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| 1 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 2 | Vascular events associated with alpha interferon therapy显示文摘 | AL-Zahrani H Gupta V Minden M D | 2003 | Leuk Lymphoma2003，44，： | 1 |
| 3 | Sustainability under combined application of mineral and organic fertilizers in a rained soybean-wheat system of the Indian Himalayas 显示文摘 | Bhattacharyya R Kundu S Prakash V Gupta H S | 2008 | European Journal of Agronomy2008，28，1： | 1 |
| 4 | Equifinality of formal (DREAM) and informal (GLUE) Bayesian approaches in hydrologic modeling?显示文摘 | Vrugt J A Braak C J F Gupta H V | 2009 | Stochastic Environmental Research and Risk Assessment2009，23，： | 1 |
| 5 | Artifical neural network modeling of the rainfall-runoff process显示文摘 | HSU K L GUPTA H V SOROOSHIAN S | 1995 | Water Resources Research1995，31，： | 1 |
| 6 | Artifical neural network modeling of the rainfall-runoff process 显示文摘 | HSU K L GUPTA H V SOROOSHIAN S | 1995 | Water Resources Research1995，31，10： | 1 |
| 7 | Role of fluxing agents in themal alteration of sandstones显示文摘 | SOMERTON W H GUPTA V S | 1965 | Journal of Petroleum Technology1965，35，4： | 1 |
| 8 | Reactive separa tion of CO2 using pressure pelletised limestone显示文摘 | Gupta H Mahesh V Sakadjian B B | 2004 | Int J En vironmental Technology and Management2004，4，12： | 1 |
| 9 | Broad Molecular Weight Poly- propylene Synthesis Using Mixed Internal Donor Incorporated Magnesium Dichloride Supported Titanium Catalyst 显示文摘 | Patil H R Naik D G Gupta V | 2011 | J Macromol Sci Part A: Pure Appl Chem2011，48，3： | 1 |
| 10 | Modeling of creep behavior of a rotating disc in the presence of both composition and thermal gradients显示文摘 | Gupta V K Singh S B Chandrawat H N Ray S | 2005 | Journal of Engineering Materials and Technology Transactions of the ASME2005，127，1： | 1 |
| 11 | Odontogenic keratocyst: a peripheral variant 显示文摘 | Vij H Vij R Gupta V | 2011 | Niger J Clin Pract2011，14，4： | 1 |
| 12 | Dual State-parameter Estimation of Hydrological Models Using Ensemble Kalman Filter显示文摘 | Moradkhani H Sorooshian S Gupta H V | 2005 | Advances in Water Resources2005，28，2： | 1 |
| 13 | Reversal of chronic molecular and cellular abnormalities due to heart failure by passive mechanical ventrlcular containment显示文摘 | Sabbah H N Sharer V G Gupta R C | 2003 | Circ Res2003，93，11： | 1 |
| 14 | Self-organizing linear output map (SOLO):an artificial neural network suitable for hydrologic modeling and analysis显示文摘 | HSU K L GUPTA H V GAO X | 2002 | Water Resour Res2002，38，12： | 1 |
| 15 | Advance midcourse guidance for air-to-air missile显示文摘 | Cheng V H L Gupta N K | | 0，，2： | 1 |
| 16 | Knowledge management in the tacit dimension显示文摘 | Shamra H Gupta V K | 2002 | Annals of Library and Information Studies2002，49，2： | 1 |
| 17 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 18 | Effective and effi- cient algorithm for multiobjective optimization of hydrologic models显示文摘 | Vmgt J A Gupta H V Bastidas L A | 2003 | Water Resources Research2003，39，8： | 1 |
| 19 | Real-time Data Assimilation for Operational Ensemble Streamflow Forecasting显示文摘 | Vrugt J A Gupta H V Nualláin B | 2006 | Journal of Hydrometeorology2006，7，3： | 1 |
| 20 | Multi cyclic study on the simultaneous carbonation and sulfation of highreactivity Ca O显示文摘 | Iyer M V Gupta H Sakadjian B B | 2004 | Industrial and Engineering chemsistry Research2004，43，14： | 1 |
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