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| 1 | A Chromosome-Level Genome Assembly of Garlic (Allium sativum) Provides Insights into Genome Evolution and Allicin Biosynthesis显示文摘Garlic,an economically important vegetable,spice,and medicinal crop,produces highly enlarged bulbs and unique organosulfur compounds.Here,we report a chromosome-level genome assembly for garlic,with a total size of approximately 16.24 Gb,as well as the annotation of 57561 predicted protein-coding genes,making garlic the first Allium species with a sequenced genome.Analysis of this garlic genome assembly reveals a recent burst of transposable elements,explaining the substantial expansion of the garlic genome.We examined the evolution of certain genes associated with the biosynthesis of allicin and inulin neoseries-type fructans,and provided new insights into the biosynthesis of these two compounds.Furthermore,a large-scale transcriptome was produced to characterize the expression patterns of garlic genes in different tissues and at various growth stages of enlarged bulbs.The reference genome and large-scale transcriptome data generated in this study provide valuable new resources for research on garlic biology and breeding. | Xiudong Sun Siyuan Zhu Ningyang Li Yi Cheng Jing Zhao Xuguang Qiao Li Lu Shiqi Liu Yanzhou Wang Chan Liu Benping Li Wu Guo Shuang Gao Zemao Yang Fu Li Zheng Zeng Qing Tang Yupeng Pan Mengjiao Guan Jian Zhao Xiaomi ng Lu Huanwe n Meng Zhenlin Han Chun she ng Gao Wenkai Jiang Xing Zhao Shilin Tian Jianguang Su Zhihui Cheng Touming Liu | 2020 | Molecular Plant2020，13，9： | 14 |
| 2 | Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism显示文摘Amycolatopsis mediterranei 被用于 rifamycin 的工业规模生产,它在 antimycobacterial 治疗起一个重要作用。作为类 Amycolatopsis 的首先定序的染色体, 236 715 底配对的包括 10 的紧张 U32 的染色体,最大的原核生物的染色体之一到目前为止曾经被定序。不同于在 streptomycetes 发现的线性拓扑学,这个染色体是圆形的,特别地类似于 Saccharopolyspora erythraea 和奴卡氏菌属 farcinica,在发展史和分类代表他们的靠近的关系。尽管在 A 预言了 9 228 编码蛋白质的基因。mediterranei 染色体 S 与那些分享了 orthologs 的最大的数字。erythraea,它被 Streptomyces coelicolor 而非 N 出人意料地跟随。farcinica,显示不同新陈代谢的特征经由改编演变到多样的生态的壁龛。除类似于那的一个核心区域以外在 streptomycetes 普通,有典型核心特征的一个新奇“伪核心”在非核心区域以内被定义,在 21 从 26 基因为第二等的代谢物生产聚类的总数被定位的地方。位于核心的 rifamycin 生合成基因簇为 rifamycin SV 的变换编码细胞色素 P450 酶必需品到 B,由比作 rifamycin 生产 B 紧张 S699 的高度相应的簇揭示了并且进一步由基因互补证实了。A 的 genomic 信息。mediterranei 表明在看起来复杂的规章的机制的控制下面不仅为各种各样的碳来源和无机的氮混合物的广泛的利用而且为新陈代谢的中介的有效 funneling 安排进第二等的抗菌素合成进程的一个新陈代谢的网络。 | Wei Zhao Yi Zhong Hua Yuan Jin Wang Huajun Zheng Ying Wang Xufeng Cen Feng Xu Jie Bai Xiaobiao Han Gang Lu Yongqiang Zhu Zhihui Shao Han Yan Chen Li Nanqiu Peng Zilong Zhang Yunyi Zhang Wei Lin Yun Fan Zhongjun Qin Yongfei Hu Baoli Zhu Shengyue Wang Xiaoming Ding Guo-Ping Zbao | 2010 | Cell Research2010，20，10： | 10 |
| 3 | Characterization of Multi-scale Morphology and Superhydrophobicity of Water Bamboo Leaves and Biomimetic Polydi- methylsiloxane (PDMS) Replicas显示文摘 | Huiying Guan Zhiwu Han Huina Cao Shichao Niu Zhihui Qian Junfeng Ye Luquan Ren | 2015 | Journal of Bionic Engineering2015，12，4： | 8 |
| 4 | Archaeal community structure along a gradient of petroleum contamination in saline-alkali soil显示文摘The response of archaeal communities to petroleum contamination in saline-alkali soil was characterized by analyses of three soil samples with different total petroleum hydrocarbon concentrations.Through the construction and screening of 16S rRNA gene clone libraries based on DNA extracts from these soils,nine distinct phylogenetic groups were identified.Statistical analyses showed that the distribution of archaeal community structures differ significantly along the gradient of petroleum contamination in these three saline- alkali soils.Five phylogenetic groups were dominant in the control soil,two of which were also abundant in the lightly contaminated soil.Four phylogenetic groups were dominant in heavily contaminated soil,one of which was also abundant in the lightly contaminated soil.The halophilic genus of Haloferax and the haloalkaliphilic genus of Natronomonas were more abundant in heavily contaminated soil.These results suggested that the genera of Haloferax and Natronomonas may have a role in the natural attenuation of petroleum- contaminated saline-alkali soil. | Xinxin Wang Zhen Han Zhihui Bai Jingchun Tang Anzhou Ma Jizheng He Guoqiang Zhuang | 2011 | Journal of Environmental Sciences2011，23，11： | 8 |
