|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mycoplasma genitalium infection is associated with microscopic signs of cervical inflammation in liquid cytology specimens显示文摘 | Dehon PM Mc Gowin CL | 2014 | J Clin Microbiol2014，52，7： | 1 |
| 2 | Osteoporosis changes the amount of vertebral trabecular bone at risk of fracture but not the vertebral load distribution显示文摘 | Homminga J Weinans H Gowin W | 2001 | Spine2001，26，14： | 1 |
| 3 | Osteoporosis changes the amount of vertebral trabecular bone at risk of fracture but not the vertebral load distribution 显示文摘 | Homminga J Weinas H Gowin W | 2001 | Spine2001，26，： | 1 |
| 4 | Osteoporosis Changes the Amount of Vertebral Trabecular Bone at Risk of Fracture but Not the Vertebral Load Distribution显示文摘 | Jasper Homminga Harrie Weinans Wolfgang Gowin Dieter Felsenberg Rik Huiskes | 2001 | Spine2001，，14： | 1 |
| 5 | Mucosal treatments for herpes simplex virus:insights on targeted immunoprophyiaxis and therapy显示文摘 | Gowin CLM Pyles RB | 2010 | Future Microbiology2010，5，1： | 1 |
| 6 | Age- and gender-related distribu- tion of bone mineral density and mechanical properties of the proximal humerus显示文摘 | Lill H Hepp P Gowin W | 2002 | Rofo2002，174，12： | 1 |
| 7 | Osteoporosis changes the amount of vertebral trabecular bone at risk of fracture but not the vertebral load distribution显示文摘 | Homminga J Weinans H Gowin W | 2001 | Spine2001，26，： | 1 |
| 8 | Flightless I deficiency enhances wound repair by increasing cell mi- gration and proliferation显示文摘 | Gowin AJ Adams DH Strudwick XL | 2007 | J Pathol2007，211，5： | 1 |
| 9 | Experience with pegylated interferon alpha-2a in advanced myelopmliferative neoplasms in an international cohort of 118 patients 显示文摘 | Gowin K Thapaliya P Samuelson J | 2012 | Haematologiea2012，97，10： | 1 |
| 10 | A mathematical model of the kinematic of a rotating disc for inter- and intra-row hoeing显示文摘 | O\'Dogherty M J Gowin R J Dedousis A P | 2007 | Biosystems Eng2007，96，2： | 1 |
| 11 | Prevalence of IFNL3 rs4803217 single nucleotide polymorphism and clinical course of chronic hepatitis C显示文摘AIM To evaluate the association of IFNL3(IL28B) SNP rs4803217 with severity of disease and treatment outcome in chronic hepatitis C(CHC).METHODS The study enrolled 196 CHC Polish patients(82 women and 114 men in age 20-64) infected with hepatitis C virus(HCV) genotype 1. They were treatment na?ve and qualified to pegylated interferon alpha(PEG-IFN-α) and ribavirin(RBV) therapy. The analyzed baseline parameters included: degree of inflammation, stage of fibrosis, viral load as well as alanine aminotransferase(ALT), asparagine aminotransferase(AST) and total bilirubin(TBIL). The analysis of response to therapy included: sustained virological response(SVR), defined as undetectable serum HCV RNA level six month after completion of 48-wk therapy, and relapse, defined as achieving undetectable viral load at the end of treatment but not SVR. HCV genotyping and HCV RNA quantification were performed using commercially available tests. DNA was isolated from peripheral blood mononuclear cells or from buccal cell swabs. In addition to rs4803217, also single nucleotide polymorphisms(SNPs)(rs12979860, rs8099917 and rs12980275) of known significance in predicting of HCV clearance were analyzed. SNPs were determined by high resolution melt analysis and confirmed by sequencing of amplicons. RESULTS Frequency of rs4803217 genotypes in studied group was as follows: 27.55%; 54.59% and 17.86% for CC, CA and AA, respectively. The rs4803217 SNP, similar to other analyzed SNPs, was not associated with severity of CHC(grade of inflammation, stage of fibrosis, baseline viral load as well as biochemical parameters: ALT, AST, TBIL). It was demonstrated that the rs4803217 C allele is associated with SVR(C vs A: P < 0.0001; dose of C allele: P = 0.0002) and nonrelapse(C vs A: P = 0.001; dose of C allele: P = 0.002). Moreover, it was found that patients with CC genotype have significantly higher response rates as compared with CA/AA patients(P < 0.0001), whereas patients carrying A allele are significantly predisposed to relapse after treatment(P = 0.0007). Moreover, the association of rs4803217 with SVR was comparable to that of rs12979860 and stronger as observed for rs12980275 and rs8099917. Association of rs4803217 with relapse, was the strongest as compared with the other SNPs. The analysis of combined rs4803217 and rs8099917 genotypes demonstrated that additional genotyping of rs8099917 had no significant impact on the prediction of SVR. Multivariate analysis revealed that among analyzed SNPs only rs4803217 is an independent predictor of SVR(P = 0.016) and relapse(P = 0.024). CONCLUSION The rs4803217 SNP is a strong, independent and superior predictor of SVR and relapse in HCV genotype 1 infected CHC patients treated with PEG-IFN-α and RBV. | Bogna Swiatek-Koscielna Ewelina Kaluzna Ewa Strauss Jerzy Nowak Iwona Bereszyńska Ewelina Gowin Jacek Wysocki Jolanta Rembowska Dominika Barcińska Iwona Mozer-Lisewska Danuta Januszkiewicz-Lewandowska | 2017 | World Journal of Gastroenterology2017，23，21： | 1 |
| 12 | Water and electrolyte content of human intervertebral disc under variable load 显示文摘 | Kraemer J Koldditz D Gowin R | 1985 | Spine1985，10，4： | 1 |
| 13 | Osteoporosis changes the amount of vertebral trabecular bone at risk of fracture but not the vertebral load distribution显示文摘 | Homminga J Weinans H Gowin W | 2001 | Spine (Phila Pa 1976)2001，26，14： | 1 |
| 14 | Osteoporosis changes the amount of vertebral trabecular bone at risk of fracture but not the vertebral load distribution显示文摘 | Homminga J Weinans H Gowin W | 2001 | Spine2001，26，： | 1 |
| 15 | Reverseburngasifi -cation for treatment of hazardous wastes: contaminated soil, mixed wastes, and spent activated carbon regeneration 显示文摘 | Kinner L L Mc Gowin A Manahan S E | 1993 | Environ Sci & Technol1993，27，： | 1 |
| 16 | Influence of lean and fat mass on bone mineral density (BMD) in postmenopausal women with osteoporosis 显示文摘 | Dyffeld J Ignaszak-Szczepaniak M Gowin E | 2011 | Arch Gerontol Geriatr2011，53，2： | 1 |
| 17 | Persistent Mycoplasma genitalium infection of human endocervical epithelial cells elicits chronicinflammatory cytokine secretion显示文摘 | Mc Gowin CL Annan RS Quayle AJ | 2012 | Infect Immun2012，80，11： | 1 |
| 18 | Osteoporosis change the of amount of vertebral trabecular bone at risk of fracture but not the vertebral load distribution显示文摘 | Weinans H Gowin W | 2001 | Spine2001，26，： | 1 |
| 19 | Sreening of composite for PAHs and pesticides using static subcritical water extraction显示文摘 | AUDREY E GOWIN M ADOM K K | 2001 | Chemosphere2001，45，： | 1 |
| 20 | Water and electrolyte content of human intervertebral discs under variable load 显示文摘 | Kr met J Kolditz D Gowin R | 1985 | Spine1985，10，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员