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| 1 | Interaction of hepatitis C virus envelope glycoprotein E2 with the large extracellular loop of tupaia CD81显示文摘AIM: To further analyze the interaction of tupaia CD81 with hepatitis C virus (HCV) envelope protein E2. METHODS: A tupaia CD81 large extracellular loop (CD81 LEL), which binds to HCV E2 protein, was cloned and expressed as a GST-fusion protein, and interaction of HCV E2 protein with a tupaia CD81 LEL was evaluated by enzyme-linked immunosorbent assay (EIA). RESULTS: Although tupaia and human CD81 LEL differed in 6 amino acid changes, tupaia CD81 LEL was strongly recognized by anti-CD81 antibodies against human CD81 LEL conformation-dependent epitopes. Investigating LEL CD81-E2 interactions by EIA, we demonstrated that binding of tupaia CD81 LEL GST fusion protein to recombinant HCV E2 protein was markedly reduced compared to binding of human CD81 LEL GST fusion protein to recombinant HCV E2 protein. CONCLUSION: These data suggest that the structural differences in-between the tupaia and human CD81 may alter the interaction of the large extracellular loop with HCV envelope glycoprotein E2. These findings may be important for the understanding of the mechanisms of binding and entry of HCV to PTHs. | Zhan-Fei Tian Hong Shen Xi-Hua Fu Yi-Chun Chen Hubert E Blum Thomas F Baumert Xi-Ping Zhao | 2009 | World Journal of Gastroenterology2009，15，2： | 16 |
| 2 | Diagnosis of clinical and subclinical varicocele: how has it evolved?显示文摘在这评论,我们为在一个精索静脉曲张病人的评估以 venography, scintigraphy,和 thermography 和他们的角色开始的精索静脉曲张检验各种各样的诊断形式的进化和申请。一些这些方法被不太侵略、更容易执行的诊断形式,特别超声和阴囊的 Doppler 检查取代了。在超声和磁性的回声成像的进展保持潜力在精索静脉曲张的视觉证实和描述的以外扩展成像的角色。基于成像调查结果识别阴囊的机能障碍的早指示物的能力以后可以为精索静脉曲张的管理有含意。 | Ruth E Belay Gene Omar Huang Jim Ken-Chie Shen Edmund Yuey Kun Ko | 2016 | Asian Journal of Andrology2016，18，2： | 10 |
| 3 | Magnetic response to atmospheric heavy metal pollution recorded by dust-loaded leaves in Shougang industrial area, western Beijing显示文摘Fifty-five evergreen tree's leaves growing less than one year were collected from Shougang industrial area in western suburb of Beijing, including steel plants and its ambient residential areas, recreational parks and farmlands. Rock magnetic properties and heavy metal contents were studied. The results show that the magnetic properties of leaf samples are predominated by low-coercivity magnetite, and both the concentration and grain size of magnetite particles gradually decreased with the distance from the main pollution source increases. Moreover, there is a significant linear relationship between magnetic parameters (the low-field magnetic susceptibility, saturation isothermal remanent magnetization and anhysteretic remanent magnetization) and heavy metals contents (Fe, Pb, V, Cr and Zn) (0.73≤R≤ 0.88). Hence, the magnetic parameters of leaves can serve as a proxy for quick detecting of the recent atmospheric metallic pollution. | HU ShouYun DUAN XueMei SHEN MingJie U BLAHA W ROESLER YAN HaiTao E APPEL V HOFFMANN | 2008 | Chinese Science Bulletin2008，53，10： | 10 |
| 4 | High-accuracy topographical information extraction based on fusion of ASTER stereo-data and ICESat/GLAS data in Antarctica显示文摘In order to better support Antarctic inland ice sheet expedition from Zhongshan Station to Dome A,the topographic data are necessary.At present,although the entire Antarctic DEM provided by RAMP(Ra-darsat Antarctic Mapping Project) was estimated at the highest horizontal(spatial) resolution of about 200 m,the real horizontal resolution of the DEM varies from place to place depending on the density and scale of the original source data.For ice shelves and the inland ice sheet,the horizontal resolution is