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| 1 | In vitro differentiation of adipose-derived stem cells and bone marrow-derived stromal stem cells into neuronal-like cells显示文摘Adipose-derived stem cells and bone marrow-derived stromal stem cells were co-cultured with untreated or Aβ1-40-treated PC12 cells, or grown in supernatant derived from untreated or Aβ1-40-treated PC12 cells. Analysis by western blot and quantitative real-time PCR showed that protein levels of Nanog, Oct4, and Sox2, and mRNA levels of miR/125a/3p were decreased, while expression of insulin-like growth factor-2 and neuron specific enolase was increased. In comparison, the generation of neuron specific enolase-positive cells was most successful when adipose-derived stem cells were co-cultured with Aβ1-40-treated PC12 cells. Our results demonstrate that adipose-derived stem cells and bone marrow-derived stromal stem cells exhibit trends of neuronal-like cell differentiation after co-culture with Aβ1-40-treated PC12 cells. This process may relate to a downregulation of miR-125a-3p mRNA expression and increased levels of insulin-like growth factor-2 expression. | Jin Zhou Guoping Tian Jing'e Wang Xuefeng Cong Xingkai Wu Siyang Zhang Li Li Bing Xu Feng Zhu Xuedan Luo Jian Han Fengjie Hu | 2011 | Neural Regeneration Research2011，6，19： | 21 |
| 2 | Atmospheric particulate pollution of Lanzhou using magnetic measurements显示文摘To differentiate between natural and anthropogenic particulate sources in the atmosphere in Lanzhou City, samples were collected in different sites. The dust flux was calculated and magnetic measurements were conducted. Results show a distinct pattern of variation of dust flux within a year and it agrees with the shifts of atmospheric circulation regime. The magnetic parameters indicate that natural sources are the major components of atmospheric particulate during late spring and early summer, while anthropogenic sources contribute much more during winter months. The data also support the earlier findings that magnetic parameters are effective for differentiating between particulate arising from natural sources such as soil erosion and from anthropogenic sources such as coal combustion. | Chen Fa\|hu, Yang Li\|ping, Wang Jian\|min, Zhang Jia\|wu Institute of Environment & Hazards, Lanzhou University, Lanzhou 730000, China. E\|mail: fhchen@lzu.edu.cn | 1999 | Journal of Environmental Sciences1999，11，3： | 14 |
| 3 | Magnetic response to atmospheric heavy metal pollution recorded by dust-loaded leaves in Shougang industrial area, western Beijing显示文摘Fifty-five evergreen tree's leaves growing less than one year were collected from Shougang industrial area in western suburb of Beijing, including steel plants and its ambient residential areas, recreational parks and farmlands. Rock magnetic properties and heavy metal contents were studied. The results show that the magnetic properties of leaf samples are predominated by low-coercivity magnetite, and both the concentration and grain size of magnetite particles gradually decreased with the distance from the main pollution source increases. Moreover, there is a significant linear relationship between magnetic parameters (the low-field magnetic susceptibility, saturation isothermal remanent magnetization and anhysteretic remanent magnetization) and heavy metals contents (Fe, Pb, V, Cr and Zn) (0.73≤R≤ 0.88). Hence, the magnetic parameters of leaves can serve as a proxy for quick detecting of the recent atmospheric metallic pollution. | HU ShouYun DUAN XueMei SHEN MingJie U BLAHA W ROESLER YAN HaiTao E APPEL V HOFFMANN | 2008 | Chinese Science Bulletin2008，53，10： | 10 |