| 5 | Velocity Modeling and Inversion Techniques for Locating Microseismic Events in Unconventional Reservoirs显示文摘A velocity model is an important factor influencing microseismic event locations.We review the velocity modeling and inversion techniques for locating microseismic events in exploration for unconventional oil and gas reservoirs.We first describe the geological and geophysical characteristics of reservoir formations related to hydraulic fracturing in heterogeneity,anisotropy,and variability,then discuss the influences of velocity estimation,anisotropy model,and their time-lapse changes on the accuracy in determining microseismic event locations,and then survey some typical methods for building velocity models in locating event locations.We conclude that the three tangled physical attributes of reservoirs make microseismic monitoring very challenging.The uncertainties in velocity model and ignoring its anisotropies and its variations in hydraulic fracturing can cause systematic mislocations of microseismic events which are unacceptable in microseismic monitoring.So,we propose some potential ways for building accurate velocity models. | Jianzhong Zhang Han Liu Zhihui Zou Zhonglai Huang | 2015 | Journal of Earth Science2015，26，4： | 7 |
| 6 | QTL Mapping for Cucumber Fruit Size and Shape with Populations from Long and Round Fruited Inbred Lines显示文摘To gain insight into the molecular and genetic basis of fruit size and shape in cucumber,we conducted Quantitative Trait Locus(QTL)mapping with F2 and BC1F1 populations derived froma cross between the Northern-China type inbred line CNS21 and the Southern-China type inbred line RNS7.Populations were evaluated during two developmental stages,ovary at anthesis and commercial fruit(immature fruit).A total of 13 major-effect QTLs(R2>10%)were detected for six traits,and one of them,fruit shape index 2.1,explained more than 50%of phenotypic variation.All QTLs distributed on chromosome(chr)1 and 2.We constructed a physical map containing almost all of the QTLs with their physical location from previous studies.For fruit size and shape,the highest number of QTLs were mapped on chr1 and chr6,and the fewest number were mapped on chr2 and chr7.At least one consensus region was presented on each chromosome.In addition,three candidate genes were predicted between the long-fruited and round-fruited inbred lines by comparing the sequences of the consensus region of chr3,where many QTLs for marketable fruit length had been detected.Our results provide a base for additional QTLs and molecular markers for fruit size and shape in cucumber breeding. | Zhihui Gao Haiyang Zhang Chenxing Cao Jing Han Hao Li Zhonghai Ren | 2020 | Horticultural Plant Journal2020，6，3： | 7 |
| 7 | Immobilization of acetylcholinesterase on one-dimensional gold nanoparticles for detection of organophosphorous insecticides显示文摘This paper reports a simple method for immobilization of acetylcholinesterase (AChE) on one-dimensional (1D) gold (Au) nanoparticles for detection of organophosphorous (OP) insecticides. 1D Au nanoparticles were prepared by electrodeposition in the pores of an alumina template which was subsequently removed by 2.0 M NaOH solution. They were characterized by XRD and FESEM. The immobilized AChE retained its biological activity and catalyzed the hydrolysis of acetylthiocholine to form thiocholine, which was subsequently oxidized to produce detectable signals. Based on the inhibition toward the enzymatic activity of AChE by OP insecticides, sensitive detection of methamidophos (an OP insecticide) was performed. Under optimal conditions, the sensors could be used for the determination of methamidophos ranging from 0.004 to 24 μg/mL with the detection limit of 0.001 μg/mL. The developed OP insecticide biosensors exhibited satisfactory stability and reproducibility. This work demonstrated that 1D Au nanoparticles could serve as an ideal carrier for immobilization of AChE to fabricate the corresponding biosensor. | LI YanRong, GAN ZhiYong, LI YanFen, Liu Qian, BAO JianChun, DAI ZhiHui & HAN Min Jiangsu Key Laboratory of Biofunctional Materials College of Chemistry and Environmental Science, Nanjing Normal University, Nanjing 210097, China | 2010 | Science China Chemistry2010，53，4： | 6 |
