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| 1 | Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles显示文摘颠倒使人重新住入肿瘤的房间(TRC ) 的药抵抗或起源的发展中的新奇途径像房间的癌症房间是迫切临床的需要改进癌症病人的结果。这里,我们显示出用肿瘤颠倒 TRC 的药抵抗的一条创新途径包含反肿瘤药的导出房间的 microparticles (T-MPs ) 。由比区分的癌症房间更可变形的优点, TRC 优先地收起 T-MPs 在进入房间以后释放反肿瘤药,它接着导致 TRC 的死亡。内在的机制包括防碍药流出并且支持这些药的原子入口。我们的调查结果在用有希望的临床的应用程序颠倒 TRC 的药抵抗在 T-MPs 的举起和一条新奇途径的有效性表明肿瘤房间柔软的重要性。 | Jingwei Ma Yi Zhang Ke Tang Huafeng Zhang Xiaonan Yin Yong Li Pingwei Xu Yanling Sun Ruihua Ma Tiantian Ji Junwei Chen Shuang Zhang Tianzhen Zhang Shunqun Luo Yang Jin Xiuli Luo Chengyin Li Hongwei Gong Zhixiong Long Jinzhi Lu Zhuowei Hu Xuetao Cao Ning Wang Xiangliang Yang Bo Huang | 2016 | Cell Research2016，26，6： | 17 |
| 2 | Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer显示文摘Metformin is currently a strong candidate anti-tumor agent in multiple cancers.However,its anti-tumor effectiveness varies among different cancers or sub-populations,potentially due to tumor heterogeneity.It thus remains unclear which hepatocellular carcinoma(HCC)patient subpopulation(s)can benefit from met-formin treatment.Here,through a genome-wide CRISPR-Cas9-based knockout screen,we find that DOCK1 levels determine the anti-tumor effects of met-formin and that DOCK1 is a synthetic lethal target of metformin in HCC.Mechanistically,metformin promotes DOCK1 phosphorylation,which activates RAC1 to facilitate cell survival,leading to metformin resistance.The DOCK1-selective inhibitor,TBOPP,potentiates anti-tumor activity by metformin in vitro in liver cancer cell lines and patient-derived HCC organoids,and in vivo in xenografted liver cancer cells and immunocompetent mouse liver cancer models.Notably,metformin improves overall survival of HCC patients with low DOCK1 levels but not among patients with high DOCK1 expression.This study shows that metformin effective-ness depends on DOCK1 levels and that combining metformin with DOCK1 inhibition may provide a promising personalized therapeutic strategy for met-formin-resistant HCC patients. | Junru Feng Hui Lu Wenhao Ma Wenjing Tian Zhuan Lu Hongying Yang Yongping Cai Pengfei Cai Yuchen Sun Zilong Zhou Jiaqian Feng Jiazhong Deng Ying Shu Kun Qu Weidong Jia Ping Gao Huafeng Zhang | 2022 | Protein & Cell2022，13，11： | 5 |
| 3 | Detection of Variants of B.1.617 Lineage from Five Returning Chinese Nationals at a Guangxi-Vietnam Border Port——Guangxi Zhuang Autonomous Region,China,April 2021显示文摘A 47-year-old male(Patient A)passenger from Vietnam whose nucleic acid results for coronavirus disease 2019(COVID-19),also known as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),were positive at Pingxiang Customs on April 29,2021,and subsequently confirmed by Guangxi CDC laboratories on April 30. | Ning Kang Yinpin Liu Fuyin Bi Jing Wang Huafeng Chen Jing Wang Zhenli Liang Min Chen Guangwu Wei Aiming Li Yonghong Li Bao Lu Zhenling Jiang Yi Tan Ge Zhong Mei Lin Yu Ju | 2021 | China CDC weekly2021，3，30： | 3 |
| 4 | Reassessment of the Distribution of Mantle CO_(2) in the Bohai Sea,China:The Perspective from the Source and Pathway System显示文摘Research on the distribution of mantle CO_(2)should involve comprehensive analysis from CO_(2)source to accumulation.The crust-mantle pathway system is the key controlling factor of the distribution of mantle CO_(2),but has received little attention.The pathway system and controlling factors of CO_(2)distribution in the Bohai Sea are analyzed using data on fault styles and information on the mantle and lithosphere.The relation between volcanic rocks and the distribution of mantle CO_(2)is reassessed using age data for CO_(2)accumulations.The distribution of mantle CO_(2)is controlled by uplift of the asthenosphere and upper mantle,magma conduits in the mantle and fault systems in the crust.Uplifted regions of the asthenosphere are accumulation areas for CO_(2).The area with uplift of the Moho exhibits accumulation of mantle CO_(2)at depth.CO_(2)was mainly derived from vertical migration through the upper mantle and lower crust.The fault style in the upper crust controls the distance of horizontal migration and the locations of CO_(2)concentrations.The distribution of mantle CO_(2)and volcanic rocks are not the same,but both probably followed the same pathways sometimes.Mantle CO_(2)in the Bohai Sea is concentrated in the Bozhong sag and the surrounding area,particularly in a trap that formed before 5.1 Ma and is connected to crustal faults(the Bozhang faults)and lithospheric faults(the Tanlu faults). | TANG Huafeng GUO Tianchan WU Keqiang LIU Zilin XU Jianyong LU Baoliang WANG Pujun | 2022 | Acta Geologica Sinica(English Edition)2022，96，1： | 2 |