| 4 | 长期食用含糖和人工甜味剂的饮料与美国成年人死亡风险的关系显示文摘摄入含糖饮料(sugar-sweetened beverages,SSB)或含人工甜味剂饮料(artificially sweetened beverages,ASB)是否与死亡风险相关,这关乎公共卫生利益。研究者分析了卫生专业人员随访研究(1986-2014年)中男性37 716人和护士健康研究(1980-2014年)中女性80 647人(基线无慢性病)的SSB和ASB的消费与总死亡率和病因特异性死亡率之间的关系。应用Cox比例风险回归估计风险比和95%CI。结果显示,在随访3415564人年期间,研究者记录了36436例死亡,其中心血管病死亡7896例,癌症死亡12380例。 | 刘青(译) 叶鹏(摘、审校) Malik VS Li Y Pan A De Koning L Schernhammer E Willett WC Hu FB | 2019 | 中华高血压杂志2019，27，5： | 9 |
| 5 | Induction of the apoptosis of cancer cell by sonodynamic therapy:a review显示文摘Ultrasound can be used not only in examination,but also in therapy,especially in the therapy of cancer.Sonodynamic therapy is an experimental cancer therapy method which uses ultrasound to enhance the cytotoxic effects of agents known as sonosensitizers.It has been tested in vitro and in vivo.The ultrasound could penetrate the tissue and cell under some of conditions which directly changes cell membrane permeability,thereby allowing the delivery of exogenous molecules into the cells in some degree.Ultrasound could inhibit the proliferation or induce the apoptosis of cancer cells in vitro or in vivo.Recent researches indicated low-frequency and low-intensity ultrasound could induce cell apoptosis,which could be strengthened by sonodynamic sensitivity,microbubbles,chemotherapeutic drugs and so on.Most kinds of ultrasound suppressed the proliferation of cancer cells through inducing the apoptosis of cancer cells.The mechanism of apoptosis is not clear.In this review,we will focus on and discuss the mechanisms of the induction of cancer cell apoptosis by ultrasound. | Wen-Kun Bai E Shen Bing Hu | 2012 | Chinese Journal of Cancer Research2012，24，4： | 9 |
| 6 | Inside-out Ostwald ripening: A facile process towards synthesizing anatase TiO2 microspheres for high- efficiency dye-sensitized solar cells显示文摘一灵巧在内外面,到 TiO 2 microspheres 的控制形态学的准备的 Ostwald 成熟线路被开发。这里, TiO 2 空 microspheres (HM ) 和稳固的 microspheres (SM ) 被在 solvothermal 过程以 acetylacetone (Acac ) 调整 isopropanol (国际语音学协会) 的体积比率准备。在 HM,稳固的核心的降水,核心的表面上的外部壳的随后的免职,和同时的核心的形成过程期间,溶解和壳再结晶被观察,它验证在内外面 Ostwald 成熟机制。TiO 2 microspheres 的性质(毛孔尺寸,表面区域,和陷井状态) 的设计和优化对 dyesensitized 太阳能电池(DSSC ) 的高效重要。优化 TiO 2 microspheres (rHM 和 rSM ) 在再结晶上由 processing 以后获得了,拥有大毛孔尺寸,高表面区域和减少的陷井状态(Ti 3+ 和氧空缺) ,并且因此是为光电的设备的理想的材料。用 rHM photoanode 制作的 DSSC 的力量变换效率是 11.22% ,它显著地与基于 rSM 的 DSSC 的 10.54% 效率相比被改进。我们的工作为综合提供策略 TiO 2 microspheres 同时提供不同物理性质以表面区域, crystallinity,形态学,和 mesoporosity。 | Yong Ding Xin Xia Wangchao Chen Linhua Hu Li'e Mo Yang Huang Songyuan Dai | 2016 | Nano Research2016，9，7： | 7 |
| 7 | F-box protein AFB4 plays a crucial role in plant growth, development and innate immunity显示文摘 | Zhubing Hu Mehmet Ali Kegeli Maria Piisila Jing Li Mantas Survila Pekka Heino Gtinter Brade E Tapio Palva | 2012 | Cell Research2012，22，4： | 7 |
| 8 | Concentration profile of jet gas in the feed injection zone of a FCC riser显示文摘喷气气体的集中侧面被使用一种氢踪迹技术在一个冷模型的 FCC 起床人的 feed 注射地区调查。试验性的结果表明喷气气体集中侧面的四种类型能被用来描述在喷气气体之间混合并且预先提起在 feed 注射地区的气体。四种类型是为弱混合,为完整的混合的为中等混合的模糊塑造 M 的侧面,为强壮的混合的锋利的侧面,和抛物线的侧面的不同塑造 M 的侧面。为起始、完整的混合还原剂的区域的高度当减少时喷气气体速度或增加预先提起气体速度。而且,动量比率, Mj/Mr,(在 Mj 是喷气气体的动量的地方,先生是混合动量预先提起煤气、稳固的粒子) 被介绍在喷气气体集中分发上描述煤气的稳固的物理性质,操作条件,和设备配置的效果。为区域的高度起始、完整在喷气气体之间混合并且预先提起气体被发现当时,是 0 0.375 和 0.375 0.675 m Mj/Mr <
0.29 , 0.375 0.675 和 1.075 1.375 m 什么时候 Mj/Mr >
0.54 ,和 0 0.375 和 0.675 1.075 m 什么时候在 0.29 和 0.54 之间的 Mj/Mr ,分别地。 | Chenglin E Yiping Fan Kai Zhang Hu Zhang | 2008 | Progress in Natural Science:Materials International2008，18，10： | 6 |