| 8 | Adapting rice anther culture to gene transformation and RNA interference显示文摘Anther culture offers a rapid method of generating homozygous lines for breeding pro- gram and genetic analysis.To produce homozygous transgenic lines of rice(Oryza sativa L.)in one step,we developed an efficient protocol of anther-callus-based transformation mediated by Agro- bacterium after optimizing several factors influencing efficient transformation,including callus induc- tion and Agrobacterium density for co-cultivation.Using this protocol,we obtained 145 independent green transformants from five cultivars of japonica rice by transformation with a binary vector pCXK1301 bearing the rice gene,Xa21 for resistance to bacterial blight,of which 140 were further confirmed by PCR and Southern hybridization analysis,including haploids(32.1%),diploids(62.1%) and mixoploids(7.5%).Fifteen diploids were found to be doubled haploids,which accounted for 10.7%of the total positive lines.Finally,by including 28 from colchicine induced or spontaneous dip- loidization of haploids later after transformation,a total of 43 doubled haploids(30.7%)of Xa21 transgenic lines were obtained.We also generated two RNAi transgenic haploids of the rice Os- MADS2 gene,a putative redundant gene of OsMADS4 based on their sequence similarity,to inves- tigate its possible roles in rice flower development by this method.Flowers from the two OsMADS2 RNAi transgenic haploids displayed obvious homeotic alternations,in which lodicules were trans- formed into palea/lemma-like tissues,whereas identities of other floral organs were maintained.The phenotypic alternations were proved to result from specific transcriptional suppression of OsMADS2 gene by the introduced RNAi transgene.The results confirmed that OsMADS2 is involved in lodicule development of rice flower and functionally redundant with OsMADS4 gene.Our results demonstrated that rice anther culture could be adapted to gene transformation and RNAi analysis in rice. | CHEN Caiyan 1,2* ,XIAO Han 1,2* ,ZHANG Wenli 1,2 ,WANG Aiju 1,2 ,XIA Zhihui 1 ,LI Xiaobing 1 , ZHAI Wenxue 1 ,CHENG Zhukuan 1 &ZHU Lihuang 1 1.State Key Laboratory of Plant Genomics and National Center for Plant Gene Research,Institute of Genetics and Develop- mental Biology,Chinese Academy of Sciences,Beijing 100101,China 2.Graduate School of the Chinese Academy of Sciences,Beijing 100039,China | 2006 | Science China(Life Sciences)2006，49，5： | 5 |
| 9 | Research on wind-induced responses of a large-scale membrane structure显示文摘The wind-induced responses of a large-scale membrane structure, Expo Boulevard, are evaluated in this study. To obtain the wind pressure distribution on the roof surface, a wind tunnel test is performed. A brief analysis of wind pressure on the membrane roof is conducted first and then an analysis of the wind-induced responses of the structure is carried out using a numerical integral method in the time domain. In the process of calculation, the geometrical nonlinearity is taken into account. Results indicate that mean, RSM and peak values of the structure responses increase nonlinearly while the approaching flow velocity increases. Strong nonlinear characteristics are observed in the displacement responses, whereas the responses of nodal stress and cable axial force show minimal nonlinear properties when the membrane structure is subjected to wind loads. Different values of the damping ratio only have a minimal impact on the RSM response of the structure because the background component is a dominant part of the total dynamic response and the resonant component is too small. As the damping ratio increases from 0.02 to 0.05, the RMS responses of vertical displacement, nodal stress and cable axial force decrease by 8.1%, 6.7% and 17.9%, respectively. Since the mean component plays a significant role in the wind-induced response, the values of the gust response factor are not high for Expo Boulevard. | Zhou Xuanyi Han Zhihui Gu Ming Zhang An-an Zhang Weiyu Fang Wei | 2013 | Earthquake Engineering and Engineering Vibration2013，12，2： | 4 |
