hideki Origasa Masunori Matsuzaki Yuji Matsuzawa Yasushi Saito Yuichi Ishikawa Shinichi Oikawa Jun Sasaki Hitoshi Hishida Hiroshige Itakura Toru Kita Akira Kitabatake Noriaki Nakaya Toshiie Sakata Kazuyuki Shimada Kunio Shirato | 2007 | The Lancet2007，，9567： | 2 |
| 7 | Reduced Diversity and Imbalance of Fecal Microbiota in Patients with Ulcerative Colitis显示文摘 | Hideyuki Nemoto Keiko Kataoka Hideki Ishikawa Kazue Ikata Hideki Arimochi Teruaki Iwasaki Yoshinari Ohnishi Tomomi Kuwahara Koji Yasutomo | 2012 | Digestive Diseases and Sciences2012，，11： | 2 |
| 8 | CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc ? and Thereby Promotes Tumor Growth显示文摘 | Takatsugu Ishimoto Osamu Nagano Toshifumi Yae Mayumi Tamada Takeshi Motohara Hiroko Oshima Masanobu Oshima Tatsuya Ikeda Rika Asaba Hideki Yagi Takashi Masuko Takatsune Shimizu Tomoki Ishikawa Kazuharu Kai Eri Takahashi Yu Imamura Yoshifumi Baba Mitsuyo O | 2011 | Cancer Cell2011，，3： | 2 |
| 9 | The impact of subjective and objective social status on psychological distress among men and women in Japan显示文摘 | Keiko Sakurai Norito Kawakami Kazue Yamaoka Hirono Ishikawa Hideki Hashimoto | 2010 | Social Science & Medicine2010，，11： | 1 |
| 10 | Use of high-strength bars for the seismic performance of high-strength concrete columns 显示文摘 | Ousalem Hassane Takatsu Hiroto Ishikawa Yuji Kimura Hideki | 2009 | Journal of Advanced Concrete Technology2009，7，1： | 1 |
| 11 | An efficient diagnostic strategy for small, depressed early gastric cancer with magnifying narrow-band imaging: a post-hoc analysis of a prospective randomized controlled trial显示文摘 | Shinya Yamada Hisashi Doyama Kenshi Yao Noriya Uedo Yasumasa Ezoe Ichiro Oda Kazuhiro Kaneko Yoshiro Kawahara Chizu Yokoi Yasushi Sugiura Hideki Ishikawa Yoji Takeuchi Yutaka Saito Manabu Muto | 2013 | Gastrointestinal Endoscopy2013，，： | 1 |
| 12 | Nature of white opaque substance in gastric epithelial neoplasia as visualized by magnifying endoscopy with narrow‐band imaging显示文摘 | Kenshi Yao Akinori Iwashita Masami Nambu Hiroshi Tanabe Takashi Nagahama Shinichiro Maki Hideki Ishikawa Toshiyuki Matsui Munechika Enjoji | 2012 | Digestive Endoscopy2012，，6： | 1 |
| 13 | Morphologic Analysis of Gastroesophageal Reflux Diseases in Patients after Distal Gastrectomy显示文摘 | Tsunehiro Takahashi Masashi Yoshida Tetsuro Kubota Yoshihide Otani Yoshiro Saikawa Hideki Ishikawa Kazuhiro Suganuma Yukako Akatsu Koichiro Kumai Masaki Kitajima | 2005 | World Journal of Surgery2005，，1： | 1 |
| 14 | Reduced Diversity and Imbalance of Fecal Microbiota in Patients with Ulcerative Colitis显示文摘 | Hideyuki Nemoto Keiko Kataoka Hideki Ishikawa Kazue Ikata Hideki Arimochi Teruaki Iwasaki Yoshinari Ohnishi Tomomi Kuwahara Koji Yasutomo | 2012 | Digestive Diseases and Sciences2012，，11： | 1 |
| 15 | Seismic Performance and Flexural Stiffness Variation of Assembled Precast High-Strength Concrete Beam Jointed at Mid-Span Using Transverse Bolts 显示文摘 | Ousalem Hassane Ishikawa Yuji Kimura Hideki | 2009 | Journal of Advanced Concrete Technology2009，7，2： | 1 |