about 5 km;the vertical accuracy is estimated to be ±50 m in interior East Antarctic ice sheet and away from the mountain ranges.Therefore,more accurate topographic data are unavailable in Antarc-tica.In order to meet the requirements of high-accuracy topographic information for further researches,this paper mainly addresses a fusion study of ASTER stereo pairs and ICESat/GLAS altimetry data for extraction of high-accuracy DEM in East Antarctica,based on the high horizontal resolution(15 m) of ASTER and vertical accuracy(13.8 cm) of ICESat/GLAS.First,some altimetry data were selected as vertical control points to reduce errors of image correlation matching during the extraction of ASTER-based DEM.Second,ice sheet altimetry data derived from ICESat were used to generate DEM ranging from 75° to 81°S because existing ASTER data do not cover this area and high density of the coverage of ICESat altimetry data.Finally,the DEM in coverage of the expedition route was produced.The analysis of result reveals that the DEM accuracy is improved significantly.The absolute vertical accuracy of DEM is higher than 15 m in some cases and higher than 30 m for all the areas along the expedition route except from the 009-001 scene;the interior accuracy is higher than 15 m and higher than 7 m in some cases.It can meet the requirements of topographic map at 1:50000 scale,which is an economic and advantageous method to produce the topographic products. | E DongChen1,3,SHEN Qiang2,XU Ying1,3 & CHEN Gang4 1 Chinese Antarctic Center of Surveying and Mapping,Wuhan University,Wuhan 430079,China 2 Institute of Seismology China Earthquake Administration,Wuhan 430071,China 3 Key Laboratory of Polar Surveying and Mapping,State Bureau of Surveying and Mapping,Wuhan University,Wuhan 430079,China 4 Department of Geography,University of Calgary,Calgary,Alberta T2N 1N4,Canada | 2009 | Science China Earth Sciences2009，52，5： | 9 |
| 5 | Induction of the apoptosis of cancer cell by sonodynamic therapy:a review显示文摘Ultrasound can be used not only in examination,but also in therapy,especially in the therapy of cancer.Sonodynamic therapy is an experimental cancer therapy method which uses ultrasound to enhance the cytotoxic effects of agents known as sonosensitizers.It has been tested in vitro and in vivo.The ultrasound could penetrate the tissue and cell under some of conditions which directly changes cell membrane permeability,thereby allowing the delivery of exogenous molecules into the cells in some degree.Ultrasound could inhibit the proliferation or induce the apoptosis of cancer cells in vitro or in vivo.Recent researches indicated low-frequency and low-intensity ultrasound could induce cell apoptosis,which could be strengthened by sonodynamic sensitivity,microbubbles,chemotherapeutic drugs and so on.Most kinds of ultrasound suppressed the proliferation of cancer cells through inducing the apoptosis of cancer cells.The mechanism of apoptosis is not clear.In this review,we will focus on and discuss the mechanisms of the induction of cancer cell apoptosis by ultrasound. | Wen-Kun Bai E Shen Bing Hu | 2012 | Chinese Journal of Cancer Research2012，24，4： | 9 |