| 10 | Multidrug-resistant Proteus mirabilis isolates carrying blaOXA-1 and blaNDM-1 from wildlife in China:increasing public health risk显示文摘The emergence of multidrug resistance(MDR)in Proteus mirabilis clinical isolates is a growing public health concern and has serious implications for wildlife.What is the role of wildlife has been become one of the hot issues in disseminating antimicrobial resistance.Here,54 P.mirabilis isolates from 12 different species were identified.Among them,25 isolates were determined to be MDR by profile of antimicrobial susceptibility;10 MDR P.mirabilis isolates were subjected to comparative genomic analysis by whole genome sequencing.Comprehensive analysis showed that chromosome of P.mirabilis isolates mainly carries multidrug-resistance complex elements harboring resistance to carbapenem genes blaOXA-1,blaNDM-1,and blaTEM-1.Class I integron is the insertion hotspot of IS26;it can be inserted into type I integron at different sites,thus forming a variety of multiple drug resistance decision sites.At the same time,Tn21,Tn7,and SXT/R391 mobile elements cause widespread spread of these drug resistance genes.In conclusion,P.mirabilis isolates from wildlife showed higher resistance to commonly used clinic drugs comparing to those from human.Therefore,wild animals carrying MDR clinical isolates should be paid attention to by the public health. | Qian KANG Xue WANG Jianan ZHAO Zhihui LIU Fang JI Han CHANG Jianchun YANG Shijia HU Ting JIA Xiaojia WANG Jiagui TANG Guoying DONG Guocheng HU Jing WANG Yanyu ZHANG Jianhua QIN Chengmin WANG | 2021 | Integrative Zoology2021，16，6： | 4 |
| 11 | Effect of Thermal Fatigue Loading on Tensile Behavior of H13 Die Steel with Biomimetic Surface显示文摘Biomimetic surface is an effective ways to promote the performance grade and applied range of materials without alteringtheir substrate.Many improved properties such as resisting fatigue,enduring wear,etc,have been achieved by applyingbiomimetic morphology or structure to some engineering material surfaces.In this paper,aiming to reveal the relationshipbetween thermal cracking behavior and mechanical properties of engineering materials with biomimetic surface,biomimeticspecimens were fabricated using laser technique by imitating the heterogeneous structure on the surface of plant leaves.Theeffect of thermal fatigue cycling on the tensile properties of H13 die steel specimens with different surfaces (several types ofbiomimetic surfaces and a smooth surface) was compared and investigated.As a result,due to the coupling effects of themorphological features on the surface and the microstructure characteristics within unit zone,these specimens with biomimeticsurface exhibit remarkably enhanced Ultimate Tensile Strength (UTS) and 0.2% Yield Strength (YS) compared with referencespecimens while corresponding ductility remains largely unaffected even heightened,whether the thermal fatigue loads or not.The relative mechanisms leading to these improvements have been discussed. | Zhihui Zhang~1,Luquan Ren~1,Hong Zhou~2,Zhiwu Han~1,Xin Tong~3,Yu Zhao~1,Li Chen~1 1.Key Laboratory of Bionic Engineering (Ministry of Education,China),Jilin University,Changchun 130022,P.R.China 2.Key Laboratory of Automobile Materials (Ministry of Education,China),Jilin University,Changchun 130022,P.R.China 3.The Department of Materials Surface Engineering,Guangzhou Research Institute of Non-Ferrous Metals,Guangzhou 510651,P.R.China | 2010 | Journal of Bionic Engineering2010，7，4： | 3 |
| 12 | Effects of drip irrigation modes on growth and physiological characteristics of Arabica coffee under different N levels显示文摘The objective of this study was to obtain the water-saving and efficient production mode of Arabica coffee. The effects of three drip irrigation modes,conventional drip irrigation( CDI),alternate drip irrigation( ADI) and fixed drip irrigation( FDI) on growth,photosynthetic characteristics,biomass accumulation and irrigation water use efficiency of Arabica coffee were investigated under three nitrogen levels,high nitrogen( NH),middle nitrogen( NM) and low nitrogen( NL). The results show that there was a significant Logistic curve between the plant height,the stem diameter of Arabica coffee and growth days. Compared with CDI,ADI had no significant effects on leaf net photosynthetic rate,stomatal conductance,instantaneous water use efficiency and biomass accumulation above ground of Arabica coffee,while FDI decreased significantly,ADI and FDI increased irrigation water use efficiency by 50. 59% and 32. 85%,respectively. Compared with NH,with the reduction of N application rate,net photosynthetic rate,stomatal conductance,biomass accumulation above ground and irrigation water use efficiency decreased by 6. 81%-12. 30%,13. 70%-22. 69%,9. 61%-16. 67% and 9. 78%-15. 64%,respectively. Compared with CDINH,ADINHdecreased net photosynthesis rate and the stomatal conductance not significantly,other treatments decreased by 9. 16%-19. 22%,14. 49%-32. 91%,and decreased biomass accumulation above ground by 8. 26%-27. 34% except ADINH,and increased irrigation water use efficiency by 16. 46%-60. 95% except CDINMand CDINL. Therefore,alternate drip irrigation under high N level( ADINH) is the best water and nitrogen coupling mode of young Arabica coffee tree for water efficiency. | HAO Kun LIU Xiaogang HAN Zhihui WU Helin YU Ning LIU Yanwei YANG Qiliang | 2017 | 排灌机械工程学报2017，35，10： | 3 |