| 5 | Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression显示文摘A well-established role of cyclic GMP-AMP synthase(cGAS)is the recognition of cytosolic DNA,which is linked to the activation of host defense programs against pathogens via stimulator of interferon genes(STING)-dependent innate immune response.Recent advance has also revealed that cGAS may be involved in several noninfectious contexts by localizing to subcellular compartments other than the cytosol.However,the subcellular localization and function of cGAS in different biological conditions is unclear;in particular,its role in cancer progression remains poorly understood.Here we show that cGAS is localized to mitochondria and protects hepatocellular carcinoma cells from ferroptosis in vitro and in vivo.cGAS anchors to the outer mitochondrial membrane where it associates with dynamin-related protein 1(DRP1)to facilitate its oligomerization.In the absence of cGAS or DRP1 oligomerization,mitochondrial ROS accumulation and ferroptosis increase,inhibiting tumor growth.Collectively,this previously unrecognized role for cGAS in orchestrating mitochondrial function and cancer progression suggests that cGAS interactions in mitochondria can serve as potential targets for new cancer interventions. | Shiqiao Qiu Xiuying Zhong Xiang Meng Shiting Li Xiaoyu Qian Hui Lu Jin Cai Yi Zhang Mingjie Wang Zijian Ye Huafeng Zhang Ping Gao | 2023 | Cell Research2023，33，4： | 2 |
| 6 | Microparticles released by Listeria monocytogenes-infected macrophages are required for dendritic cell-elicited protective immunity显示文摘在在为 T 房间有免疫力的回答处理和细菌的抗原的表示的巨噬细胞和树枝状的房间之间的相互影响仍然保持糟糕理解。用 Listeria monocytogenes (Lm ) 感染模型,我们证明树枝状的房间(DC ) 要求巨噬细胞的支持对 Lm 感染得到保护的免疫。DC 自己在收起 Lm 是低效的但是能够收起感染 Lm 的巨噬细胞释放的 microparticles (MP ) 。这些 MP 把 Lm 抗原转移了到 DC,允许 DC 介绍 Lm 抗原给受动器 T 房间。调停 MP 的 Lm 抗原转移要求了 MHC 一级参予,自从在巨噬细胞的 MHC 一级缺乏导致了 T 房间激活的重要减小。而且,有从感染 Lm 的巨噬细胞的 MP 的老鼠的种痘对 Lm 感染生产了强壮的保护的免疫。我们这里在 Lm 感染期间识别在巨噬细胞和 DC 之间的一个内在的抗原转移节目,并且强调巨噬细胞也在得到 DC 的 Lm 特定的 T 房间回答起一个必要作用。 | Yi Zhang Ruihua Zhang Huafeng Zhang Jing Liu Zhuoshun Yang Pingwei Xu Wenqian Cai Geming Lu Miao Cui Reto A Schwendener Huang-Zhong Shi Huabao Xiong Bo Huang | 2012 | Cellular & Molecular Immunology2012，9，6： | 1 |
| 7 | Effect of Al_(2)O_(3) Nanoparticle on Cavitation Strengthening of Magnesium Alloys显示文摘In order to study the effect of Al_(2)O_(3) nanoparticles in the cavitation-based strengthening process of magnesium alloys,the impact of a micro-jet generated by bubble collapse has been considered.The strengthening mechanism is based on the transfer of the energy of cavitation due to bubble collapse to Al_(2)O_(3) particles,which then undergo collision with the surface of the sample.The hardness,surface morphology,element content and chemical state of the strengthened samples have been analyzed by microhardness tests,SEM(scanning electron microscopy)and XPS(X-ray photoelectron spectroscopy)techniques.The results show that:after 5 min of strengthening,nanoparticles can be found on the surface of the sample through SEM.Combined with XPS tests,the content of Al_(2)O_(3) in the sample can be significantly increased,indicating that Al_(2)O_(3) particles penetrate into the surface and increase its hardness by 29.1 HV. | Lei Liu Chuanhui Huang Xinghua Lu Ping Yu Longhai Li Huafeng Guo | 2021 | Fluid Dynamics & Materials Processing2021，17，2： | 1 |
