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| 1 | Association between TNF-a and IL-1β genotypes vs Helicobacter pylori infection in Indonesia显示文摘AIM:To investigate the correlation between the Helicobacter pylori(H.pylori)infection and host genetic background of healthy populations in Indonesia.METHODS:In March 2007,epidemiological studies were undertaken on the general population of a city in Indonesia(Mataram,Lombok).The participants included 107 men and 187 women,whose ages ranged from6 to 74 years old,with an average age of 34.0(±14.4)(±SD).The H.pylori of subject by UBT method determination,and through the polymerase chain reaction with confronting two-pair primers(PCR-CTPP)method parsing the single nucleotide polymorphism of interleukin(IL)-8,IL-4,IL-1β,CD14,tumor necrosis factor(TNF-a)and tyrosine-protein phosphates non-receptor type 11(PTPN11)genotypes.The experimental data were analyzed by the statistical software SAS.RESULTS:The H.pylori infection rates in the healthy Indonesian population studied were 8.4%for men and12.8%for women;no obvious differences were noted for H.pylori infection rates by sex or age.TC genotypes of IL-4,TC and CC genotypes of TNF-a,and GA genotypes of PTPN11,were higher in frequency.Both CC and TC genotype of TNF-a T-1031C loci featured higher expressions in the healthy Indonesian population Indonesia studied of(OR=1.99;95%CI:0.67-5.89)and(OR=1.66;95%CI:0.73-3.76),respectively.C allele of IL-1βT-31C gene locus was at a higher risk(OR=1.11;95%CI:0.70-1.73)of H.pylori infection,but no statistical significance was found in our study.CONCLUSION:We reveal that the association between the TNF-a and IL-1βgenotypes may be the susceptibility of H.pylori in the studied population. | Yang Zhao Jing-Wen Wang Tsutomu Tanaka Akihiro Hosono Ryosuke Ando Shinkan Tokudome Soeripto FX Ediati Triningsih Tegu Triono Suwignyo Sumoharjo EY Wenny Astuti Achwan Stephanus Gunawan Yu-Min Li | 2013 | World Journal of Gastroenterology2013，19，46： | 5 |
| 2 | 生命科学研究与时空两要素显示文摘五维的(四维时空加一维时间)宇宙,让世上事物各自披上特定的时空印迹。动态大千世界中的万物,它的静态不过是特定时空短暂的表象。认知万物的有效语言,就是时空。科学本身,就富含严谨的时空内涵。生命物质和无生命物质都由相同的结构单元——碳、氢、氧、氮、磷原子构建而成,唯一的重要区别就是这些原子在三维空间随时间变动的排列形式。时间和空间本属于宇宙,两者同时存在,不可分割地构成万物的自我和他我。万物在期间发生发展。 | 崔允文 邓一夫 李国君 Shinkan Tokudome | 2000 | 中国优生与遗传杂志2000，8，S1： | 4 |
| 3 | Effect of Choto‐san, a Kampo medicine, on impairment of passive avoidance performance in senescence accelerated mouse (SAM)显示文摘 | YutakaMizushima ShinKan SatoshiYoshida YoshifumiIrie YukitomoUrata | 2003 | Phytother Res2003，，5： | 1 |
| 4 | Effect of Physical Activity on Breast Cancer Risk: Findings of the Japan Collaborative Cohort Study显示文摘 | Sadao S Masayo K Shinkan T | 2008 | Cancer Epidemiol Biomarkers Prey2008，17，33： | 1 |
| 5 | Effects of Dietary, Drinking, and Smoking Habits on the Prognosis of Gastric Cancer显示文摘 | Xin-En Huang Kazuo Tajima Nobuyuki Hamajima Yasuhiro Kodera Yoshitaka Yamamura Jin Xiang Suketami Tominaga Shinkan Tokudome | 2000 | Nutrition and Cancer2000，，1： | 1 |
| 6 | Increased intake of n-3 polyunsaturated fatty acids elevates the level of apoptosis in the normal sigmoid colon of patients polypectomized for adenomas/tumors显示文摘 | Jinglei Cheng Kumiko Ogawa Kiyonori Kuriki Yoshifumi Yokoyama Takeshi Kamiya Kyoji Seno Harumi Okuyama Jingwen Wang Chenhong Luo Toshiko Fujii Hiromitsu Ichikawa Tomoyuki Shirai Shinkan Tokudome | 2003 | Cancer Letters2003，，1： | 1 |
| 7 | Rare Helicobacter pylori infection as a factor for the very low stomach cancer incidence in Yogyakarta, Indonesia显示文摘 | Shinkan Tokudome Soeripto F.X. Ediati Triningsih Indrawati Ananta Sadao Suzuki Kiyonori Kuriki Susumu Akasaka Hiroshi Kosaka Hideki Ishikawa Takeshi Azuma Malcolm A. Moore | 2004 | Cancer Letters2004，，1： | 1 |
| 8 | Psychological attitudes and risk of breast cancer in Japan: a prospective study显示文摘 | Kenji Wakai Masayo Kojima Kazuko Nishio Sadao Suzuki Yoshimitsu Niwa Yingsong Lin Takaaki Kondo Hiroshi Yatsuya Koji Tamakoshi Akio Yamamoto Shinkan Tokudome Hideaki Toyoshima Akiko Tamakoshi | 2007 | Cancer Causes & Control2007，，3： | 1 |
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