| 6 | N_2O emissions from agricultural soils in the North China Plain: the effect of chemical nitrogen fertilizer and organic manure显示文摘An enclosed chamber technique was used to measure N 2O emissions from intensively agricultural soils of the North China Plain during the periods of 1995—1996 and 1997—1998, to reflect distinct components of winter wheat and summer maize growing seasons. The results showed that the continuous application of fertilizer in agricultural soils increased N\-2O emissions by a factor of 24.1—28.1, the calculated annual chemical N fertilizer\|transformed N\-2O\|N emissions was 0.67%. Our results indicated that the application of organic manure also had a significant influence on soil N 2O emissions, which combined with the use of chemical N increased about 20% in a year. It was calculated that there were about 0.11% N of organic manure transformed as N 2O N. Annual mean N 2O emission from our study area of fertilized soils was estimated to be 57.1 μgN 2O/(m 2·h). A weak correlation was also found between N 2O emissions and soil available nitrogen content NH + 4. | DONG Yun\|she 1,2,3 , Dieter Scharffe 2, Manfred Domroes 3, QI Yu chun 1, ZHANG Shen 1 (1. Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China E\|mail: dongys@dls.iog.ac.cn 2. M | 2000 | Journal of Environmental Sciences2000，12，4： | 6 |
| 7 | 金刚石中的冰-Ⅶ相包裹体:来自地球深部地幔的含水流体证据显示文摘水在地球内部不同圈层的存在形态、分布、含量以及全球水循环一直以来都是固体地球科学研究的前沿热点问题之一。冰-Ⅶ相作为水的一种高压相,目前已经被国际矿物学会认定为一种新矿物。 | Tschauner O Huang S Greenberg E Prakapenka V B Rossman G R Shen A H Zhang D Newville M Lanzirotti A Tait K 张宝华 | 2018 | 矿物岩石地球化学通报2018，37，6： | 4 |
| 8 | Frequency-multiplexing photon-counting multi-beam LiDAR显示文摘We report a frequency-multiplexing method for multi-beam photon-counting light detection and ranging(Li DAR),where only one single-pixel single-photon detector is employed to simultaneously detect the multibeam echoes.In this frequency-multiplexing multi-beam Li DAR,each beam is from an independent laser source with different repetition rates and independent phases.As a result,the photon counts from different beams could be discriminated from each other due to the strong correlation between the laser pulses and their respective echo photons.A 16-beam Li DAR system was demonstrated in three-dimensional laser imaging with 16 pulsed laser diodes at 850 nm and one single-photon detector based on a Si-avalanche photodiode.This frequencymultiplexing method can greatly reduce the number of single-photon detectors in multi-beam Li DAR systems,which may be useful for low-cost and eye-safe Li DAR applications. | TIANXIANG ZHENG GUANGYUE SHEN ZHAOHUI LI LEI YANG HAIYAN ZHANG E WU GUANG WU | 2019 | Photonics Research2019，7，12： | 4 |
| 9 | A confidence limit for the empirical mode decomposition and Hilbert spectral analysis显示文摘 | Huang Norden E Wu Man-Li C Long Steven R Shen Samuel S.P Qu Wendong Gloersen Per Fan Kuang L | 2003 | Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences . 2003 (2037)2003，，2037： | 3 |
| 10 | Valency Study of Vanadium in Stone Coal of Southern China显示文摘Vanadium-bearing stone coal is a new resource of vanadium. V in stone coal mainly exists in three oxidation states: 7.84%V(Ⅲ), 72.08% Ⅴ(Ⅳ) and 20.08% Ⅴ(Ⅴ). The change and distribution of valency of Ⅴ during oxidizing roasting shows that organicmatter in the coal determines valency of Ⅴ at low temperature; at about 450℃, Ⅴ(Ⅲ) is completely oxidized to Ⅴ(Ⅳ); above500℃, temperature is the most important factor for the oxidation of Ⅴ. At 700~1000℃, 92% of Ⅴ in the coal has been oxidizedto Ⅴ(Ⅴ), at still higher temperature no more oxidation of Ⅴ takes place, an equilibrium being established. The roles of NaCl in therecovery of V2O5 from the coal were discussed. The best conditions for roasting are: the oxidation-chlorination atmosphere,temperature 800℃ for 30 minutes, ore: NaCl=100:10,ηroast reaching 90%. | Xu, Guozhen Ge, Nai'e Chen, Jianping Shen, Shaobo | 1990 | Rare Metals1990，10，2： | 3 |
