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| 1 | 选择性环氧化酶2抑制剂和传统非甾体抗炎药增加粥样血栓形成的风险吗?随机试验的荟萃分析显示文摘目的:评价选择性环氧化酶2(COX-2)抑制剂和传统的非甾体类抗炎药(NSMDs)在发生血管事件上的风险性。设计:对已发表和未发表随机试验的表格式资料进行荟萃分析,对传统 NSAIDs 的作用进行间接评估。资料来源:资料分别来源于 Medline 和 Embase(1966年1月至2005年4月);食品与药品管理局记录;以及诺华、辉瑞、默克公司的资料。回顾方法:符合以下条件的随机试验入组本研究:一种选择性 COX-2抑制剂与安慰剂比较或一种选择性 COX-2抑制剂与一种传统的 NSAID之间对比;用药持续时间至少4周;包含严重血管事件方面的信息,如心肌梗死、卒中或由于血管事件死亡。各个独立研究者和药厂为本研究提供了有关随机化的病人数目、血管事件的数目以及每个随机化小组中随访的人时(Person time)等信息。结果:在与安慰剂对比的试验中,选择性COX-2抑制剂使严重血管事件发生率增加42%(1.2%/年比0.9%/年;率比1.42,95%可信区间1.13~1.78;P=0.005);不同的选择性 COX-2抑制剂之间没有显著性差异。这主要归因于心肌梗死的风险增加(0.6%/年比0.3%/年;1.86,1.33~2.59;P=0.0003),在其他血管性事件上没有明显的区别。在为时至少1年的试验中(平均2.7年),血管事件的率比是1.45(1.12~1.89;P=0.005)。总的来说,严重血管事件的发生率在选择性 COX-2抑制剂和任何传统 NSAID 之间没有差异(1.0%/年比0.9%/年;1.16,0.97~1.38;P=0.1)。然而,在选择性 COX-2抑制剂与萘普生对比的试验(1.57,1.21~2.03)和选择性COX-2抑制剂与非萘普生类 NSAIDs 相比较的试验之间(0.88,O.69~1.12),我们发现了统计学差异。与安慰剂比较血管事件的总体比率如下:萘普生0.92(0.67~1.26),布洛芬1.51(0.96~2.37),双氯芬酸1.63(1.12~2.37)。结论:选择性 COX-2抑制剂可以中等度增加血管事件的风险性,大剂量布洛芬和双氯芬酸同样具有此作用,但大剂量萘普生不明显增加血管事件的风险性。 | Patricia M Kearney Colin Baigent Jon Godwin Heather Halls Jonathan R Emberson Carlo Patrono 徐东(译) 张卓莉(校) | 2006 | 英国医学杂志中文版2006，9，5： | 4 |
| 2 | Assessment of the Progress of the Back-Pain Patient显示文摘 | R MILLION W HALL K HAAVIK NILSEN R D BAKER M I V JAYSON | 1982 | Spine1982，，3： | 2 |
| 3 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 4 | Polycrystalline diamond: manufacturing, wear mechanisms, and implications for bit design显示文摘 | Sneddon M V Hall D R | 1988 | J of Petroleum Technology1988，，： | 2 |
| 5 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 6 | Detection of Eperythrozoon suis DNA from swine blood by whole organism DNA hybridizations显示文摘 | Oberst R D Hall S M Schoneweis D A | 1990 | Vet Microb1990，24，： | 1 |
| 7 | Carburization behavior of HK40 steel in furnaces used for ethylene production 显示文摘 | D J Hall M K Hossain and R F Atkinson | 1982 | High Temperature High Pressure1982，14，： | 1 |
| 8 | Objective methods for registration landmarks and determining cloud motions from satellite data显示文摘 | Endlich R M Wolf D E and Brain A E | 1972 | IEEE Trans1972，21，： | 1 |
| 9 | Diagnostic assay recommended by the World Health Organization for swine origin influenza A (H1N1) virus cross-reacts with H5N1 influenza virus显示文摘 | Peacey M Hall R J Bocacao J | 2009 | J Clin Microbiol2009，47，： | 1 |
| 10 | Identification and characterization of the Escherichia coli RecT protein, a protein encoded by the recE region that promotes renaturtion of homologous single-stranded DNA显示文摘 | Hall S D Kane M F Kolodner R D | 1993 | J Bacteriol1993，175，： | 1 |
| 11 | A novel family of potentially mobile DNA elements encoding site-specific gene-integration functions :integrons 显示文摘 | Stokes H W Hall R M | 1989 | Mol Microbiol1989，3，12： | 1 |
| 12 | Image Processing on Augmented Mesh- Connected Parallel Computers 显示文摘 | Hamdi M Hall R W | 1994 | Journal of Computer and Software Engineering1994，2，3： | 1 |
| 13 | Freezing point de- pression of NaC1-KCI-H20 solutions 显示文摘 | Hall D L Sterner S M and Bodner R J | 1988 | Economic Geology1988，100，5： | 1 |
| 14 | Origin of themobile gene cassettes found in integrons显示文摘 | Recchia G D Hall R M | 1997 | Trends Microbio1997，5，10： | 1 |
| 15 | Real-time control of buses for schedule coordination at a terminal 显示文摘 | DESSOUKY M HALL R ZHANG Lei SINGH A | 2003 | Transportation Research Part A: Policy and Practice2003，37，2： | 1 |
| 16 | Risk factors,inpatient care,and outcomes of pneumonia after ischemic stroke显示文摘 | Finlayson O Kapral M Hall R | 2011 | Neurology2011，77，14： | 1 |
| 17 | Effects of seawater ozonation on biofilm development in aquaculture tanks显示文摘 | Wietz M Hall M R Hj L | 2009 | Systematic and Applied Microbiology2009，32，4： | 1 |
| 18 | New mobile gene cassettes containing an aminogly coside resistance gene,aaeA 7,and a chloramphenico resistance gene, catB, in an integron in pBWH301 显示文摘 | Bunny K L Hall R M Stokes H W | 1995 | Antimicrob A gents Chem other1995，39，： | 1 |
| 19 | Site-specific insertion of genes into integrons: role of the 59-base element and determination of the recombination cross over point 显示文摘 | Hall R M Brookes D E Stokes H W | 1991 | Journal of Molecular Microbiology and Biotechnology1991，5，8： | 1 |
| 20 | Performance on a measure of category fluency in cognitively impaired elderly 显示文摘 | Hall J R Harvey M Vo H T | 2011 | Neuropsychol Dev Cogn B Aging Neuropsychol Cogn2011，18，3： | 1 |
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