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| 1 | Heparanase activates the syndecan-syntenin-ALIX exosome pathway显示文摘 | Bart Roucourt Sofie Meeussen Jie Bao Pascale Zimmermann Guido David | 2015 | Cell Research2015，25，4： | 29 |
| 2 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 3 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 4 | Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade显示文摘PD-1 blockade represents a major therapeutic avenue in anticancer immunotherapy.Delineating mechanisms of secondary resistance to this strategy is increasingly important.Here,we identified the deleterious role of signaling via the type I interferon(IFN)receptor in tumor and antigen presenting cells,that induced the expression of nitric oxide synthase 2(N0S2),associated with intratumor accumulation of regulatory T cells(Treg)and myeloid cells and acquired resistance to anti-PD-1 monoclonal antibody(mAb).Sustained IFNP transcription was observed in resistant tumors,in turn inducing PD-L1 and N0S2 expression in both tumor and dendritic cells(DC).Whereas PD-L1 was not involved in secondary resistance to anti-PD-1 mAb,pharmacological or genetic inhibition of N0S2 maintained long-term control of tumors by PD-1 blockade,through reduction of Treg and DC activation.Resistance to immunotherapies,including anti-PD-1 mAb in melanoma patients,was also correlated with the induction of a type I IFN signature.Hence,the role of type I IFN in response to PD-1 blockade should be revisited as sustained type I IFN signaling may contribute to resistance to therapy. | Nicolas Jacquelot Takahiro Yamazaki Maria PRoberti Connie PMDuong Miles CAndrews Loic Verlingue Gladys Ferrere Sonia Becharef Marie Vetizou Romain Daillere Meriem Messaoudene David PEnot Gautier Stoll Stefano Ugel Maria Marigo Shin Foong Ngiow Aurelien Marabelle Armelle Prevost-Blondel Pierre-Olivier Gaudreau Vancheswaran Gopalakrishnan Alexander MEggermont Paule Opolon Christophe Klein Gabriele Madonna Paolo AAscierto Antje Sucker Dirk Schadendorf Mark JSm yth Jean-Charles Soria Guido Kroemer Vincenzo Bronte Jennifer Wargo and Laurence Zitvogel | 2019 | Cell Research2019，29，10： | 6 |
| 5 | The Development and Validation of an Endoscopic Grading System for Barrett’s Esophagus: The Prague C & M Criteria显示文摘 | Prateek Sharma John Dent David Armstrong Jacques J.G.H.M. Bergman Liebwin Gossner Yoshio Hoshihara Janusz A. Jankowski Ola Junghard Lars Lundell Guido N.J. Tytgat Michael Vieth | 2006 | Gastroenterology2006，，5： | 3 |
| 6 | Agile patency system eliminates risk of capsule retention in patients with known intestinal strictures who undergo capsule endoscopy显示文摘 | Juan M. Herrerias Jonathan A. Leighton Guido Costamagna Anthony Infantolino Rami Eliakim Doron Fischer David T. Rubin Howard D. Manten Eitan Scapa Douglas R. Morgan Ari J. Bergwerk Binyamin Koslowsky Samuel N. Adler | 2008 | Gastrointestinal Endoscopy2008，，6： | 2 |
| 7 | Differential diagnosis in patients with suspected bile acid synthesis defects显示文摘AIM: To investigate the clinical presentations associated with bile acid synthesis defects and to describe identification of individual disorders and diagnostic pitfalls. METHODS: We describe semiquantitative determination of 16 urinary bile acid metabolites by electrospray ionization-tandem mass spectrometry. Sample preparation was performed by solid-phase extraction. The total analysis time was 2 min per sample. We determined bile acid metabolites in 363 patients with suspected defects in bile acid metabolism. RESULTS: Abnormal bile acid metabolites were found in 36 patients. Two patients had bile acid synthesis defects but presented with atypical presentations. In 2 other patients who were later shown to be affected by biliary atresia and cystic fibrosis the profile of bile acid metabolites was initially suggestive of a bile acid synthesis defect. Three adult patients suffered from cerebrotendinous xanthomatosis. Nineteen patients had peroxisomal disorders, and 10 patients had cholestatic hepatopathy of other cause. CONCLUSION: Screening for urinary cholanoids should be done in every infant with cholestatic hepatopathy as well as in children with progressive neurological disease to provide specific therapy. | Dorothea Haas Hongying Gan-Schreier Claus-Dieter Langhans Tilman Rohrer Guido Engelmann Maura Heverin David W Russell Peter T Clayton Georg F Hoffmann Jürgen G Okun | 2012 | World Journal of Gastroenterology2012，18，10： | 2 |