| 11 | Statistical survey on the magnetic field in magnetotail current sheets: Cluster observations显示文摘The distribution properties of the magnetic field in magnetotail current sheets have been explored statistically with the magnetic measurement data of the Cluster mission from June to November of the years 2001–2005.It is found that,on average,the strength of the magnetic field and its Bz component in the current sheet are weaker in the region close to midnight but stronger near the dawnside and duskside flanks,which implies that,in general,a thinner current sheet occurs near midnight and thicker ones near both flanks.The occurrence of tail current sheet flapping is higher on both flanks than in the midnight region,although it is most frequent in the dawn flank.Current sheets with a negative Bz component or a strong By component have a higher probability of occurring at magnetic local times of 21:00–01:00,indicating that magnetic activity,e.g.magnetic reconnection and current disruption occur more frequently there.Statistically,the probability distributions of the By component and the tilt angle of magnetic field lines in the current sheet are approximately normal distributions,and the occurrence probability of the flattened current sheet is about one third that of the normal current sheet.The magnetic field and Bz component in the current sheet mainly vary from 1 nT to 10 nT.The By component in the tail central current sheet is on average twice the IMF By at 1 AU. | RONG ZhaoJin SHEN Chao LUCEK E BALOGH A YAO Li | 2010 | Chinese Science Bulletin2010，55，23： | 3 |
| 12 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis显示文摘 | Huang N E Shen Z Long S R | | 0，，： | 3 |
| 13 | Treatment of PC-3 cells with ultrasound combined with microbubbles induces distinct alterations in the expression of Bcl-2 and Bax显示文摘The objective of the present study was to investigate whether ultrasound combined with microbubbles induces apoptotic cell death in androgen-independent prostate cancer cells and to identify the probable mechanism.We used ultrasound in continuous wave mode with a frequency of 21 kHz and a spatial-average temporal-average intensity of 46 mW/cm2.Ultrasound combined with microbubbles(200μL SonoVue)was used to treat androgen-independent human prostate cancer PC-3 cells for 30 s.PC-3 cells were divided into three groups:the control group,the ultrasound group and the ultrasound combined with microbubbles group.Immediately after treatment,trypan blue exclusion was used to assess cell viability.Cell apoptosis at 24 h after treatment was measured using transmission electron microscopy and flow cytometry.Western blotting was used to evaluate the expression of the apoptosis-related proteins,Bcl-2 and Bax.Ultrasound combined with microbubbles had a minimal effect on the viability of PC-3cells and induced minimal levels of cell lysis.The level of apoptosis in PC-3 cells induced by this modality was significantly higher than in controls(12.77±0.31%vs.2.56±0.22%,P<0.01).Treatment with ultrasound combined with microbubbles increased the expression of Bax,a pro-apoptotic protein,and decreased the expression of Bcl-2,an anti-apoptotic protein.It was concluded that ultrasound combined with microbubbles induces apoptotic cell death in human prostate cancer PC-3 cells through down-regulation of Bcl-2 and up-regulation of Bax. | BAI WenKun YANG ShaoLing SHEN E ZHANG JiZhen SHEN ZhiYong HU Bing | 2013 | Chinese Science Bulletin2013，58，28： | 2 |
| 14 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis显示文摘 | Huang N E Shen Z Long S R | | 0，，1971： | 2 |
| 15 | Medial temporal lobe atrophy on MRI scans and the diagnosis of Alzheimer disease显示文摘 | R Duara D A. Loewenstein E Potter J Appel M T. Greig R Urs Q Shen A Raj B Small W Barker E Schofield Y Wu H Potter | 2008 | Neurology2008，，24： | 2 |
