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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | Global prevalence of dementia: a Delphi consensus study显示文摘 | Cleusa P Ferri Martin Prince Carol Brayne Henry Brodaty Laura Fratiglioni Mary Ganguli Kathleen Hall Kazuo Hasegawa Hugh Hendrie Yueqin Huang Anthony Jorm Colin Mathers Paulo R Menezes Elizabeth Rimmer Marcia Scazufca | 2005 | The Lancet2005，，9503： | 2 |
| 4 | Global prevalence of dementia: a Delphi consensus study显示文摘 | Cleusa P Ferri Martin Prince Carol Brayne Henry Brodaty Laura Fratiglioni Mary Ganguli Kathleen Hall Kazuo Hasegawa Hugh Hendrie Yueqin Huang Anthony Jorm Colin Mathers Paulo R Menezes Elizabeth Rimmer Marcia Scazufca | 2005 | The Lancet . 2005 (9503)2005，，9503： | 2 |
| 5 | Tropical forests and the global carbon Cycle 显示文摘 | Detwiler R P Hall C A S | 1988 | Science1988，239，： | 1 |
| 6 | Software unit test coverage and adequacy 显示文摘 | ZHUH HALL P A V MAY J H R | 1997 | ACM Computing Surveys1997，29，4： | 1 |
| 7 | Estimation of HIV incidence in the United States显示文摘 | Hall HI Song R Rhodes P | 2008 | JAMA2008，300，5： | 1 |
| 8 | BiOhemical factors underlying the age - related sensitivity of turkeys to aflatoxin B1显示文摘 | Klein P J Van - Vleet T R Hall J O | | 0，，： | 1 |
| 9 | Travel outcome and performance: the effect of uncertainty on accessibility 显示文摘 | Hall P R | 1983 | Transportation Research Part B1983，17，4： | 1 |
| 10 | Effect of luteinizing hormone deprivation in situ on steroidogenesis of rat Leydig cells purified by a multi step procedure 显示文摘 | Klinefelter G R Hall P F Ewing L L | 1987 | Biol Reprod1987，36，3： | 1 |
| 11 | Patterns of interorganizational relationships显示文摘 | Hall R H Clark J P Giordano P C | 1977 | Administrative Science Quarterly1977，22，3： | 1 |
| 12 | Integrated processing equipment显示文摘 | Bader M E Hall R P Strasser G | 1990 | Solid State Technology1990，33，5： | 1 |
| 13 | The Relationship be- tween the Intake of Selenium and Vitamin E on the Inci- dence of Retained Placentae in Dairy Cows Vet Rec显示文摘 | Trinder N Hall R J Renton C P | 1973 | 93:641-6431973，93，： | 1 |
| 14 | Test coverage and adequacy 显示文摘 | Zhu H Hall P A May J H R | 1997 | ACMComputing Surveys1997，29，4： | 1 |
| 15 | Glutathione and the response of malignant cells to chemotherapy显示文摘 | KEARNS P R HALL A G | 1998 | DDT1998，3，： | 1 |
| 16 | Nonlinear-optical properties of lead tin fluorophospate glass containing acridine dyes显示文摘 | TOMPKIN W R BOYD R W HALL D W TICK P A | 1987 | J Opt Soc Am1987，4，6： | 1 |
| 17 | Managing Knowledge Associated with Innovation 显示文摘 | Hall R Andriani P | 2003 | Jorunal Business Research2003，，56： | 1 |
| 18 | Integrated processing equipment显示文摘 | M E Bader R P Hall G Strasser | 1990 | Solid State Technology1990，33，5： | 1 |
| 19 | Managing knowledge for innovation 显示文摘 | Hall R Andriani P | 2002 | Long Range Planning2002，35，1： | 1 |
| 20 | Optimal rates of convergence for decon- voluting a density 显示文摘 | Carroll R J Hall P | 1988 | Journal of American Statistical Asso- ciation1988，83，： | 1 |
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