| 13 | Awareness, Treatment, and Rehabilitation of Elderly with Parkinson’s Disease — China, 2015–2017显示文摘What is already known about this topic?Parkinson’s disease(PD)affects 1%of the population over the age of 60 years old and 4%or more over the age of 80 years old.An estimated nearly 3 million elderly people are currently affected by Parkinson’s disease in China,and the number of patients of all ages will be close to 5 million by 2030.What is added by this report?Rates of awareness,drug treatment,and rehabilitation among PD patients were 32.4%,37.8%,and 16.0%,respectively.The rates of awareness and treatment were lower in rural areas than in urban areas and in older age groups.What are the implications for public health practice?Efforts should be made to improve health education among the elderly,to improve professional training of primary care and other health care institutions,and to strengthen the construction of community-based rehabilitative intervention for the elderly with PD. | Han Zhang Zhihui Wang Shige Qi Jing Wu Zhixin Li | 2020 | China CDC weekly2020，2，15： | 3 |
| 14 | Enhanced perovskite electronic properties via A-site cation engineering显示文摘Organic-inorganic halide perovskites have emerged as excellent candidates for low-cost photovoltaics and optoelectronics.While the predominant recent trend in designing perovskites for efficient and stable solar cells has been to mix different A-site cations,the role of A-site cations is still limited to tune the lattice and bandgap of perovskites.Herein we compare the optoelectronic properties of acetamidinum(Ace)and guanidinium(Gua)mixed methylammonium lead iodide perovskites and shed a light on the hidden role of A-site cation on the carrier mobility of mixed-cation lead iodide perovskites.The cations do not affect the bandgap of the perovskites since the orbitals from Ace and Gua do not contribute to the band edges of the material.However,the mobility of the Ace mixed perovskite is significantly enhanced to be an order of magnitude higher than that of the pristine perovskite.We apply the Ace mixed perovskite in hole-conductor-free printable mesoscopic perovskite solar cells and obtain a stabilized PCE of over 18%(certified 17.7%),which is the highest certified efficiency so far. | Xufeng Xiao Yanmeng Chu Chunyu Zhang Zhihui Zhang Zexiong Qiu Cheng Qiu Huaixing Wang Anyi Mei Yaoguang Rong Gengzhao Xu Yue Hu Hongwei Han | 2021 | Fundamental Research2021，1，4： | 2 |
| 15 | The in vivo expectorant and antitussive activity of extract and fractions from Reineckia carnea显示文摘 | Na Han Chunling Chang Yichun Wang Ting Huang Zhihui Liu Jun Yin | 2010 | Journal of Ethnopharmacology2010，，1： | 1 |
| 16 | Studies on Surface Properties and Cell Adhesion Properties of BSA Modified DBM Scaffold显示文摘As a scaffold material for bone tissue engineering, demineralized bone matrix(DBM) has such a limited ability to load cells and growth factors that the surface of the DBM scaffold was modified with bovine serum albumin(BSA) with different concentrations to improve the protein stmcture and physicochemical properties of the scaffold surface so as to enhance the adhesion of the cells. And the appropriate BSA concentration was explored. Compared with DBM, the scaffold with BSA coating had a smaller pore size and a lower porosity, also, the degradation rate was accelerated and the hydrophilic property was improved. Cells adhesion was observed inside the DBM seaffold before and after it had been modified, and the BSA modified scaffold had a good cell compatibility. Wlien the concentration of BSA was 20 mg/mL, the adhesion ability of the cells to modified scaffold was significantly increased, and the cell proliferation was facilitated. | SUN Mengjie FENG Wei WANG Bowei HAN Bing ZOU Jundong YANG Chunying LIU Zhihui | 2019 | Chemical Research in Chinese Universities2019，35，4： | 1 |