| 16 | MODELING OF SEDIMENT AND NONPOINT SOURCE POLLUTANT YIELD显示文摘For water and soil conservation and water pollution control, it is very important to simulate and predict the load of sediment and pollutant during storm-runoff. On the basis of analyzing the simultaneous measurements of flow, sediment and pollutants observed at watershed outlet, a practical sediment yield model is developed by standardizing the load rate. The results show that the standardized pollutant yield equals effective rainfall and the process of effective load yield is the same as effective rainfall hyetograph. Comparison with measured data show that this model is applicable to various pollutants. | Huai’en LI, Xiaokang Hong and Bing SHEN Professor, Institute of Environmental Sciences, Xi’an University of Technology, Xi’an 710048, Shaanxi Province, P.R.China. Ph.D. studdent in Hydrology and Water Resources, Xi’an University of Techology, and Senior E | 2001 | International Journal of Sediment Research2001，16，3： | 2 |
| 17 | Strong paleoearthquakes along the Talas-Fergana Fault,Kyrgyzstan显示文摘The Talas-Fergana Fault,the largest strike-slip structure in Central Asia,forms an obliquely oriented boundary between the northeastern and southwestern parts of the Tianshan mountain belt. The fault underwent active right-lateral strike-slip during the Paleozoic,with right-lateral movements being rejuvenated in the Late Cenozoic. Tectonic movements along the intracontinental strike-slip faults contribute to absorb part of the regional crustal shortening linked to the India-Eurasia collision; knowledge of strike-slip motions along the Talas-Fergana Fault are necessary for a complete assessment of the active deformation of the Tianshan orogen. To improve our understanding of the intracontinental deformation of the Tianshan mountain belt and the occurrence of strong earthquakes along the whole length of the Talas-Fergana Fault,we identify features of relief arising during strong paleoearthquakes along the Talas-Fergana Fault,fault segmentation,the length of seismogenic ruptures,and the energy and age of ancient catastrophes. We show that during neotectonic time the fault developed as a dextral strike-slip fault,with possible dextral displacements spreading to secondary fault planes north of the main fault trace. We determine rates of Holocene and Late Pleistocene dextral movements,and our radiocarbon dating indicates tens of strong earthquakes occurring along the fault zone during and interval of 15800years. The reoccurrence of strong earthquakes along the Talas-Fergana Fault zone during the second half of the Holocene is about 300 years. The next strong earthquake along the fault will most probably occur along its southeastern chain during the next several decades. Seismotectonic deformation parameters indicate that M>7earthquakes with oscillation intensity I>IX have occurred. | Korzhenkov A M Rogozhin E A Shen Xuhui Tian Qinjian Xu Yueren | 2014 | Geodesy and Geodynamics2014，5，1： | 2 |
| 18 | Wavelet base rate scalable video compression显示文摘 | K Shen E J Delp | 1999 | IEEE Trans on Circuits and Systems1999，9，1： | 2 |
| 19 | 糖尿病、糖尿病前期与亚临床心肌损害发生率显示文摘众所周知,处于糖尿病前期者和糖尿病患者存在较高的心血管事件发生风险。然而,糖尿病前期和糖尿病与亚临床心肌损害发生间的关系尚不明确。方法与结果:应用高敏心肌肌钙蛋白T (highly sensitive cardiac troponin T hs-cTnT)分析,测定社区动脉粥样硬化风险研究中9331例受试者两个时间点(间隔6年)的心肌肌钙蛋白T(cardiac troponin T,cTnT)水平,所有受试者为无糖尿病或处于糖尿病前期,或糖尿病不伴心血管疾病(包括心电图检测出来的无临床症状的心肌梗死)。 | Selvin E Lazo M Chen Y Shen L Rubin J McEvoy JW Hoogeveen RC Sharrett AR Ballantyne CM Coresh J 刘莉 | 2014 | 中华高血压杂志2014，22，9： | 2 |
| 20 | Open and Endovascular Treatment of Trans-Atlantic Inter-Society Consensus Ⅱ D Aortoiliac Occlusive Lesions: What Determines the Rate of Restenosis?显示文摘 | Chen-Yang Shen Yun-Feng Liu Qing-Le Li Yong-Bao Zhang Yang Jiao Miltiadis E Krokidis Xiao-Ming Zhang | 2015 | Chinese Medical Journal2015，，22： | 2 |
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