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| 1 | 全球药物滥用的疾病负担:来自2010年全球疾病负担研究显示文摘背景:直到目前还没有研究者系统地估计过全球及区域性的苯丙胺类、大麻、可卡因和阿片类药物依赖的患病率及其造成的疾病负担。我们旨在用伤残损失寿命年(YLDs)、过早死亡损失寿命年(YLLs)和伤残调整寿命年(DALYs)来估计药物依赖的患病率和其造成的疾病负担。方法:采用贝叶斯Meta回归的方法(Dis Mod-MR)对药物依赖的流行病学研究及2010年全球疾病、伤害及危险因素负担研究(GBD 2010)进行了系统综述,估计人群水平的药物依赖患病率。GBD 2010通过代表性社区调查和基于互联网的调查计算出新的失能权重。我们把估计的药物依赖患病率和新的失能权重结合起来估算药物依赖导致的YLDs、YLLs、DALYs和其作为相关疾病危险因素时导致的YLDs、YLLs和DALYs。结果:2010年,药物依赖直接造成了2千万的DALYs(95%UI(不确定区间)1.3-2.54千万),占全球全因DALYs的0.8%(0.6%-1.0%)。世界范围内,相比于其他药物,越来越多的人依赖于阿片类和苯丙胺类药物。阿片类药物依赖直接造成的疾病负担最大(DALYs为920万,95%UI为710-1140万)。在某些地区,药物依赖导致的DALYs所占比例比其他地区高出20倍,收入越高的国家药物依赖造成的负担所占比例也越高。注射吸毒所致HIV感染造成210万的DALYs(95%UI 110-360万),所致HCV感染导致50.2万的DALYs(95%UI 28.6-89.1万)。苯丙胺类药物依赖所致自杀造成85.4万的DALYs(95%UI 29.1-179.1万),阿片类药物依赖所致自杀造成67.1万的DALYs(95%UI 32.9-173.0万),可卡因依赖所致自杀造成32.4万的DALYs(95%UI 10.9-68.2万)。药物依赖导致的疾病负担最高的国家(>650 DALYs/10万人)包括美国,英国,俄罗斯和澳大利亚。结论:药物滥用是造成全球疾病负担的一个重要因素。为减少人群水平的疾病负担,我们需采取有效的措施(比如给予阿片类药物依赖者替代治疗及针具交换等)降低阿片类药物依赖和注射吸毒导致的疾病负担。 | 王同瑜 Degenhardt L Whiteford HA Ferrari AJ Baxter AJ Charlson FJ Hall WD Freedman G Burstein R Johns Engell RE Flaxman A Murray CJ Vos T | 2015 | 中国药物依赖性杂志2015，24，6： | 3 |
| 2 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 3 | Pond heat and temperature regulation (PHATR) : Modeling temperature and energy balances in earthen outdoor aquaculture ponds显示文摘 | Lamoureux J Tiersch T R Hall S G | 2006 | Aquaculural Engineering2006，34，2： | 1 |
| 4 | COX-2 selective non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease显示文摘 | Wayne A Ray C Michael Stein James R Daugherty Kathi Hall Patrick G Arbogast Marie R Griffin | 2002 | The Lancet2002，，9339： | 1 |
| 5 | Origin of themobile gene cassettes found in integrons显示文摘 | Recchia G D Hall R M | 1997 | Trends Microbio1997，5，10： | 1 |
| 6 | Identity, deep structure and the development of leadership skill 显示文摘 | Robert G Lord T Hall R J | 2005 | The Leadership Quarterly2005，16，： | 1 |
| 7 | Risk Analysis Techniques and Their Application to Software Development 显示文摘 | BENNETT J C BOHORIS G A ASHNWALL E M HALL R C | 1996 | European Journal of Operational Research1996，95，： | 1 |
| 8 | Spectral mixture analysis and geometric-optical reflectance modeling of boreal forest biophysical structure 显示文摘 | Peddle D R Hall F G LeDrew E F | 1999 | Remote Sensing of Environment1999，67，3： | 1 |
| 9 | Effect of luteinizing hormone deprivation in situ on steroidogenesis of rat Leydig cells purified by a multi step procedure 显示文摘 | Klinefelter G R Hall P F Ewing L L | 1987 | Biol Reprod1987，36，3： | 1 |
| 10 | Index of plant hosts of Sclerotinia sclerotirum 显示文摘 | Boland G J Hall R | 1994 | Can J Plant Pathol1994，16，： | 1 |
| 11 | Applications of Doppler Spectroscopy to Photofragmentation显示文摘 | R J Gordon G E Hall | | 0，，96： | 1 |
| 12 | The significance of deterministic empty vehicle trips in the design of a unidirec- tional loop flow path 显示文摘 | ASEF-VAZIRI A HALL N G GEORGE R | 2008 | Computers : Operations Research2008，35，5： | 1 |
| 13 | Evaluating soybean cultivars for resistance to Sclerotinia scleratiorum under field conditions 显示文摘 | Boland G J Hall R | 1987 | Plant Disease1987，71，10： | 1 |
| 14 | Integrated processing equipment显示文摘 | Bader M E Hall R P Strasser G | 1990 | Solid State Technology1990，33，5： | 1 |
| 15 | Temporal variation in properties of an uneropped, ploughed Miamian soil in relation to seasonal erodibility显示文摘 | Bajracharya R M Lal R Hall G F | 1998 | Hydrological Processes1998，12，： | 1 |
| 16 | Glutathione and the response of malignant cells to chemotherapy显示文摘 | KEARNS P R HALL A G | 1998 | DDT1998，3，： | 1 |
| 17 | Integrated processing equipment显示文摘 | M E Bader R P Hall G Strasser | 1990 | Solid State Technology1990，33，5： | 1 |
| 18 | Identification the female sex pheromones of the moth,Chilo suppressaliz显示文摘 | Nesbitt B g Beevor P S Hall D R | 1975 | Journal of Insect Physiology1975，21，12： | 1 |
| 19 | The interpretation of spectral vegetation indexes显示文摘 | MYNENI R B HALL F G SELLERS P J | 1995 | Geoscience and Remote Sensing IEEE Transactions on1995，33，2： | 1 |
| 20 | NMR spectra of iminobis(methylenephosphonic acid), HN(CH2PO3H2)2, and related ligands and of their complexes with platinum( Ⅱ )显示文摘 | Appleton T G Hall J R McMahon I J | 1986 | Inorg Chem1986，25，： | 1 |
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