| 8 | Immunity:研究开发出最优的HIV疫苗递送模式显示文摘HIV已不再占据头条新闻。这主要是因为抗逆转录病毒药物的成功开发已将HIV病毒感染导致的艾滋病(AIDS)转化为一种慢性的可控制的疾病。然而。当前在全世界大约0.367亿名HIV感染者中,仅约一半的人能够获得控制这种病毒所需的药物。与此同时。新的HIV感染率持续保持在非常高的水平,这突出强调了需要开发一种预防性疫苗。然而,几十年来。 | Matthias Pauthner Colin Havenar-Daughton Devin Sok Joseph P. Nkolola Raiza Bastidas Archana V. Boopathy Diane G. Carnathan Abishek Chandrashekar Kimberly M. Cirelli Christopher A. Cottrell Alexey M. Eroshkin Javier Guenaga Kirti Kaushik Daniel W. Kulp Jinyan Liu Laura E. McCoy Aaron L. Oom Gabriel Ozorowski Kai W. Post Shailendra K. Sharma Jon M. Steichen Steven W. de Taeye Talar Tokatlian Alba Torrents de la Peña Salvatore T. Butera Celia C. LaBranche David C. Montefiori Guido Silvestri Ian A. Wilson Darrell J. Irvine Rogier W. Sanders William R. Schief Andrew B. Ward Richard T. Wyatt Dan H. Barouch Shane Crotty Dennis R. Burton | 2017 | 现代生物医学进展2017，17，27： | 2 |
| 9 | Cardiac Magnetic Resonance With T2-Weighted Imaging Improves Detection of Patients With Acute Coronary Syndrome in the Emergency Department显示文摘 | Ricardo C. Cury Khalid Shash John T. Nagurney Guido Rosito Michael D. Shapiro Cesar H. Nomura Suhny Abbara Fabian Bamberg Maros Ferencik Ehud J. Schmidt David F. Brown Udo Hoffmann Thomas J. Brady | 2008 | Circulation2008，，8： | 1 |
| 10 | Ovarian pregnancy: a case report 显示文摘 | Concetta Strazzanti Davide De Santo Guido Tracanzan etal | 2000 | Acta Obstet Gynecol Scand2000，80，： | 1 |
| 11 | Ultrasound guided high intensity focused ultrasound (USgHIFU) ablation for uterine fibroids: Do we need the microbubbles?显示文摘 | Franco Orsi Lorenzo Monfardini Guido Bonomo Miltiadis Krokidis Paolo Della Vigna Davide Disalvatore | 2015 | International Journal of Hyperthermia2015，，3： | 1 |
| 12 | Palliation of patients with malignant gastric outlet obstruction with the enteral Wallstent: outcomes from a multicenter study显示文摘 | Jennifer J. Telford David L. Carr-Locke Todd H. Baron Andrea Tringali Willis G. Parsons Armando Gabbrielli Guido Costamagna | 2004 | Gastrointestinal Endoscopy2004，，6： | 1 |
| 13 | Noise analysis of conventional and gain-clamped semiconductor optical amplifiers 显示文摘 | Guido G Davide D A | 2000 | IEEE Journal of Lightwave Technology2000，18，9： | 1 |
| 14 | Overexpression of CXCL5 Is Associated With Poor Survival in Patients With Pancreatic Cancer显示文摘 | Aihua Li Jonathan King Aune Moro Mark D. Sugi David W. Dawson Jeffrey Kaplan Gang Li Xuyang Lu Robert M. Strieter Marie Burdick Vay Liang W. Go Howard A. Reber Guido Eibl O. Joe Hines | 2011 | The American Journal of Pathology2011，，3： | 1 |
| 15 | QUANTUM ESPRESSO: a modular and open-source software project for quantumsimulations of materials显示文摘 | Paolo Giannozzi Stefano Baroni Nicola Bonini Matteo Calandra Roberto Car Carlo Cavazzoni Davide Ceresoli Guido L Chiarotti Matteo Cococcioni Ismaila Dabo Andrea Dal Corso Stefano de Gironcoli Stefano Fabris Guido Fratesi Ralph Gebauer Uwe Gerstmann Christ | 2009 | Journal of Physics: Condensed Matter2009，，39： | 1 |
| 16 | Impact of Microvascular Dysfunction on Left Ventricular Remodeling and Long-Term Clinical Outcome After Primary Coronary Angioplasty for Acute Myocardial Infarction显示文摘 | Leonardo Bolognese Nazario Carrabba Guido Parodi Giovanni M. Santoro Piergiovanni Buonamici Giampaolo Cerisano David Antoniucci | 2004 | Circulation: Journal of the American Heart Association2004，，9： | 1 |
| 17 | Cell wall active antifungal compounds produced by the marine fungus Hypoxylon oceanicum LL-15G256, Ⅲ, biological properties of 15 G256γ显示文摘 | David Albaugh Guido Albert Patericia Bradford | 1998 | An-tibiotics1998，51，3： | 1 |
| 18 | Flash flood flow experiment in a simplified urban district显示文摘 | Guido Testa David Zuccalà Francisco Alcrudo | 2007 | Journal of Hydraulic Research2007，45，1： | 1 |
| 19 | Abciximab-Supported Infarct Artery Stent Implantation for Acute Myocardial Infarction and Long-Term Survival: A Prospective, Multicenter, Randomized Trial Comparing Infarct Artery Stenting Plus Abciximab With Stenting Alone显示文摘 | David Antoniucci Angela Migliorini Guido Parodi Renato Valenti Alfredo Rodriguez Albrecht Hempel Gentian Memisha Giovanni Maria Santoro | 2004 | Circulation: Journal of the American Heart Association2004，，： | 1 |
| 20 | The neural substrates of social emotion perception and regulation are modulated by adult attachment style显示文摘 | Pascal Vrti?ka Guido Bondolfi David Sander Patrik Vuilleumier | 2012 | Social Neuroscience2012，，5： | 1 |
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