| 17 | Controlled Growth of Pt–Au Alloy Nanowires and Their Performance for Formic Acid Electrooxidation显示文摘Pt–Au alloy nanowires have been controllably electrodeposited on microelectrodes by applying an alternating current and were used as the electrocatalyst for formic acid oxidation. The frequency and voltage of the alternating current and the electrolyte composition were adjusted to precisely control the morphologies, alloying structures and composition. The characteristics of Pt–Au alloy nanowires were analyzed by scanning electron microscopy, X-ray diffraction and transmission electron spectroscopy. Electrocatalytic performance of formic acid oxidation at Pt–Au alloy nanowires electrode was investigated by cyclic voltammetry and chronoamperometry. The results showed that the Pt–Au alloy nanowires possessed highlycrystalline morphologies, the controllable bimetallic composition and single-phase alloy structures, which mainly grow in the <111> crystal orientation. The electrocatalytic activity of formic acid oxidation strongly depended on the bimetallic Pt/Au composition. The Pt35Au65 alloy nanowires displayed superior electrocatalytic performance and high stability toward the electrooxidation of formic acid in acidic solution, owing to the ensemble effect of the Pt and Au components. These ?ndings provided insights into the design of the Pt–Au bimetallic nanomaterials as electrocatalysts for formic acid oxidation. | Yu Han Yuejun Ouyang Zhihui Xie Jinri Chen Fangfang Chang Gang Yu | 2016 | Journal of Materials Science & Technology2016，32，7： | 1 |
| 18 | A Joint Delay-and-Sum and Fourier Beamforming Method for High Frame Rate Ultrasound Imaging显示文摘Frame rate is an important metric for ultrasound imaging systems,and high frame rates(HFR)benefit moving-target imaging.One common way to obtain HFR imaging is to transmit a plane wave.Delay-and-sum(DAS)beamformer is a conventional beamforming algorithm,which is simple and has been widely implemented in clinical application.Fourier beamforming is an alternative method for HFR imaging and has high levels of imaging efficiency,imaging speed,and good temporal dynamic characteristics.Nevertheless,the resolution and contrast performance of HFR imaging based on DAS or Fourier beamforming are insufficient due to the single plane wave transmission.To address this problem,a joint DAS and Fourier beamforming method is introduced in this study.The proposed method considers the different distributions of sidelobes in DAS imaging and Fourier imaging and combines the angular spectrum and DAS to reconstruct ultrasound images.The proposed method is evaluated on simulation and experimental phantom datasets to compare its performance with DAS and Fourier beamforming methods.Results demonstrate that the proposed method improves image effective dynamic range and resolution while also retaining a high frame rate of the ultrasound imaging systems.The proposed method improves the effective dynamic range along axial and lateral directions by 10 dB,compared to standard DAS and Fourier beamforming. | Wei Zhao Shuai Feng Yadan Wang Yuanguo Wang Zhihui Han Hu Peng | 2020 | Computer Modeling in Engineering & Sciences2020，，4： | 1 |
| 19 | Research on analysis of brand value and its positive analysis in air condition enterprises based on IAHP显示文摘 | Zhihui Han Junhai Ma | 2013 | Journal of Convergence Information Technology2013，8，1： | 1 |
| 20 | The progress and related pharmacological mechanism of hyperlipidemia treatment显示文摘Hyperlipidemia(HLP)is a long-known risk factor for a series of cardiovascular and cerebrovascular diseases,such as atherosclerosis,coronary heart disease,hypertension and so on.With its increasing incidence,the prevention and treatment of HLP has also become an important research topic around the world.Traditional Chinese medicine(TCM)has been used to treat HLP for a long time with its better therapeutic efficacy,less side effects and wider indications compared with western medicine.In this review,we summarized the pathogenesis of HLP,the research situation of disease-related targets,and the treatment progress of TCM by conducting literature research and sorting out relevant information,in order to provide reference for further research of HLP and prevent the occurrence of cardiovascular and cerebrovascular diseases. | Zhaohui Ren Jianxiu Zhai Na Han Zhihui Liu Jun Yin | 2019 | Asian Journal of Traditional Medicines2019，14，6： | 1 |
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