| 16 | Rare Helicobacter pylori infection as a factor for the very low stomach cancer incidence in Yogyakarta, Indonesia显示文摘 | Shinkan Tokudome Soeripto F.X. Ediati Triningsih Indrawati Ananta Sadao Suzuki Kiyonori Kuriki Susumu Akasaka Hiroshi Kosaka Hideki Ishikawa Takeshi Azuma Malcolm A. Moore | 2004 | Cancer Letters2004，，1： | 1 |
| 17 | Preoperative Parameters Expanding the Indication of Sphincter Preserving Surgery in Patients With Advanced Low Rectal Cancer显示文摘 | Hideki Ueno Hidetaka Mochizuki Yojiro Hashiguchi Keiichi Ishikawa Hajime Fujimoto Eiji Shinto Kazuo Hase | 2004 | Annals of Surgery2004，，1： | 1 |
| 18 | Preoperative Serum Testosterone Level as an Independent Predictor of Treatment Failure following Radical Prostatectomy <ce:link locator='eulogo1'/>显示文摘 | Shinya Yamamoto Junji Yonese Satoru Kawakami Yuhei Ohkubo Manabu Tatokoro Yoshinobu Komai Hideki Takeshita Yuichi Ishikawa Iwao Fukui | 2007 | European Urology2007，，3： | 1 |
| 19 | Comparison of peg-interferon, ribavirin plus telaprevir vs simeprevir by propensity score matching显示文摘AIM: To compare efficacy of telaprevir(TVR) and simeprevir(SMV) combined with pegylated interferon(PEG-IFN) and ribavirin(RBV) while treating chronic hepatitis C(CHC). METHODS: In all, 306 CHC patients were included in this study. There were 159 patients in the TVR combination therapy group and 147 patients in the SMV combination therapy group. To evaluate pretreatment factors contributing to sustained virological response at 12 wk(SVR12), univariate and multivariate analyses were performed in TVR and SMV groups. To adjust for patient background between TVR and SMV groups, propensity score matching was performed. Virological response during treatment and SVR12 were evaluated.RESULTS: Overall rates of SVR12 [undetectable serum hepatitis C virus(HCV) RNA levels] were 79.2% and 69.4% in TVR and SMV groups, respectively. Patients in the SMV group were older, had higher serum HCV RNA levels, lower hemoglobin, higher prevalence of unfavorable interleukin-28B(IL28B) genotype(rs8099917), and poorer response to previous PEG-IFN and RBV treatment. Propensity score matching was performed to adjust for backgrounds(n = 104) and demonstrated SVR12 rates of 74.0% and 73.1% in the TVR and SMV groups, respectively. In the TVR group, discontinuation rates were higher because of adverse events; however, breakthrough and nonresponse was more frequent in the in SMV group. Multivariate analysis revealed IL28 B genotype(rs8099917) as the only independent predictive factor of SVR12 in both groups.CONCLUSION: SVR12 rates were almost identical following propensity score matching. | Hideki Fujii Takeshi Nishimura Atsushi Umemura Taichiro Nishikawa Kanji Yamaguchi Michihisa Moriguchi Yoshio Sumida Hironori Mitsuyoshi Chihiro Yokomizo Saiyu Tanaka Hiroki Ishikawa Kenichi Nishioji Hiroyuki Kimura Shiro Takami Yasuyuki Nagao Takayuki Takeuchi Toshihide Shima Yoshihiko Sawa Masahito Minami Kohichiroh Yasui Yoshito Itoh | 2015 | World Journal of Hepatology2015，7，28： | 1 |
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