| 9 | Sol-gel derived HA/TiO_2 double coatings on Ti scaffolds for orthopaedic applications显示文摘Hydroxyapatite/titania (HA/TiO2) double layers were coated onto Ti scaffolds throughout for orthopaedic applications by sol-gel method. Differential scanning calorimetry (DSC), thermogravimetric analysis (TG) and X-ray diffractometry (XRD) were used for the characterisation of the phase transformations of the dried gels and coated surface structures. Scanning electron microscope (SEM) equipped with energy dispersive spectrometry (EDS) was used for the observation and evaluation of the morphology and phases of the surface layers and for the assessment of the in vitro tests. The in vitro assessments were performed by soaking the HA/TiO2 double coated samples into the simulated body fluid (SBF) for various periods. The TiO2 dipping-coating method at a speed of 12 cm/min, followed by a heat treatment at 600 ℃ for 20 min. The HA la lyaeyre wr wasa ssu cbosaetqeude bnytl ya dipping-coated on the outer surface at the same speed and then heat-treated at difference temperatures. The results indicat that the HA phase begins to crystallize after a heat treatment at 560 ℃. The crystallinity increases obviously at 760 ℃. SEM observations find no delamination or crack at the interfaces of HA/TiO2 and TiO2/Ti. The HA/TiO2 coated Ti scaffolds displays excellent bone-like apatite forming ability when it is soaked into SBF. Ti scaffolds after HA/TiO2 double coatings can be anticipated as promising implant materials for orthopaedic | XU W HU W Y LI M H MA Q Q P. D. HODGSON WEN C E | 2006 | 中国有色金属学会会刊:英文版2006，16，B01： | 5 |
| 10 | A post-classical theory of enamel biomineralization… and why we need one显示文摘Enamel crystals are unique in shape,orientation and organization.They are hundreds of thousands times longer than they are wide,run parallel to each other,are oriented with respect to the ameloblast membrane at the mineralization front and are organized into rod or interrod enamel.The classical theory of amelogenesis postulates that extracellular matrix proteins shape crystallites by specifically inhibiting ion deposition on the crystal sides,orient them by binding multiple crystallites and establish higher levels of crystal organization.Elements of the classical theory are supported in principle by in vitro studies;however,the classical theory does not explain how enamel forms in vivo.In this review,we describe how amelogenesis is highly integrated with ameloblast cell activities and how the shape,orientation and organization of enamel mineral ribbons are established by a mineralization front apparatus along the secretory surface of the ameloblast cell membrane. | James P Simmer Amelia S Richardson Yuan-Yuan Hu Charles E Smith Jan Ching-Chun Hu | 2012 | International Journal of Oral Science2012，4，3： | 4 |
| 11 | Development and calibration of the Moon-based EUV camera for Chang'e-3显示文摘The process of development and calibration for the first Moon-based extreme ultraviolet(EUV) camera to observe Earth's plasmasphere is introduced and the design, test and calibration results are presented. The EUV camera is composed of a multilayer film mirror, a thin film filter, a photon-counting imaging detector, a mechanism that can adjust the direction in two dimensions, a protective cover, an electronic unit and a thermal control unit. The center wavelength of the EUV camera is 30.2 nm with a bandwidth of 4.6 nm. The field of view is 14.7° with an angular resolution of 0.08°, and the sensitivity of the camera is 0.11 count s-1Rayleigh-1. The geometric calibration, the absolute photometric calibration and the relative photometric calibration are carried out under different temperatures before launch to obtain a matrix that can correct geometric distortion and a matrix for relative photometric correction,which are used for in-orbit correction of the images to ensure their accuracy. | Bo Chen Ke-Fei Song Zhao-Hui Li Qing-Wen Wu Qi-Liang Ni Xiao-Dong Wang Jin-Jiang Xie Shi-Jie Liu Ling-Ping He Fei He Xiao-Guang Wang Bin Chen Hong-Ji Zhang Xiao-Dong Wang Hai-Feng Wang Xin Zheng Shu-Lin E Yong-Cheng Wang Tao Yu Liang Sun Jin-Ling Wang Zhi Wang Liang Yang Qing-Long Hu Ke Qiao Zhong-Su Wang Xian-Wei Yang Hai-Ming Bao Wen-Guang Liu Zhe Li Ya Chen Yang Gao Hui Sun Wen-Chang Chen | 2014 | Research in Astronomy and Astrophysics2014，14，12： | 4 |