| 8 | Characteristics of the Density and Magnetic Susceptibility of Rocks in Northern Borneo and their Constraints on the Lithologic Identification of the Mesozoic Rocks in the Southern South China Sea显示文摘Based on the volume magnetic susceptibility and specific gravity measurements and mineral and lithologic identification results for 540 samples,the rock type,density,and magnetic susceptibility of rocks from northern Borneo were analyzed,and the applicability of gravity and magnetic data to the lithologic identification of the Mesozoic strata in the southern South China Sea was assessed accordingly.The results show that there are 3 types and 25 subtypes of rocks in northern Borneo,mainly intermediate-mafic igneous rocks and exogenous clastic sedimentary rocks,with small amounts of endogenous sedimentary rocks,felsic igneous rocks,and metamorphic rocks.The rocks that are very strongly-strongly magnetic and have high-medium densities are mostly igneous rocks,tuffaceous sandstones,and their metamorphic equivalents.The rocks that are weakly magnetic-non-magnetic and have medium-very low densities are mostly conglomerates,sandstones,siltstones,mudstones,and coal.The rocks that are weakly magnetic-diamagnetic and have highmedium densities are mostly limestones and siliceous rocks.The Cenozoic rocks are characterized by low densities and medium susceptibilities;the Mesozoic rocks are characterized by medium densities and medium-high susceptibilities;and the pre-Mesozoic rocks are characterized by high densities and low magnetism.Based on these results and the distribution characteristics of the various rock types,it was found that the pre-Mesozoic rocks produce weak regional gravity anomalies;the Mesozoic sedimentary rocks produce negative regional gravity anomalies;whereas the Mesozoic igneous rocks produce positive regional gravity anomalies;and the Cenozoic igneous rocks produce positive regional gravity anomalies.The regional high magnetic anomalies in the southern part of the South China Sea originate from the Mesozoic mafic igneous rocks and their metamorphic equivalents;and the regional medium magnetic anomalies may be produced by the felsic igneous rocks and their metamorphic equivalents.Accordingly,the identification of the Mesozoic lithology in the southern South China Sea shows that the Mesozoic sedimentary rocks are distributed over a large area of the southern South China Sea.Thus,it is concluded that the Mesozoic strata in this area have the potential for oil and gas exploration. | TANG Huafeng ZHAO Zhigang TIAN Zhiwen LU Baoliang TANG Wu HE Kailun ZHU Chenxi WANG Pujun | 2021 | Acta Geologica Sinica(English Edition)2021，95，1： | 1 |
| 9 | The pre-Devonian tectonic patterns and evolution of South China 显示文摘 | Guo Lingzhi Shi Yangshen Lu Huafeng | 1989 | Journal of Southeast Asian Earth Science1989，3，14： | 1 |
| 10 | A primary method for determination of optical parameters of turbid samples and application to intralipid between 550 and 1 630 nm 显示文摘 | Chen Cheng Lu Jun Q Ding Huafeng | 2006 | Optics Express2006，14，16： | 1 |
| 11 | KDELR2 promotes breast cancer proliferation via HDAC3-mediated cell cycle progression显示文摘Background:Histone deacetylases(HDACs)engage in the regulation of various cellular processes by controlling global gene expression.The dysregulation of HDACs leads to carcinogenesis,making HDACs ideal targets for cancer therapy.However,the use of HDAC inhibitors(HDACi)as single agents has been shown to have limited success in treating solid tumors in clinical studies.This study aimed to identify a novel downstream effector of HDACs to provide a potential target for combination therapy.Methods:Transcriptome sequencing and bioinformatics analysis were performed to screen for genes responsive toHDACi in breast cancer cells.The effects of HDACi on cell viability were detected using the MTT assay.The mRNA and protein levels of genes were determined by quantitative reverse transcription-PCR(qRT-PCR)andWestern blotting.Cell cycle distribution and apoptosis were analyzed by flow cytometry.The binding of CREB1(cAMP-response element binding protein 1)to the promoter of the KDELR(The KDEL(Lys-Asp-Glu-Leu)receptor)gene was validated by the ChIP(chromatin immunoprecipitation assay).The association between KDELR2 and protein of centriole 5(POC5)was detected by immunoprecipitation.A breast cancer-bearing mouse model was employed to analyze the effect of the HDAC3-KDELR2 axis on tumor growth.Results:KDELR2 was identified as a novel target of HDAC3,and its aberrant expression indicated the poor prognosis of breast cancer patients.We found a strong correlation between the protein expression patterns of HADC3 and KDELR2 in tumor tissues from breast cancer patients.The results of the ChIP assay and qRT-PCR analysis validated that HDAC3 transactivated KDELR2 via CREB1.The HDAC3-KDELR2 axis accelerated the cell cycle progression of cancer cells by protecting