| 12 | Parkin deficiency accentuates chronic alcohol intake-induced tissue injury and autophagy defects in brain,liver and skeletal muscle显示文摘Alcoholism leads to organ injury including mitochondrial defect and apoptosis with evidence favoring a role for autophagy dysregulation in alcoholic damage.Parkin represents an autosomal recessive in herited gene for Parkins on's disease and an important member of selective autophagy for mitoch on dria.The associati on between Parkins on's disease and alcoholic injury remains elusive.This study aimed to examine the effect of parki n deficiency on chr onic alcohol in takeinduced organ injury in brain,liver and skeletal muscle(rectus femoris muscle).Adult parkinknockout(PRK-/-)and wild-type mice were placed on Liber-De Carli alcohol liquid diet(4%)for 12 weeks prior to assessment of liver enzymes,intraperitoneal glucose toleranee,protein carbonyl content apoptosis,hematoxylin and eosin morphological staining,and mitochondrial respiration(cytochrome c oxidase,NADH:cytochrome c reductase and succinate:cytochrome c reductase).Autophagy protein markers were monitored by western blot analysis.Our data revealed that chronic alcohol intake imposed liver injury as evidenced by elevated aspartate aminotransferase and alanine transaminase,glucose intoleranee,elevated protein carbonyl formation,apoptosis,focal inflammation,necrosis,microvesiculation,autophagy/mitophagy failure and dampened mitochondrial respiration(complexⅣ,complexesⅠandⅢ,and complexesⅡandⅢ)in the brain,liver and rectus femoris skeletal muscle.Although parkin ablation itself did not generate any notable effects on liver enzymes,insulin sensitivity,tissue carbonyl damage,apoptosis,tissue morphology,autophagy or mitochondrial respiration,it accentuated alcohol intake-induced tissue damage,apoptosis,morphological change,autophagy/mitophagy failure and mitochondrial injury without affecting insulin sensitivity.These data suggest that parkin plays an integral role in the preservation against alcohol-induced organ injury,apoptosis and mitochondrial damage. | Hu Peng Xing Qin Sainan Chen Asli E Ceylan Maolong Dong Zhaofen Lin Jun Ren | 2020 | Acta Biochimica et Biophysica Sinica2020，52，6： | 3 |
| 13 | Maize WI5 encodes an endo-1,4-β-xylanase required for secondary cell wall synthesis and water transport in xylem显示文摘Water transport from roots to leaves through xylem is important for plant growth and development.Defects in water transport can cause drought stress,even when there is adequate water in the soil.Here,we identi-fied the maize(Zea mays)wilty5(wi5)mutant,which ex-hibits marked dwarfing and leaf wilting throughout most of its life cycle under normal growth conditions.wilty5 seed-lings exhibited lower xylem conductivity and wilted more rapidly under drought,NaCl,and high temperature treat-ments than wild-type plants.Map-based cloning revealed that WI5 encodes an active endo-1,4-β-xylanase from gly-cosyl dehydration family 10,which mainly functions in degrading and reorganizing cell wall xylan.Reverse-transcription polymerase chain reaction andβ-glucuronidase assays revealed that WI5 is highly expressed in stems,especially in internodes undergoing secondary wall as-sembly.RNA sequencing suggested that WI5 plays a unique role in internode growth.Immunohistochemistry and electron microscopy confirmed that wi5 is defective in xylan deposition and secondary cell wall thickening.Lignin deposition and xylan content were markedly re-duced in wi5 compared to the wild-type plants.Our results suggest that WI5 functions in xylem cell wall thickening through its xylanase activity and thereby regulates xylem water transport,the drought stress response,and plant growth in maize. | Xiaojiao Hu Yang Cui Xiaomin Lu Weibin Song Lei Lei Jinjie Zhu Jinsheng Lai Lizhu E Haiming Zhao | 2020 | Journal of Integrative Plant Biology2020，62，10： | 3 |
| 14 | Surface states in TiO2 submicrosphere films and their effect on electron transport显示文摘 | Li'e Mo Wangchao Chen Ling Jiang Yong Ding Zhaoqian Li Linhua Hu Songyuan Dai | 2017 | Nano Research2017，10，11： | 3 |
| 15 | High-level Expression of Functional Tumor Suppressor LKB1 in Escherichia coil显示文摘人的 LKB1 肿瘤压制或作为许多细胞的过程和发信号的小径的一个重要管理者被含有,显示它能是好候选人 foranticancer 药。它的 obtain 的失败高级表示是一个主要障碍在 vitro 学习它的蛋白质结构和函数。这里,我们在它一个肿瘤房间上的激酶活动和反癌症效果衬里的 Escherichia 关口 i 和表演描述人的 LKB1 的高级表示。编码 LKB 1 的基因被用经常使用的鳕鱼 ons 代替稀罕鳕鱼 ons 优化 inE。关口 i 并且与重叠教材综合了。recombinant His-LKB1 在 hostsBL21 (DE3 )(BL ) 和 Rosetta-gami (DE3 ) 被表示 pLysS (RG ) 。从 BL 的 His-LKB1 作为包括身体主要在场。从 RG 的可溶的 His-LKB1 占了 34。1% 全部的蛋白质和 purifiedHis-LKB1 的收益是约 92 亩 g/ml。从两位主人的净化的 His-LKB1 蛋白质是机能上地活跃的,作为当任何另外的联系激酶不在时由可逆 autophosphorylation 和激酶活动出现。生长禁止的比率在肝的癌 SMMC-7721 房间上净化了导出 BL 、导出 RG 的 His-LKB1 分别地,是 24.97% 和 45.68% ,两个能生产重要房间周期拘捕。 | Jun'e LIU Tingmao HU Xin HOU | 2007 | Acta Biochimica et Biophysica Sinica2007，39，10： | 3 |
| 16 | Treatment of PC-3 cells with ultrasound combined with microbubbles induces distinct alterations in the expression of Bcl-2 and Bax显示文摘The objective of the present study was to investigate whether ultrasound combined with microbubbles induces apoptotic cell death in androgen-independent prostate cancer cells and to identify the probable mechanism.We used ultrasound in continuous wave mode with a frequency of 21 kHz and a spatial-average temporal-average intensity of 46 mW/cm2.Ultrasound combined with microbubbles(200μL SonoVue)was used to treat androgen-independent human prostate cancer PC-3 cells for 30 s.PC-3 cells were divided into three groups:the control group,the ultrasound group and the ultrasound combined with microbubbles group.Immediately after treatment,trypan blue exclusion was used to assess cell viability.Cell apoptosis at 24 h after treatment was measured using transmission electron microscopy and flow cytometry.Western blotting was used to evaluate the expression of the apoptosis-related proteins,Bcl-2 and Bax.Ultrasound combined with microbubbles had a minimal effect on the viability of PC-3cells and induced minimal levels of cell lysis.The level of apoptosis in PC-3 cells induced by this modality was significantly higher than in controls(12.77±0.31%vs.2.56±0.22%,P<0.01).Treatment with ultrasound combined with microbubbles increased the expression of Bax,a pro-apoptotic protein,and decreased the expression of Bcl-2,an anti-apoptotic protein.It was concluded that ultrasound combined with microbubbles induces apoptotic cell death in human prostate cancer PC-3 cells through down-regulation of Bcl-2 and up-regulation of Bax. | BAI WenKun YANG ShaoLing SHEN E ZHANG JiZhen SHEN ZhiYong HU Bing | 2013 | Chinese Science Bulletin2013，58，28： | 2 |
| 17 | Influence of External Electric Field and Pre-ionization on Characteristics of Discharge Plasma in High-power Xenon Flashlamp显示文摘This work is devoted to experimentally study the characteristics of discharge plasma in high power xenon flashlamps.In the experiments,plasma channel profiles are captured by using a high speed CCD camera,and the radiation energy of the flashlamp is obtained by a pyroelectric energy meter.Voltage and current curves are recorded to shed light on the plasma characteristics.With these diagnostic methods,typical factors influencing the evolution process of plasma channel are studied,including the external electric field and the pre-ionization.The electric potential distribution in the flashlamp influence the plasma channel characteristics the most significantly.The plasma channel pattern for the cases with grounded wires is different from that with ungrounded metal wires.When the wire is ungrounded,it is the coupling voltage between the metal wire and the flashlamp that influences the development of plasma channel.In terms of radiation efficiency,it is proven that there is an optimal interval within 200~300μs between the pre-ionization pulse and the main pulse. | LIU Jianjun LI Haibing HU Lili LI Xingwen YANG Zefeng JIA Shenli e | 2013 | 高电压技术2013，39，9： | 2 |