the centrosomal protein POC5 from proteasomal degradation.Moreover,the HDAC3-KDELR2 axis promoted breast cancer cell proliferation and tumorigenesis in vitro and in vivo.Conclusion:Our results uncovered a previously unappreciated function of KDELR2 in tumorigenesis,linking a critical Golgi-the endoplasmic reticulum traffic transport protein to HDAC-controlled cell cycle progression on the path of cancer development and thus revealing a potential therapeutical target for breast cancer. | Haoran Wei Wenhao Ma Xiaofei Lu Haiying Liu Kashuai Lin Yinghui Wang Zijian Ye Linchong Sun Zhitong Huang Tingting Pan Zilong Zhou Eric Y.Cheng Huafeng Zhang Ping Gao Xiuying Zhong | 2021 | Cancer Communications2021，41，9： | 0 |
| 12 | Design and analysis of longitudinal–flexural hybrid transducer for ultrasonic peen forming显示文摘Ultrasonic peen forming(UPF)is an emerging technology that exhibits great superiority in both its flexible operating modes and the deep residual stress that it produces compared with conventional plastic forming methods.Although ultrasonic transducers with longitudinal vibration have been widely studied,they have seldom been incorporated into UPF devices for machining in confined spaces.To meet the requirements of this type of machining,a sandwich-type piezoelectric transducer with coupled longitudinal-flexural vibrational modes is proposed.The basic structure of the transducer is designed to obtain large vibrational amplitudes in both modes.Experimental results obtained with a prototype device demonstrate the feasibility of the proposed transducer.The measured vibrational amplitude for the working face in the longitudinal vibrational mode is 1.0μm,and electrical matching increases this amplitude by 40%.The flexural vibration characteristics of the same prototype transducer are also tested and are found to be slightly smaller than those of longitudinal mode.The resultant working strokes of the UPF impact pins reach 1.7 mm and 1.2 mm in the longitudinal and flexural modes,respectively.The forming capability of the prototype has been evaluated via 15-min machining on standard 2024-T351 aluminum plates.After UPF,an improved surface morphology with lower surface roughness is obtained.The aluminum plate test piece has an apparent upper deformation with an arc height of 0.64 mm.The measured peak value of the compressive residual stress is around 250 MPa,appearing at a depth of 100μm.The proposed longitudinal-flexural hybrid transducer thus provides a high-performance tool for plate peen forming in confined spaces. | Wuqin Li Yongyong Zhu Xiaolong Lu Huafeng Li Ying Wei Pengwei Shang Bo Feng | 2023 | Nanotechnology and Precision Engineering2023，6，4： | 0 |
| 13 | Impact of three different processing methods on the digestibility and allergenicity of Chinese mitten crab(Eriocheir sinensis)tropomyosin显示文摘The tropomyosin(TM)fractions of crab protems may cause allergic reactions in mdividuals susceptible to allergies;however,efficient and safe methods by which to reduce such allergenicity are not currently available.Therefore,in this study,the effects of three different processing methods,i.e.,microwave,ultrasound,and high temperature-pressure(HTP)treatments,on the digestion stability of TM from Chinese mitten crab muscle and the allergenicity of TM digestion products were explored.sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis showed that microwaving had little effect on the digestion stability of TM.In contrast,ultrasound and HTP treatments facilitated the degradation of TM.Similarly,Western blotting and inhibition ELISA indicated that the IgE-binding activity of TM was significantly reduced after treatment with ultrasound or HTP.Among the three different proces sing methods,HTP was the most effective method for improving digestibility of TM and reducing immunoreactivity.This finding provides new insights into treatments for crab allergies. | Yufeng Lu Huafeng Cheng Shaotong Jiang Lin Lin Jianfeng Lu | 2023 | Food Science and Human Wellness2023，12，3： | 0 |