| 18 | Photocatalytic decompositions of gaseous HCHO and methylene blue with highly ordered TiO_2 nanotube arrays显示文摘The highly ordered Ti O_2nanotubes(NTs) were fabricated by the anodic oxidation method.Their morphology,structure and crystalline phase were characterized by scanning electron microscopy(SEM) and X-ray diffractometer(XRD).The effects of morphology,specific surface area,pore structures and photocatalytic activity of the Ti O_2 NTs were investigated.UV–vis spectra analysis showed that its light absorption had been extended to the visible light range.The photocatalytic activity of the as-prepared samples was evaluated by photocatalytic oxidation of gaseous HCHO and MB aqueous solution.The samples had better adhesion strength in the dark and showed a higher photocatalytic activity than nanoparticles.Especially,with ultraviolet light pretreatment,the nanotubes exhibited more stable active for photocatalytic decomposition and the photodecomposition rate remained at high level after 3 cycles of the photocatalysis experiment.Thus,how the number of surface active group ·OH increased and the mechanism for the great improvement for the photocatalytic activity are discussed. | Lixia Li Jing Ya Fengjiao Hu Zhifeng Liu Lei E | 2016 | Journal of Energy Chemistry2016，25，4： | 2 |
| 19 | Isolation and identifi cation of antimicrobial metabolites from sea anemone-derived fungus Emericella sp.SMA01显示文摘Marine symbiotic fungi represent an intriguing source of discovery of novel secondary metabolites with various biological activities.Sea anemones are benthic marine invertebrates,however,the cultivable symbiotic fungi residing in the sea anemones are paid few attentions compared to those derived from their cnidarian counterparts.Here we show the identification of antimicrobial secondary metabolites from the sea anemone-derived symbiotic fungi.Out offive isolated fungal strains,only the strain SMA01 showed strong antimicrobial activities,which was assigned into the genus Emericella based on the morphological characteristics and the ITS sequencing.Media swift from liquid fermentation to solid rice medium presented little influence on its antibacterial activity.A chemical investigation of the ethyl acetate extract of the Emericella sp.SMA01 led to discovery of the primary antibiotic metabolite phenazine-1-carboxylic acid.The IC_(50) values of the phenazine-1-carboxylic acid against Phytophthora capsici,Gibberella zeae,and Verticillium dahliae were determined to be 23.26-53.89μg/mL.To the best of our knowledge,this was the first report of Emericella sp.in sea anemones.The current study may benefit understanding of the defensive chemical interactions between the symbiotic fungi and their host sea anemones. | Yang YUE Huahua YU Rongfeng LI Linfeng HU Song LIU Rong’e XING Pengcheng LI | 2021 | Journal of Oceanology and Limnology2021，39，3： | 2 |
| 20 | 地中海膳食干预研究中来自胆碱通路的血浆代谢物与心血管病风险的关系显示文摘血浆甜菜碱水平以及胆碱代谢水平与主要心血管病终点之间的联系仍不清楚。研究者评估了胆碱通路的代谢物与偶发心血管病风险以及地中海膳食干预的潜在调节效应之间的相关性。 | 黄洁 叶鹏 Guasch-Ferré M Hu FB Ruiz-Canela M Bulló M Toledo E Wang DD Corella D Gómez-Gracia E Fiol M Estruch R Lapetra J Fitó M Arós F Serra-Majem L Ros E Dennis C Liang L Clish CB Martínez-González MA Salas-Salvadó J | 2017 | 中华高血压杂志2017，25，12： | 2 |
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