| 14 | Dynamics of a dispersion-tuned swept-fiber laser显示文摘In this paper,we studied the dynamics of a dispersion-tuned swept-fiber laser both experimentally and theoretically.By adding a dispersion compensation fiber and an electro-optic modulator in the laser cavity,an actively mode-locked laser was obtained by using intensity modulation,and wavelength sweeping was realized by changing the modulation frequency.Using a high-speed real-time oscilloscope,the dynamic behaviors of the swept laser were investigated during wavelength switching,static-sweeping cycle,and continuous sweeping,respectively.It was found that the laser generates relaxation oscillation at the start of the sweeping mode.The relaxation oscillation process lasted for about 0.7 ms,and then the laser started to operate stably.Due to the nonlinear effect,new wavelengths were generated in the relaxation oscillation process,which is not beneficial for applications.Fortunately,relaxation oscillation disappears if the laser starts up and operates in the continuous sweeping mode,and the good sweeping symmetry between the positive sweep and negative sweep increases the application potential of the laser.In addition,the instantaneous linewidth is almost the same as that in the static state.These results describe the characteristics of the laser from a new perspective and reveal,to the best our knowledge,the intensity dynamics of such lasers for the first time.This paper provides some new research basis for understanding the establishment process of dispersion-tuned swept-fiber lasers and their potential application in the future. | DUIDUI LI GUOLU YIN LIGANG HUANG LEI GAO LAIYANG DANG ZEHENG ZHANG JINGSHENG HUANG HUAFENG LU TAO ZHU | 2023 | Photonics Research2023，11，6： | 0 |
| 15 | Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker and therapeutic target显示文摘Amyotrophic lateral sclerosis(ALS)is the most common motor neuron disease.At present,no definite ALS biomarkers are available.In this study,exosomes from the plasma of patients with ALS and healthy controls were extracted,and differentially expressed exosomal proteins were compared.Among them,the expression of exosomal coronin-1a(CORO1A)was 5.3-fold higher than that in the controls.CORO1A increased with disease progression at a certain proportion in the plasma of patients with ALS and in the spinal cord of ALS mice.CORO1A was also overexpressed in NSC-34 motor neuron-like cells,and apoptosis,oxidative stress,and autophagic protein expression were evaluated.CORO1A overexpression resulted in increased apoptosis and oxidative stress,overactivated autophagy,and hindered the formation of autolysosomes.Moreover,CORO1A activated Ca^(2+)-dependent phosphatase calcineurin,thereby blocking the fusion of autophagosomes and lysosomes.The inhibition of calcineurin activation by cyclosporin A reversed the damaged autolysosomes.In conclusion,the role of CORO1A in ALS pathogenesis was discovered,potentially affecting the disease onset and progression by blocking autophagic flux.Therefore,CORO1A might be a potential biomarker and therapeutic target for ALS. | Qinming Zhou Lu He Jin Hu Yining Gao Dingding Shen You Ni Yuening Qin Huafeng Liang Jun Liu Weidong Le Sheng Chen | 2022 | Frontiers of Medicine2022，16，5： | 0 |
| 16 | Analysis on the Breeding and Major Traits of Wide-adaptability Indica CMS Line Yungu 3A显示文摘Breeding sterile lines is the key to the development of hybrid rice with wide adaptability. However,at present,few wide-adaptability sterile lines have been applied in production practice. In this study,Yungu 3A,a new WA-type Indica CMS line with good grain quality,was developed by hybridization between Yunfeng 66 A with wide adaptability as female parent and F1 plants of Yunfeng 66 B / D62 B as male parent and continuous backcrossing. According to the results,the finally obtained Indica CMS line Yungu 3A has good plant type and leaf shape,strong tillering ability,excellent flowering habit,stable and complete male sterility with the sterile plant rate and pollen sterility rate of 100%,strong combining ability,high outcrossing rate,low sensitivity to light and temperature,and strong disease resistance,which was approved by Yunnan Provincial Crop Variety Appraisal Committee in 2013. Yungu 3A is conducive to the development of new hybrid rice combinations with good quality and wide adaptability,exhibiting a promising prospect of application. | Yonggang LU Huafeng DENG Jinwen ZHANG Wei DENG Yuran XU Anyu GU Wei NIAN Zhiliang LU Xiaolin LI | 2015 | Agricultural Biotechnology2015，4，3： | 0 |
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